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Q59SJ9

- DPH2_CANAL

UniProt

Q59SJ9 - DPH2_CANAL

Protein

Diphthamide biosynthesis protein 2

Gene

DPH2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 By similarity.By similarity

    Pathwayi

    GO - Biological processi

    1. peptidyl-diphthamide biosynthetic process from peptidyl-histidine Source: UniProtKB-UniPathway

    Enzyme and pathway databases

    UniPathwayiUPA00559.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diphthamide biosynthesis protein 2
    Gene namesi
    Name:DPH2
    ORF Names:CaO19.11649, CaO19.1174, CaO19.13123, CaO19.4173, CaO19.5678
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005815. orf19.4173.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Diphthamide biosynthesis protein 2PRO_0000083384Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0000723.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59SJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DPH1/DPH2 family. DPH2 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG1736.
    KOiK17866.
    OrthoDBiEOG7D59X9.

    Family and domain databases

    InterProiIPR010014. DHP2_eu.
    IPR002728. DPH1/DPH2.
    [Graphical view]
    PANTHERiPTHR10762. PTHR10762. 1 hit.
    PTHR10762:SF2. PTHR10762:SF2. 1 hit.
    PfamiPF01866. Diphthamide_syn. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00322. diphth2_R. 1 hit.
    TIGR00272. DPH2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59SJ9-1 [UniParc]FASTAAdd to Basket

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    MTSETVIAPS LSTAQNDGTF TYDKVKSTAK ERKHLNLKNP SDANEIKSKI    50
    WNYYSLSELI QYLGQKENDD FKYKRITLQF PDNLICDSAT IVHELQRELN 100
    IVPQANQDTG ESNTAQRVWI LADTSYSACC VDEVAAEHVR SDLVVHFGDA 150
    CLNEIDKLQA VFVLGKPTLD VDAIVKQIKT AYSTEQKVVL MSDAPHTYLL 200
    PEIAKQLPDY DILIADLPKT SRAKIIGYTP PPTGHKKFNR VFNTDTVEFG 250
    EYELFHITSP ESPRLLQLTT NFASVTTYDP ISGTVSTGPF PNLMRRYKYV 300
    HQARMAGTVG ILVNTLSLAN TKVLLNTIKE EIKEAGKKHY IFVVGKPNVA 350
    KLANFESVDI WCILGCDHQG IIIDQINEYY KPIVTPYELL LGLSDELSWT 400
    GKWVVDYKSV LEEYGNEVIQ QNEDPDTDED LPPVFDPVTG RYVSTSKPLR 450
    QINHLMVTSS EQGGVDDHDN QLVKRFSNAV AIKGTVSTSA IHLQNRHWTG 500
    LGSDYTEDEN ATGALVEDGR KGIARGYDI 529
    Length:529
    Mass (Da):59,200
    Last modified:April 26, 2005 - v1
    Checksum:iB349DD84ACA4F05F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000151 Genomic DNA. Translation: EAK93452.1.
    AACQ01000146 Genomic DNA. Translation: EAK93606.1.
    AACQ01000129 Genomic DNA. Translation: EAK94242.1.
    AACQ01000128 Genomic DNA. Translation: EAK94289.1.
    AACQ01000370 Genomic DNA. Translation: EAK90746.1.
    RefSeqiXP_710022.1. XM_704930.1.
    XP_712627.1. XM_707534.1.
    XP_712777.1. XM_707684.1.
    XP_713359.1. XM_708266.1.
    XP_713406.1. XM_708313.1.

    Genome annotation databases

    GeneIDi3644993.
    3645013.
    3645606.
    3645752.
    3648380.
    KEGGical:CaO19.11649.
    cal:CaO19.1174.
    cal:CaO19.13123.
    cal:CaO19.4173.
    cal:CaO19.5678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000151 Genomic DNA. Translation: EAK93452.1 .
    AACQ01000146 Genomic DNA. Translation: EAK93606.1 .
    AACQ01000129 Genomic DNA. Translation: EAK94242.1 .
    AACQ01000128 Genomic DNA. Translation: EAK94289.1 .
    AACQ01000370 Genomic DNA. Translation: EAK90746.1 .
    RefSeqi XP_710022.1. XM_704930.1.
    XP_712627.1. XM_707534.1.
    XP_712777.1. XM_707684.1.
    XP_713359.1. XM_708266.1.
    XP_713406.1. XM_708313.1.

    3D structure databases

    ProteinModelPortali Q59SJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000723.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3644993.
    3645013.
    3645606.
    3645752.
    3648380.
    KEGGi cal:CaO19.11649.
    cal:CaO19.1174.
    cal:CaO19.13123.
    cal:CaO19.4173.
    cal:CaO19.5678.

    Organism-specific databases

    CGDi CAL0005815. orf19.4173.

    Phylogenomic databases

    eggNOGi COG1736.
    KOi K17866.
    OrthoDBi EOG7D59X9.

    Enzyme and pathway databases

    UniPathwayi UPA00559 .

    Family and domain databases

    InterProi IPR010014. DHP2_eu.
    IPR002728. DPH1/DPH2.
    [Graphical view ]
    PANTHERi PTHR10762. PTHR10762. 1 hit.
    PTHR10762:SF2. PTHR10762:SF2. 1 hit.
    Pfami PF01866. Diphthamide_syn. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00322. diphth2_R. 1 hit.
    TIGR00272. DPH2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiDPH2_CANAL
    AccessioniPrimary (citable) accession number: Q59SJ9
    Secondary accession number(s): Q59JU1, Q59UP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3