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Protein

Diphthamide biosynthesis protein 2

Gene

DPH2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. peptidyl-diphthamide biosynthetic process from peptidyl-histidine Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

UniPathwayiUPA00559.

Names & Taxonomyi

Protein namesi
Recommended name:
Diphthamide biosynthesis protein 2
Gene namesi
Name:DPH2
ORF Names:CaO19.11649, CaO19.1174, CaO19.13123, CaO19.4173, CaO19.5678
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005815. orf19.4173.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Diphthamide biosynthesis protein 2PRO_0000083384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000723.

Structurei

3D structure databases

ProteinModelPortaliQ59SJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH2 subfamily.Curated

Phylogenomic databases

eggNOGiCOG1736.
InParanoidiQ59SJ9.
KOiK17866.
OrthoDBiEOG7D59X9.

Family and domain databases

InterProiIPR010014. DHP2_eu.
IPR016435. DPH1/DPH2.
[Graphical view]
PANTHERiPTHR10762. PTHR10762. 1 hit.
PTHR10762:SF2. PTHR10762:SF2. 1 hit.
PfamiPF01866. Diphthamide_syn. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00322. diphth2_R. 1 hit.
TIGR00272. DPH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59SJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSETVIAPS LSTAQNDGTF TYDKVKSTAK ERKHLNLKNP SDANEIKSKI
60 70 80 90 100
WNYYSLSELI QYLGQKENDD FKYKRITLQF PDNLICDSAT IVHELQRELN
110 120 130 140 150
IVPQANQDTG ESNTAQRVWI LADTSYSACC VDEVAAEHVR SDLVVHFGDA
160 170 180 190 200
CLNEIDKLQA VFVLGKPTLD VDAIVKQIKT AYSTEQKVVL MSDAPHTYLL
210 220 230 240 250
PEIAKQLPDY DILIADLPKT SRAKIIGYTP PPTGHKKFNR VFNTDTVEFG
260 270 280 290 300
EYELFHITSP ESPRLLQLTT NFASVTTYDP ISGTVSTGPF PNLMRRYKYV
310 320 330 340 350
HQARMAGTVG ILVNTLSLAN TKVLLNTIKE EIKEAGKKHY IFVVGKPNVA
360 370 380 390 400
KLANFESVDI WCILGCDHQG IIIDQINEYY KPIVTPYELL LGLSDELSWT
410 420 430 440 450
GKWVVDYKSV LEEYGNEVIQ QNEDPDTDED LPPVFDPVTG RYVSTSKPLR
460 470 480 490 500
QINHLMVTSS EQGGVDDHDN QLVKRFSNAV AIKGTVSTSA IHLQNRHWTG
510 520
LGSDYTEDEN ATGALVEDGR KGIARGYDI
Length:529
Mass (Da):59,200
Last modified:April 25, 2005 - v1
Checksum:iB349DD84ACA4F05F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000151 Genomic DNA. Translation: EAK93452.1.
AACQ01000146 Genomic DNA. Translation: EAK93606.1.
AACQ01000129 Genomic DNA. Translation: EAK94242.1.
AACQ01000128 Genomic DNA. Translation: EAK94289.1.
AACQ01000370 Genomic DNA. Translation: EAK90746.1.
RefSeqiXP_710022.1. XM_704930.1.
XP_712627.1. XM_707534.1.
XP_712777.1. XM_707684.1.
XP_713359.1. XM_708266.1.
XP_713406.1. XM_708313.1.

Genome annotation databases

GeneIDi3644993.
3645013.
3645606.
3645752.
3648380.
KEGGical:CaO19.11649.
cal:CaO19.1174.
cal:CaO19.13123.
cal:CaO19.4173.
cal:CaO19.5678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000151 Genomic DNA. Translation: EAK93452.1.
AACQ01000146 Genomic DNA. Translation: EAK93606.1.
AACQ01000129 Genomic DNA. Translation: EAK94242.1.
AACQ01000128 Genomic DNA. Translation: EAK94289.1.
AACQ01000370 Genomic DNA. Translation: EAK90746.1.
RefSeqiXP_710022.1. XM_704930.1.
XP_712627.1. XM_707534.1.
XP_712777.1. XM_707684.1.
XP_713359.1. XM_708266.1.
XP_713406.1. XM_708313.1.

3D structure databases

ProteinModelPortaliQ59SJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0000723.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3644993.
3645013.
3645606.
3645752.
3648380.
KEGGical:CaO19.11649.
cal:CaO19.1174.
cal:CaO19.13123.
cal:CaO19.4173.
cal:CaO19.5678.

Organism-specific databases

CGDiCAL0005815. orf19.4173.

Phylogenomic databases

eggNOGiCOG1736.
InParanoidiQ59SJ9.
KOiK17866.
OrthoDBiEOG7D59X9.

Enzyme and pathway databases

UniPathwayiUPA00559.

Family and domain databases

InterProiIPR010014. DHP2_eu.
IPR016435. DPH1/DPH2.
[Graphical view]
PANTHERiPTHR10762. PTHR10762. 1 hit.
PTHR10762:SF2. PTHR10762:SF2. 1 hit.
PfamiPF01866. Diphthamide_syn. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00322. diphth2_R. 1 hit.
TIGR00272. DPH2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiDPH2_CANAL
AccessioniPrimary (citable) accession number: Q59SJ9
Secondary accession number(s): Q59JU1, Q59UP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2005
Last sequence update: April 25, 2005
Last modified: March 31, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.