Q59SJ9 (DPH2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diphthamide biosynthesis protein 2

Gene names

Name:	DPH2
ORF Names:	CaO19.11649, CaO19.1174, CaO19.13123, CaO19.4173, CaO19.5678

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the DPH1/DPH2 family. DPH2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-diphthamide biosynthetic process from peptidyl-histidine Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Diphthamide biosynthesis protein 2		PRO_0000083384

Sequences

	Sequence		Length	Mass (Da)
	Q59SJ9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: B349DD84ACA4F05F	FASTA	529	59,200
	10 20 30 40 50 60 MTSETVIAPS LSTAQNDGTF TYDKVKSTAK ERKHLNLKNP SDANEIKSKI WNYYSLSELI 70 80 90 100 110 120 QYLGQKENDD FKYKRITLQF PDNLICDSAT IVHELQRELN IVPQANQDTG ESNTAQRVWI 130 140 150 160 170 180 LADTSYSACC VDEVAAEHVR SDLVVHFGDA CLNEIDKLQA VFVLGKPTLD VDAIVKQIKT 190 200 210 220 230 240 AYSTEQKVVL MSDAPHTYLL PEIAKQLPDY DILIADLPKT SRAKIIGYTP PPTGHKKFNR 250 260 270 280 290 300 VFNTDTVEFG EYELFHITSP ESPRLLQLTT NFASVTTYDP ISGTVSTGPF PNLMRRYKYV 310 320 330 340 350 360 HQARMAGTVG ILVNTLSLAN TKVLLNTIKE EIKEAGKKHY IFVVGKPNVA KLANFESVDI 370 380 390 400 410 420 WCILGCDHQG IIIDQINEYY KPIVTPYELL LGLSDELSWT GKWVVDYKSV LEEYGNEVIQ 430 440 450 460 470 480 QNEDPDTDED LPPVFDPVTG RYVSTSKPLR QINHLMVTSS EQGGVDDHDN QLVKRFSNAV 490 500 510 520 AIKGTVSTSA IHLQNRHWTG LGSDYTEDEN ATGALVEDGR KGIARGYDI

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000151 Genomic DNA. Translation: EAK93452.1. AACQ01000146 Genomic DNA. Translation: EAK93606.1. AACQ01000129 Genomic DNA. Translation: EAK94242.1. AACQ01000128 Genomic DNA. Translation: EAK94289.1. AACQ01000370 Genomic DNA. Translation: EAK90746.1.
RefSeq	XP_710022.1. XM_704930.1. XP_712627.1. XM_707534.1. XP_712777.1. XM_707684.1. XP_713359.1. XM_708266.1. XP_713406.1. XM_708313.1.
3D structure databases
ProteinModelPortal	Q59SJ9.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000723.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3644993. 3645013. 3645606. 3645752. 3648380.
KEGG	cal:CaO19.11649. cal:CaO19.1174. cal:CaO19.13123. cal:CaO19.4173. cal:CaO19.5678.
Organism-specific databases
CGD	CAL0005815. orf19.4173.
Phylogenomic databases
eggNOG	COG1736.
Family and domain databases
InterPro	IPR010014. DHP2_eu. IPR002728. DPH1/DPH2. [Graphical view]
PANTHER	PTHR10762. PTHR10762. 1 hit. PTHR10762:SF2. PTHR10762:SF2. 1 hit.
Pfam	PF01866. Diphthamide_syn. 1 hit. [Graphical view]
TIGRFAMs	TIGR00322. diphth2_R. 1 hit. TIGR00272. DPH2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DPH2_CANAL

Accession

Primary (citable) accession number: Q59SJ9
Secondary accession number(s): Q59JU1, Q59UP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program