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Q59SJ9 (DPH2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Diphthamide biosynthesis protein 2
Gene names
Name:DPH2
ORF Names:CaO19.11649, CaO19.1174, CaO19.13123, CaO19.4173, CaO19.5678
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 By similarity.

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpeptidyl-diphthamide biosynthetic process from peptidyl-histidine

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Diphthamide biosynthesis protein 2
PRO_0000083384

Sequences

Sequence LengthMass (Da)Tools
Q59SJ9 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: B349DD84ACA4F05F

FASTA52959,200
        10         20         30         40         50         60 
MTSETVIAPS LSTAQNDGTF TYDKVKSTAK ERKHLNLKNP SDANEIKSKI WNYYSLSELI 

        70         80         90        100        110        120 
QYLGQKENDD FKYKRITLQF PDNLICDSAT IVHELQRELN IVPQANQDTG ESNTAQRVWI 

       130        140        150        160        170        180 
LADTSYSACC VDEVAAEHVR SDLVVHFGDA CLNEIDKLQA VFVLGKPTLD VDAIVKQIKT 

       190        200        210        220        230        240 
AYSTEQKVVL MSDAPHTYLL PEIAKQLPDY DILIADLPKT SRAKIIGYTP PPTGHKKFNR 

       250        260        270        280        290        300 
VFNTDTVEFG EYELFHITSP ESPRLLQLTT NFASVTTYDP ISGTVSTGPF PNLMRRYKYV 

       310        320        330        340        350        360 
HQARMAGTVG ILVNTLSLAN TKVLLNTIKE EIKEAGKKHY IFVVGKPNVA KLANFESVDI 

       370        380        390        400        410        420 
WCILGCDHQG IIIDQINEYY KPIVTPYELL LGLSDELSWT GKWVVDYKSV LEEYGNEVIQ 

       430        440        450        460        470        480 
QNEDPDTDED LPPVFDPVTG RYVSTSKPLR QINHLMVTSS EQGGVDDHDN QLVKRFSNAV 

       490        500        510        520 
AIKGTVSTSA IHLQNRHWTG LGSDYTEDEN ATGALVEDGR KGIARGYDI 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000151 Genomic DNA. Translation: EAK93452.1.
AACQ01000146 Genomic DNA. Translation: EAK93606.1.
AACQ01000129 Genomic DNA. Translation: EAK94242.1.
AACQ01000128 Genomic DNA. Translation: EAK94289.1.
AACQ01000370 Genomic DNA. Translation: EAK90746.1.
RefSeqXP_710022.1. XM_704930.1.
XP_712627.1. XM_707534.1.
XP_712777.1. XM_707684.1.
XP_713359.1. XM_708266.1.
XP_713406.1. XM_708313.1.

3D structure databases

ProteinModelPortalQ59SJ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000723.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3644993.
3645013.
3645606.
3645752.
3648380.
KEGGcal:CaO19.11649.
cal:CaO19.1174.
cal:CaO19.13123.
cal:CaO19.4173.
cal:CaO19.5678.

Organism-specific databases

CGDCAL0005815. orf19.4173.

Phylogenomic databases

eggNOGCOG1736.
KOK17866.
OrthoDBEOG7D59X9.

Enzyme and pathway databases

UniPathwayUPA00559.

Family and domain databases

InterProIPR010014. DHP2_eu.
IPR002728. DPH1/DPH2.
[Graphical view]
PANTHERPTHR10762. PTHR10762. 1 hit.
PTHR10762:SF2. PTHR10762:SF2. 1 hit.
PfamPF01866. Diphthamide_syn. 1 hit.
[Graphical view]
TIGRFAMsTIGR00322. diphth2_R. 1 hit.
TIGR00272. DPH2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPH2_CANAL
AccessionPrimary (citable) accession number: Q59SJ9
Secondary accession number(s): Q59JU1, Q59UP2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names