Q59SI5 (MMM1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maintenance of mitochondrial morphology protein 1

Gene names

Name:	MMM1
ORF Names:	CaO19.11664, CaO19.4187

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids By similarity. HAMAP-Rule MF_03103
Subunit structure	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34 By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids By similarity. HAMAP-Rule MF_03103
Sequence similarities	Belongs to the MMM1 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Maintenance of mitochondrial morphology protein 1 HAMAP-Rule MF_03103		PRO_0000384221
Regions
	Topological domain	1 – 76	76	Lumenal By similarity
	Transmembrane	77 – 97	21	Helical; Potential
	Topological domain	98 – 439	342	Cytoplasmic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59SI5 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 0708C94CFC9402F6	FASTA	439	49,018
	10 20 30 40 50 60 MSQDLIETTA TTTKIVEARE LGHQIHDSLL EQLKLQQEEL LQQQRDLFFQ EQQLQLQQQV 70 80 90 100 110 120 TQPVSNNGNT WSFTQGLVIG QVSVIFIIIV FVKFFVFADS SSHIPTKPGL DGATGVIVKR 130 140 150 160 170 180 NKNKKHSNGQ FANDGENEDD TSLDSNQSKI SSILEKTYYD VNNHASESLD WFNVLVAQTI 190 200 210 220 230 240 SQLRSEALLK DNIYHSLNNF LTNAKLPDFI DTINLTEIDI GDDFPIFSNC RIKYGEDLKR 250 260 270 280 290 300 LEAKIDVDLS DTLTLGIATK LLLNQPRPLT AVLPVSMTVS IVRFSGCLTV SLINTKDIDL 310 320 330 340 350 360 KNVDKTSNMN GYSKENANGD GASSSNNDED EDDGGTALMF SFSPDYRLEF IVKSLIGSRA 370 380 390 400 410 420 KLQDVPKISS LIENQLRTWF IERCVEPRFQ VVRLPSLWPR TKNTREPVTK KTTTTPSTTV 430 NGTSAATVTT PGEYVNSNI

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000151 Genomic DNA. Translation: EAK93466.1. AACQ01000146 Genomic DNA. Translation: EAK93621.1.
RefSeq	XP_712641.1. XM_707548.1. XP_712792.1. XM_707699.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005858.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645589. 3645744.
KEGG	cal:CaO19.11664. cal:CaO19.4187.
Organism-specific databases
CGD	CAL0005858. orf19.4187.
Phylogenomic databases
eggNOG	NOG79949.
Family and domain databases
HAMAP	MF_03103. Mmm1.
InterPro	IPR019411. DUF2404. [Graphical view]
Pfam	PF10296. DUF2404. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MMM1_CANAL

Accession

Primary (citable) accession number: Q59SI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program