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Protein

Mitochondrial import inner membrane translocase subunit TIM14

Gene

PAM18

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM14
Alternative name(s):
Presequence translocated-associated motor subunit PAM18
Gene namesi
Name:PAM18
Synonyms:TIM14
ORF Names:CaO19.11667, CaO19.4190
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005879. orf19.4190.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei57 – 7418HelicalSequence AnalysisAdd
BLAST
Topological domaini75 – 15783Mitochondrial matrixSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Mitochondrial import inner membrane translocase subunit TIM14PRO_0000071109Add
BLAST

Interactioni

Subunit structurei

Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59SI2.
SMRiQ59SI2. Positions 85-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 15759JPROSITE-ProRule annotationAdd
BLAST

Domaini

The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.By similarity

Sequence similaritiesi

Belongs to the TIM14 family.Curated
Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2214.
InParanoidiQ59SI2.
KOiK09539.
OrthoDBiEOG7FFN55.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59SI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLEAPILA IPGENNTHQQ QQQQFQYTGQ LQKKKAAEGS IEWYFDQTIN
60 70 80 90 100
FMGDHPVITG IGAFAVAYFA AGFIKSNQPG INGKAFVKGG FGAKMTAKEA
110 120 130 140 150
LQILNLKETN LSKLKLKEQH RKLMMANHPD KGGSSYIATK INEAKDFLDK

RGGMKPK
Length:157
Mass (Da):17,297
Last modified:April 26, 2005 - v1
Checksum:i764D3BD9383B7366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000151 Genomic DNA. Translation: EAK93469.1.
AACQ01000146 Genomic DNA. Translation: EAK93624.1.
RefSeqiXP_712644.1. XM_707551.1.
XP_712795.1. XM_707702.1.

Genome annotation databases

GeneIDi3645592.
3645747.
KEGGical:CaO19.11667.
cal:CaO19.4190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000151 Genomic DNA. Translation: EAK93469.1.
AACQ01000146 Genomic DNA. Translation: EAK93624.1.
RefSeqiXP_712644.1. XM_707551.1.
XP_712795.1. XM_707702.1.

3D structure databases

ProteinModelPortaliQ59SI2.
SMRiQ59SI2. Positions 85-152.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3645592.
3645747.
KEGGical:CaO19.11667.
cal:CaO19.4190.

Organism-specific databases

CGDiCAL0005879. orf19.4190.

Phylogenomic databases

eggNOGiCOG2214.
InParanoidiQ59SI2.
KOiK09539.
OrthoDBiEOG7FFN55.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTIM14_CANAL
AccessioniPrimary (citable) accession number: Q59SI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: June 24, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.