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Q59SI2

- TIM14_CANAL

UniProt

Q59SI2 - TIM14_CANAL

Protein

Mitochondrial import inner membrane translocase subunit TIM14

Gene

PAM18

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) By similarity.By similarity

    GO - Biological processi

    1. protein import into mitochondrial matrix Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import inner membrane translocase subunit TIM14
    Alternative name(s):
    Presequence translocated-associated motor subunit PAM18
    Gene namesi
    Name:PAM18
    Synonyms:TIM14
    ORF Names:CaO19.11667, CaO19.4190
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005879. orf19.4190.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane presequence translocase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157Mitochondrial import inner membrane translocase subunit TIM14PRO_0000071109Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005879.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59SI2.
    SMRiQ59SI2. Positions 85-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini75 – 15783Mitochondrial matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7418HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini99 – 15759JPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.By similarity

    Sequence similaritiesi

    Belongs to the TIM14 family.Curated
    Contains 1 J domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2214.
    KOiK09539.
    OrthoDBiEOG7FFN55.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR027134. Tim14.
    [Graphical view]
    PANTHERiPTHR12763:SF28. PTHR12763:SF28. 1 hit.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59SI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLEAPILA IPGENNTHQQ QQQQFQYTGQ LQKKKAAEGS IEWYFDQTIN    50
    FMGDHPVITG IGAFAVAYFA AGFIKSNQPG INGKAFVKGG FGAKMTAKEA 100
    LQILNLKETN LSKLKLKEQH RKLMMANHPD KGGSSYIATK INEAKDFLDK 150
    RGGMKPK 157
    Length:157
    Mass (Da):17,297
    Last modified:April 26, 2005 - v1
    Checksum:i764D3BD9383B7366
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000151 Genomic DNA. Translation: EAK93469.1.
    AACQ01000146 Genomic DNA. Translation: EAK93624.1.
    RefSeqiXP_712644.1. XM_707551.1.
    XP_712795.1. XM_707702.1.

    Genome annotation databases

    GeneIDi3645592.
    3645747.
    KEGGical:CaO19.11667.
    cal:CaO19.4190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000151 Genomic DNA. Translation: EAK93469.1 .
    AACQ01000146 Genomic DNA. Translation: EAK93624.1 .
    RefSeqi XP_712644.1. XM_707551.1.
    XP_712795.1. XM_707702.1.

    3D structure databases

    ProteinModelPortali Q59SI2.
    SMRi Q59SI2. Positions 85-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645592.
    3645747.
    KEGGi cal:CaO19.11667.
    cal:CaO19.4190.

    Organism-specific databases

    CGDi CAL0005879. orf19.4190.

    Phylogenomic databases

    eggNOGi COG2214.
    KOi K09539.
    OrthoDBi EOG7FFN55.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR027134. Tim14.
    [Graphical view ]
    PANTHERi PTHR12763:SF28. PTHR12763:SF28. 1 hit.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiTIM14_CANAL
    AccessioniPrimary (citable) accession number: Q59SI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3