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Q59SI2 (TIM14_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import inner membrane translocase subunit TIM14
Alternative name(s):
Presequence translocated-associated motor subunit PAM18
Gene names
Name:PAM18
Synonyms:TIM14
ORF Names:CaO19.11667, CaO19.4190
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) By similarity.

Subunit structure

Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 By similarity.

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein By similarity.

Domain

The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16 By similarity.

Sequence similarities

Belongs to the TIM14 family.

Contains 1 J domain.

Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Mitochondrial import inner membrane translocase subunit TIM14
PRO_0000071109

Regions

Topological domain1 – 5656Mitochondrial intermembrane Potential
Transmembrane57 – 7418Helical; Potential
Topological domain75 – 15783Mitochondrial matrix Potential
Domain99 – 15759J

Sequences

Sequence LengthMass (Da)Tools
Q59SI2 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 764D3BD9383B7366

FASTA15717,297
        10         20         30         40         50         60 
MAPLEAPILA IPGENNTHQQ QQQQFQYTGQ LQKKKAAEGS IEWYFDQTIN FMGDHPVITG 

        70         80         90        100        110        120 
IGAFAVAYFA AGFIKSNQPG INGKAFVKGG FGAKMTAKEA LQILNLKETN LSKLKLKEQH 

       130        140        150 
RKLMMANHPD KGGSSYIATK INEAKDFLDK RGGMKPK 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000151 Genomic DNA. Translation: EAK93469.1.
AACQ01000146 Genomic DNA. Translation: EAK93624.1.
RefSeqXP_712644.1. XM_707551.1.
XP_712795.1. XM_707702.1.

3D structure databases

ProteinModelPortalQ59SI2.
SMRQ59SI2. Positions 85-152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005879.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645592.
3645747.
KEGGcal:CaO19.11667.
cal:CaO19.4190.

Organism-specific databases

CGDCAL0005879. orf19.4190.

Phylogenomic databases

eggNOGCOG2214.
KOK09539.
OrthoDBEOG7FFN55.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
InterProIPR001623. DnaJ_domain.
[Graphical view]
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
PROSITEPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTIM14_CANAL
AccessionPrimary (citable) accession number: Q59SI2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names