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Protein

Mitochondrial import inner membrane translocase subunit TIM14

Gene

PAM18

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM14
Alternative name(s):
Presequence translocated-associated motor subunit PAM18
Gene namesi
Name:PAM18
Synonyms:TIM14
Ordered Locus Names:CAALFM_C400520WA
ORF Names:CaO19.11667, CaO19.4190
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Organism-specific databases

CGDiCAL0000200634 PAM18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56Mitochondrial intermembraneSequence analysisAdd BLAST56
Transmembranei57 – 74HelicalSequence analysisAdd BLAST18
Topological domaini75 – 157Mitochondrial matrixSequence analysisAdd BLAST83

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000711091 – 157Mitochondrial import inner membrane translocase subunit TIM14Add BLAST157

Proteomic databases

PRIDEiQ59SI2

Interactioni

Subunit structurei

Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59SI2
SMRiQ59SI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 157JPROSITE-ProRule annotationAdd BLAST59

Domaini

The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.By similarity

Sequence similaritiesi

Belongs to the TIM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ59SI2
KOiK09539
OMAiMANHPDK
OrthoDBiEOG092C5SDV

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q59SI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLEAPILA IPGENNTHQQ QQQQFQYTGQ LQKKKAAEGS IEWYFDQTIN
60 70 80 90 100
FMGDHPVITG IGAFAVAYFA AGFIKSNQPG INGKAFVKGG FGAKMTAKEA
110 120 130 140 150
LQILNLKETN LSKLKLKEQH RKLMMANHPD KGGSSYIATK INEAKDFLDK

RGGMKPK
Length:157
Mass (Da):17,297
Last modified:April 26, 2005 - v1
Checksum:i764D3BD9383B7366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA Translation: AOW28845.1
RefSeqiXP_712644.1, XM_707551.1

Genome annotation databases

EnsemblFungiiAOW28845; AOW28845; CAALFM_C400520WA
GeneIDi3645747
KEGGical:CAALFM_C400520WA

Similar proteinsi

Entry informationi

Entry nameiTIM14_CANAL
AccessioniPrimary (citable) accession number: Q59SI2
Secondary accession number(s): A0A1D8PL20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health