SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q59SI2

- TIM14_CANAL

UniProt

Q59SI2 - TIM14_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitochondrial import inner membrane translocase subunit TIM14

Gene
PAM18, TIM14, CaO19.11667, CaO19.4190
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) By similarity.

GO - Biological processi

  1. protein import into mitochondrial matrix Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM14
Alternative name(s):
Presequence translocated-associated motor subunit PAM18
Gene namesi
Name:PAM18
Synonyms:TIM14
ORF Names:CaO19.11667, CaO19.4190
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005879. orf19.4190.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei57 – 7418Helical; Reviewed predictionAdd
BLAST
Topological domaini75 – 15783Mitochondrial matrix Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Mitochondrial import inner membrane translocase subunit TIM14PRO_0000071109Add
BLAST

Interactioni

Subunit structurei

Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0005879.

Structurei

3D structure databases

ProteinModelPortaliQ59SI2.
SMRiQ59SI2. Positions 85-152.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 15759JAdd
BLAST

Domaini

The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16 By similarity.

Sequence similaritiesi

Belongs to the TIM14 family.
Contains 1 J domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2214.
KOiK09539.
OrthoDBiEOG7FFN55.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR027134. Tim14.
[Graphical view]
PANTHERiPTHR12763:SF28. PTHR12763:SF28. 1 hit.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59SI2-1 [UniParc]FASTAAdd to Basket

« Hide

MAPLEAPILA IPGENNTHQQ QQQQFQYTGQ LQKKKAAEGS IEWYFDQTIN    50
FMGDHPVITG IGAFAVAYFA AGFIKSNQPG INGKAFVKGG FGAKMTAKEA 100
LQILNLKETN LSKLKLKEQH RKLMMANHPD KGGSSYIATK INEAKDFLDK 150
RGGMKPK 157
Length:157
Mass (Da):17,297
Last modified:April 26, 2005 - v1
Checksum:i764D3BD9383B7366
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000151 Genomic DNA. Translation: EAK93469.1.
AACQ01000146 Genomic DNA. Translation: EAK93624.1.
RefSeqiXP_712644.1. XM_707551.1.
XP_712795.1. XM_707702.1.

Genome annotation databases

GeneIDi3645592.
3645747.
KEGGical:CaO19.11667.
cal:CaO19.4190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000151 Genomic DNA. Translation: EAK93469.1 .
AACQ01000146 Genomic DNA. Translation: EAK93624.1 .
RefSeqi XP_712644.1. XM_707551.1.
XP_712795.1. XM_707702.1.

3D structure databases

ProteinModelPortali Q59SI2.
SMRi Q59SI2. Positions 85-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645592.
3645747.
KEGGi cal:CaO19.11667.
cal:CaO19.4190.

Organism-specific databases

CGDi CAL0005879. orf19.4190.

Phylogenomic databases

eggNOGi COG2214.
KOi K09539.
OrthoDBi EOG7FFN55.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
IPR027134. Tim14.
[Graphical view ]
PANTHERi PTHR12763:SF28. PTHR12763:SF28. 1 hit.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTIM14_CANAL
AccessioniPrimary (citable) accession number: Q59SI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi