ID   LPE10_CANAL             Reviewed;         453 AA.
AC   Q59S85; A0A1D8PPV1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter LPE10;
DE   Flags: Precursor;
GN   Name=LPE10; OrderedLocusNames=CAALFM_C602150CA;
GN   ORFNames=CaO19.10959, CaO19.3455;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Mitochondrial inner membrane magnesium transporter required
CC       for mitochondrial magnesium homeostasis. Modulates the conductance of
CC       the MRS2 channel. Involved in the splicing of mRNA group II introns in
CC       mitochondria by affecting mitochondrial magnesium concentrations, which
CC       are critical for group II intron splicing.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBUNIT: Forms homooligomers. Interacts with MRS2.
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q02783}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q02783}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CP017628; AOW30150.1; -; Genomic_DNA.
DR   RefSeq; XP_712495.2; XM_707402.2.
DR   AlphaFoldDB; Q59S85; -.
DR   SMR; Q59S85; -.
DR   EnsemblFungi; C6_02150C_A-T; C6_02150C_A-T-p1; C6_02150C_A.
DR   GeneID; 3645888; -.
DR   KEGG; cal:CAALFM_C602150CA; -.
DR   CGD; CAL0000183380; orf19.10959.
DR   VEuPathDB; FungiDB:C6_02150C_A; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q59S85; -.
DR   OrthoDB; 73031at2759; -.
DR   PRO; PR:Q59S85; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   Gene3D; 2.40.128.330; -; 1.
DR   Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890:SF26; MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13890; RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..19
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..453
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   LPE10"
FT                   /id="PRO_0000043236"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          108..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           400..403
FT                   /note="YGMN"
SQ   SEQUENCE   453 AA;  51091 MW;  D637CD86460DCEAA CRC64;
     MIPIRSSITR ILPNGFLSKP FLRQLNKKSK PNPHKNKNFD SFNEVFIHKT LLSSIKQHND
     TDYVRCSIFN ANGDMIQHGK EILKSQFIKR YNLTPRDFRK FNWQRSATGT TTTSSSSSSS
     AGQTSSGTSK SSSSSSSSSS PHSTISALSL SNSSLGSSTN VDIVPNITIR RNSILVQLLN
     IRALINHDQL IIFDNSSSFQ NSHVSSYTHS QCLKDLSQRL KSTNLDGLPF EFKALEGILI
     YIVSNLNMEM KVHNTVLQNI ITGLEDSIDR NKLRYLLIES KKIHQFHRKI TLIKNCLEDL
     LENDDELNDL YITEKFNSEG DGQPRQGTNH EEIEMLLENY YQTIDEIVQI VENLKNQIKT
     TEDLINVVLD SNRNQLMLLG LKFSTGLLSM GVALYVSALY GMNLENFIEE IDGGFEVVTV
     VSTIALIALL LFSVKQLKKV EKVTMTSLND QRK
//