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Q59S85 (LPE10_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial inner membrane magnesium transporter LPE10
Gene names
Name:LPE10
ORF Names:CaO19.10959, CaO19.3455
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1919Mitochondrion Potential
Chain20 – 453434Mitochondrial inner membrane magnesium transporter LPE10
PRO_0000043236

Regions

Transmembrane376 – 39621Helical; Potential
Transmembrane414 – 43421Helical; Potential
Motif400 – 4034YGMN
Compositional bias113 – 15846Ser-rich

Sequences

Sequence LengthMass (Da)Tools
Q59S85 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 42052F3D16AA8E4F

FASTA45351,123
        10         20         30         40         50         60 
MIPIRSSITR ILPNGFSSKL FLRQLNKKSK PNPHKNKNFD SFNEVFIHKT LLSSINQHND 

        70         80         90        100        110        120 
TDYVRCSIFN ANGDMIQHGK EILKSQFIKR YNLTPRDFRK FNWQRSATGT TTSSSSSSSS 

       130        140        150        160        170        180 
AGQTSSGTSK SSSLSSSSSS PHSTISALSL SNSSLGSSTN VDIVPNITIR RNSILVQLLN 

       190        200        210        220        230        240 
IRALINHDQL IIFDNSSSFQ NSHVSSYTHS QFLKDLSQRL KSTNLDGLPF EFKALEGILI 

       250        260        270        280        290        300 
YIVSNLNMEM KVHNTVLQNI ITGLEDSIDR NKLRYLLIES KKIHQFHRKI TLIKNCLEDL 

       310        320        330        340        350        360 
LENDDELNDL YITEKFNSEG DGQPRQGTNH EEIEMLLENY YQTIDEIVQI VENLKNQIKT 

       370        380        390        400        410        420 
TEDLINVVLD SNRNQLMLLG LKFSTGLLSM GVALYVSALY GMNLENFIEE IDGGFEVVTV 

       430        440        450 
VSTIALIALL LFSVKQLKKV EKVTMTSLND QRK 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000154 Genomic DNA. Translation: EAK93344.1.
AACQ01000155 Genomic DNA. Translation: EAK93313.1.
RefSeqXP_712495.1. XM_707402.1.
XP_712525.1. XM_707432.1.

3D structure databases

ProteinModelPortalQ59S85.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005011.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645833.
3645888.
KEGGcal:CaO19.10959.
cal:CaO19.3455.

Organism-specific databases

CGDCAL0005011. orf19.3455.

Phylogenomic databases

eggNOGNOG284534.
KOK16075.
OrthoDBEOG7SXWCP.

Family and domain databases

InterProIPR026573. MRS2/LPE10.
[Graphical view]
PANTHERPTHR13890. PTHR13890. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPE10_CANAL
AccessionPrimary (citable) accession number: Q59S85
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names