Q59S85 (LPE10_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial inner membrane magnesium transporter LPE10

Gene names

Name:	LPE10
ORF Names:	CaO19.10959, CaO19.3455

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Magnesium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	magnesium ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 19	19	Mitochondrion Potential
	Chain	20 – 453	434	Mitochondrial inner membrane magnesium transporter LPE10		PRO_0000043236
Regions
	Transmembrane	376 – 396	21	Helical; Potential
	Transmembrane	414 – 434	21	Helical; Potential
	Motif	400 – 403	4	YGMN
	Compositional bias	113 – 158	46	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	Q59S85 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 42052F3D16AA8E4F	FASTA	453	51,123
	10 20 30 40 50 60 MIPIRSSITR ILPNGFSSKL FLRQLNKKSK PNPHKNKNFD SFNEVFIHKT LLSSINQHND 70 80 90 100 110 120 TDYVRCSIFN ANGDMIQHGK EILKSQFIKR YNLTPRDFRK FNWQRSATGT TTSSSSSSSS 130 140 150 160 170 180 AGQTSSGTSK SSSLSSSSSS PHSTISALSL SNSSLGSSTN VDIVPNITIR RNSILVQLLN 190 200 210 220 230 240 IRALINHDQL IIFDNSSSFQ NSHVSSYTHS QFLKDLSQRL KSTNLDGLPF EFKALEGILI 250 260 270 280 290 300 YIVSNLNMEM KVHNTVLQNI ITGLEDSIDR NKLRYLLIES KKIHQFHRKI TLIKNCLEDL 310 320 330 340 350 360 LENDDELNDL YITEKFNSEG DGQPRQGTNH EEIEMLLENY YQTIDEIVQI VENLKNQIKT 370 380 390 400 410 420 TEDLINVVLD SNRNQLMLLG LKFSTGLLSM GVALYVSALY GMNLENFIEE IDGGFEVVTV 430 440 450 VSTIALIALL LFSVKQLKKV EKVTMTSLND QRK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000154 Genomic DNA. Translation: EAK93344.1. AACQ01000155 Genomic DNA. Translation: EAK93313.1.
RefSeq	XP_712495.1. XM_707402.1. XP_712525.1. XM_707432.1.
3D structure databases
ProteinModelPortal	Q59S85.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005011.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645833. 3645888.
KEGG	cal:CaO19.10959. cal:CaO19.3455.
Organism-specific databases
CGD	CAL0005011. orf19.3455.
Phylogenomic databases
eggNOG	NOG284534.
KO	K16075.
Family and domain databases
InterPro	IPR026573. MRS2/LPE10. [Graphical view]
PANTHER	PTHR13890. PTHR13890. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPE10_CANAL

Accession

Primary (citable) accession number: Q59S85

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program