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Protein

Mitochondrial inner membrane magnesium transporter LPE10

Gene

LPE10

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane magnesium transporter LPE10
Gene namesi
Name:LPE10
ORF Names:CaO19.10959, CaO19.3455
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000183380. orf19.3455.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000004323620 – 453Mitochondrial inner membrane magnesium transporter LPE10Add BLAST434

Proteomic databases

PRIDEiQ59S85.

Interactioni

Subunit structurei

Forms homooligomers. Interacts with MRS2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59S85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi400 – 403YGMN4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 158Ser-richAdd BLAST46

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ59S85.
KOiK16075.
OrthoDBiEOG092C23OZ.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59S85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPIRSSITR ILPNGFSSKL FLRQLNKKSK PNPHKNKNFD SFNEVFIHKT
60 70 80 90 100
LLSSINQHND TDYVRCSIFN ANGDMIQHGK EILKSQFIKR YNLTPRDFRK
110 120 130 140 150
FNWQRSATGT TTSSSSSSSS AGQTSSGTSK SSSLSSSSSS PHSTISALSL
160 170 180 190 200
SNSSLGSSTN VDIVPNITIR RNSILVQLLN IRALINHDQL IIFDNSSSFQ
210 220 230 240 250
NSHVSSYTHS QFLKDLSQRL KSTNLDGLPF EFKALEGILI YIVSNLNMEM
260 270 280 290 300
KVHNTVLQNI ITGLEDSIDR NKLRYLLIES KKIHQFHRKI TLIKNCLEDL
310 320 330 340 350
LENDDELNDL YITEKFNSEG DGQPRQGTNH EEIEMLLENY YQTIDEIVQI
360 370 380 390 400
VENLKNQIKT TEDLINVVLD SNRNQLMLLG LKFSTGLLSM GVALYVSALY
410 420 430 440 450
GMNLENFIEE IDGGFEVVTV VSTIALIALL LFSVKQLKKV EKVTMTSLND

QRK
Length:453
Mass (Da):51,123
Last modified:April 26, 2005 - v1
Checksum:i42052F3D16AA8E4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000154 Genomic DNA. Translation: EAK93344.1.
AACQ01000155 Genomic DNA. Translation: EAK93313.1.
RefSeqiXP_712495.1. XM_707402.1.
XP_712525.1. XM_707432.1.

Genome annotation databases

EnsemblFungiiEAK93313; EAK93313; CaO19.3455.
EAK93344; EAK93344; CaO19.10959.
GeneIDi3645833.
3645888.
KEGGical:CaO19.10959.
cal:CaO19.3455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000154 Genomic DNA. Translation: EAK93344.1.
AACQ01000155 Genomic DNA. Translation: EAK93313.1.
RefSeqiXP_712495.1. XM_707402.1.
XP_712525.1. XM_707432.1.

3D structure databases

ProteinModelPortaliQ59S85.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59S85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK93313; EAK93313; CaO19.3455.
EAK93344; EAK93344; CaO19.10959.
GeneIDi3645833.
3645888.
KEGGical:CaO19.10959.
cal:CaO19.3455.

Organism-specific databases

CGDiCAL0000183380. orf19.3455.

Phylogenomic databases

InParanoidiQ59S85.
KOiK16075.
OrthoDBiEOG092C23OZ.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLPE10_CANAL
AccessioniPrimary (citable) accession number: Q59S85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.