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Q59S85

- LPE10_CANAL

UniProt

Q59S85 - LPE10_CANAL

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Protein
Mitochondrial inner membrane magnesium transporter LPE10
Gene
LPE10, CaO19.10959, CaO19.3455
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing By similarity.

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane magnesium transporter LPE10
Gene namesi
Name:LPE10
ORF Names:CaO19.10959, CaO19.3455
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005011. orf19.3455.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei376 – 39621Helical; Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1919Mitochondrion Reviewed prediction
Add
BLAST
Chaini20 – 453434Mitochondrial inner membrane magnesium transporter LPE10
PRO_0000043236Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005011.

Structurei

3D structure databases

ProteinModelPortaliQ59S85.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi400 – 4034YGMN

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi113 – 15846Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284534.
KOiK16075.
OrthoDBiEOG7SXWCP.

Family and domain databases

InterProiIPR026573. MRS2/LPE10.
[Graphical view]
PANTHERiPTHR13890. PTHR13890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59S85-1 [UniParc]FASTAAdd to Basket

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MIPIRSSITR ILPNGFSSKL FLRQLNKKSK PNPHKNKNFD SFNEVFIHKT    50
LLSSINQHND TDYVRCSIFN ANGDMIQHGK EILKSQFIKR YNLTPRDFRK 100
FNWQRSATGT TTSSSSSSSS AGQTSSGTSK SSSLSSSSSS PHSTISALSL 150
SNSSLGSSTN VDIVPNITIR RNSILVQLLN IRALINHDQL IIFDNSSSFQ 200
NSHVSSYTHS QFLKDLSQRL KSTNLDGLPF EFKALEGILI YIVSNLNMEM 250
KVHNTVLQNI ITGLEDSIDR NKLRYLLIES KKIHQFHRKI TLIKNCLEDL 300
LENDDELNDL YITEKFNSEG DGQPRQGTNH EEIEMLLENY YQTIDEIVQI 350
VENLKNQIKT TEDLINVVLD SNRNQLMLLG LKFSTGLLSM GVALYVSALY 400
GMNLENFIEE IDGGFEVVTV VSTIALIALL LFSVKQLKKV EKVTMTSLND 450
QRK 453
Length:453
Mass (Da):51,123
Last modified:April 26, 2005 - v1
Checksum:i42052F3D16AA8E4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000154 Genomic DNA. Translation: EAK93344.1.
AACQ01000155 Genomic DNA. Translation: EAK93313.1.
RefSeqiXP_712495.1. XM_707402.1.
XP_712525.1. XM_707432.1.

Genome annotation databases

GeneIDi3645833.
3645888.
KEGGical:CaO19.10959.
cal:CaO19.3455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000154 Genomic DNA. Translation: EAK93344.1 .
AACQ01000155 Genomic DNA. Translation: EAK93313.1 .
RefSeqi XP_712495.1. XM_707402.1.
XP_712525.1. XM_707432.1.

3D structure databases

ProteinModelPortali Q59S85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645833.
3645888.
KEGGi cal:CaO19.10959.
cal:CaO19.3455.

Organism-specific databases

CGDi CAL0005011. orf19.3455.

Phylogenomic databases

eggNOGi NOG284534.
KOi K16075.
OrthoDBi EOG7SXWCP.

Family and domain databases

InterProi IPR026573. MRS2/LPE10.
[Graphical view ]
PANTHERi PTHR13890. PTHR13890. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiLPE10_CANAL
AccessioniPrimary (citable) accession number: Q59S85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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