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Q59S72

- ALG11_CANAL

UniProt

Q59S72 - ALG11_CANAL

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.By similarity

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    Pathwayi

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Alpha-1,2-mannosyltransferase ALG11
    Asparagine-linked glycosylation protein 11
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:ALG11
    ORF Names:CaO19.10972, CaO19.3468
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005040. ALG11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 609609GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0005040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59S72.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase group 1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    KOiK03844.
    OrthoDBiEOG7673KQ.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59S72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLILLVVLA VYVTYKLITT VLPHHLLIPS QNWREKISYV VKYPKPIYLK    50
    VGTKRSSYRR RLILASENPA FYTNFINNKL KISPNDCENG DGFLNEMSRR 100
    DIDDPKRRII YGFFHPYANN GGGGERVLWQ AVKATLLADD KNICVIYTTN 150
    IEAQPLDILN KANKKFQIDG LDHSRVVFIY LRKFNNLIDG NYWKHFTLIG 200
    QLFGGILLSL EAMYELSPDV WIDTMGLPSS YLLVSLSLKI PILAYTHFPI 250
    LQEDMFGKLK FQKLKDLWKF NIIKFNDYFA LGKFIYWSIL YYFYVYLGSK 300
    VNIALANGSW TFNHLSKIWV FNTALGNVLD VLYPPCGTEF LIKQANLNQP 350
    RSNKLLYLAQ FRPEKRHALL LKEYSNFLSN NFPNVTQITN KFPTLVFAGS 400
    CRTADDTATL KFLQEQVAKL DLSRFVEFRI DISYDEVVEL LSSCKFGLNA 450
    MWNEHFGIGV VEYMARGCIP IVHASAGPLL DMIGRNDQQE NCLNNWKTDG 500
    GFFFKSYDDP DLDPNLQKNT ETGYIKFELF DQFIDYPTFE TLLKELYVND 550
    PTIIEDSKLL KMRQIDQNRV AEKFSNKAFN KKWIEYINDL NTLEKQYREE 600
    KRTKVEQVY 609
    Length:609
    Mass (Da):70,941
    Last modified:April 26, 2005 - v1
    Checksum:iD640E1C5D0115CC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000155 Genomic DNA. Translation: EAK93326.1.
    AACQ01000154 Genomic DNA. Translation: EAK93357.1.
    RefSeqiXP_712508.1. XM_707415.1.
    XP_712538.1. XM_707445.1.

    Genome annotation databases

    GeneIDi3645846.
    3645871.
    KEGGical:CaO19.10972.
    cal:CaO19.3468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000155 Genomic DNA. Translation: EAK93326.1 .
    AACQ01000154 Genomic DNA. Translation: EAK93357.1 .
    RefSeqi XP_712508.1. XM_707415.1.
    XP_712538.1. XM_707445.1.

    3D structure databases

    ProteinModelPortali Q59S72.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645846.
    3645871.
    KEGGi cal:CaO19.10972.
    cal:CaO19.3468.

    Organism-specific databases

    CGDi CAL0005040. ALG11.

    Phylogenomic databases

    eggNOGi COG0438.
    KOi K03844.
    OrthoDBi EOG7673KQ.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiALG11_CANAL
    AccessioniPrimary (citable) accession number: Q59S72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3