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Q59S72 (ALG11_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:ALG11
ORF Names:CaO19.10972, CaO19.3468
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length609 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase group 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 609609GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000080273

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane278 – 29821Helical; Potential

Amino acid modifications

Glycosylation3071N-linked (GlcNAc...) Potential
Glycosylation3841N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q59S72 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: D640E1C5D0115CC4

FASTA60970,941
        10         20         30         40         50         60 
MYLILLVVLA VYVTYKLITT VLPHHLLIPS QNWREKISYV VKYPKPIYLK VGTKRSSYRR 

        70         80         90        100        110        120 
RLILASENPA FYTNFINNKL KISPNDCENG DGFLNEMSRR DIDDPKRRII YGFFHPYANN 

       130        140        150        160        170        180 
GGGGERVLWQ AVKATLLADD KNICVIYTTN IEAQPLDILN KANKKFQIDG LDHSRVVFIY 

       190        200        210        220        230        240 
LRKFNNLIDG NYWKHFTLIG QLFGGILLSL EAMYELSPDV WIDTMGLPSS YLLVSLSLKI 

       250        260        270        280        290        300 
PILAYTHFPI LQEDMFGKLK FQKLKDLWKF NIIKFNDYFA LGKFIYWSIL YYFYVYLGSK 

       310        320        330        340        350        360 
VNIALANGSW TFNHLSKIWV FNTALGNVLD VLYPPCGTEF LIKQANLNQP RSNKLLYLAQ 

       370        380        390        400        410        420 
FRPEKRHALL LKEYSNFLSN NFPNVTQITN KFPTLVFAGS CRTADDTATL KFLQEQVAKL 

       430        440        450        460        470        480 
DLSRFVEFRI DISYDEVVEL LSSCKFGLNA MWNEHFGIGV VEYMARGCIP IVHASAGPLL 

       490        500        510        520        530        540 
DMIGRNDQQE NCLNNWKTDG GFFFKSYDDP DLDPNLQKNT ETGYIKFELF DQFIDYPTFE 

       550        560        570        580        590        600 
TLLKELYVND PTIIEDSKLL KMRQIDQNRV AEKFSNKAFN KKWIEYINDL NTLEKQYREE 


KRTKVEQVY 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000155 Genomic DNA. Translation: EAK93326.1.
AACQ01000154 Genomic DNA. Translation: EAK93357.1.
RefSeqXP_712508.1. XM_707415.1.
XP_712538.1. XM_707445.1.

3D structure databases

ProteinModelPortalQ59S72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645846.
3645871.
KEGGcal:CaO19.10972.
cal:CaO19.3468.

Organism-specific databases

CGDCAL0005040. ALG11.

Phylogenomic databases

eggNOGCOG0438.
KOK03844.
OrthoDBEOG7673KQ.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALG11_CANAL
AccessionPrimary (citable) accession number: Q59S72
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names