Q59S72 (ALG11_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
EC=2.4.1.131

Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase

Gene names

Name:	ALG11
ORF Names:	CaO19.3468, CaO19.10972

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.
Catalytic activity	2 GDP-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase group 1 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase		PRO_0000080273
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Transmembrane	278 – 298	21	Helical; Potential
Amino acid modifications
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
	Glycosylation	384	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59S72 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: D640E1C5D0115CC4	FASTA	609	70,941
	10 20 30 40 50 60 MYLILLVVLA VYVTYKLITT VLPHHLLIPS QNWREKISYV VKYPKPIYLK VGTKRSSYRR 70 80 90 100 110 120 RLILASENPA FYTNFINNKL KISPNDCENG DGFLNEMSRR DIDDPKRRII YGFFHPYANN 130 140 150 160 170 180 GGGGERVLWQ AVKATLLADD KNICVIYTTN IEAQPLDILN KANKKFQIDG LDHSRVVFIY 190 200 210 220 230 240 LRKFNNLIDG NYWKHFTLIG QLFGGILLSL EAMYELSPDV WIDTMGLPSS YLLVSLSLKI 250 260 270 280 290 300 PILAYTHFPI LQEDMFGKLK FQKLKDLWKF NIIKFNDYFA LGKFIYWSIL YYFYVYLGSK 310 320 330 340 350 360 VNIALANGSW TFNHLSKIWV FNTALGNVLD VLYPPCGTEF LIKQANLNQP RSNKLLYLAQ 370 380 390 400 410 420 FRPEKRHALL LKEYSNFLSN NFPNVTQITN KFPTLVFAGS CRTADDTATL KFLQEQVAKL 430 440 450 460 470 480 DLSRFVEFRI DISYDEVVEL LSSCKFGLNA MWNEHFGIGV VEYMARGCIP IVHASAGPLL 490 500 510 520 530 540 DMIGRNDQQE NCLNNWKTDG GFFFKSYDDP DLDPNLQKNT ETGYIKFELF DQFIDYPTFE 550 560 570 580 590 600 TLLKELYVND PTIIEDSKLL KMRQIDQNRV AEKFSNKAFN KKWIEYINDL NTLEKQYREE KRTKVEQVY

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000155 Genomic DNA. Translation: EAK93326.1. AACQ01000154 Genomic DNA. Translation: EAK93357.1.
RefSeq	XP_712508.1. XM_707415.1. XP_712538.1. XM_707445.1.
3D structure databases
ProteinModelPortal	Q59S72.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59S72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645846. 3645871.
KEGG	cal:CaO19.10972. cal:CaO19.3468.
Organism-specific databases
CGD	CAL0005040. ALG11.
Phylogenomic databases
PhylomeDB	Q59S72.
Family and domain databases
InterPro	IPR001296. Glyco_trans_1. [Graphical view]
KO	K03844.
Pfam	PF00534. Glycos_transf_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALG11_CANAL

Accession

Primary (citable) accession number: Q59S72

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program