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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc2-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:ALG11
Ordered Locus Names:CAALFM_C602270CA
ORF Names:CaO19.10972, CaO19.3468
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 6

Organism-specific databases

CGDiCAL0000201912. ALG11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802731 – 609GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferaseAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ59S72.

Structurei

3D structure databases

ProteinModelPortaliQ59S72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ59S72.
KOiK03844.
OrthoDBiEOG092C21XK.

Family and domain databases

InterProiView protein in InterPro
IPR031814. ALG11_N.
IPR001296. Glyco_trans_1.
PfamiView protein in Pfam
PF15924. ALG11_N. 1 hit.
PF00534. Glycos_transf_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59S72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLILLVVLA VYVTYKLITT VLPHHLLIPS QNWREKISYV VKYPKPIYLK
60 70 80 90 100
VGTKRSSYRR RLILASENPA FYTNFINNKL KISPNDCENG DGFLNEMSRR
110 120 130 140 150
DIDDPKRRII YGFFHPYANN GGGGERVLWQ AVKATLLADD KNICVIYTTN
160 170 180 190 200
IEAQPLDILN KANKKFQIDG LDHSRVVFIY LRKFNNLIDG NYWKHFTLIG
210 220 230 240 250
QLFGGILLSL EAMYELSPDV WIDTMGLPSS YLLVSLSLKI PILAYTHFPI
260 270 280 290 300
LQEDMFGKLK FQKLKDLWKF NIIKFNDYFA LGKFIYWSIL YYFYVYLGSK
310 320 330 340 350
VNIALANGSW TFNHLSKIWV FNTALGNVLD VLYPPCGTEF LIKQANLNQP
360 370 380 390 400
RSNKLLYLAQ FRPEKRHALL LKEYSNFLSN NFPNVTQITN KFPTLVFAGS
410 420 430 440 450
CRTADDTATL KFLQEQVAKL DLSRFVEFRI DISYDEVVEL LSSCKFGLNA
460 470 480 490 500
MWNEHFGIGV VEYMARGCTP IVHASAGPLL DMIGRNDQQE NCLNNWKTDG
510 520 530 540 550
GFFFKSYDDP DLDPNLQKNT ETGYIKFELF DQFIDYPTFE TLLKELYVND
560 570 580 590 600
PTIIEDSKLL KMRQIDQNRV AEKFSNKAFN KKWIEYINDL NTLEKQYREE

KRTKVEQVY
Length:609
Mass (Da):70,929
Last modified:March 15, 2017 - v2
Checksum:iD640F41FEFE276ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017628 Genomic DNA. Translation: AOW30162.1.
RefSeqiXP_712508.2. XM_707415.2.

Genome annotation databases

GeneIDi3645871.
KEGGical:CAALFM_C602270CA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017628 Genomic DNA. Translation: AOW30162.1.
RefSeqiXP_712508.2. XM_707415.2.

3D structure databases

ProteinModelPortaliQ59S72.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59S72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3645871.
KEGGical:CAALFM_C602270CA.

Organism-specific databases

CGDiCAL0000201912. ALG11.

Phylogenomic databases

InParanoidiQ59S72.
KOiK03844.
OrthoDBiEOG092C21XK.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiPR:Q59S72.

Family and domain databases

InterProiView protein in InterPro
IPR031814. ALG11_N.
IPR001296. Glyco_trans_1.
PfamiView protein in Pfam
PF15924. ALG11_N. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALG11_CANAL
AccessioniPrimary (citable) accession number: Q59S72
Secondary accession number(s): A0A1D8PPV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.