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Q59S52 (MDM12_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial distribution and morphology protein 12
Alternative name(s):
Mitochondrial inheritance component MDM12
Gene names
Name:MDM12
ORF Names:CaJ7.0134, CaO19.6900
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids By similarity. HAMAP-Rule MF_03104

Subunit structure

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.

Subcellular location

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids By similarity. HAMAP-Rule MF_03104

Sequence similarities

Belongs to the MDM12 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Mitochondrial distribution and morphology protein 12 HAMAP-Rule MF_03104
PRO_0000384277

Sequences

Sequence LengthMass (Da)Tools
Q59S52 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 9603798B40CBFDC4

FASTA42848,101
        10         20         30         40         50         60 
MSFDINWNQL TIDDTINQSI KEFLDQQFKN ISLPSFISNL AVTDFNLGEI PPEVTIRHIG 

        70         80         90        100        110        120 
DPFEEFYEDE NNLGVMNEAN NDSKDEHLKN HGDGINKDSG YNSQNLDDED EDDEDDDEDD 

       130        140        150        160        170        180 
EDEEEEDEDD YDDHDLGTIN EGISLLNFNE NSTTPSANSF AGSAAPPLPP PLNPSRDSFH 

       190        200        210        220        230        240 
SILHPYGVNS IIGATGAGSE TPTNILNQNY LSSRVLPKIS VKQKQPHHDD NDIQLIVEIN 

       250        260        270        280        290        300 
YKGDMHINLL VNLLVNYPSP NFISLPIKLH ITDIVIHSIA TIAYLKKSVF LSFLCDVDDT 

       310        320        330        340        350        360 
FPDFDSNVQT PTSTTGGNFV DYYSNDATIN KERIDIVKKI KIESEIGEVE NNILRNVGKV 

       370        380        390        400        410        420 
EKFLVEQLRN ILRDEIAWPS WICIDMNDDD DEEEEEEESE DNDGGNSDLN DNDGKHGDGR 


TDETEAGE 

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References

[1]"Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006852 Genomic DNA. Translation: BAE44640.1.
AACQ01000156 Genomic DNA. Translation: EAK93289.1.
RefSeqXP_712472.1. XM_707379.1.
XP_888743.1. XM_883650.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000114.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645915.
3704145.
KEGGcal:CaO19.6900.
cal:CaO19_6900.

Organism-specific databases

CGDCAL0000114. orf19.6900.

Phylogenomic databases

eggNOGNOG73343.
KOK17765.
OrthoDBEOG7TJ3TH.

Family and domain databases

HAMAPMF_03104. Mdm12.
InterProIPR019411. DUF2404.
IPR027532. Mdm12.
[Graphical view]
PfamPF10296. DUF2404. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDM12_CANAL
AccessionPrimary (citable) accession number: Q59S52
Secondary accession number(s): Q3MPM0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names