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Protein

Mitochondrial distribution and morphology protein 12

Gene

MDM12

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.UniRule annotation

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 12UniRule annotation
Alternative name(s):
Mitochondrial inheritance component MDM12UniRule annotation
Gene namesi
Name:MDM12UniRule annotation
ORF Names:CaJ7.0134, CaO19.6900
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000114. orf19.6900.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Endoplasmic reticulum membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

  • Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Mitochondrial distribution and morphology protein 12PRO_0000384277Add
BLAST

Interactioni

Subunit structurei

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.

Protein-protein interaction databases

STRINGi5476.CAL0000114.

Family & Domainsi

Sequence similaritiesi

Belongs to the MDM12 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG73343.
InParanoidiQ59S52.
KOiK17765.
OrthoDBiEOG7TJ3TH.

Family and domain databases

HAMAPiMF_03104. Mdm12.
InterProiIPR019411. DUF2404.
IPR027532. Mdm12.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59S52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDINWNQL TIDDTINQSI KEFLDQQFKN ISLPSFISNL AVTDFNLGEI
60 70 80 90 100
PPEVTIRHIG DPFEEFYEDE NNLGVMNEAN NDSKDEHLKN HGDGINKDSG
110 120 130 140 150
YNSQNLDDED EDDEDDDEDD EDEEEEDEDD YDDHDLGTIN EGISLLNFNE
160 170 180 190 200
NSTTPSANSF AGSAAPPLPP PLNPSRDSFH SILHPYGVNS IIGATGAGSE
210 220 230 240 250
TPTNILNQNY LSSRVLPKIS VKQKQPHHDD NDIQLIVEIN YKGDMHINLL
260 270 280 290 300
VNLLVNYPSP NFISLPIKLH ITDIVIHSIA TIAYLKKSVF LSFLCDVDDT
310 320 330 340 350
FPDFDSNVQT PTSTTGGNFV DYYSNDATIN KERIDIVKKI KIESEIGEVE
360 370 380 390 400
NNILRNVGKV EKFLVEQLRN ILRDEIAWPS WICIDMNDDD DEEEEEEESE
410 420
DNDGGNSDLN DNDGKHGDGR TDETEAGE
Length:428
Mass (Da):48,101
Last modified:April 26, 2005 - v1
Checksum:i9603798B40CBFDC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006852 Genomic DNA. Translation: BAE44640.1.
AACQ01000156 Genomic DNA. Translation: EAK93289.1.
RefSeqiXP_712472.1. XM_707379.1.
XP_888743.1. XM_883650.1.

Genome annotation databases

GeneIDi3645915.
3704145.
KEGGical:CaO19.6900.
cal:CaO19_6900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006852 Genomic DNA. Translation: BAE44640.1.
AACQ01000156 Genomic DNA. Translation: EAK93289.1.
RefSeqiXP_712472.1. XM_707379.1.
XP_888743.1. XM_883650.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0000114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3645915.
3704145.
KEGGical:CaO19.6900.
cal:CaO19_6900.

Organism-specific databases

CGDiCAL0000114. orf19.6900.

Phylogenomic databases

eggNOGiNOG73343.
InParanoidiQ59S52.
KOiK17765.
OrthoDBiEOG7TJ3TH.

Family and domain databases

HAMAPiMF_03104. Mdm12.
InterProiIPR019411. DUF2404.
IPR027532. Mdm12.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
    Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
    Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMDM12_CANAL
AccessioniPrimary (citable) accession number: Q59S52
Secondary accession number(s): Q3MPM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 26, 2005
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.