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Protein

Mitochondrial distribution and morphology protein 12

Gene

MDM12

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 12UniRule annotation
Alternative name(s):
Mitochondrial inheritance component MDM12UniRule annotation
Gene namesi
Name:MDM12UniRule annotation
Ordered Locus Names:CAALFM_C701180WA
ORF Names:CaJ7.0134, CaO19.6900
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi

Organism-specific databases

CGDiCAL0000201825 MDM12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003842771 – 428Mitochondrial distribution and morphology protein 12Add BLAST428

Interactioni

Subunit structurei

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 387SMP-LTDUniRule annotationAdd BLAST387

Domaini

The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.UniRule annotation

Sequence similaritiesi

Belongs to the MDM12 family.UniRule annotation

Phylogenomic databases

InParanoidiQ59S52
KOiK17765
OMAiINYPSPM
OrthoDBiEOG092C2W17

Family and domain databases

HAMAPiMF_03104 Mdm12, 1 hit
InterProiView protein in InterPro
IPR027532 Mdm12
IPR031468 SMP_LBD
PROSITEiView protein in PROSITE
PS51847 SMP, 1 hit

Sequencei

Sequence statusi: Complete.

Q59S52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDINWNQL TIDDTINQSI KEFLDQQFKN ISLPSFISNL AVTDFNLGEI
60 70 80 90 100
PPEVTIRHIG DPFEEFYEDE NNLGVMNEAN NDSKDEHLKN HGDGINKDSG
110 120 130 140 150
YNSQNLDDED EDDEDDDEDD EDEEEEDEDD YDDHDLGTIN EGISLLNFNE
160 170 180 190 200
NSTTPSANSF AGSAAPPLPP PLNPSRDSFH SILHPYGVNS IIGATGAGSE
210 220 230 240 250
TPTNILNQNY LSSRVLPKIS VKQKQPHHDD NDIQLIVEIN YKGDMHINLL
260 270 280 290 300
VNLLVNYPSP NFISLPIKLH ITDIVIHSIA TIAYLKKSVF LSFLCDVDDT
310 320 330 340 350
FPDFDSNVQT PTSTTGGNFV DYYSNDATIN KERIDIVKKI KIESEIGEVE
360 370 380 390 400
NNILRNVGKV EKFLVEQLRN ILRDEIAWPS WICIDMNDDD DEEEEEEESE
410 420
DNDGGNSDLN DNDGKHGDGR TDETEAGE
Length:428
Mass (Da):48,101
Last modified:April 26, 2005 - v1
Checksum:i9603798B40CBFDC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006852 Genomic DNA Translation: BAE44640.1
CP017629 Genomic DNA Translation: AOW30488.1
RefSeqiXP_712472.1, XM_707379.1

Genome annotation databases

EnsemblFungiiAOW30488; AOW30488; CAALFM_C701180WA
GeneIDi3645915
KEGGical:CAALFM_C701180WA

Similar proteinsi

Entry informationi

Entry nameiMDM12_CANAL
AccessioniPrimary (citable) accession number: Q59S52
Secondary accession number(s): A0A1D8PQR1, Q3MPM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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