Q59S52 (MDM12_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial distribution and morphology protein 12

Alternative name(s):
Mitochondrial inheritance component MDM12

Gene names

Name:	MDM12
ORF Names:	CaJ7.0134, CaO19.6900

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids By similarity. HAMAP-Rule MF_03104
Subunit structure	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.
Subcellular location	Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids By similarity. HAMAP-Rule MF_03104
Sequence similarities	Belongs to the MDM12 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Mitochondrion Mitochondrion outer membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Mitochondrial distribution and morphology protein 12 HAMAP-Rule MF_03104		PRO_0000384277

Sequences

	Sequence		Length	Mass (Da)
	Q59S52 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 9603798B40CBFDC4	FASTA	428	48,101
	10 20 30 40 50 60 MSFDINWNQL TIDDTINQSI KEFLDQQFKN ISLPSFISNL AVTDFNLGEI PPEVTIRHIG 70 80 90 100 110 120 DPFEEFYEDE NNLGVMNEAN NDSKDEHLKN HGDGINKDSG YNSQNLDDED EDDEDDDEDD 130 140 150 160 170 180 EDEEEEDEDD YDDHDLGTIN EGISLLNFNE NSTTPSANSF AGSAAPPLPP PLNPSRDSFH 190 200 210 220 230 240 SILHPYGVNS IIGATGAGSE TPTNILNQNY LSSRVLPKIS VKQKQPHHDD NDIQLIVEIN 250 260 270 280 290 300 YKGDMHINLL VNLLVNYPSP NFISLPIKLH ITDIVIHSIA TIAYLKKSVF LSFLCDVDDT 310 320 330 340 350 360 FPDFDSNVQT PTSTTGGNFV DYYSNDATIN KERIDIVKKI KIESEIGEVE NNILRNVGKV 370 380 390 400 410 420 EKFLVEQLRN ILRDEIAWPS WICIDMNDDD DEEEEEEESE DNDGGNSDLN DNDGKHGDGR TDETEAGE

References

[1]	"Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome." Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y. Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006852 Genomic DNA. Translation: BAE44640.1. AACQ01000156 Genomic DNA. Translation: EAK93289.1.
RefSeq	XP_712472.1. XM_707379.1. XP_888743.1. XM_883650.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000114.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645915. 3704145.
KEGG	cal:CaO19.6900. cal:CaO19_6900.
Organism-specific databases
CGD	CAL0000114. orf19.6900.
Phylogenomic databases
eggNOG	NOG73343.
Family and domain databases
HAMAP	MF_03104. Mdm12.
InterPro	IPR019411. DUF2404. [Graphical view]
Pfam	PF10296. DUF2404. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDM12_CANAL

Accession

Primary (citable) accession number: Q59S52
Secondary accession number(s): Q3MPM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program