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Q59S52

- MDM12_CANAL

UniProt

Q59S52 - MDM12_CANAL

Protein

Mitochondrial distribution and morphology protein 12

Gene

MDM12

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.UniRule annotation

    GO - Biological processi

    1. mitochondrial genome maintenance Source: UniProtKB-HAMAP
    2. protein import into mitochondrial outer membrane Source: UniProtKB-HAMAP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial distribution and morphology protein 12UniRule annotation
    Alternative name(s):
    Mitochondrial inheritance component MDM12UniRule annotation
    Gene namesi
    Name:MDM12UniRule annotation
    ORF Names:CaJ7.0134, CaO19.6900
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000114. orf19.6900.

    Subcellular locationi

    Mitochondrion outer membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Endoplasmic reticulum membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
    Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.UniRule annotation

    GO - Cellular componenti

    1. ERMES complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Mitochondrial distribution and morphology protein 12PRO_0000384277Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.

    Protein-protein interaction databases

    STRINGi5476.CAL0000114.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MDM12 family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG73343.
    KOiK17765.
    OrthoDBiEOG7TJ3TH.

    Family and domain databases

    HAMAPiMF_03104. Mdm12.
    InterProiIPR019411. DUF2404.
    IPR027532. Mdm12.
    [Graphical view]
    PfamiPF10296. DUF2404. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59S52-1 [UniParc]FASTAAdd to Basket

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    MSFDINWNQL TIDDTINQSI KEFLDQQFKN ISLPSFISNL AVTDFNLGEI    50
    PPEVTIRHIG DPFEEFYEDE NNLGVMNEAN NDSKDEHLKN HGDGINKDSG 100
    YNSQNLDDED EDDEDDDEDD EDEEEEDEDD YDDHDLGTIN EGISLLNFNE 150
    NSTTPSANSF AGSAAPPLPP PLNPSRDSFH SILHPYGVNS IIGATGAGSE 200
    TPTNILNQNY LSSRVLPKIS VKQKQPHHDD NDIQLIVEIN YKGDMHINLL 250
    VNLLVNYPSP NFISLPIKLH ITDIVIHSIA TIAYLKKSVF LSFLCDVDDT 300
    FPDFDSNVQT PTSTTGGNFV DYYSNDATIN KERIDIVKKI KIESEIGEVE 350
    NNILRNVGKV EKFLVEQLRN ILRDEIAWPS WICIDMNDDD DEEEEEEESE 400
    DNDGGNSDLN DNDGKHGDGR TDETEAGE 428
    Length:428
    Mass (Da):48,101
    Last modified:April 26, 2005 - v1
    Checksum:i9603798B40CBFDC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006852 Genomic DNA. Translation: BAE44640.1.
    AACQ01000156 Genomic DNA. Translation: EAK93289.1.
    RefSeqiXP_712472.1. XM_707379.1.
    XP_888743.1. XM_883650.1.

    Genome annotation databases

    GeneIDi3645915.
    3704145.
    KEGGical:CaO19.6900.
    cal:CaO19_6900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006852 Genomic DNA. Translation: BAE44640.1 .
    AACQ01000156 Genomic DNA. Translation: EAK93289.1 .
    RefSeqi XP_712472.1. XM_707379.1.
    XP_888743.1. XM_883650.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000114.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645915.
    3704145.
    KEGGi cal:CaO19.6900.
    cal:CaO19_6900.

    Organism-specific databases

    CGDi CAL0000114. orf19.6900.

    Phylogenomic databases

    eggNOGi NOG73343.
    KOi K17765.
    OrthoDBi EOG7TJ3TH.

    Family and domain databases

    HAMAPi MF_03104. Mdm12.
    InterProi IPR019411. DUF2404.
    IPR027532. Mdm12.
    [Graphical view ]
    Pfami PF10296. DUF2404. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
      Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
      Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiMDM12_CANAL
    AccessioniPrimary (citable) accession number: Q59S52
    Secondary accession number(s): Q3MPM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3