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Q59S52

- MDM12_CANAL

UniProt

Q59S52 - MDM12_CANAL

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Protein

Mitochondrial distribution and morphology protein 12

Gene
MDM12, CaJ7.0134, CaO19.6900
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids By similarity.UniRule annotation

GO - Biological processi

  1. mitochondrial genome maintenance Source: UniProtKB-HAMAP
  2. protein import into mitochondrial outer membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 12
Alternative name(s):
Mitochondrial inheritance component MDM12
Gene namesi
Name:MDM12
ORF Names:CaJ7.0134, CaO19.6900
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000114. orf19.6900.

Subcellular locationi

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids By similarity.UniRule annotation

GO - Cellular componenti

  1. ERMES complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Mitochondrial distribution and morphology protein 12UniRule annotationPRO_0000384277Add
BLAST

Interactioni

Subunit structurei

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.

Protein-protein interaction databases

STRINGi5476.CAL0000114.

Family & Domainsi

Sequence similaritiesi

Belongs to the MDM12 family.

Phylogenomic databases

eggNOGiNOG73343.
KOiK17765.
OrthoDBiEOG7TJ3TH.

Family and domain databases

HAMAPiMF_03104. Mdm12.
InterProiIPR019411. DUF2404.
IPR027532. Mdm12.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59S52-1 [UniParc]FASTAAdd to Basket

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MSFDINWNQL TIDDTINQSI KEFLDQQFKN ISLPSFISNL AVTDFNLGEI    50
PPEVTIRHIG DPFEEFYEDE NNLGVMNEAN NDSKDEHLKN HGDGINKDSG 100
YNSQNLDDED EDDEDDDEDD EDEEEEDEDD YDDHDLGTIN EGISLLNFNE 150
NSTTPSANSF AGSAAPPLPP PLNPSRDSFH SILHPYGVNS IIGATGAGSE 200
TPTNILNQNY LSSRVLPKIS VKQKQPHHDD NDIQLIVEIN YKGDMHINLL 250
VNLLVNYPSP NFISLPIKLH ITDIVIHSIA TIAYLKKSVF LSFLCDVDDT 300
FPDFDSNVQT PTSTTGGNFV DYYSNDATIN KERIDIVKKI KIESEIGEVE 350
NNILRNVGKV EKFLVEQLRN ILRDEIAWPS WICIDMNDDD DEEEEEEESE 400
DNDGGNSDLN DNDGKHGDGR TDETEAGE 428
Length:428
Mass (Da):48,101
Last modified:April 26, 2005 - v1
Checksum:i9603798B40CBFDC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44640.1.
AACQ01000156 Genomic DNA. Translation: EAK93289.1.
RefSeqiXP_712472.1. XM_707379.1.
XP_888743.1. XM_883650.1.

Genome annotation databases

GeneIDi3645915.
3704145.
KEGGical:CaO19.6900.
cal:CaO19_6900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44640.1 .
AACQ01000156 Genomic DNA. Translation: EAK93289.1 .
RefSeqi XP_712472.1. XM_707379.1.
XP_888743.1. XM_883650.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645915.
3704145.
KEGGi cal:CaO19.6900.
cal:CaO19_6900.

Organism-specific databases

CGDi CAL0000114. orf19.6900.

Phylogenomic databases

eggNOGi NOG73343.
KOi K17765.
OrthoDBi EOG7TJ3TH.

Family and domain databases

HAMAPi MF_03104. Mdm12.
InterProi IPR019411. DUF2404.
IPR027532. Mdm12.
[Graphical view ]
Pfami PF10296. DUF2404. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
    Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
    Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMDM12_CANAL
AccessioniPrimary (citable) accession number: Q59S52
Secondary accession number(s): Q3MPM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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