ID   MED11_CANAL             Reviewed;         168 AA.
AC   Q59S43; A0A1D8PQT5; Q3MPL1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   24-JAN-2024, entry version 83.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 11;
DE   AltName: Full=Mediator complex subunit 11;
GN   Name=MED11; OrderedLocusNames=CAALFM_C701290WA;
GN   ORFNames=CaJ7.0143, CaO19.6909;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA   Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA   Mikami Y.;
RT   "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT   syntenic analysis against the Saccharomyces cerevisiae genome.";
RL   Genetics 170:1525-1537(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional pre-initiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity).
CC       {ECO:0000250|UniProtKB:Q99278}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC       {ECO:0000305}.
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DR   EMBL; AP006852; BAE44649.1; -; Genomic_DNA.
DR   EMBL; CP017629; AOW30497.1; -; Genomic_DNA.
DR   RefSeq; XP_712481.1; XM_707388.1.
DR   AlphaFoldDB; Q59S43; -.
DR   SMR; Q59S43; -.
DR   BioGRID; 1229003; 2.
DR   STRING; 237561.Q59S43; -.
DR   EnsemblFungi; C7_01290W_A-T; C7_01290W_A-T-p1; C7_01290W_A.
DR   GeneID; 3645910; -.
DR   KEGG; cal:CAALFM_C701290WA; -.
DR   CGD; CAL0000188346; MED11.
DR   VEuPathDB; FungiDB:C7_01290W_A; -.
DR   eggNOG; ENOG502S3YW; Eukaryota.
DR   HOGENOM; CLU_121031_0_0_1; -.
DR   InParanoid; Q59S43; -.
DR   OMA; IMDDNIG; -.
DR   OrthoDB; 1977335at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.287.3490; -; 1.
DR   InterPro; IPR019404; Mediator_Med11.
DR   Pfam; PF10280; Med11; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..168
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   11"
FT                   /id="PRO_0000304318"
FT   REGION          126..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   168 AA;  19417 MW;  B74D0F3D474F63AC CRC64;
     MSSLDNDKTE NFIQERLDSL HEIDCKVVTL LDQFSSIFQS FYTKSKEDFS QQTSDIYSTL
     SKVAIDLRKE IKIMDDNIGA YDKNDDNVMI LPISNVDQKN TKLGRKRLDL ELAELKRLIS
     DEKQVETLEN ESNNEIQPKT ESDTNQVETN ENGNDINNKE SEDIEMKE
//