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Q59S43 (MED11_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mediator of RNA polymerase II transcription subunit 11
Alternative name(s):
Mediator complex subunit 11
Gene names
Name:MED11
ORF Names:CaJ7.0143, CaO19.6909
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.

Subunit structure

Component of the Mediator complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Mediator complex subunit 11 family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmediator complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA polymerase II transcription cofactor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 168168Mediator of RNA polymerase II transcription subunit 11
PRO_0000304318

Sequences

Sequence LengthMass (Da)Tools
Q59S43 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: B74D0F3D474F63AC

FASTA16819,417
        10         20         30         40         50         60 
MSSLDNDKTE NFIQERLDSL HEIDCKVVTL LDQFSSIFQS FYTKSKEDFS QQTSDIYSTL 

        70         80         90        100        110        120 
SKVAIDLRKE IKIMDDNIGA YDKNDDNVMI LPISNVDQKN TKLGRKRLDL ELAELKRLIS 

       130        140        150        160 
DEKQVETLEN ESNNEIQPKT ESDTNQVETN ENGNDINNKE SEDIEMKE 

« Hide

References

[1]"Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006852 Genomic DNA. Translation: BAE44649.1.
AACQ01000156 Genomic DNA. Translation: EAK93298.1.
RefSeqXP_712481.1. XM_707388.1.
XP_888752.1. XM_883659.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1231843. 1 interaction.
STRING5476.CAL0000135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645910.
3704154.
KEGGcal:CaO19.6909.
cal:CaO19_6909.

Organism-specific databases

CGDCAL0000135. orf19.6909.

Phylogenomic databases

eggNOGNOG46016.
KOK15132.
OrthoDBEOG76TB3R.

Family and domain databases

InterProIPR019404. Mediator_Med11.
[Graphical view]
PfamPF10280. Med11. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMED11_CANAL
AccessionPrimary (citable) accession number: Q59S43
Secondary accession number(s): Q3MPL1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names