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Protein

Mediator of RNA polymerase II transcription subunit 11

Gene

MED11

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11
Alternative name(s):
Mediator complex subunit 11
Gene namesi
Name:MED11
Ordered Locus Names:CAALFM_C701290WA
ORF Names:CaJ7.0143, CaO19.6909
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 7

Organism-specific databases

CGDiCAL0000188346 MED11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003043181 – 168Mediator of RNA polymerase II transcription subunit 11Add BLAST168

Interactioni

Subunit structurei

Component of the Mediator complex.By similarity

Protein-protein interaction databases

BioGridi1229003, 1 interactor

Structurei

3D structure databases

SMRiQ59S43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 11 family.Curated

Phylogenomic databases

InParanoidiQ59S43
KOiK15132
OMAiVMILPIS
OrthoDBiEOG092C5RAD

Family and domain databases

InterProiView protein in InterPro
IPR019404 Mediator_Med11
PfamiView protein in Pfam
PF10280 Med11, 1 hit

Sequencei

Sequence statusi: Complete.

Q59S43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLDNDKTE NFIQERLDSL HEIDCKVVTL LDQFSSIFQS FYTKSKEDFS
60 70 80 90 100
QQTSDIYSTL SKVAIDLRKE IKIMDDNIGA YDKNDDNVMI LPISNVDQKN
110 120 130 140 150
TKLGRKRLDL ELAELKRLIS DEKQVETLEN ESNNEIQPKT ESDTNQVETN
160
ENGNDINNKE SEDIEMKE
Length:168
Mass (Da):19,417
Last modified:April 26, 2005 - v1
Checksum:iB74D0F3D474F63AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006852 Genomic DNA Translation: BAE44649.1
CP017629 Genomic DNA Translation: AOW30497.1
RefSeqiXP_712481.1, XM_707388.1

Genome annotation databases

EnsemblFungiiAOW30497; AOW30497; CAALFM_C701290WA
GeneIDi3645910
KEGGical:CAALFM_C701290WA

Similar proteinsi

Entry informationi

Entry nameiMED11_CANAL
AccessioniPrimary (citable) accession number: Q59S43
Secondary accession number(s): A0A1D8PQT5, Q3MPL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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