Q59S43 (MED11_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mediator of RNA polymerase II transcription subunit 11

Alternative name(s):
Mediator complex subunit 11

Gene names

Name:	MED11
ORF Names:	CaJ7.0143, CaO19.6909

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.
Subunit structure	Component of the Mediator complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Mediator complex subunit 11 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mediator complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA polymerase II transcription cofactor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Mediator of RNA polymerase II transcription subunit 11		PRO_0000304318

Sequences

	Sequence		Length	Mass (Da)
	Q59S43 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: B74D0F3D474F63AC	FASTA	168	19,417
	10 20 30 40 50 60 MSSLDNDKTE NFIQERLDSL HEIDCKVVTL LDQFSSIFQS FYTKSKEDFS QQTSDIYSTL 70 80 90 100 110 120 SKVAIDLRKE IKIMDDNIGA YDKNDDNVMI LPISNVDQKN TKLGRKRLDL ELAELKRLIS 130 140 150 160 DEKQVETLEN ESNNEIQPKT ESDTNQVETN ENGNDINNKE SEDIEMKE

References

[1]	"Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome." Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y. Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006852 Genomic DNA. Translation: BAE44649.1. AACQ01000156 Genomic DNA. Translation: EAK93298.1.
RefSeq	XP_712481.1. XM_707388.1. XP_888752.1. XM_883659.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645910. 3704154.
KEGG	cal:CaO19.6909. cal:CaO19_6909.
Organism-specific databases
CGD	CAL0000135. orf19.6909.
Phylogenomic databases
eggNOG	NOG46016.
KO	K15132.
Family and domain databases
InterPro	IPR019404. Mediator_Med11. [Graphical view]
Pfam	PF10280. Med11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MED11_CANAL

Accession

Primary (citable) accession number: Q59S43
Secondary accession number(s): Q3MPL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	April 26, 2005
Last modified:	June 13, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program