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Q59S43

- MED11_CANAL

UniProt

Q59S43 - MED11_CANAL

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Protein
Mediator of RNA polymerase II transcription subunit 11
Gene
MED11, CaJ7.0143, CaO19.6909
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11
Alternative name(s):
Mediator complex subunit 11
Gene namesi
Name:MED11
ORF Names:CaJ7.0143, CaO19.6909
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000135. orf19.6909.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. mediator complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Mediator of RNA polymerase II transcription subunit 11
PRO_0000304318Add
BLAST

Interactioni

Subunit structurei

Component of the Mediator complex By similarity.

Protein-protein interaction databases

BioGridi1231843. 1 interaction.
STRINGi5476.CAL0000135.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG46016.
KOiK15132.
OrthoDBiEOG76TB3R.

Family and domain databases

InterProiIPR019404. Mediator_Med11.
[Graphical view]
PfamiPF10280. Med11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59S43-1 [UniParc]FASTAAdd to Basket

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MSSLDNDKTE NFIQERLDSL HEIDCKVVTL LDQFSSIFQS FYTKSKEDFS    50
QQTSDIYSTL SKVAIDLRKE IKIMDDNIGA YDKNDDNVMI LPISNVDQKN 100
TKLGRKRLDL ELAELKRLIS DEKQVETLEN ESNNEIQPKT ESDTNQVETN 150
ENGNDINNKE SEDIEMKE 168
Length:168
Mass (Da):19,417
Last modified:April 26, 2005 - v1
Checksum:iB74D0F3D474F63AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44649.1.
AACQ01000156 Genomic DNA. Translation: EAK93298.1.
RefSeqiXP_712481.1. XM_707388.1.
XP_888752.1. XM_883659.1.

Genome annotation databases

GeneIDi3645910.
3704154.
KEGGical:CaO19.6909.
cal:CaO19_6909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44649.1 .
AACQ01000156 Genomic DNA. Translation: EAK93298.1 .
RefSeqi XP_712481.1. XM_707388.1.
XP_888752.1. XM_883659.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1231843. 1 interaction.
STRINGi 5476.CAL0000135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645910.
3704154.
KEGGi cal:CaO19.6909.
cal:CaO19_6909.

Organism-specific databases

CGDi CAL0000135. orf19.6909.

Phylogenomic databases

eggNOGi NOG46016.
KOi K15132.
OrthoDBi EOG76TB3R.

Family and domain databases

InterProi IPR019404. Mediator_Med11.
[Graphical view ]
Pfami PF10280. Med11. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
    Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
    Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMED11_CANAL
AccessioniPrimary (citable) accession number: Q59S43
Secondary accession number(s): Q3MPL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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