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Q59S06 (NOP58_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleolar protein 58
Gene names
Name:NOP58
ORF Names:CaO19.1199, CaO19.8790
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for pre-18S rRNA processing. May bind microtubules By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the NOP5/NOP56 family.

Contains 1 Nop domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
rRNA processing
   Cellular componentNucleus
   Molecular functionRibonucleoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfilamentous growth

Inferred from mutant phenotype PubMed 12773383. Source: CGD

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

small-subunit processome

Inferred from direct assay PubMed 19055720. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Nucleolar protein 58
PRO_0000350979

Regions

Domain283 – 403121Nop
Compositional bias435 – 4406Poly-Ala

Natural variations

Natural variant2031V → A in allele CaO19.1199.
Natural variant4401A → AA in allele CaO19.1199.

Sequences

Sequence LengthMass (Da)Tools
Q59S06 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: FE29ED1097D92E8A

FASTA51557,072
        10         20         30         40         50         60 
MAYVLTETAA GYALLKAADK KIHKSSSLVE DLNTAEKVAE QFKIHRFEKF QSAANALEEA 

        70         80         90        100        110        120 
NAIIEGKVSE NLQKLLEDAK SDKKATLIVS EAKLGNAINK LGLNFQVVSD AASLDLQRAI 

       130        140        150        160        170        180 
KQFLPELLPG LDDSALKQMS LGLAHSMGRH KLKFSADKVD TMIIQAIALL DDLDKELNTY 

       190        200        210        220        230        240 
AMRCKEWYGW HFPELAKMIT DSVAYARIIL TMGVRSNASE TDLSEILPEE VEEQVKAAAE 

       250        260        270        280        290        300 
VSMGTEITED DLNNIKALAE QIVDFAAYRE QLSNYLSSRM KAIAPNLTAM VGELVGARLI 

       310        320        330        340        350        360 
AHAGSLTSLA KAPASTVQIL GAEKALFRAL KTKHDTPKYG IIYHASLVGQ ASGKNKGRIA 

       370        380        390        400        410        420 
RTLAAKAAVS LRYDCFDEER DESDDFGLEN RAKVEGRLSQ LEGRDMRTTS KVVREQPKVE 

       430        440        450        460        470        480 
ITEARAYNAD ADSTAAAAAA PTADSDDEES ETEEVEEKKS KKDKKKDKKE KKDKKKDKKR 

       490        500        510 
KRDDDKEDKE SSKKSKKDKK EKKEKKEKKA KKEKK 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000157 Genomic DNA. Translation: EAK93277.1.
AACQ01000161 Genomic DNA. Translation: EAK93126.1.
RefSeqXP_712316.1. XM_707223.1.
XP_712460.1. XM_707367.1.

3D structure databases

ProteinModelPortalQ59S06.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1229177. 1 interaction.
STRING5476.CAL0002164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645922.
3646084.
KEGGcal:CaO19.1199.
cal:CaO19.8790.

Phylogenomic databases

eggNOGCOG1498.
KOK14565.
OrthoDBEOG7C5MJW.

Family and domain databases

InterProIPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view]
PfamPF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
PF08060. NOSIC. 1 hit.
[Graphical view]
SMARTSM00931. NOSIC. 1 hit.
[Graphical view]
PROSITEPS51358. NOP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNOP58_CANAL
AccessionPrimary (citable) accession number: Q59S06
Secondary accession number(s): Q59RK5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names