Q59RN6 (CHZ1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone H2A.Z-specific chaperone CHZ1

Gene names

Name:	CHZ1
ORF Names:	CaO19.13566, CaO19.6147

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin By similarity.
Subunit structure	Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the CHZ1 family.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Histone H2A.Z-specific chaperone CHZ1		PRO_0000330205
Regions
	Compositional bias	4 – 157	154	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q59RN6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 3AC187C49AF8A4FB	FASTA	167	19,694
	10 20 30 40 50 60 MSDESKPIEE PPIESKPQEE QDTEKESVTN SEESKKRAVE PSTDKKKKRR RRNYDEEDKE 70 80 90 100 110 120 LEKEEAKEKN AKTENNEEGD DDDEDEDDDY EQGKLEDEEE EEDELLEIDE SNIITTGRRT 130 140 150 160 RGKVIDFTKA AEELDKERGV VAEEDEEEEE EEEKENEDDD FKEQVQN

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000160 Genomic DNA. Translation: EAK93165.1. AACQ01000159 Genomic DNA. Translation: EAK93203.1.
RefSeq	XP_712353.1. XM_707260.1. XP_712389.1. XM_707296.1.
3D structure databases
ProteinModelPortal	Q59RN6.
SMR	Q59RN6. Positions 99-137.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0006032.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646009. 3646031.
KEGG	cal:CaO19.13566. cal:CaO19.6147.
Organism-specific databases
CGD	CAL0006032. orf19.6147.
Phylogenomic databases
eggNOG	NOG42843.
Family and domain databases
InterPro	IPR019098. Histone_chaperone_domain_CHZ. [Graphical view]
Pfam	PF09649. CHZ. 1 hit. [Graphical view]
SMART	SM01082. CHZ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHZ1_CANAL

Accession

Primary (citable) accession number: Q59RN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program