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Protein

Histone H2A.Z-specific chaperone CHZ1

Gene

CHZ1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.By similarity

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.Z-specific chaperone CHZ1
Gene namesi
Name:CHZ1
Ordered Locus Names:CAALFM_CR07230WA
ORF Names:CaO19.13566, CaO19.6147
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000184636. orf19.6147.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003302051 – 167Histone H2A.Z-specific chaperone CHZ1Add BLAST167

Proteomic databases

PRIDEiQ59RN6.

Interactioni

Subunit structurei

Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59RN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 157Glu-richAdd BLAST154

Sequence similaritiesi

Belongs to the CHZ1 family.Curated

Phylogenomic databases

InParanoidiQ59RN6.
OrthoDBiEOG092C5Z0N.

Family and domain databases

InterProiView protein in InterPro
IPR019098. Histone_chaperone_domain_CHZ.
PfamiView protein in Pfam
PF09649. CHZ. 1 hit.
SMARTiView protein in SMART
SM01082. CHZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59RN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDESKPIEE PPIESKPQEE QDTEKESLTN SEESKKRAVE PSTDKKKKRR
60 70 80 90 100
RRNYDEEDKE LEKEEAKEKN AKTENNEEGD DDEDDEDDDY EQGKLEDEEE
110 120 130 140 150
EEDELLEIDE SNIITTGRRT RGKVIDFTKA AEELDKERGV VAEEDEEEEE
160
EEEKENEDDD FKEQVQN
Length:167
Mass (Da):19,708
Last modified:March 15, 2017 - v2
Checksum:i7AC14CA969F58C50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW31418.1.
RefSeqiXP_712353.2. XM_707260.2.

Genome annotation databases

GeneIDi3646031.
KEGGical:CAALFM_CR07230WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCHZ1_CANAL
AccessioniPrimary (citable) accession number: Q59RN6
Secondary accession number(s): A0A1D8PTF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families