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Q59RK9

- PMIP_CANAL

UniProt

Q59RK9 - PMIP_CANAL

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
Active sitei566 – 5661PROSITE-ProRule annotation
Metal bindingi569 – 5691Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi572 – 5721Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CaO19.1195, CaO19.8786
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
BLAST
Chaini34 – 783750Mitochondrial intermediate peptidasePRO_0000338576Add
BLAST

Proteomic databases

PRIDEiQ59RK9.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002161.

Structurei

3D structure databases

ProteinModelPortaliQ59RK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 315Poly-Thr

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
InParanoidiQ59RK9.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59RK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAGIPLSRC TQRLPLLVAR QVSRNITTTT TKFSLAPEYN HIRKVFDSQK
60 70 80 90 100
YFNHFTKQGS HATLFSSPQT GLFHNEYLTT PQGLVDFSQQ SLSQAKQLVS
110 120 130 140 150
EMLSQVNTVD GKLKFIKKLD QLSDILCRVI DVAEFIRVVH PSVKWINAAQ
160 170 180 190 200
QTHEMMFEFM NQLNTNVELY SSLRDILNNP LITEQLTPEE IKVGEYLRQD
210 220 230 240 250
FERSGIHMDP QTRENFVTIT QEISLLGSQF GNQINGLKSY WCPVTVTEWE
260 270 280 290 300
SIEDPQLKKE IKNYQSKYDG IRQPETIQIP LVANIPYTIL TNCSSDTLRK
310 320 330 340 350
KVWVALHNSP DEQIETLNRF ISYRALLSKM LNYKSFADYQ LEHKMAKTPE
360 370 380 390 400
NVITFLSNLQ KSLIKKGVVE ELSQLSEIKH NGSGSASVND IVNDIKPWDR
410 420 430 440 450
DYLLARLQQR MQSEVSAGNV KEYFSVGTVI AGLNELFTRL YDISFVPMAA
460 470 480 490 500
LKGETWDSHQ VRKIKVVDNA ANKTLGFLYL DFWSTKVLPS HFTIVCSRRL
510 520 530 540 550
NTSIGSETIE GMEKLVQLDE DYQLPVVSLV CNFASSGNFS FGRFAGVENE
560 570 580 590 600
KPTLLTLDQV DTIFHEMGHA MHSMIGRTEL HNLSGTRCST DFVELPSVLM
610 620 630 640 650
ESFSKDPRVI CQIGRHFDTD EKLPESLLGQ AHEHRIMLDA CETFMQSKMA
660 670 680 690 700
MLDQKLHNEE MVNLLAKGLY EVDSTKVYHS VEKELKVFAD EWSTWHGKFP
710 720 730 740 750
HLFSYGAVYY SYLLDRAIAD KIWQGLFAKD PWNGEAGKKY KESVLKWGGT
760 770 780
RDPWECLADA LGNDELKQGD SRAMEIIGQN SNL
Length:783
Mass (Da):89,368
Last modified:April 26, 2005 - v1
Checksum:i88739AB0D0DA1928
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000161 Genomic DNA. Translation: EAK93122.1.
AACQ01000157 Genomic DNA. Translation: EAK93273.1.
RefSeqiXP_712312.1. XM_707219.1.
XP_712456.1. XM_707363.1.

Genome annotation databases

GeneIDi3645934.
3646074.
KEGGical:CaO19.1195.
cal:CaO19.8786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000161 Genomic DNA. Translation: EAK93122.1 .
AACQ01000157 Genomic DNA. Translation: EAK93273.1 .
RefSeqi XP_712312.1. XM_707219.1.
XP_712456.1. XM_707363.1.

3D structure databases

ProteinModelPortali Q59RK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002161.

Proteomic databases

PRIDEi Q59RK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645934.
3646074.
KEGGi cal:CaO19.1195.
cal:CaO19.8786.

Phylogenomic databases

eggNOGi COG0339.
InParanoidi Q59RK9.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPMIP_CANAL
AccessioniPrimary (citable) accession number: Q59RK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3