SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q59RK9

- PMIP_CANAL

UniProt

Q59RK9 - PMIP_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitochondrial intermediate peptidase

Gene
OCT1, CaO19.1195, CaO19.8786
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi565 – 5651Zinc; catalytic By similarity
Active sitei566 – 5661 By similarity
Metal bindingi569 – 5691Zinc; catalytic By similarity
Metal bindingi572 – 5721Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CaO19.1195, CaO19.8786
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333Mitochondrion Reviewed predictionAdd
BLAST
Chaini34 – 783750Mitochondrial intermediate peptidasePRO_0000338576Add
BLAST

Proteomic databases

PRIDEiQ59RK9.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002161.

Structurei

3D structure databases

ProteinModelPortaliQ59RK9.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 315Poly-Thr

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59RK9-1 [UniParc]FASTAAdd to Basket

« Hide

MKAGIPLSRC TQRLPLLVAR QVSRNITTTT TKFSLAPEYN HIRKVFDSQK    50
YFNHFTKQGS HATLFSSPQT GLFHNEYLTT PQGLVDFSQQ SLSQAKQLVS 100
EMLSQVNTVD GKLKFIKKLD QLSDILCRVI DVAEFIRVVH PSVKWINAAQ 150
QTHEMMFEFM NQLNTNVELY SSLRDILNNP LITEQLTPEE IKVGEYLRQD 200
FERSGIHMDP QTRENFVTIT QEISLLGSQF GNQINGLKSY WCPVTVTEWE 250
SIEDPQLKKE IKNYQSKYDG IRQPETIQIP LVANIPYTIL TNCSSDTLRK 300
KVWVALHNSP DEQIETLNRF ISYRALLSKM LNYKSFADYQ LEHKMAKTPE 350
NVITFLSNLQ KSLIKKGVVE ELSQLSEIKH NGSGSASVND IVNDIKPWDR 400
DYLLARLQQR MQSEVSAGNV KEYFSVGTVI AGLNELFTRL YDISFVPMAA 450
LKGETWDSHQ VRKIKVVDNA ANKTLGFLYL DFWSTKVLPS HFTIVCSRRL 500
NTSIGSETIE GMEKLVQLDE DYQLPVVSLV CNFASSGNFS FGRFAGVENE 550
KPTLLTLDQV DTIFHEMGHA MHSMIGRTEL HNLSGTRCST DFVELPSVLM 600
ESFSKDPRVI CQIGRHFDTD EKLPESLLGQ AHEHRIMLDA CETFMQSKMA 650
MLDQKLHNEE MVNLLAKGLY EVDSTKVYHS VEKELKVFAD EWSTWHGKFP 700
HLFSYGAVYY SYLLDRAIAD KIWQGLFAKD PWNGEAGKKY KESVLKWGGT 750
RDPWECLADA LGNDELKQGD SRAMEIIGQN SNL 783
Length:783
Mass (Da):89,368
Last modified:April 26, 2005 - v1
Checksum:i88739AB0D0DA1928
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000161 Genomic DNA. Translation: EAK93122.1.
AACQ01000157 Genomic DNA. Translation: EAK93273.1.
RefSeqiXP_712312.1. XM_707219.1.
XP_712456.1. XM_707363.1.

Genome annotation databases

GeneIDi3645934.
3646074.
KEGGical:CaO19.1195.
cal:CaO19.8786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000161 Genomic DNA. Translation: EAK93122.1 .
AACQ01000157 Genomic DNA. Translation: EAK93273.1 .
RefSeqi XP_712312.1. XM_707219.1.
XP_712456.1. XM_707363.1.

3D structure databases

ProteinModelPortali Q59RK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002161.

Protein family/group databases

MEROPSi M03.006.

Proteomic databases

PRIDEi Q59RK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645934.
3646074.
KEGGi cal:CaO19.1195.
cal:CaO19.8786.

Phylogenomic databases

eggNOGi COG0339.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPMIP_CANAL
AccessioniPrimary (citable) accession number: Q59RK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi