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Q59RK9

- PMIP_CANAL

UniProt

Q59RK9 - PMIP_CANAL

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
    Active sitei566 – 5661PROSITE-ProRule annotation
    Metal bindingi569 – 5691Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi572 – 5721Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:CaO19.1195, CaO19.8786
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 783750Mitochondrial intermediate peptidasePRO_0000338576Add
    BLAST

    Proteomic databases

    PRIDEiQ59RK9.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0002161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59RK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 315Poly-Thr

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q59RK9-1 [UniParc]FASTAAdd to Basket

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    MKAGIPLSRC TQRLPLLVAR QVSRNITTTT TKFSLAPEYN HIRKVFDSQK    50
    YFNHFTKQGS HATLFSSPQT GLFHNEYLTT PQGLVDFSQQ SLSQAKQLVS 100
    EMLSQVNTVD GKLKFIKKLD QLSDILCRVI DVAEFIRVVH PSVKWINAAQ 150
    QTHEMMFEFM NQLNTNVELY SSLRDILNNP LITEQLTPEE IKVGEYLRQD 200
    FERSGIHMDP QTRENFVTIT QEISLLGSQF GNQINGLKSY WCPVTVTEWE 250
    SIEDPQLKKE IKNYQSKYDG IRQPETIQIP LVANIPYTIL TNCSSDTLRK 300
    KVWVALHNSP DEQIETLNRF ISYRALLSKM LNYKSFADYQ LEHKMAKTPE 350
    NVITFLSNLQ KSLIKKGVVE ELSQLSEIKH NGSGSASVND IVNDIKPWDR 400
    DYLLARLQQR MQSEVSAGNV KEYFSVGTVI AGLNELFTRL YDISFVPMAA 450
    LKGETWDSHQ VRKIKVVDNA ANKTLGFLYL DFWSTKVLPS HFTIVCSRRL 500
    NTSIGSETIE GMEKLVQLDE DYQLPVVSLV CNFASSGNFS FGRFAGVENE 550
    KPTLLTLDQV DTIFHEMGHA MHSMIGRTEL HNLSGTRCST DFVELPSVLM 600
    ESFSKDPRVI CQIGRHFDTD EKLPESLLGQ AHEHRIMLDA CETFMQSKMA 650
    MLDQKLHNEE MVNLLAKGLY EVDSTKVYHS VEKELKVFAD EWSTWHGKFP 700
    HLFSYGAVYY SYLLDRAIAD KIWQGLFAKD PWNGEAGKKY KESVLKWGGT 750
    RDPWECLADA LGNDELKQGD SRAMEIIGQN SNL 783
    Length:783
    Mass (Da):89,368
    Last modified:April 26, 2005 - v1
    Checksum:i88739AB0D0DA1928
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000161 Genomic DNA. Translation: EAK93122.1.
    AACQ01000157 Genomic DNA. Translation: EAK93273.1.
    RefSeqiXP_712312.1. XM_707219.1.
    XP_712456.1. XM_707363.1.

    Genome annotation databases

    GeneIDi3645934.
    3646074.
    KEGGical:CaO19.1195.
    cal:CaO19.8786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000161 Genomic DNA. Translation: EAK93122.1 .
    AACQ01000157 Genomic DNA. Translation: EAK93273.1 .
    RefSeqi XP_712312.1. XM_707219.1.
    XP_712456.1. XM_707363.1.

    3D structure databases

    ProteinModelPortali Q59RK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002161.

    Protein family/group databases

    MEROPSi M03.006.

    Proteomic databases

    PRIDEi Q59RK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645934.
    3646074.
    KEGGi cal:CaO19.1195.
    cal:CaO19.8786.

    Phylogenomic databases

    eggNOGi COG0339.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPMIP_CANAL
    AccessioniPrimary (citable) accession number: Q59RK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3