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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi565Zinc; catalyticPROSITE-ProRule annotation1
Active sitei566PROSITE-ProRule annotation1
Metal bindingi569Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi572Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:CAALFM_C600340CA
ORF Names:CaO19.1195, CaO19.8786
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 6

Organism-specific databases

CGDiCAL0000183469. orf19.1195.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000033857634 – 783Mitochondrial intermediate peptidaseAdd BLAST750

Proteomic databases

PRIDEiQ59RK9.

Structurei

3D structure databases

ProteinModelPortaliQ59RK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 31Poly-Thr5

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ59RK9.
KOiK01410.
OrthoDBiEOG092C0JU2.

Family and domain databases

CDDicd06457. M3A_MIP. 1 hit.
Gene3Di1.20.1050.40. 1 hit.
InterProiView protein in InterPro
IPR033851. M3A_MIP.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
PANTHERiPTHR11804:SF57. PTHR11804:SF57. 1 hit.
PfamiView protein in Pfam
PF01432. Peptidase_M3. 1 hit.
PROSITEiView protein in PROSITE
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59RK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAGIPLSRC TQRIPLLVAR QVSRNITTTT TKFSLAPEYN HIRKVFDSQK
60 70 80 90 100
YFNHFTKQGS HATLFSSPQT GLFHNEYLTT PQGLVDFSQQ SLSQAKQLVS
110 120 130 140 150
EMLSQVNTVD GKLKFIKKLD QLSDILCRVI DVAEFIRVVH PSVKWINAAQ
160 170 180 190 200
QTHEMMFEFM NQLNTNVELY SSLRDILNNP LITEQLTPEE IKVGEYLRQD
210 220 230 240 250
FERSGIHMDP QTRENFVTIT QEISLLGSQF GNQINGLKSY WCPVTVAEWE
260 270 280 290 300
SIEDPQLKKE IKNYQSKYDG IRQSETIQIP LVANIPYTIL TNCSSDTLRK
310 320 330 340 350
KVWVALHNSP DEQIETLNRF ISYRALLSKM LNYKSFADYQ LEHKMAKTPE
360 370 380 390 400
NVITFLFNLQ KSLIKKGVVE ELSQLSEIKH NGSGSASVND IVNDIKPWDR
410 420 430 440 450
DYLLARLQQR MQSEVSAGNV KEYFSVGTVI AGLNELFTRL YDISFVPMAA
460 470 480 490 500
LKGETWDSHQ VRKIKVVDNA ANKTLGFLYL DFWSTKVLPS HFTIVCSRRL
510 520 530 540 550
NTSIGSETIE GMEKLVQLDE DYQLPVVSLV CNFASSGNFS FGRFAGVENE
560 570 580 590 600
KPTLLTLDQV DTIFHEMGHA MHSMIGRTEL HNLSGTRCST DFVELPSVLM
610 620 630 640 650
ESFSKDPRVI CQIGRHFDTD EKLPESLLGQ AHEHRIMLDA CETFMQSKMA
660 670 680 690 700
MLDQKLHNEE MVNLLAKGLY EVDSTKVYHS VEKELKVFAD EWSTWHGKFP
710 720 730 740 750
HLFSYGAVYY SYLLDRAIAD KIWQGLFAKD PWNGEAGKKY KESVLKWGGT
760 770 780
RDPWECLADA LGNDELKQGD SRAMEIIGQN SNL
Length:783
Mass (Da):89,388
Last modified:March 15, 2017 - v2
Checksum:i1FFEF3589BA8DB51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017628 Genomic DNA. Translation: AOW29983.1.
RefSeqiXP_712312.2. XM_707219.2.

Genome annotation databases

GeneIDi3646074.
KEGGical:CAALFM_C600340CA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPMIP_CANAL
AccessioniPrimary (citable) accession number: Q59RK9
Secondary accession number(s): A0A1D8PPC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families