Reviewed, UniProtKB/Swiss-Prot Q59RH5 (HAT2_CANAL)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase type B subunit 2
    EC=2.3.1.48

Gene names

Name:	HAT2
ORF Names:	CaO19.2146, CaO19.9693

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Subunit structure	Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Molecular function	Acyltransferase Chromatin regulator Transferase
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Histone acetyltransferase type B subunit 2		PRO_0000227735
Regions
	Repeat	98 – 138	41	WD 1
	Repeat	141 – 181	41	WD 2
	Repeat	184 – 224	41	WD 3
	Repeat	228 – 268	41	WD 4
	Repeat	275 – 315	41	WD 5
	Repeat	332 – 372	41	WD 6

Sequences

	Sequence		Length	Mass (Da)
	Q59RH5-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: EC2E4DE6C2A4022E	FASTA	382	42,856
	10 20 30 40 50 60 MSEQPTEPLS IKEEYQLWRK NCRYMYEFVS ETALMWPSLT IQWLPNYTTT NGLIDAKLLL 70 80 90 100 110 120 GTHTSNQSAN QLKVASTQLS ADPNVKANSK IKTVQKLENN AEICRARYMP QDANIVATIN 130 140 150 160 170 180 GLGEVDLYNL DTETRYSHFA PHTKNGYGLS WNPKQKGLLV TGADDNFVCV TDTTTNKTTF 190 200 210 220 230 240 KSDIQKDIVN DVKWHQFNGN LFASVSEDSH VYLFDARDNK VVSQYYAESS NGINSLAFSP 250 260 270 280 290 300 FAENLVAIGN TSSNINLLDL RKLGENSGLL HTMMGHSEGI TCMEFSPHHD GILATGSQDR 310 320 330 340 350 360 RIIIWDLFKV GEEQQQEDAE DGCPELFMMH AGHTAGVSDL SWCPFKDWMI GSVADDNIVH 370 380 LWEISKKLIT NEEAEVDVSI LE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000162 Genomic DNA. Translation: EAK93085.1. AACQ01000158 Genomic DNA. Translation: EAK93235.1.
RefSeq	XP_712278.1. XP_712421.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3645973. 3646093.
KEGG	cal:CaO19.2146. cal:CaO19.9693.
Organism-specific databases
CGD	CAL0005349. orf19.2146.
Phylogenomic databases
OMA	IIQKINH.
Enzyme and pathway databases
BRENDA	2.3.1.48. 1124.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 4 hits. [Graphical view]
ProDom	PD000018. WD40. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00320. WD40. 5 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT2_CANAL

Accession

Primary (citable) accession number: Q59RH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	April 26, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)