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Protein

Mitochondrial import inner membrane translocase subunit TIM9

Gene

TIM9

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Translocation, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM9
Gene namesi
Name:TIM9
Ordered Locus Names:CAALFM_C703630CA
ORF Names:CaJ7.0415, CaO19.13988, CaO19.6696
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 7

Organism-specific databases

CGDiCAL0000177007. TIM9.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002280411 – 87Mitochondrial import inner membrane translocase subunit TIM9Add BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi39 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ59R24.

Interactioni

Subunit structurei

Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59R24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 59Twin CX3C motifAdd BLAST25

Domaini

The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).By similarity

Sequence similaritiesi

Belongs to the small Tim family.Curated

Phylogenomic databases

InParanoidiQ59R24.
OrthoDBiEOG092C5RBL.

Family and domain databases

InterProiView protein in InterPro
IPR004217. Tim10/DDP_fam_Znf.
PfamiView protein in Pfam
PF02953. zf-Tim10_DDP. 1 hit.
SUPFAMiSSF144122. SSF144122. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59R24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQLNVKEQQ EFQQIVEQKQ MKDFMNLYSN LVSRCFDDCV NDFTSNSLTS
60 70 80
KETSCIAKCS EKFLKHSERV GQRFQEQNAL LMQQGPK
Length:87
Mass (Da):10,202
Last modified:March 15, 2017 - v2
Checksum:i5E78FE30BDA92055
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78 – 87NALLMQQGPK → KYVDLSRVTNGNMPLMIIII YHQIILTNKLILL in BAE44866 (PubMed:15937140).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006852 Genomic DNA. Translation: BAE44866.1.
CP017629 Genomic DNA. Translation: AOW30705.1.
RefSeqiXP_019331040.1. XM_019475495.1.

Genome annotation databases

GeneIDi3646243.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTIM9_CANAL
AccessioniPrimary (citable) accession number: Q59R24
Secondary accession number(s): A0A1D8PRE3, Q3MNZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families