Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iron-sulfur clusters transporter ATM1, mitochondrial

Gene

ATM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei407Glutathione; via amide nitrogenBy similarity1
Binding sitei475ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi499 – 510ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: CGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial
Gene namesi
Name:ATM1
Ordered Locus Names:CAALFM_C604210CA
ORF Names:CaO19.1077, CaO19.8678
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 6

Organism-specific databases

CGDiCAL0000178930. ATM1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 124Mitochondrial matrixBy similarityAdd BLAST108
Transmembranei125 – 146HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini147 – 169Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei170 – 193HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini194 – 242Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei243 – 266HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini267Mitochondrial intermembraneBy similarity1
Transmembranei268 – 288HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini289 – 354Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei355 – 373HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini374 – 388Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei389 – 410HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini411 – 750Mitochondrial matrixBy similarityAdd BLAST340

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000025544017 – 750Iron-sulfur clusters transporter ATM1, mitochondrialAdd BLAST734

Proteomic databases

PRIDEiQ59R09.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59R09.
SMRiQ59R09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 415ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini466 – 702ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni294 – 298Glutathione bindingBy similarity5
Regioni357 – 360Glutathione bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 103Ser-richAdd BLAST81
Compositional biasi445 – 460Asn-richAdd BLAST16

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ59R09.
KOiK05663.
OrthoDBiEOG092C3H79.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59R09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIRNVKLIK PSPVRFISPI PFSFPISRSI KISSIRYFTN KSTSNFKSTS
60 70 80 90 100
SSSSLKSTST STSTSTSKTT PKTLSKPPPK VKPPIQDNDT TSSGSSSSEN
110 120 130 140 150
SESFMLKSLF KTIWPKNNLN FKIRVIIALS LLVGAKILNV QVPFYFKQII
160 170 180 190 200
DTMNIDWTNE VGVFSTVIGS LILAYGGARF GAVLFGELRN AIFASVAQSA
210 220 230 240 250
IRRVAYNTFV KLLNMDLQFH LSRQTGGLTR AIDRGTKGIS YVLSAMVFHI
260 270 280 290 300
IPITLEISIV CGILTYNYGA SFAAMTFVTM LAYSIFTIQT TAWRTKFRRQ
310 320 330 340 350
ANNADNQAAN VALDSLINYE SVKIFNNELY QASKYDKALM KYQQSSVKIA
360 370 380 390 400
TSLAFLNSGQ NFIFTSALTA MMYMGCQGVY TGELTVGDLV LINQLVFQLS
410 420 430 440 450
VPLNFLGSVY RELKQSLLDM ENLFQLQNQP IRIKEIPNAP PLKLNNNNNN
460 470 480 490 500
NNNNNNNNNN SLPGEIRFEN VSFGYHPDRP ILNNASFTIP AGQKVAIVGP
510 520 530 540 550
SGSGKSTILR LIFRFYDINQ GRILIDGQDI SKVSLESLRK LIGIVPQETP
560 570 580 590 600
LFNDTILENI RYGRLDASDE EIYRVINQVQ LNKLIDDLPD GVQTIVGERG
610 620 630 640 650
MMISGGEKQR LAMARLLLKR APITFFDEAT SALDTHTEQA LLKTIRSVFK
660 670 680 690 700
QQHQTNVSIA HRLRTIADAD KIIVLNKGQV VEEGTHWQLL NEQPNSLYAQ
710 720 730 740 750
LWNIQENLDI EKELLQGDEE EEELTEKLKL DKQELEQEAK LFNSQTFEKK
Length:750
Mass (Da):84,059
Last modified:March 15, 2017 - v2
Checksum:i894F340D6347FE7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017628 Genomic DNA. Translation: AOW30340.1.
RefSeqiXP_712090.2. XM_706997.2.

Genome annotation databases

GeneIDi3646284.
KEGGical:CAALFM_C604210CA.

Similar proteinsi

Entry informationi

Entry nameiATM1_CANAL
AccessioniPrimary (citable) accession number: Q59R09
Secondary accession number(s): A0A1D8PQD0, Q59QY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 15, 2017
Last modified: October 25, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families