Reviewed, UniProtKB/Swiss-Prot Q59R09 (ATM1_CANAL)

Names and origin

Protein names

Recommended name:
    Iron-sulfur clusters transporter ATM1, mitochondrial

Gene names

Name:	ATM1
ORF Names:	CaO19.1077, CaO19.8678

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	750 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors from the mitochondrion By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.
Sequence caution	The sequence EAK92868.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane
Ligand	ATP-binding Iron Nucleotide-binding
Gene Ontology (GO)
Biological process	iron ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 16	16	Mitochondrion Potential
	Chain	17 – 750	734	Iron-sulfur clusters transporter ATM1, mitochondrial		PRO_0000255440
Regions
	Topological domain	17 – 125	109	Mitochondrial matrix Potential
	Transmembrane	126 – 146	21	Potential
	Topological domain	147 – 165	19	Mitochondrial intermembrane Potential
	Transmembrane	166 – 186	21	Potential
	Topological domain	187 – 244	58	Mitochondrial matrix Potential
	Transmembrane	245 – 265	21	Potential
	Topological domain	266 – 267	2	Mitochondrial intermembrane Potential
	Transmembrane	268 – 288	21	Potential
	Topological domain	289 – 348	60	Mitochondrial matrix Potential
	Transmembrane	349 – 371	23	Potential
	Topological domain	372 – 750	379	Mitochondrial intermembrane Potential
	Domain	125 – 415	291	ABC transmembrane type-1
	Domain	466 – 702	237	ABC transporter
	Nucleotide binding	499 – 506	8	ATP Potential
	Compositional bias	23 – 103	81	Ser-rich
	Compositional bias	445 – 460	16	Asn-rich

Sequences

	Sequence		Length	Mass (Da)
	Q59R09-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A3EE9EA5B9732D37	FASTA	750	84,132
	10 20 30 40 50 60 MFIRNVKLIK PSPVRFISPI PFSFPISRSI KISSIRYFTN KSTSNFKSTS SSSSLKSTST 70 80 90 100 110 120 STSTSTSKTT PKTLSKPPPK VKPPIQDNDT TSSGSSSSEN SESFMLKSLF KTIWPKNNLN 130 140 150 160 170 180 FKIRVIIALS LLVGAKILNV QVPFYFKQII DTMNIDWTNE VGVFSTVIGS LILAYGGARF 190 200 210 220 230 240 GAVLFGELRN AIFASVAQSA IRRVAYNTFV KLLNMDLQFH LSRQTGGLTR AIDRGTKGIS 250 260 270 280 290 300 YVLSAMVFHI IPITLEISIV CGILTYNYGA SFAAMTFVTM LAYSIFTIQT TAWRTKFRRQ 310 320 330 340 350 360 ANNADNQAAN VALDSLINYE SVKIFNNELY QASKYDKALM KYQQSSVKIA TSLAFLNSGQ 370 380 390 400 410 420 NFIFTSALTA MMYMGCQGVY TGELTVGDLV LINQWVFQLS VPLNFLGSVY RELKQSLLDM 430 440 450 460 470 480 ENLFQLQNQP IRIKEIPNAP PLKLNNNNNN NNNNNNNNNN SLPGEIRFEN VSFGYHPDRP 490 500 510 520 530 540 ILNNASFTIP AGQKVAIVGP SGSGKSTILR LIFRFYDINQ GRILIDGQDI SKVSLESLRK 550 560 570 580 590 600 LIGIVPQETP LFNDTILENI RYGRLDASDE EIYRVINQVQ LNKLIDDLPD GVQTIVGERG 610 620 630 640 650 660 MMISGGEKQR LAMARLLLKR APITFFDEAT SALDTHTEQA LLKTIRSVFK QQHQTNVSIA 670 680 690 700 710 720 HRLRTIADAD KIIVLNKGQV VEEGTHWQLL NEQPNSLYAQ LWNIQENLDI EKELLQGDEE 730 740 750 EEELTEKLKL DKQELEQEAK LFNSQTFEKK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000168 Genomic DNA. Translation: EAK92894.1. AACQ01000169 Genomic DNA. Translation: EAK92868.1. Sequence problems.
RefSeq	XP_712065.1. XP_712090.1.
3D structure databases
HSSP	HSSP built from PDB template 2GHI based on UniProtKB Q7RBT4.
ModBase	Search...
Genome annotation databases
GeneID	3646284. 3646309.
KEGG	cal:CaO19.1077. cal:CaO19.8678.
Organism-specific databases
CGD	CAL0001228. ATM1.
Phylogenomic databases
OrthoDB	EOG95DZ62.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATM1_CANAL

Accession

Primary (citable) accession number: Q59R09
Secondary accession number(s): Q59QY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	April 26, 2005
Last modified:	November 24, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)