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Q59QD6

- EF1A2_CANAL

UniProt

Q59QD6 - EF1A2_CANAL

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Protein

Elongation factor 1-alpha 2

Gene
TEF2, CaO19.382, CaO19.8012
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTP By similarity
Nucleotide bindingi91 – 955GTP By similarity
Nucleotide bindingi153 – 1564GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. protein binding Source: CGD
  4. translation elongation factor activity Source: CGD

GO - Biological processi

  1. interaction with host Source: CGD
  2. translational elongation Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alpha 2
Short name:
EF-1-alpha 2
Gene namesi
Name:TEF2
ORF Names:CaO19.382, CaO19.8012
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004916. TEF2.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: CGD
  2. cytoplasm Source: UniProtKB-SubCell
  3. fungal-type cell wall Source: CGD
  4. hyphal cell wall Source: CGD
  5. yeast-form cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Elongation factor 1-alpha 2UniRule annotationPRO_0000413176Add
BLAST

Proteomic databases

PRIDEiQ59QD6.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0004916.

Structurei

3D structure databases

ProteinModelPortaliQ59QD6.
SMRiQ59QD6. Positions 2-441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 240236tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 218G1 By similarity
Regioni70 – 745G2 By similarity
Regioni91 – 944G3 By similarity
Regioni153 – 1564G4 By similarity
Regioni192 – 1943G5 By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK03231.
OrthoDBiEOG715QCW.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_A. EF_Tu_A.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59QD6-1 [UniParc]FASTAAdd to Basket

« Hide

MGKEKTHVNV VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAELG    50
KGSFKYAWVL DKLKAERERG ITIDIALWKF ETPKYHVTVI DAPGHRDFIK 100
NMITGTSQAD CAILIIAGGT GEFEAGISKD GQTREHALLA YTLGVKQLIV 150
AVNKMDSVKW DKNRFEEIIK ETSNFVKKVG YNPKTVPFVP ISGWNGDNMI 200
EASTNCPWYK GWEKETKSGK VTGKTLLEAI DAIEPPTRPT DKPLRLPLQD 250
VYKIGGIGTV PVGRVETGII KAGMVVTFAP AGVTTEVKSV EMHHEQLAEG 300
VPGDNVGFNV KNVSVKEIRR GNVCGDSKND PPKGCDSFNA QVIVLNHPGQ 350
ISAGYSPVLD CHTAHIACKF DTLVEKIDRR TGKKLEENPK FVKSGDAAIV 400
KMVPTKPMCV EAFTDYPPLG RFAVRDMRQT VAVGVIKSVE KSDKAGKVTK 450
AAQKAAKK 458
Length:458
Mass (Da):49,986
Last modified:April 26, 2005 - v1
Checksum:iC1EBB498F1373B09
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021A → P in AAA34340. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29935 Genomic DNA. Translation: AAA34340.1.
AACQ01000177 Genomic DNA. Translation: EAK92662.1.
AACQ01000176 Genomic DNA. Translation: EAK92691.1.
RefSeqiXP_711870.1. XM_706777.1.
XP_711899.1. XM_706806.1.

Genome annotation databases

GeneIDi3646463.
3646502.
KEGGical:CaO19.382.
cal:CaO19.8012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29935 Genomic DNA. Translation: AAA34340.1 .
AACQ01000177 Genomic DNA. Translation: EAK92662.1 .
AACQ01000176 Genomic DNA. Translation: EAK92691.1 .
RefSeqi XP_711870.1. XM_706777.1.
XP_711899.1. XM_706806.1.

3D structure databases

ProteinModelPortali Q59QD6.
SMRi Q59QD6. Positions 2-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0004916.

Proteomic databases

PRIDEi Q59QD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3646463.
3646502.
KEGGi cal:CaO19.382.
cal:CaO19.8012.

Organism-specific databases

CGDi CAL0004916. TEF2.

Phylogenomic databases

KOi K03231.
OrthoDBi EOG715QCW.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_A. EF_Tu_A.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00483. EF-1_alpha. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans."
    Sundstrom P., Smith D., Sypherd P.S.
    J. Bacteriol. 172:2036-2045(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiEF1A2_CANAL
AccessioniPrimary (citable) accession number: Q59QD6
Secondary accession number(s): P16017, Q5A743
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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