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Q59QD6 (EF1A2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor 1-alpha 2

Short name=EF-1-alpha 2
Gene names
Name:TEF2
ORF Names:CaO19.382, CaO19.8012
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. HAMAP-Rule MF_00118_A

Subcellular location

Cytoplasm HAMAP-Rule MF_00118_A.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Elongation factor 1-alpha 2 HAMAP-Rule MF_00118_A
PRO_0000413176

Regions

Nucleotide binding14 – 218GTP By similarity
Nucleotide binding91 – 955GTP By similarity
Nucleotide binding153 – 1564GTP By similarity

Experimental info

Sequence conflict2021A → P in AAA34340. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q59QD6 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: C1EBB498F1373B09

FASTA45849,986
        10         20         30         40         50         60 
MGKEKTHVNV VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAELG KGSFKYAWVL 

        70         80         90        100        110        120 
DKLKAERERG ITIDIALWKF ETPKYHVTVI DAPGHRDFIK NMITGTSQAD CAILIIAGGT 

       130        140        150        160        170        180 
GEFEAGISKD GQTREHALLA YTLGVKQLIV AVNKMDSVKW DKNRFEEIIK ETSNFVKKVG 

       190        200        210        220        230        240 
YNPKTVPFVP ISGWNGDNMI EASTNCPWYK GWEKETKSGK VTGKTLLEAI DAIEPPTRPT 

       250        260        270        280        290        300 
DKPLRLPLQD VYKIGGIGTV PVGRVETGII KAGMVVTFAP AGVTTEVKSV EMHHEQLAEG 

       310        320        330        340        350        360 
VPGDNVGFNV KNVSVKEIRR GNVCGDSKND PPKGCDSFNA QVIVLNHPGQ ISAGYSPVLD 

       370        380        390        400        410        420 
CHTAHIACKF DTLVEKIDRR TGKKLEENPK FVKSGDAAIV KMVPTKPMCV EAFTDYPPLG 

       430        440        450 
RFAVRDMRQT VAVGVIKSVE KSDKAGKVTK AAQKAAKK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans."
Sundstrom P., Smith D., Sypherd P.S.
J. Bacteriol. 172:2036-2045(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29935 Genomic DNA. Translation: AAA34340.1.
AACQ01000177 Genomic DNA. Translation: EAK92662.1.
AACQ01000176 Genomic DNA. Translation: EAK92691.1.
RefSeqXP_711870.1. XM_706777.1.
XP_711899.1. XM_706806.1.

3D structure databases

ProteinModelPortalQ59QD6.
SMRQ59QD6. Positions 2-441.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0004916.

Proteomic databases

PRIDEQ59QD6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646463.
3646502.
KEGGcal:CaO19.382.
cal:CaO19.8012.

Organism-specific databases

CGDCAL0004916. TEF2.

Phylogenomic databases

KOK03231.
OrthoDBEOG715QCW.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00118_A. EF_Tu_A.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00483. EF-1_alpha. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEF1A2_CANAL
AccessionPrimary (citable) accession number: Q59QD6
Secondary accession number(s): P16017, Q5A743
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names