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Protein

Elongation factor 1-alpha 2

Gene

TEF2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi153 – 156GTPBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alpha 2
Short name:
EF-1-alpha 2
Gene namesi
Name:TEF2
ORF Names:CaO19.382, CaO19.8012
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004131761 – 458Elongation factor 1-alpha 2Add BLAST458

Proteomic databases

PRIDEiQ59QD6.

Structurei

3D structure databases

ProteinModelPortaliQ59QD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 240tr-type GAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21G1By similarity8
Regioni70 – 74G2By similarity5
Regioni91 – 94G3By similarity4
Regioni153 – 156G4By similarity4
Regioni192 – 194G5By similarity3

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ59QD6.
KOiK03231.
OrthoDBiEOG092C2HV8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_A. EF_Tu_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59QD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEKTHVNV VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAELG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDIALWKF ETPKYHVTVI DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAILIIAGGT GEFEAGISKD GQTREHALLA YTLGVKQLIV
160 170 180 190 200
AVNKMDSVKW DKNRFEEIIK ETSNFVKKVG YNPKTVPFVP ISGWNGDNMI
210 220 230 240 250
EASTNCPWYK GWEKETKSGK VTGKTLLEAI DAIEPPTRPT DKPLRLPLQD
260 270 280 290 300
VYKIGGIGTV PVGRVETGII KAGMVVTFAP AGVTTEVKSV EMHHEQLAEG
310 320 330 340 350
VPGDNVGFNV KNVSVKEIRR GNVCGDSKND PPKGCDSFNA QVIVLNHPGQ
360 370 380 390 400
ISAGYSPVLD CHTAHIACKF DTLVEKIDRR TGKKLEENPK FVKSGDAAIV
410 420 430 440 450
KMVPTKPMCV EAFTDYPPLG RFAVRDMRQT VAVGVIKSVE KSDKAGKVTK

AAQKAAKK
Length:458
Mass (Da):49,986
Last modified:April 26, 2005 - v1
Checksum:iC1EBB498F1373B09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202A → P in AAA34340 (PubMed:2180914).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29935 Genomic DNA. Translation: AAA34340.1.
AACQ01000177 Genomic DNA. Translation: EAK92662.1.
AACQ01000176 Genomic DNA. Translation: EAK92691.1.
RefSeqiXP_711870.1. XM_706777.1.
XP_711899.1. XM_706806.1.

Genome annotation databases

EnsemblFungiiEAK92662; EAK92662; CaO19.382.
EAK92691; EAK92691; CaO19.8012.
GeneIDi3646463.
3646502.
KEGGical:CaO19.382.
cal:CaO19.8012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29935 Genomic DNA. Translation: AAA34340.1.
AACQ01000177 Genomic DNA. Translation: EAK92662.1.
AACQ01000176 Genomic DNA. Translation: EAK92691.1.
RefSeqiXP_711870.1. XM_706777.1.
XP_711899.1. XM_706806.1.

3D structure databases

ProteinModelPortaliQ59QD6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59QD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK92662; EAK92662; CaO19.382.
EAK92691; EAK92691; CaO19.8012.
GeneIDi3646463.
3646502.
KEGGical:CaO19.382.
cal:CaO19.8012.

Phylogenomic databases

InParanoidiQ59QD6.
KOiK03231.
OrthoDBiEOG092C2HV8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_A. EF_Tu_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEF1A2_CANAL
AccessioniPrimary (citable) accession number: Q59QD6
Secondary accession number(s): P16017, Q5A743
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.