Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q59QD6

- EF1A2_CANAL

UniProt

Q59QD6 - EF1A2_CANAL

Protein

Elongation factor 1-alpha 2

Gene

TEF2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 218GTPBy similarity
    Nucleotide bindingi91 – 955GTPBy similarity
    Nucleotide bindingi153 – 1564GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. protein binding Source: CGD
    4. translation elongation factor activity Source: CGD

    GO - Biological processi

    1. interaction with host Source: CGD
    2. translational elongation Source: CGD

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor 1-alpha 2
    Short name:
    EF-1-alpha 2
    Gene namesi
    Name:TEF2
    ORF Names:CaO19.382, CaO19.8012
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0004916. TEF2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: CGD
    2. cytoplasm Source: UniProtKB-SubCell
    3. fungal-type cell wall Source: CGD
    4. hyphal cell wall Source: CGD
    5. yeast-form cell wall Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Elongation factor 1-alpha 2PRO_0000413176Add
    BLAST

    Proteomic databases

    PRIDEiQ59QD6.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0004916.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59QD6.
    SMRiQ59QD6. Positions 2-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 240236tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 218G1By similarity
    Regioni70 – 745G2By similarity
    Regioni91 – 944G3By similarity
    Regioni153 – 1564G4By similarity
    Regioni192 – 1943G5By similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK03231.
    OrthoDBiEOG715QCW.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_A. EF_Tu_A.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004539. Transl_elong_EF1A_euk/arc.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59QD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKEKTHVNV VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAELG    50
    KGSFKYAWVL DKLKAERERG ITIDIALWKF ETPKYHVTVI DAPGHRDFIK 100
    NMITGTSQAD CAILIIAGGT GEFEAGISKD GQTREHALLA YTLGVKQLIV 150
    AVNKMDSVKW DKNRFEEIIK ETSNFVKKVG YNPKTVPFVP ISGWNGDNMI 200
    EASTNCPWYK GWEKETKSGK VTGKTLLEAI DAIEPPTRPT DKPLRLPLQD 250
    VYKIGGIGTV PVGRVETGII KAGMVVTFAP AGVTTEVKSV EMHHEQLAEG 300
    VPGDNVGFNV KNVSVKEIRR GNVCGDSKND PPKGCDSFNA QVIVLNHPGQ 350
    ISAGYSPVLD CHTAHIACKF DTLVEKIDRR TGKKLEENPK FVKSGDAAIV 400
    KMVPTKPMCV EAFTDYPPLG RFAVRDMRQT VAVGVIKSVE KSDKAGKVTK 450
    AAQKAAKK 458
    Length:458
    Mass (Da):49,986
    Last modified:April 26, 2005 - v1
    Checksum:iC1EBB498F1373B09
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021A → P in AAA34340. (PubMed:2180914)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29935 Genomic DNA. Translation: AAA34340.1.
    AACQ01000177 Genomic DNA. Translation: EAK92662.1.
    AACQ01000176 Genomic DNA. Translation: EAK92691.1.
    RefSeqiXP_711870.1. XM_706777.1.
    XP_711899.1. XM_706806.1.

    Genome annotation databases

    GeneIDi3646463.
    3646502.
    KEGGical:CaO19.382.
    cal:CaO19.8012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29935 Genomic DNA. Translation: AAA34340.1 .
    AACQ01000177 Genomic DNA. Translation: EAK92662.1 .
    AACQ01000176 Genomic DNA. Translation: EAK92691.1 .
    RefSeqi XP_711870.1. XM_706777.1.
    XP_711899.1. XM_706806.1.

    3D structure databases

    ProteinModelPortali Q59QD6.
    SMRi Q59QD6. Positions 2-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0004916.

    Proteomic databases

    PRIDEi Q59QD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646463.
    3646502.
    KEGGi cal:CaO19.382.
    cal:CaO19.8012.

    Organism-specific databases

    CGDi CAL0004916. TEF2.

    Phylogenomic databases

    KOi K03231.
    OrthoDBi EOG715QCW.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_A. EF_Tu_A.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004539. Transl_elong_EF1A_euk/arc.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00483. EF-1_alpha. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans."
      Sundstrom P., Smith D., Sypherd P.S.
      J. Bacteriol. 172:2036-2045(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiEF1A2_CANAL
    AccessioniPrimary (citable) accession number: Q59QD6
    Secondary accession number(s): P16017, Q5A743
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3