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Protein

Kynureninase

Gene

BNA5

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei115 – 1151Pyridoxal phosphateUniRule annotation
Binding sitei228 – 2281Pyridoxal phosphateUniRule annotation
Binding sitei231 – 2311Pyridoxal phosphateUniRule annotation
Binding sitei253 – 2531Pyridoxal phosphateUniRule annotation
Binding sitei288 – 2881Pyridoxal phosphateUniRule annotation
Binding sitei316 – 3161Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: CGD
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: CGD
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:CaO19.394, CaO19.8024
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004950. orf19.394.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461KynureninasePRO_0000356973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei254 – 2541N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi5476.CAL0004950.

Structurei

3D structure databases

ProteinModelPortaliQ59QC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni142 – 1454Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
InParanoidiQ59QC4.
KOiK01556.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59QC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAEAKKLD KKFPTFKNEF AIPTFGSLGI KNNKYESSTE SIYLCGNSLG
60 70 80 90 100
LMPKNTKKAI NDELNAWVER GVESHFNHPD KSLTPWVDID LPLLPLIAPI
110 120 130 140 150
VGAKENEVAV MGSLTANLNA LLIHFYKPEG KRTKILFEKQ AFPSDYYAFL
160 170 180 190 200
NIVKLFGYDE KHLIQLEVQP GETYIKTERI IKAIDENSDE LALVCFPGIQ
210 220 230 240 250
YYTGQFFKIE EITKYAKEKS QQIKVGWDLA HAVGNVPLNL HDWGVDFAAW
260 270 280 290 300
CSYKYLNSGP GAIGGIFVHE KYTIENKKSS FVPRLAGWWG NNSQERFKML
310 320 330 340 350
EEFDPINSAL SYRQSNPSVL DVVAVKSSLE VYAKVGGVSK LREKSVALTQ
360 370 380 390 400
FLQDLLTNSK YYIPQSSTSN SKFGFKILTP LNPAERGCQL SIMFQPHFDE
410 420 430 440 450
KDKNVMERVN AYLHDHAIIC DERRPDVIRL APLPLYNTFE ETFIAVQRLF
460
EALDNISKEY M
Length:461
Mass (Da):52,384
Last modified:April 25, 2005 - v1
Checksum:iC96FCFF707B7CEDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000176 Genomic DNA. Translation: EAK92703.1.
AACQ01000177 Genomic DNA. Translation: EAK92674.1.
RefSeqiXP_711882.1. XM_706789.1.
XP_711911.1. XM_706818.1.

Genome annotation databases

GeneIDi3646483.
3646492.
KEGGical:CaO19.394.
cal:CaO19.8024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000176 Genomic DNA. Translation: EAK92703.1.
AACQ01000177 Genomic DNA. Translation: EAK92674.1.
RefSeqiXP_711882.1. XM_706789.1.
XP_711911.1. XM_706818.1.

3D structure databases

ProteinModelPortaliQ59QC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0004950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3646483.
3646492.
KEGGical:CaO19.394.
cal:CaO19.8024.

Organism-specific databases

CGDiCAL0004950. orf19.394.

Phylogenomic databases

eggNOGiCOG3844.
InParanoidiQ59QC4.
KOiK01556.
OrthoDBiEOG7V1G0J.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiKYNU_CANAL
AccessioniPrimary (citable) accession number: Q59QC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2008
Last sequence update: April 25, 2005
Last modified: January 6, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.