Q59Q79 (ALG1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chitobiosyldiphosphodolichol beta-mannosyltransferase
EC=2.4.1.142

Alternative name(s):
Asparagine-linked glycosylation protein 1
Beta-1,4-mannosyltransferase
GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase

Gene names

Name:	ALG1
ORF Names:	CaO19.4410, CaO19.11888

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man5 intermediate on the cytoplasmic surface of the ER By similarity.
Catalytic activity	GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase group 1 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chitobiosyldiphosphodolichol beta-mannosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Chitobiosyldiphosphodolichol beta-mannosyltransferase		PRO_0000080253
Regions
	Topological domain	1 – 22	22	Cytoplasmic Potential
	Transmembrane	23 – 43	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	44 – 456	413	Lumenal Potential
Amino acid modifications
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
	Glycosylation	214	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59Q79 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 91C937DB823D4A11	FASTA	456	52,325
	10 20 30 40 50 60 MGEIIKYKGF DHVWQYSGPW LYCLIGIYIS LPVLAYHILP WIFHKNRSNK RKTISIFVLG 70 80 90 100 110 120 DLGHSPRMCY HASSFSKLDY YVNLCGYVET EPSHQIVDDV NIDIIPIEAI KNTNNLPYIM 130 140 150 160 170 180 FAILKVVRQC GKIWSILWDT RGSDYIMIQN PPSIPILLIV ILFKTVFSRE TKLIIDWHNL 190 200 210 220 230 240 NYTILNLRYN NLNHPFVKLV KLYEKILGQF ANLNITVTKS MKKYLVKEFG FQKSKIVTLY 250 260 270 280 290 300 DRPGVQFQPL SNKREFMSEH KLFEDIDIEK YKVLISSTSF TPDEDFNILL DALKNYENTP 310 320 330 340 350 360 NTPPILLIVT GKGPLKGKFL ETVDKLEFTN KVCVKSAWLS SEDYPKVLAC ADLGISLHTS 370 380 390 400 410 420 SSGIDLPMKI VDFFGCGVPV VSLDFPAIDE LVKNKVNGLI TNSKSDQTKE VARLVTEVFT 430 440 450 DDALLRSIKE GALEESNSRW DENWMQTFSS IFENKS

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000179 Genomic DNA. Translation: EAK92630.1. AACQ01000178 Genomic DNA. Translation: EAK92650.1.
RefSeq	XP_711858.1. XM_706765.1. XP_723598.1. XM_718505.1.
3D structure databases
ProteinModelPortal	Q59Q79.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59Q79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646517. 3646537.
KEGG	cal:CaO19.11888. cal:CaO19.4410.
Organism-specific databases
CGD	CAL0001745. ALG1.
Phylogenomic databases
PhylomeDB	Q59Q79.
Family and domain databases
InterPro	IPR001296. Glyco_trans_1. [Graphical view]
KO	K03842.
Pfam	PF00534. Glycos_transf_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALG1_CANAL

Accession

Primary (citable) accession number: Q59Q79

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program