Q59Q39 (TRM10_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
tRNA (guanine(9)-N1)-methyltransferase
EC=2.1.1.221

Alternative name(s):
tRNA methyltransferase 10
tRNA(m1G9)-methyltransferase
Short name=tRNA(m1G9)MTase

Gene names

Name:	TRM10
ORF Names:	CaO19.25, CaO19.7696

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + guanine9 in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine9 in tRNA.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the RNA methyltransferase TrmD family. TRM10 subfamily.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Cytoplasm Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	tRNA (guanine(9)-N1)-methyltransferase		PRO_0000060511

Sequences

	Sequence		Length	Mass (Da)
	Q59Q39 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: FFBC5E16F5B11B6A	FASTA	323	37,760
	10 20 30 40 50 60 MTEQTSEATV VNNSPAPTIP KIKREKPTPE EIEERRKLKQ LEVVPEGFSR KQWKRELKKQ 70 80 90 100 110 120 RWQDTKQEYL EVQREKKRLA RQRKRERLKD LDENDELRKA QPIPSRQIST NNVSVIIDCD 130 140 150 160 170 180 FDELMHEKEI VSLSNQIKAC YSAMRHCTYK LPIQITSFNK RLKQRFEAQL HDYHLWQGNI 190 200 210 220 230 240 SFTDRSLTEY VTGAPNSESK DNDGNSNSNT TNSTDTINTE NLVYLTADTD EEITKLEPNH 250 260 270 280 290 300 TYIIGGIVDK NRHKQLCYNK AKELGIKVAR LPIGKYIEMN GRHVLVTSHV YELLCKWFEN 310 320 DGDWETAFNK VLPPRKIKSK SPS

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000181 Genomic DNA. Translation: EAK92588.1. AACQ01000180 Genomic DNA. Translation: EAK92610.1.
RefSeq	XP_711810.1. XM_706718.1. XP_711832.1. XM_706740.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q59Q39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646568. 3646590.
KEGG	cal:CaO19.25. cal:CaO19.7696.
Organism-specific databases
CGD	CAL0000523. orf19.25.
Phylogenomic databases
PhylomeDB	Q59Q39.
Family and domain databases
InterPro	IPR016009. tRNA_m1G_MeTrfase. IPR007356. tRNA_m1G_MeTrfase_euk. IPR016653. tRNA_m1G_mtfrase_met. [Graphical view]
KO	K15445.
PANTHER	PTHR13563. DUF425. 1 hit.
Pfam	PF01746. tRNA_m1G_MT. 1 hit. [Graphical view]
PIRSF	PIRSF016323. tRNA_m1G_mtfrase_met. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRM10_CANAL

Accession

Primary (citable) accession number: Q59Q39

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program