Q59PZ3 (ATG7_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like modifier-activating enzyme ATG7

Alternative name(s):
ATG12-activating enzyme E1 ATG7
Autophagy-related protein 7

Gene names

Name:	ATG7
Synonyms:	APG7
ORF Names:	CaO19.707, CaO19.8326

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	639 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probable E1-like activating enzyme involved in cytoplasm to vacuole transport (Cvt) and autophagy By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	The GxGxxG motif is important for the function, possibly through binding with ATP By similarity.
Sequence similarities	Belongs to the ATG7 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport Ubl conjugation pathway
Cellular component	Cytoplasm
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 639	639	Ubiquitin-like modifier-activating enzyme ATG7		PRO_0000212811
Regions
	Motif	322 – 327	6	GXGXXG motif
Sites
	Active site	502	1	Glycyl thioester intermediate By similarity
Natural variations
	Natural variant	2	1	T → S in allele CaO19.8326.
	Natural variant	5 – 6	2	KY → SD in allele CaO19.8326.

Sequences

	Sequence		Length	Mass (Da)
	Q59PZ3 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8721845428215972	FASTA	639	72,966
	10 20 30 40 50 60 MTNHKYQIVK KYILNQSFVE SSFFTKLSEL KLEKYKLDSS YIAIHGFQTH PTKLNKFNDT 70 80 90 100 110 120 PVLNLDQSSF DDTLNDSRIN IPGELFNVNT IEEFKSLDKL KLLNTWGQNV YSEVTNATSF 130 140 150 160 170 180 DYKLFNKFYI LTYSDLKKYK FYYWVAYPTL SNTWTVESES QETDTTITQL VETELDNEYG 190 200 210 220 230 240 QFFQYYGGKL HKSVQADKEH TFVFIDTCLS KDRKPSSQLK NYLYFIAYKG IKEIDLVTYR 250 260 270 280 290 300 NNNLSFTQHL KLDAFTDSPK ISGWERTNQG KLGPKLADLG SLINPLQLAE QAVELNLKLM 310 320 330 340 350 360 KWRIAPDIDL EIIKKQKVLL LGAGTLGSYV ARALLGWGVR SITFVDSGRI SFSNPVRQPL 370 380 390 400 410 420 FNFEDCFSDS GQGEYKALRA AENLKRVFPG VDAKGICLAV PMVGHPVTDE HKERENYETL 430 440 450 460 470 480 VKLFEEHDVI FLLMDSRESR WLPTLIGAAN EKIVINAALG FDSYLVMRHG VTNQKDRLGC 490 500 510 520 530 540 YYCNDVVAPN DSLSDRTLDQ MCTVTRPGGA LMASSLAVEL LVAILQHPER NLAPHDAETK 550 560 570 580 590 600 FGNIPHQIRG FLHNFQQTKL FAPSYVHCSA CSPRVITEFK QEGWEFVRKC LDDSQYLEDI 610 620 630 SGLTKVQQEA ELAAKQLLED LSLDDDVSND IDEDSEWLS

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000183 Genomic DNA. Translation: EAK92558.1. AACQ01000182 Genomic DNA. Translation: EAK92576.1.
RefSeq	XP_711780.1. XM_706688.1. XP_711798.1. XM_706706.1.
3D structure databases
ProteinModelPortal	Q59PZ3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59PZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646601. 3646615.
KEGG	cal:CaO19.707. cal:CaO19.8326.
Organism-specific databases
CGD	CAL0001705. APG7.
Phylogenomic databases
PhylomeDB	Q59PZ3.
Family and domain databases
InterPro	IPR006285. E1-like_Apg7. IPR009036. Molybdenum_cofac_synth_MoeB. IPR016040. NAD(P)-bd_dom. IPR000594. ThiF_NAD_FAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K08337.
Pfam	PF00899. ThiF. 1 hit. [Graphical view]
SUPFAM	SSF69572. MoeB. 1 hit.
TIGRFAMs	TIGR01381. E1_like_apg7. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ATG7_CANAL

Accession

Primary (citable) accession number: Q59PZ3
Secondary accession number(s): Q59Q11

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program