ID DBP8_CANAL Reviewed; 440 AA. AC Q59PR3; A0A1D8PT34; DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot. DT 26-APR-2005, sequence version 1. DT 27-MAR-2024, entry version 100. DE RecName: Full=ATP-dependent RNA helicase DBP8; DE EC=3.6.4.13; GN Name=DBP8; OrderedLocusNames=CAALFM_CR05630WA; GN ORFNames=CaO19.13973, CaO19.6652; OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=237561; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., RA Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). RN [2] RP GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52; RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D., RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M., RA Chibana H., Nantel A., Magee P.T.; RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned RT on the eight chromosomes."; RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97; RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.; RT "Assembly of a phased diploid Candida albicans genome facilitates allele- RT specific measurements and provides a simple model for repeat and indel RT structure."; RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013). CC -!- FUNCTION: ATP-binding RNA helicase involved in 40S ribosomal subunit CC biogenesis and is required for the normal formation of 18S rRNAs CC through pre-rRNA processing at A0, A1 and A2 sites. Required for CC vegetative growth (By similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box CC family of RNA helicases and controls ATP binding and hydrolysis. CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX49/DBP8 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP017630; AOW31279.1; -; Genomic_DNA. DR RefSeq; XP_711718.1; XM_706626.1. DR AlphaFoldDB; Q59PR3; -. DR SMR; Q59PR3; -. DR BioGRID; 1229284; 1. DR STRING; 237561.Q59PR3; -. DR EnsemblFungi; CR_05630W_A-T; CR_05630W_A-T-p1; CR_05630W_A. DR GeneID; 3646692; -. DR KEGG; cal:CAALFM_CR05630WA; -. DR CGD; CAL0000181153; DBP8. DR VEuPathDB; FungiDB:CR_05630W_A; -. DR eggNOG; KOG0340; Eukaryota. DR HOGENOM; CLU_003041_1_1_1; -. DR InParanoid; Q59PR3; -. DR OrthoDB; 149428at2759; -. DR PRO; PR:Q59PR3; -. DR Proteomes; UP000000559; Chromosome R. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblFungi. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC. DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi. DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi. DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi. DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central. DR CDD; cd17955; DEADc_DDX49; 1. DR CDD; cd18787; SF2_C_DEAD; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS. DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif. DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1. DR PANTHER; PTHR47959:SF21; RNA HELICASE; 1. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. DR PROSITE; PS51195; Q_MOTIF; 1. PE 3: Inferred from homology; KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; KW Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing. FT CHAIN 1..440 FT /note="ATP-dependent RNA helicase DBP8" FT /id="PRO_0000232283" FT DOMAIN 32..208 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541" FT DOMAIN 247..387 FT /note="Helicase C-terminal" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542" FT REGION 405..440 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 1..29 FT /note="Q motif" FT MOTIF 154..157 FT /note="DEAD box" FT COMPBIAS 405..432 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 45..52 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541" SQ SEQUENCE 440 AA; 48832 MW; 5A2483E47C9368DB CRC64; MSFNDLGVAK WLSESLDAMK IYTPTAIQSA CIPAILKGHD CIGGAKTGSG KTIAFAAPML TQWSEDPFGI FGLILTPTRE LALQIAEQFA ALGANMNIKV AVVVGGEDFV QQTLALQRKP HFVIATPGRL ADHILNSGEE TISGLRRVKY LVLDEADRLL SNSFGSDLQR CFDVLPTSDK RQTLLFTATI TDAVRALKEK PPTPGKPPVF MHEVETVDKV AIPSTLQISY VFVPSYVKEA YLNSILHLEQ FKDSTAVIFV NRTTTAEVLR RMLRKLDFRV ASLHSEMPQS ERTNSLHRFK AGAARILIAT DVASRGLDIP TVELVINFDI PADPDDFIHR VGRTARAGRK GDAVSIIGEK DIDRIQSIEE RINKKMELLE DVNDDNVIKE SLSATSVAKR ESLMEMDKEN FGERKKINRK KHGLDKVKPE RVTKPKKSKK //