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Q59PR3

- DBP8_CANAL

UniProt

Q59PR3 - DBP8_CANAL

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Protein
ATP-dependent RNA helicase DBP8
Gene
DBP8, CaO19.13973, CaO19.6652
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 528ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DBP8 (EC:3.6.4.13)
Gene namesi
Name:DBP8
ORF Names:CaO19.13973, CaO19.6652
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004058. DBP8.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440ATP-dependent RNA helicase DBP8
PRO_0000232283Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi1229785. 1 interaction.
STRINGi5476.CAL0004058.

Structurei

3D structure databases

ProteinModelPortaliQ59PR3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 208177Helicase ATP-binding
Add
BLAST
Domaini247 – 387141Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1 – 2929Q motif
Add
BLAST
Motifi154 – 1574DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0513.
KOiK14778.
OrthoDBiEOG7FR7R5.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59PR3-1 [UniParc]FASTAAdd to Basket

« Hide

MSFNDLGVAK WLSESLDAMK IYTPTAIQSA CIPAILKGHD CIGGAKTGSG    50
KTIAFAAPML TQWSEDPFGI FGLILTPTRE LALQIAEQFA ALGANMNIKV 100
AVVVGGEDFV QQTLALQRKP HFVIATPGRL ADHILNSGEE TISGLRRVKY 150
LVLDEADRLL SNSFGSDLQR CFDVLPTSDK RQTLLFTATI TDAVRALKEK 200
PPTPGKPPVF MHEVETVDKV AIPSTLQISY VFVPSYVKEA YLNSILHLEQ 250
FKDSTAVIFV NRTTTAEVLR RMLRKLDFRV ASLHSEMPQS ERTNSLHRFK 300
AGAARILIAT DVASRGLDIP TVELVINFDI PADPDDFIHR VGRTARAGRK 350
GDAVSIIGEK DIDRIQSIEE RINKKMELLE DVNDDNVIKE SLSATSVAKR 400
ESLMEMDKEN FGERKKINRK KHGLDKVKPE RVTKPKKSKK 440
Length:440
Mass (Da):48,832
Last modified:April 26, 2005 - v1
Checksum:i5A2483E47C9368DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000165 Genomic DNA. Translation: EAK92999.1.
AACQ01000186 Genomic DNA. Translation: EAK92496.1.
RefSeqiXP_711718.1. XM_706626.1.
XP_712192.1. XM_707099.1.

Genome annotation databases

GeneIDi3646191.
3646692.
KEGGical:CaO19.13973.
cal:CaO19.6652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000165 Genomic DNA. Translation: EAK92999.1 .
AACQ01000186 Genomic DNA. Translation: EAK92496.1 .
RefSeqi XP_711718.1. XM_706626.1.
XP_712192.1. XM_707099.1.

3D structure databases

ProteinModelPortali Q59PR3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1229785. 1 interaction.
STRINGi 5476.CAL0004058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3646191.
3646692.
KEGGi cal:CaO19.13973.
cal:CaO19.6652.

Organism-specific databases

CGDi CAL0004058. DBP8.

Phylogenomic databases

eggNOGi COG0513.
KOi K14778.
OrthoDBi EOG7FR7R5.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiDBP8_CANAL
AccessioniPrimary (citable) accession number: Q59PR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi