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Q59PR3

- DBP8_CANAL

UniProt

Q59PR3 - DBP8_CANAL

Protein

ATP-dependent RNA helicase DBP8

Gene

DBP8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 528ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent RNA helicase DBP8 (EC:3.6.4.13)
    Gene namesi
    Name:DBP8
    ORF Names:CaO19.13973, CaO19.6652
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0004058. DBP8.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440ATP-dependent RNA helicase DBP8PRO_0000232283Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi1229785. 1 interaction.
    STRINGi5476.CAL0004058.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59PR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 208177Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 387141Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1 – 2929Q motifAdd
    BLAST
    Motifi154 – 1574DEAD box

    Domaini

    The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0513.
    KOiK14778.
    OrthoDBiEOG7FR7R5.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59PR3-1 [UniParc]FASTAAdd to Basket

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    MSFNDLGVAK WLSESLDAMK IYTPTAIQSA CIPAILKGHD CIGGAKTGSG    50
    KTIAFAAPML TQWSEDPFGI FGLILTPTRE LALQIAEQFA ALGANMNIKV 100
    AVVVGGEDFV QQTLALQRKP HFVIATPGRL ADHILNSGEE TISGLRRVKY 150
    LVLDEADRLL SNSFGSDLQR CFDVLPTSDK RQTLLFTATI TDAVRALKEK 200
    PPTPGKPPVF MHEVETVDKV AIPSTLQISY VFVPSYVKEA YLNSILHLEQ 250
    FKDSTAVIFV NRTTTAEVLR RMLRKLDFRV ASLHSEMPQS ERTNSLHRFK 300
    AGAARILIAT DVASRGLDIP TVELVINFDI PADPDDFIHR VGRTARAGRK 350
    GDAVSIIGEK DIDRIQSIEE RINKKMELLE DVNDDNVIKE SLSATSVAKR 400
    ESLMEMDKEN FGERKKINRK KHGLDKVKPE RVTKPKKSKK 440
    Length:440
    Mass (Da):48,832
    Last modified:April 26, 2005 - v1
    Checksum:i5A2483E47C9368DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000165 Genomic DNA. Translation: EAK92999.1.
    AACQ01000186 Genomic DNA. Translation: EAK92496.1.
    RefSeqiXP_711718.1. XM_706626.1.
    XP_712192.1. XM_707099.1.

    Genome annotation databases

    GeneIDi3646191.
    3646692.
    KEGGical:CaO19.13973.
    cal:CaO19.6652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000165 Genomic DNA. Translation: EAK92999.1 .
    AACQ01000186 Genomic DNA. Translation: EAK92496.1 .
    RefSeqi XP_711718.1. XM_706626.1.
    XP_712192.1. XM_707099.1.

    3D structure databases

    ProteinModelPortali Q59PR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1229785. 1 interaction.
    STRINGi 5476.CAL0004058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646191.
    3646692.
    KEGGi cal:CaO19.13973.
    cal:CaO19.6652.

    Organism-specific databases

    CGDi CAL0004058. DBP8.

    Phylogenomic databases

    eggNOGi COG0513.
    KOi K14778.
    OrthoDBi EOG7FR7R5.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiDBP8_CANAL
    AccessioniPrimary (citable) accession number: Q59PR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3