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Protein

ATP-dependent RNA helicase DBP8

Gene

DBP8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 528ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DBP8 (EC:3.6.4.13)
Gene namesi
Name:DBP8
ORF Names:CaO19.13973, CaO19.6652
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004058. DBP8.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440ATP-dependent RNA helicase DBP8PRO_0000232283Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi1229785. 1 interaction.
STRINGi5476.CAL0004058.

Structurei

3D structure databases

ProteinModelPortaliQ59PR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 208177Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini247 – 387141Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1 – 2929Q motifAdd
BLAST
Motifi154 – 1574DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0513.
InParanoidiQ59PR3.
KOiK14778.
OrthoDBiEOG7FR7R5.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59PR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNDLGVAK WLSESLDAMK IYTPTAIQSA CIPAILKGHD CIGGAKTGSG
60 70 80 90 100
KTIAFAAPML TQWSEDPFGI FGLILTPTRE LALQIAEQFA ALGANMNIKV
110 120 130 140 150
AVVVGGEDFV QQTLALQRKP HFVIATPGRL ADHILNSGEE TISGLRRVKY
160 170 180 190 200
LVLDEADRLL SNSFGSDLQR CFDVLPTSDK RQTLLFTATI TDAVRALKEK
210 220 230 240 250
PPTPGKPPVF MHEVETVDKV AIPSTLQISY VFVPSYVKEA YLNSILHLEQ
260 270 280 290 300
FKDSTAVIFV NRTTTAEVLR RMLRKLDFRV ASLHSEMPQS ERTNSLHRFK
310 320 330 340 350
AGAARILIAT DVASRGLDIP TVELVINFDI PADPDDFIHR VGRTARAGRK
360 370 380 390 400
GDAVSIIGEK DIDRIQSIEE RINKKMELLE DVNDDNVIKE SLSATSVAKR
410 420 430 440
ESLMEMDKEN FGERKKINRK KHGLDKVKPE RVTKPKKSKK
Length:440
Mass (Da):48,832
Last modified:April 26, 2005 - v1
Checksum:i5A2483E47C9368DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000165 Genomic DNA. Translation: EAK92999.1.
AACQ01000186 Genomic DNA. Translation: EAK92496.1.
RefSeqiXP_711718.1. XM_706626.1.
XP_712192.1. XM_707099.1.

Genome annotation databases

GeneIDi3646191.
3646692.
KEGGical:CaO19.13973.
cal:CaO19.6652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000165 Genomic DNA. Translation: EAK92999.1.
AACQ01000186 Genomic DNA. Translation: EAK92496.1.
RefSeqiXP_711718.1. XM_706626.1.
XP_712192.1. XM_707099.1.

3D structure databases

ProteinModelPortaliQ59PR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1229785. 1 interaction.
STRINGi5476.CAL0004058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3646191.
3646692.
KEGGical:CaO19.13973.
cal:CaO19.6652.

Organism-specific databases

CGDiCAL0004058. DBP8.

Phylogenomic databases

eggNOGiCOG0513.
InParanoidiQ59PR3.
KOiK14778.
OrthoDBiEOG7FR7R5.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiDBP8_CANAL
AccessioniPrimary (citable) accession number: Q59PR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 26, 2005
Last modified: March 4, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.