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Protein

ATP-dependent RNA helicase DBP8

Gene

DBP8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 52ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DBP8 (EC:3.6.4.13)
Gene namesi
Name:DBP8
Ordered Locus Names:CAALFM_CR05630WA
ORF Names:CaO19.13973, CaO19.6652
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000181153. DBP8.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002322831 – 440ATP-dependent RNA helicase DBP8Add BLAST440

Proteomic databases

PRIDEiQ59PR3.

Interactioni

Protein-protein interaction databases

BioGridi1229284. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ59PR3.
SMRiQ59PR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 208Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST177
Domaini247 – 387Helicase C-terminalPROSITE-ProRule annotationAdd BLAST141

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 29Q motifAdd BLAST29
Motifi154 – 157DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ59PR3.
KOiK14778.
OrthoDBiEOG092C1VLP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59PR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNDLGVAK WLSESLDAMK IYTPTAIQSA CIPAILKGHD CIGGAKTGSG
60 70 80 90 100
KTIAFAAPML TQWSEDPFGI FGLILTPTRE LALQIAEQFA ALGANMNIKV
110 120 130 140 150
AVVVGGEDFV QQTLALQRKP HFVIATPGRL ADHILNSGEE TISGLRRVKY
160 170 180 190 200
LVLDEADRLL SNSFGSDLQR CFDVLPTSDK RQTLLFTATI TDAVRALKEK
210 220 230 240 250
PPTPGKPPVF MHEVETVDKV AIPSTLQISY VFVPSYVKEA YLNSILHLEQ
260 270 280 290 300
FKDSTAVIFV NRTTTAEVLR RMLRKLDFRV ASLHSEMPQS ERTNSLHRFK
310 320 330 340 350
AGAARILIAT DVASRGLDIP TVELVINFDI PADPDDFIHR VGRTARAGRK
360 370 380 390 400
GDAVSIIGEK DIDRIQSIEE RINKKMELLE DVNDDNVIKE SLSATSVAKR
410 420 430 440
ESLMEMDKEN FGERKKINRK KHGLDKVKPE RVTKPKKSKK
Length:440
Mass (Da):48,832
Last modified:April 26, 2005 - v1
Checksum:i5A2483E47C9368DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW31279.1.
RefSeqiXP_711718.1. XM_706626.1.

Genome annotation databases

EnsemblFungiiEAK92496; EAK92496; CaO19.6652.
EAK92999; EAK92999; CaO19.13973.
GeneIDi3646692.
KEGGical:CaO19.13973.
cal:CaO19.6652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW31279.1.
RefSeqiXP_711718.1. XM_706626.1.

3D structure databases

ProteinModelPortaliQ59PR3.
SMRiQ59PR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1229284. 1 interactor.

Proteomic databases

PRIDEiQ59PR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK92496; EAK92496; CaO19.6652.
EAK92999; EAK92999; CaO19.13973.
GeneIDi3646692.
KEGGical:CaO19.13973.
cal:CaO19.6652.

Organism-specific databases

CGDiCAL0000181153. DBP8.

Phylogenomic databases

InParanoidiQ59PR3.
KOiK14778.
OrthoDBiEOG092C1VLP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDBP8_CANAL
AccessioniPrimary (citable) accession number: Q59PR3
Secondary accession number(s): A0A1D8PT34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 26, 2005
Last modified: March 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.