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Q59P50 (YSH1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoribonuclease YSH1

EC=3.1.27.-
Alternative name(s):
mRNA 3'-end-processing protein YSH1
Gene names
Name:YSH1
ORF Names:CaO19.12941, CaO19.5486
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length870 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   LigandMetal-binding
Zinc
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

response to drug

Inferred from mutant phenotype PubMed 19623926. Source: CGD

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionendonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 870870Endoribonuclease YSH1
PRO_0000238898

Regions

Compositional bias212 – 2176Poly-Gly

Sites

Active site4991Proton donor Potential
Metal binding1591Zinc 1 By similarity
Metal binding1611Zinc 1 By similarity
Metal binding1631Zinc 2 By similarity
Metal binding1641Zinc 2 By similarity
Metal binding2561Zinc 1 By similarity
Metal binding2771Zinc 1 By similarity
Metal binding2771Zinc 2 By similarity
Metal binding5211Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59P50 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: D403C2942B7B87B7

FASTA87097,899
        10         20         30         40         50         60 
MCIQPDSLED AYKIPRPVHR EEFTQLSPSF FQTATFQLEK TNEKNNIEEP KKNKAFLNSK 

        70         80         90        100        110        120 
IIYKDLFEIR KLSNNFVNTS HPTCTETMNE QNEFSDEENF KFFGLGGCNE VGRSCHIIEY 

       130        140        150        160        170        180 
KNKVIMLDSG MHPALSGHAS FPYFDEYDIS KVDILLISHF HVDHSASLPY VMQQSNFRGK 

       190        200        210        220        230        240 
VFMTHATKAI YRWLMQDFVR VTSIGNSRSE DGGGGEGSNL YTDDDIMKSF DRIETIDYHS 

       250        260        270        280        290        300 
TMEIDGIRFT AYHAGHVLGA CMYFIEIGGL KVLFTGDYSR EENRHLHAAE VPPLKPDILI 

       310        320        330        340        350        360 
SESTFGTGTL EPRIELERKL TTHIHATIAK GGRVLLPVFA LGNAQELLLI LDEYWSQNED 

       370        380        390        400        410        420 
LQNVNVFYAS NLAKKCMAVY ETYTGIMNDK IRLSSASSEK SNPFDFKYIK SIKDLSKFQD 

       430        440        450        460        470        480 
MGPSVVVATP GMLQAGVSRQ LLEKWAPDGK NLVILTGYSV EGTMAKELLK EPTMIQSATN 

       490        500        510        520        530        540 
PDMTIPRRIG IEEISFAAHV DFQQNSEFIE KVSPSKVILV HGDSVPMGRL KSALLSKYAS 

       550        560        570        580        590        600 
RKGTDQEVKV YNPKNCEELI IGFKGLKIAK VLGSLAEEQL QVLKKIIQDE VSAENSKITE 

       610        620        630        640        650        660 
LTEEKEEADE IKEDNGETDT TQKPNESSIN VLKTGQVVSG VLVSKDFNLN LLQLQDLHEF 

       670        680        690        700        710        720 
TQLSTSIVKS KMHLKINADI SLMVWHLEQM FGYINVINDD DEEWECVIMD VVDVFIDRSK 

       730        740        750        760        770        780 
GPGLFITVEW INDNLMADSL ADSVIAILYS IDSSPASVKL SSQNHNHGDN HIVKKEDSME 

       790        800        810        820        830        840 
IDRPVEAHAK TDIKSRIERI ALLLKAQFGD SLKELPEEKA IIQIGKTVAN VDYKRLEVEC 

       850        860        870 
SSKVLKDRVE NVIKRGCQLT APLSQNPKIA 

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References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000196 Genomic DNA. Translation: EAK92250.1.
AACQ01000195 Genomic DNA. Translation: EAK92275.1.
RefSeqXP_711478.1. XM_706386.1.
XP_711502.1. XM_706410.1.

3D structure databases

ProteinModelPortalQ59P50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646887.
3646911.
KEGGcal:CaO19.12941.
cal:CaO19.5486.

Organism-specific databases

CGDCAL0005344. orf19.5486.

Phylogenomic databases

eggNOGCOG1236.
KOK14403.
OrthoDBEOG7TN01H.

Family and domain databases

Gene3D3.60.15.10. 2 hits.
InterProIPR001279. Beta-lactamas-like.
IPR022712. Beta_Casp.
IPR021718. CPSF73-100_C.
IPR011108. RMMBL.
[Graphical view]
PfamPF10996. Beta-Casp. 1 hit.
PF11718. CPSF73-100_C. 1 hit.
PF00753. Lactamase_B. 1 hit.
PF07521. RMMBL. 1 hit.
[Graphical view]
SMARTSM01027. Beta-Casp. 1 hit.
SM01098. CPSF73-100_C. 1 hit.
SM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMSSF56281. SSF56281. 1 hit.
ProtoNetSearch...

Entry information

Entry nameYSH1_CANAL
AccessionPrimary (citable) accession number: Q59P50
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names