Q59P50 (YSH1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endoribonuclease YSH1
EC=3.1.27.-

Alternative name(s):
mRNA 3'-end-processing protein YSH1

Gene names

Name:	YSH1
ORF Names:	CaO19.12941, CaO19.5486

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	870 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.

Ontologies

Keywords
Biological process	mRNA processing
Cellular component	Nucleus
Ligand	Metal-binding Zinc
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC response to drug Inferred from mutant phenotype PubMed 19623926. Source: CGD
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 870	870	Endoribonuclease YSH1		PRO_0000238898
Regions
	Compositional bias	212 – 217	6	Poly-Gly
Sites
	Active site	499	1	Proton donor Potential
	Metal binding	159	1	Zinc 1 By similarity
	Metal binding	161	1	Zinc 1 By similarity
	Metal binding	163	1	Zinc 2 By similarity
	Metal binding	164	1	Zinc 2 By similarity
	Metal binding	256	1	Zinc 1 By similarity
	Metal binding	277	1	Zinc 1 By similarity
	Metal binding	277	1	Zinc 2 By similarity
	Metal binding	521	1	Zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59P50 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: D403C2942B7B87B7	FASTA	870	97,899
	10 20 30 40 50 60 MCIQPDSLED AYKIPRPVHR EEFTQLSPSF FQTATFQLEK TNEKNNIEEP KKNKAFLNSK 70 80 90 100 110 120 IIYKDLFEIR KLSNNFVNTS HPTCTETMNE QNEFSDEENF KFFGLGGCNE VGRSCHIIEY 130 140 150 160 170 180 KNKVIMLDSG MHPALSGHAS FPYFDEYDIS KVDILLISHF HVDHSASLPY VMQQSNFRGK 190 200 210 220 230 240 VFMTHATKAI YRWLMQDFVR VTSIGNSRSE DGGGGEGSNL YTDDDIMKSF DRIETIDYHS 250 260 270 280 290 300 TMEIDGIRFT AYHAGHVLGA CMYFIEIGGL KVLFTGDYSR EENRHLHAAE VPPLKPDILI 310 320 330 340 350 360 SESTFGTGTL EPRIELERKL TTHIHATIAK GGRVLLPVFA LGNAQELLLI LDEYWSQNED 370 380 390 400 410 420 LQNVNVFYAS NLAKKCMAVY ETYTGIMNDK IRLSSASSEK SNPFDFKYIK SIKDLSKFQD 430 440 450 460 470 480 MGPSVVVATP GMLQAGVSRQ LLEKWAPDGK NLVILTGYSV EGTMAKELLK EPTMIQSATN 490 500 510 520 530 540 PDMTIPRRIG IEEISFAAHV DFQQNSEFIE KVSPSKVILV HGDSVPMGRL KSALLSKYAS 550 560 570 580 590 600 RKGTDQEVKV YNPKNCEELI IGFKGLKIAK VLGSLAEEQL QVLKKIIQDE VSAENSKITE 610 620 630 640 650 660 LTEEKEEADE IKEDNGETDT TQKPNESSIN VLKTGQVVSG VLVSKDFNLN LLQLQDLHEF 670 680 690 700 710 720 TQLSTSIVKS KMHLKINADI SLMVWHLEQM FGYINVINDD DEEWECVIMD VVDVFIDRSK 730 740 750 760 770 780 GPGLFITVEW INDNLMADSL ADSVIAILYS IDSSPASVKL SSQNHNHGDN HIVKKEDSME 790 800 810 820 830 840 IDRPVEAHAK TDIKSRIERI ALLLKAQFGD SLKELPEEKA IIQIGKTVAN VDYKRLEVEC 850 860 870 SSKVLKDRVE NVIKRGCQLT APLSQNPKIA

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000196 Genomic DNA. Translation: EAK92250.1. AACQ01000195 Genomic DNA. Translation: EAK92275.1.
RefSeq	XP_711478.1. XM_706386.1. XP_711502.1. XM_706410.1.
3D structure databases
ProteinModelPortal	Q59P50.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005344.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646887. 3646911.
KEGG	cal:CaO19.12941. cal:CaO19.5486.
Organism-specific databases
CGD	CAL0005344. orf19.5486.
Phylogenomic databases
eggNOG	COG1236.
KO	K14403.
Family and domain databases
InterPro	IPR001279. Beta-lactamas-like. IPR022712. Beta_Casp. IPR021718. CPSF73-100_C. IPR011108. RMMBL. [Graphical view]
Pfam	PF10996. Beta-Casp. 1 hit. PF11718. CPSF73-100_C. 1 hit. PF00753. Lactamase_B. 1 hit. PF07521. RMMBL. 1 hit. [Graphical view]
SMART	SM01027. Beta-Casp. 1 hit. SM01098. CPSF73-100_C. 1 hit. SM00849. Lactamase_B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YSH1_CANAL

Accession

Primary (citable) accession number: Q59P50

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program