Q59NY7 (CUE1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coupling of ubiquitin conjugation to ER degradation protein 1

Gene names

Name:	CUE1
ORF Names:	CaO19.6668

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) By similarity.
Subunit structure	Forms a heterodimer with UBC7 By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the CUE1 family. Contains 1 CUE domain.
Sequence caution	The sequence EAK92191.1 differs from that shown. Reason: Frameshift at position 28.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Coupling of ubiquitin conjugation to ER degradation protein 1		PRO_0000280670
Regions
	Topological domain	1 – 5	5	Lumenal By similarity
	Transmembrane	6 – 26	21	Helical; Potential
	Topological domain	27 – 189	163	Cytoplasmic By similarity
	Domain	72 – 114	43	CUE

Sequences

	Sequence		Length	Mass (Da)
	Q59NY7 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 0F922E879E5AD5F4	FASTA	189	21,192
	10 20 30 40 50 60 MDSSTVLFIG AVAVAFIFLK WMVSPIPPQN EFTIDHLSQA QSTGSTTSSN AHQNRDTHSI 70 80 90 100 110 120 STQSHRNSRR AVSESMIEVV QSIAPMLTVE QIRYDLETTG NVEATVNRFM ELGDLPFPPG 130 140 150 160 170 180 YVRPQQPPTP SEEPKKQEVI GKRSVNLLEK YNIDAKNPKS DHNSLLHQRR QEMILGARKR LAAQLSNEL

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000199 Genomic DNA. Translation: EAK92191.1. Frameshift.
RefSeq	XP_711420.1. XM_706328.1.
3D structure databases
ProteinModelPortal	Q59NY7.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0004096.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646976.
KEGG	cal:CaO19.6668.
Phylogenomic databases
eggNOG	NOG295444.
KO	K14022.
Family and domain databases
InterPro	IPR003892. CUE. [Graphical view]
Pfam	PF02845. CUE. 1 hit. [Graphical view]
PROSITE	PS51140. CUE. 1 hit. PS00014. ER_TARGET. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CUE1_CANAL

Accession

Primary (citable) accession number: Q59NY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	April 3, 2013
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program