Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coupling of ubiquitin conjugation to ER degradation protein 1

Gene

CUE1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Coupling of ubiquitin conjugation to ER degradation protein 1
Gene namesi
Name:CUE1
ORF Names:CaO19.6668
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55LumenalBy similarity
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Topological domaini27 – 189163CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Coupling of ubiquitin conjugation to ER degradation protein 1PRO_0000280670Add
BLAST

Interactioni

Subunit structurei

Forms a heterodimer with UBC7.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0004096.

Structurei

3D structure databases

ProteinModelPortaliQ59NY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 11443CUEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CUE1 family.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295444.
InParanoidiQ59NY7.
KOiK14022.
OrthoDBiEOG7JX3GD.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59NY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSTVLFIG AVAVAFIFLK WMVSPIPPQN EFTIDHLSQA QSTGSTTSSN
60 70 80 90 100
AHQNRDTHSI STQSHRNSRR AVSESMIEVV QSIAPMLTVE QIRYDLETTG
110 120 130 140 150
NVEATVNRFM ELGDLPFPPG YVRPQQPPTP SEEPKKQEVI GKRSVNLLEK
160 170 180
YNIDAKNPKS DHNSLLHQRR QEMILGARKR LAAQLSNEL
Length:189
Mass (Da):21,192
Last modified:March 20, 2007 - v2
Checksum:i0F922E879E5AD5F4
GO

Sequence cautioni

The sequence EAK92191.1 differs from that shown. Reason: Frameshift at position 28. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000199 Genomic DNA. Translation: EAK92191.1. Frameshift.
RefSeqiXP_711420.1. XM_706328.1.

Genome annotation databases

GeneIDi3646976.
KEGGical:CaO19.6668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000199 Genomic DNA. Translation: EAK92191.1. Frameshift.
RefSeqiXP_711420.1. XM_706328.1.

3D structure databases

ProteinModelPortaliQ59NY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0004096.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3646976.
KEGGical:CaO19.6668.

Phylogenomic databases

eggNOGiNOG295444.
InParanoidiQ59NY7.
KOiK14022.
OrthoDBiEOG7JX3GD.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCUE1_CANAL
AccessioniPrimary (citable) accession number: Q59NY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 27, 2015
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.