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Q59NY7

- CUE1_CANAL

UniProt

Q59NY7 - CUE1_CANAL

Protein

Coupling of ubiquitin conjugation to ER degradation protein 1

Gene

CUE1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) By similarity.By similarity

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coupling of ubiquitin conjugation to ER degradation protein 1
    Gene namesi
    Name:CUE1
    ORF Names:CaO19.6668
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Subcellular locationi

    Endoplasmic reticulum membrane PROSITE-ProRule annotation; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Coupling of ubiquitin conjugation to ER degradation protein 1PRO_0000280670Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a heterodimer with UBC7.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0004096.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59NY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55LumenalBy similarity
    Topological domaini27 – 189163CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 11443CUEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CUE1 family.Curated
    Contains 1 CUE domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295444.
    KOiK14022.
    OrthoDBiEOG7JX3GD.

    Family and domain databases

    InterProiIPR003892. CUE.
    [Graphical view]
    PfamiPF02845. CUE. 1 hit.
    [Graphical view]
    PROSITEiPS51140. CUE. 1 hit.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59NY7-1 [UniParc]FASTAAdd to Basket

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    MDSSTVLFIG AVAVAFIFLK WMVSPIPPQN EFTIDHLSQA QSTGSTTSSN    50
    AHQNRDTHSI STQSHRNSRR AVSESMIEVV QSIAPMLTVE QIRYDLETTG 100
    NVEATVNRFM ELGDLPFPPG YVRPQQPPTP SEEPKKQEVI GKRSVNLLEK 150
    YNIDAKNPKS DHNSLLHQRR QEMILGARKR LAAQLSNEL 189
    Length:189
    Mass (Da):21,192
    Last modified:March 20, 2007 - v2
    Checksum:i0F922E879E5AD5F4
    GO

    Sequence cautioni

    The sequence EAK92191.1 differs from that shown. Reason: Frameshift at position 28.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000199 Genomic DNA. Translation: EAK92191.1. Frameshift.
    RefSeqiXP_711420.1. XM_706328.1.

    Genome annotation databases

    GeneIDi3646976.
    KEGGical:CaO19.6668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000199 Genomic DNA. Translation: EAK92191.1 . Frameshift.
    RefSeqi XP_711420.1. XM_706328.1.

    3D structure databases

    ProteinModelPortali Q59NY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0004096.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646976.
    KEGGi cal:CaO19.6668.

    Phylogenomic databases

    eggNOGi NOG295444.
    KOi K14022.
    OrthoDBi EOG7JX3GD.

    Family and domain databases

    InterProi IPR003892. CUE.
    [Graphical view ]
    Pfami PF02845. CUE. 1 hit.
    [Graphical view ]
    PROSITEi PS51140. CUE. 1 hit.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiCUE1_CANAL
    AccessioniPrimary (citable) accession number: Q59NY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3