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Protein

Coupling of ubiquitin conjugation to ER degradation protein 1

Gene

CUE1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).By similarity

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Coupling of ubiquitin conjugation to ER degradation protein 1
Gene namesi
Name:CUE1
Ordered Locus Names:CAALFM_C503570WA
ORF Names:CaO19.6668
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 5

Organism-specific databases

CGDiCAL0000179547. orf19.6668.
EuPathDBiFungiDB:C5_03570W_A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5LumenalBy similarity5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 189CytoplasmicBy similarityAdd BLAST163

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002806701 – 189Coupling of ubiquitin conjugation to ER degradation protein 1Add BLAST189

Proteomic databases

PRIDEiQ59NY7.

Interactioni

Subunit structurei

Forms a heterodimer with UBC7.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59NY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 114CUEPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the CUE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ59NY7.
KOiK14022.
OrthoDBiEOG092C5I2D.

Family and domain databases

InterProiView protein in InterPro
IPR003892. CUE.
PfamiView protein in Pfam
PF02845. CUE. 1 hit.
SMARTiView protein in SMART
SM00546. CUE. 1 hit.
PROSITEiView protein in PROSITE
PS51140. CUE. 1 hit.
PS00014. ER_TARGET. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59NY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSTVLFIG AVAVAFIFLK WMVSPIPPQN EFTIDHLSQD QSTGSTTSSN
60 70 80 90 100
AHQNRDTHSI STQSHRNSRR AVSESMIEVV QSIAPMLTVE QIRYDLETTG
110 120 130 140 150
NVEATVNRFM ELGDLPFPPG YVRPQQPPTP SEEPKKQEVI GKRSVNLLEK
160 170 180
YNIDAKNPKS DHNSLLHQRR QEMILGARKR LAAQLSNEL
Length:189
Mass (Da):21,236
Last modified:March 15, 2017 - v3
Checksum:iFFC72E82CE0C3317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017627 Genomic DNA. Translation: AOW29769.1.
RefSeqiXP_711420.2. XM_706328.2.

Genome annotation databases

GeneIDi3646976.
KEGGical:CAALFM_C503570WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCUE1_CANAL
AccessioniPrimary (citable) accession number: Q59NY7
Secondary accession number(s): A0A1D8PNQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 66 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families