Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q59NY7 (CUE1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coupling of ubiquitin conjugation to ER degradation protein 1
Gene names
Name:CUE1
ORF Names:CaO19.6668
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) By similarity.

Subunit structure

Forms a heterodimer with UBC7 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the CUE1 family.

Contains 1 CUE domain.

Sequence caution

The sequence EAK92191.1 differs from that shown. Reason: Frameshift at position 28.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Coupling of ubiquitin conjugation to ER degradation protein 1
PRO_0000280670

Regions

Topological domain1 – 55Lumenal By similarity
Transmembrane6 – 2621Helical; Potential
Topological domain27 – 189163Cytoplasmic By similarity
Domain72 – 11443CUE

Sequences

Sequence LengthMass (Da)Tools
Q59NY7 [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: 0F922E879E5AD5F4

FASTA18921,192
        10         20         30         40         50         60 
MDSSTVLFIG AVAVAFIFLK WMVSPIPPQN EFTIDHLSQA QSTGSTTSSN AHQNRDTHSI 

        70         80         90        100        110        120 
STQSHRNSRR AVSESMIEVV QSIAPMLTVE QIRYDLETTG NVEATVNRFM ELGDLPFPPG 

       130        140        150        160        170        180 
YVRPQQPPTP SEEPKKQEVI GKRSVNLLEK YNIDAKNPKS DHNSLLHQRR QEMILGARKR 


LAAQLSNEL 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000199 Genomic DNA. Translation: EAK92191.1. Frameshift.
RefSeqXP_711420.1. XM_706328.1.

3D structure databases

ProteinModelPortalQ59NY7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0004096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646976.
KEGGcal:CaO19.6668.

Phylogenomic databases

eggNOGNOG295444.
KOK14022.
OrthoDBEOG7JX3GD.

Family and domain databases

InterProIPR003892. CUE.
[Graphical view]
PfamPF02845. CUE. 1 hit.
[Graphical view]
PROSITEPS51140. CUE. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCUE1_CANAL
AccessionPrimary (citable) accession number: Q59NY7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names