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Protein

Palmitoyltransferase PFA5

Gene

PFA5

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri111 – 16151DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase PFA5 (EC:2.3.1.225)
Alternative name(s):
Protein fatty acyltransferase 5
Gene namesi
Name:PFA5
ORF Names:CaO19.11611, CaO19.4134
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005671. orf19.4134.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Palmitoyltransferase PFA5PRO_0000212975Add
BLAST

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri111 – 16151DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
InParanoidiQ59NR8.
KOiK18932.
OrthoDBiEOG73NGFX.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59NR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWSKEYLKK NYIKLLVPIC VVLVLAYLNY AINYAVGYKL VYVHHSHAVA
60 70 80 90 100
IILWVLLGFF QLELLVYWVL IFLVGPGKSP VFPPIDLYGE NNKGLIPLPD
110 120 130 140 150
LFFCDEKGFP YYCSNSNSIK LERSFFSKDV GYNVIKFDHY CIWIGQPIGQ
160 170 180 190 200
DNYLFFMKFM MGFLAFFIIV LIYCARFTRE SIQQGEIDHN FIVLFVMSGF
210 220 230 240 250
WIIMIGCLFG IHLRYVSINM TTLDEITINQ RKRYNRWKDA RKNPNMPSWM
260 270 280 290 300
KTKHPPRKET GRRYVNVKHK TGRAIVRYYI DERPFDMGFR RNWINLVFNG
310 320 330 340 350
NRNHGKDDEF YTLWRLAAAF VVFIIPFIDI PFSFRGKLQV KDDVEQELHE
360 370 380 390 400
QENLLAKYTV YSSVVNDKFM NMIDEKLKKN SYSAPGYLVE TTPQNNQSTI

DKDSI
Length:405
Mass (Da):47,772
Last modified:April 26, 2005 - v1
Checksum:i00070D5F9D7ADFAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000202 Genomic DNA. Translation: EAK92107.1.
AACQ01000200 Genomic DNA. Translation: EAK92156.1.
RefSeqiXP_711338.1. XM_706246.1.
XP_711386.1. XM_706294.1.

Genome annotation databases

GeneIDi3646991.
3647043.
KEGGical:CaO19.11611.
cal:CaO19.4134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000202 Genomic DNA. Translation: EAK92107.1.
AACQ01000200 Genomic DNA. Translation: EAK92156.1.
RefSeqiXP_711338.1. XM_706246.1.
XP_711386.1. XM_706294.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3646991.
3647043.
KEGGical:CaO19.11611.
cal:CaO19.4134.

Organism-specific databases

CGDiCAL0005671. orf19.4134.

Phylogenomic databases

eggNOGiCOG5273.
InParanoidiQ59NR8.
KOiK18932.
OrthoDBiEOG73NGFX.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPFA5_CANAL
AccessioniPrimary (citable) accession number: Q59NR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: April 26, 2005
Last modified: June 24, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.