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Q59NR8 (PFA5_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Palmitoyltransferase PFA5

EC=2.3.1.225
Alternative name(s):
Protein fatty acyltransferase 5
Gene names
Name:PFA5
ORF Names:CaO19.11611, CaO19.4134
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Domain

The DHHC domain is required for palmitoyltransferase activity By similarity.

Post-translational modification

Autopalmitoylated By similarity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.

Contains 1 DHHC-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Palmitoyltransferase PFA5
PRO_0000212975

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane310 – 33021Helical; Potential
Zinc finger111 – 16151DHHC-type

Sequences

Sequence LengthMass (Da)Tools
Q59NR8 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 00070D5F9D7ADFAF

FASTA40547,772
        10         20         30         40         50         60 
MIWSKEYLKK NYIKLLVPIC VVLVLAYLNY AINYAVGYKL VYVHHSHAVA IILWVLLGFF 

        70         80         90        100        110        120 
QLELLVYWVL IFLVGPGKSP VFPPIDLYGE NNKGLIPLPD LFFCDEKGFP YYCSNSNSIK 

       130        140        150        160        170        180 
LERSFFSKDV GYNVIKFDHY CIWIGQPIGQ DNYLFFMKFM MGFLAFFIIV LIYCARFTRE 

       190        200        210        220        230        240 
SIQQGEIDHN FIVLFVMSGF WIIMIGCLFG IHLRYVSINM TTLDEITINQ RKRYNRWKDA 

       250        260        270        280        290        300 
RKNPNMPSWM KTKHPPRKET GRRYVNVKHK TGRAIVRYYI DERPFDMGFR RNWINLVFNG 

       310        320        330        340        350        360 
NRNHGKDDEF YTLWRLAAAF VVFIIPFIDI PFSFRGKLQV KDDVEQELHE QENLLAKYTV 

       370        380        390        400 
YSSVVNDKFM NMIDEKLKKN SYSAPGYLVE TTPQNNQSTI DKDSI 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000202 Genomic DNA. Translation: EAK92107.1.
AACQ01000200 Genomic DNA. Translation: EAK92156.1.
RefSeqXP_711338.1. XM_706246.1.
XP_711386.1. XM_706294.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005671.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646991.
3647043.
KEGGcal:CaO19.11611.
cal:CaO19.4134.

Organism-specific databases

CGDCAL0005671. orf19.4134.

Phylogenomic databases

eggNOGCOG5273.
OrthoDBEOG73NGFX.

Family and domain databases

InterProIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePFA5_CANAL
AccessionPrimary (citable) accession number: Q59NR8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names