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Q59NR8

- PFA5_CANAL

UniProt

Q59NR8 - PFA5_CANAL

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Protein
Palmitoyltransferase PFA5
Gene
PFA5, CaO19.11611, CaO19.4134
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri111 – 16151DHHC-type
Add
BLAST

GO - Molecular functioni

  1. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Palmitoyltransferase PFA5 (EC:2.3.1.225)
    Alternative name(s):
    Protein fatty acyltransferase 5
    Gene namesi
    Name:PFA5
    ORF Names:CaO19.11611, CaO19.4134
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005671. orf19.4134.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei51 – 7121Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei154 – 17421Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei191 – 21121Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei310 – 33021Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Palmitoyltransferase PFA5
    PRO_0000212975Add
    BLAST

    Post-translational modificationi

    Autopalmitoylated By similarity.

    Keywords - PTMi

    Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0005671.

    Family & Domainsi

    Domaini

    The DHHC domain is required for palmitoyltransferase activity By similarity.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5273.
    OrthoDBiEOG73NGFX.

    Family and domain databases

    InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view]
    PfamiPF01529. zf-DHHC. 1 hit.
    [Graphical view]
    PROSITEiPS50216. ZF_DHHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59NR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIWSKEYLKK NYIKLLVPIC VVLVLAYLNY AINYAVGYKL VYVHHSHAVA    50
    IILWVLLGFF QLELLVYWVL IFLVGPGKSP VFPPIDLYGE NNKGLIPLPD 100
    LFFCDEKGFP YYCSNSNSIK LERSFFSKDV GYNVIKFDHY CIWIGQPIGQ 150
    DNYLFFMKFM MGFLAFFIIV LIYCARFTRE SIQQGEIDHN FIVLFVMSGF 200
    WIIMIGCLFG IHLRYVSINM TTLDEITINQ RKRYNRWKDA RKNPNMPSWM 250
    KTKHPPRKET GRRYVNVKHK TGRAIVRYYI DERPFDMGFR RNWINLVFNG 300
    NRNHGKDDEF YTLWRLAAAF VVFIIPFIDI PFSFRGKLQV KDDVEQELHE 350
    QENLLAKYTV YSSVVNDKFM NMIDEKLKKN SYSAPGYLVE TTPQNNQSTI 400
    DKDSI 405
    Length:405
    Mass (Da):47,772
    Last modified:April 26, 2005 - v1
    Checksum:i00070D5F9D7ADFAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000202 Genomic DNA. Translation: EAK92107.1.
    AACQ01000200 Genomic DNA. Translation: EAK92156.1.
    RefSeqiXP_711338.1. XM_706246.1.
    XP_711386.1. XM_706294.1.

    Genome annotation databases

    GeneIDi3646991.
    3647043.
    KEGGical:CaO19.11611.
    cal:CaO19.4134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000202 Genomic DNA. Translation: EAK92107.1 .
    AACQ01000200 Genomic DNA. Translation: EAK92156.1 .
    RefSeqi XP_711338.1. XM_706246.1.
    XP_711386.1. XM_706294.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005671.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646991.
    3647043.
    KEGGi cal:CaO19.11611.
    cal:CaO19.4134.

    Organism-specific databases

    CGDi CAL0005671. orf19.4134.

    Phylogenomic databases

    eggNOGi COG5273.
    OrthoDBi EOG73NGFX.

    Family and domain databases

    InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view ]
    Pfami PF01529. zf-DHHC. 1 hit.
    [Graphical view ]
    PROSITEi PS50216. ZF_DHHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPFA5_CANAL
    AccessioniPrimary (citable) accession number: Q59NR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: April 26, 2005
    Last modified: April 16, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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