Q59NR8 (PFA5_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Palmitoyltransferase PFA5
EC=2.3.1.-

Alternative name(s):
Protein fatty acyltransferase 5

Gene names

Name:	PFA5
ORF Names:	CaO19.11611, CaO19.4134

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The DHHC domain is required for palmitoyltransferase activity By similarity.
Post-translational modification	Autopalmitoylated By similarity.
Sequence similarities	Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily. Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Palmitoyltransferase PFA5		PRO_0000212975
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Transmembrane	310 – 330	21	Helical; Potential
	Zinc finger	111 – 161	51	DHHC-type

Sequences

	Sequence		Length	Mass (Da)
	Q59NR8 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 00070D5F9D7ADFAF	FASTA	405	47,772
	10 20 30 40 50 60 MIWSKEYLKK NYIKLLVPIC VVLVLAYLNY AINYAVGYKL VYVHHSHAVA IILWVLLGFF 70 80 90 100 110 120 QLELLVYWVL IFLVGPGKSP VFPPIDLYGE NNKGLIPLPD LFFCDEKGFP YYCSNSNSIK 130 140 150 160 170 180 LERSFFSKDV GYNVIKFDHY CIWIGQPIGQ DNYLFFMKFM MGFLAFFIIV LIYCARFTRE 190 200 210 220 230 240 SIQQGEIDHN FIVLFVMSGF WIIMIGCLFG IHLRYVSINM TTLDEITINQ RKRYNRWKDA 250 260 270 280 290 300 RKNPNMPSWM KTKHPPRKET GRRYVNVKHK TGRAIVRYYI DERPFDMGFR RNWINLVFNG 310 320 330 340 350 360 NRNHGKDDEF YTLWRLAAAF VVFIIPFIDI PFSFRGKLQV KDDVEQELHE QENLLAKYTV 370 380 390 400 YSSVVNDKFM NMIDEKLKKN SYSAPGYLVE TTPQNNQSTI DKDSI

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000202 Genomic DNA. Translation: EAK92107.1. AACQ01000200 Genomic DNA. Translation: EAK92156.1.
RefSeq	XP_711338.1. XM_706246.1. XP_711386.1. XM_706294.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646991. 3647043.
KEGG	cal:CaO19.11611. cal:CaO19.4134.
Organism-specific databases
CGD	CAL0005671. orf19.4134.
Phylogenomic databases
eggNOG	COG5273.
Family and domain databases
InterPro	IPR001594. Znf_DHHC_palmitoyltrfase. [Graphical view]
Pfam	PF01529. zf-DHHC. 1 hit. [Graphical view]
PROSITE	PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PFA5_CANAL

Accession

Primary (citable) accession number: Q59NR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program