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Q59NR8

- PFA5_CANAL

UniProt

Q59NR8 - PFA5_CANAL

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Protein

Palmitoyltransferase PFA5

Gene
PFA5, CaO19.11611, CaO19.4134
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri111 – 16151DHHC-typeAdd
BLAST

GO - Molecular functioni

  1. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase PFA5 (EC:2.3.1.225)
Alternative name(s):
Protein fatty acyltransferase 5
Gene namesi
Name:PFA5
ORF Names:CaO19.11611, CaO19.4134
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005671. orf19.4134.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Reviewed predictionAdd
BLAST
Transmembranei51 – 7121Helical; Reviewed predictionAdd
BLAST
Transmembranei154 – 17421Helical; Reviewed predictionAdd
BLAST
Transmembranei191 – 21121Helical; Reviewed predictionAdd
BLAST
Transmembranei310 – 33021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Palmitoyltransferase PFA5PRO_0000212975Add
BLAST

Post-translational modificationi

Autopalmitoylated By similarity.

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005671.

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri111 – 16151DHHC-typeAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
OrthoDBiEOG73NGFX.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59NR8-1 [UniParc]FASTAAdd to Basket

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MIWSKEYLKK NYIKLLVPIC VVLVLAYLNY AINYAVGYKL VYVHHSHAVA    50
IILWVLLGFF QLELLVYWVL IFLVGPGKSP VFPPIDLYGE NNKGLIPLPD 100
LFFCDEKGFP YYCSNSNSIK LERSFFSKDV GYNVIKFDHY CIWIGQPIGQ 150
DNYLFFMKFM MGFLAFFIIV LIYCARFTRE SIQQGEIDHN FIVLFVMSGF 200
WIIMIGCLFG IHLRYVSINM TTLDEITINQ RKRYNRWKDA RKNPNMPSWM 250
KTKHPPRKET GRRYVNVKHK TGRAIVRYYI DERPFDMGFR RNWINLVFNG 300
NRNHGKDDEF YTLWRLAAAF VVFIIPFIDI PFSFRGKLQV KDDVEQELHE 350
QENLLAKYTV YSSVVNDKFM NMIDEKLKKN SYSAPGYLVE TTPQNNQSTI 400
DKDSI 405
Length:405
Mass (Da):47,772
Last modified:April 26, 2005 - v1
Checksum:i00070D5F9D7ADFAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000202 Genomic DNA. Translation: EAK92107.1.
AACQ01000200 Genomic DNA. Translation: EAK92156.1.
RefSeqiXP_711338.1. XM_706246.1.
XP_711386.1. XM_706294.1.

Genome annotation databases

GeneIDi3646991.
3647043.
KEGGical:CaO19.11611.
cal:CaO19.4134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000202 Genomic DNA. Translation: EAK92107.1 .
AACQ01000200 Genomic DNA. Translation: EAK92156.1 .
RefSeqi XP_711338.1. XM_706246.1.
XP_711386.1. XM_706294.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3646991.
3647043.
KEGGi cal:CaO19.11611.
cal:CaO19.4134.

Organism-specific databases

CGDi CAL0005671. orf19.4134.

Phylogenomic databases

eggNOGi COG5273.
OrthoDBi EOG73NGFX.

Family and domain databases

InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view ]
Pfami PF01529. zf-DHHC. 1 hit.
[Graphical view ]
PROSITEi PS50216. ZF_DHHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPFA5_CANAL
AccessioniPrimary (citable) accession number: Q59NR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi