ID   FES1_CANAL              Reviewed;         284 AA.
AC   Q59NN8; A0A1D8PPG6; Q59NT5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-MAY-2023, entry version 88.
DE   RecName: Full=Hsp70 nucleotide exchange factor FES1;
GN   Name=FES1; OrderedLocusNames=CAALFM_C600760WA;
GN   ORFNames=CaO19.11133, CaO19.3649;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Functions as a nucleotide exchange factor (NEF) for Hsp70
CC       chaperones which accelerates the release of ADP. Required for fully
CC       efficient Hsp70-mediated folding of proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FES1 family. {ECO:0000305}.
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DR   EMBL; CP017628; AOW30022.1; -; Genomic_DNA.
DR   RefSeq; XP_711322.2; XM_706230.2.
DR   AlphaFoldDB; Q59NN8; -.
DR   SMR; Q59NN8; -.
DR   STRING; 237561.Q59NN8; -.
DR   EnsemblFungi; C6_00760W_A-T; C6_00760W_A-T-p1; C6_00760W_A.
DR   GeneID; 3647080; -.
DR   KEGG; cal:CAALFM_C600760WA; -.
DR   CGD; CAL0000195916; orf19.11133.
DR   VEuPathDB; FungiDB:C6_00760W_A; -.
DR   HOGENOM; CLU_046722_1_0_1; -.
DR   InParanoid; Q59NN8; -.
DR   OMA; LHWSIAN; -.
DR   OrthoDB; 5473057at2759; -.
DR   PRO; PR:Q59NN8; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013918; Nucleotide_exch_fac_Fes1.
DR   PANTHER; PTHR19316:SF18; HSP70-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR19316; PROTEIN FOLDING REGULATOR; 1.
DR   Pfam; PF08609; Fes1; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; Translation regulation.
FT   CHAIN           1..284
FT                   /note="Hsp70 nucleotide exchange factor FES1"
FT                   /id="PRO_0000285388"
FT   REPEAT          74..115
FT                   /note="ARM 1"
FT   REPEAT          118..158
FT                   /note="ARM 2"
FT   REPEAT          202..243
FT                   /note="ARM 3"
SQ   SEQUENCE   284 AA;  31833 MW;  BC7A8988DAB76ED0 CRC64;
     MEKLLHWTIA QQSGDKAALE KIGEPDQKAL NQLFGGPDEA TLMKESIKVV ESTDVSLEDK
     EIALENFEML IENLDNANNI GNLKLWNPLI DILAKEDTPV ELKVLICGII GTAVQNNPKS
     QEDFNETEGL SELIELAQDD KKFELQSKAL FAISSFIRNF QPGYAKFEKL QGLKLINFDN
     KNNKYQLRIL SLISSILSNG LDDSLKAQFK EAKLPHYLAS VLNEDSNTSL VDKSLNIVSQ
     LNQLNYEFSL EEKYEINRGI QVVEGLSEKL NIDDLNNAKQ ATSS
//