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Protein

Hsp70 nucleotide exchange factor FES1

Gene

FES1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp70 nucleotide exchange factor FES1
Gene namesi
Name:FES1
Ordered Locus Names:CAALFM_C600760WA
ORF Names:CaO19.11133, CaO19.3649
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 6

Organism-specific databases

CGDiCAL0000195916 orf19.3649

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002853881 – 284Hsp70 nucleotide exchange factor FES1Add BLAST284

Proteomic databases

PRIDEiQ59NN8

Structurei

3D structure databases

ProteinModelPortaliQ59NN8
SMRiQ59NN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 115ARM 1Add BLAST42
Repeati118 – 158ARM 2Add BLAST41
Repeati202 – 243ARM 3Add BLAST42

Sequence similaritiesi

Belongs to the FES1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ59NN8
OMAiFEMLIEN
OrthoDBiEOG092C5GYG

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013918 Nucleotide_exch_fac_Fes1
PfamiView protein in Pfam
PF08609 Fes1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q59NN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLHWTIA QQSGDKAALE KIGEPDQKAL NQLFGGPDEA TLMKESIKVV
60 70 80 90 100
ESTDVSLEDK EIALENFEML IENLDNANNI GNLKLWNPLI DILAKEDTPV
110 120 130 140 150
ELKVLICGII GTAVQNNPKS QEDFNETEGL SELIELAQDD KKFELQSKAL
160 170 180 190 200
FAISSFIRNF QPGYAKFEKL QGLKLINFDN KNNKYQLRIL SLISSILSNG
210 220 230 240 250
LDDSLKAQFK EAKLPHYLAS VLNEDSNTSL VDKSLNIVSQ LNQLNYEFSL
260 270 280
EEKYEINRGI QVVEGLSEKL NIDDLNNAKQ ATSS
Length:284
Mass (Da):31,833
Last modified:March 15, 2017 - v2
Checksum:iBC7A8988DAB76ED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017628 Genomic DNA Translation: AOW30022.1
RefSeqiXP_711322.2, XM_706230.2

Genome annotation databases

EnsemblFungiiAOW30022; AOW30022; CAALFM_C600760WA
GeneIDi3647080
KEGGical:CAALFM_C600760WA

Similar proteinsi

Entry informationi

Entry nameiFES1_CANAL
AccessioniPrimary (citable) accession number: Q59NN8
Secondary accession number(s): A0A1D8PPG6, Q59NT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 15, 2017
Last modified: April 25, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health