Q59NN8 (FES1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hsp70 nucleotide exchange factor FES1

Gene names

Name:	FES1
ORF Names:	CaO19.11133, CaO19.3649

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FES1 family. Contains 3 ARM repeats.

Ontologies

Keywords
Biological process	Translation regulation
Cellular component	Cytoplasm
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Hsp70 nucleotide exchange factor FES1		PRO_0000285388
Regions
	Repeat	74 – 115	42	ARM 1
	Repeat	118 – 158	41	ARM 2
	Repeat	202 – 243	42	ARM 3
Natural variations
	Natural variant	151	1	C → F in allele CaO19.11133.
	Natural variant	159	1	Y → N in allele CaO19.11133.

Sequences

	Sequence		Length	Mass (Da)
	Q59NN8 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: FD7A89939BBC5FC0	FASTA	284	31,838
	10 20 30 40 50 60 MEKLLHWTIA QQSGDKAALE KIGEPDQKAL NQLFGGPDEA TLMKESIKVV ESTDVSLEDK 70 80 90 100 110 120 EIALENFEML IENLDNANNI GNLKLWNPLI DILAKEDTPV ELKVLICGII GTAVQNNPKS 130 140 150 160 170 180 QEDFNETEGL SELIELAQDD KKFELQSKAL CAISSFIRYF QPGYAKFEKL QGLKLINFDN 190 200 210 220 230 240 KNNKYQLRIL SLISSILSNG LDDSLKAQFK EAKLPHYLAS VLNEDSNTSL VDKSLNIVSQ 250 260 270 280 LNQLNYEFSL EEKYEINRGI QVVEGLSEKL NIDDLNNAKQ ATSS

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000203 Genomic DNA. Translation: EAK92090.1. AACQ01000201 Genomic DNA. Translation: EAK92139.1.
RefSeq	XP_711322.1. XM_706230.1. XP_711370.1. XM_706278.1.
3D structure databases
ProteinModelPortal	Q59NN8.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000409.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3647037. 3647080.
KEGG	cal:CaO19.11133. cal:CaO19.3649.
Organism-specific databases
CGD	CAL0000409. orf19.3649.
Phylogenomic databases
eggNOG	NOG310365.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR013918. Nucleotide_exch_fac_Fes1. [Graphical view]
Pfam	PF08609. Fes1. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FES1_CANAL

Accession

Primary (citable) accession number: Q59NN8
Secondary accession number(s): Q59NT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program