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Q59NN8

- FES1_CANAL

UniProt

Q59NN8 - FES1_CANAL

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Protein

Hsp70 nucleotide exchange factor FES1

Gene
FES1, CaO19.11133, CaO19.3649
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins By similarity.

GO - Biological processi

  1. regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp70 nucleotide exchange factor FES1
Gene namesi
Name:FES1
ORF Names:CaO19.11133, CaO19.3649
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000409. orf19.3649.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Hsp70 nucleotide exchange factor FES1PRO_0000285388Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000409.

Structurei

3D structure databases

ProteinModelPortaliQ59NN8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati74 – 11542ARM 1Add
BLAST
Repeati118 – 15841ARM 2Add
BLAST
Repeati202 – 24342ARM 3Add
BLAST

Sequence similaritiesi

Belongs to the FES1 family.
Contains 3 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG310365.
OrthoDBiEOG776T0T.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013918. Nucleotide_exch_fac_Fes1.
[Graphical view]
PfamiPF08609. Fes1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59NN8-1 [UniParc]FASTAAdd to Basket

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MEKLLHWTIA QQSGDKAALE KIGEPDQKAL NQLFGGPDEA TLMKESIKVV    50
ESTDVSLEDK EIALENFEML IENLDNANNI GNLKLWNPLI DILAKEDTPV 100
ELKVLICGII GTAVQNNPKS QEDFNETEGL SELIELAQDD KKFELQSKAL 150
CAISSFIRYF QPGYAKFEKL QGLKLINFDN KNNKYQLRIL SLISSILSNG 200
LDDSLKAQFK EAKLPHYLAS VLNEDSNTSL VDKSLNIVSQ LNQLNYEFSL 250
EEKYEINRGI QVVEGLSEKL NIDDLNNAKQ ATSS 284
Length:284
Mass (Da):31,838
Last modified:April 26, 2005 - v1
Checksum:iFD7A89939BBC5FC0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511C → F in allele CaO19.11133.
Natural varianti159 – 1591Y → N in allele CaO19.11133.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000203 Genomic DNA. Translation: EAK92090.1.
AACQ01000201 Genomic DNA. Translation: EAK92139.1.
RefSeqiXP_711322.1. XM_706230.1.
XP_711370.1. XM_706278.1.

Genome annotation databases

GeneIDi3647037.
3647080.
KEGGical:CaO19.11133.
cal:CaO19.3649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000203 Genomic DNA. Translation: EAK92090.1 .
AACQ01000201 Genomic DNA. Translation: EAK92139.1 .
RefSeqi XP_711322.1. XM_706230.1.
XP_711370.1. XM_706278.1.

3D structure databases

ProteinModelPortali Q59NN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647037.
3647080.
KEGGi cal:CaO19.11133.
cal:CaO19.3649.

Organism-specific databases

CGDi CAL0000409. orf19.3649.

Phylogenomic databases

eggNOGi NOG310365.
OrthoDBi EOG776T0T.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013918. Nucleotide_exch_fac_Fes1.
[Graphical view ]
Pfami PF08609. Fes1. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiFES1_CANAL
AccessioniPrimary (citable) accession number: Q59NN8
Secondary accession number(s): Q59NT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi