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Q59NN8 (FES1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hsp70 nucleotide exchange factor FES1
Gene names
Name:FES1
ORF Names:CaO19.11133, CaO19.3649
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FES1 family.

Contains 3 ARM repeats.

Ontologies

Keywords
   Biological processTranslation regulation
   Cellular componentCytoplasm
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Hsp70 nucleotide exchange factor FES1
PRO_0000285388

Regions

Repeat74 – 11542ARM 1
Repeat118 – 15841ARM 2
Repeat202 – 24342ARM 3

Natural variations

Natural variant1511C → F in allele CaO19.11133.
Natural variant1591Y → N in allele CaO19.11133.

Sequences

Sequence LengthMass (Da)Tools
Q59NN8 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: FD7A89939BBC5FC0

FASTA28431,838
        10         20         30         40         50         60 
MEKLLHWTIA QQSGDKAALE KIGEPDQKAL NQLFGGPDEA TLMKESIKVV ESTDVSLEDK 

        70         80         90        100        110        120 
EIALENFEML IENLDNANNI GNLKLWNPLI DILAKEDTPV ELKVLICGII GTAVQNNPKS 

       130        140        150        160        170        180 
QEDFNETEGL SELIELAQDD KKFELQSKAL CAISSFIRYF QPGYAKFEKL QGLKLINFDN 

       190        200        210        220        230        240 
KNNKYQLRIL SLISSILSNG LDDSLKAQFK EAKLPHYLAS VLNEDSNTSL VDKSLNIVSQ 

       250        260        270        280 
LNQLNYEFSL EEKYEINRGI QVVEGLSEKL NIDDLNNAKQ ATSS 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000203 Genomic DNA. Translation: EAK92090.1.
AACQ01000201 Genomic DNA. Translation: EAK92139.1.
RefSeqXP_711322.1. XM_706230.1.
XP_711370.1. XM_706278.1.

3D structure databases

ProteinModelPortalQ59NN8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000409.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647037.
3647080.
KEGGcal:CaO19.11133.
cal:CaO19.3649.

Organism-specific databases

CGDCAL0000409. orf19.3649.

Phylogenomic databases

eggNOGNOG310365.
OrthoDBEOG776T0T.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013918. Nucleotide_exch_fac_Fes1.
[Graphical view]
PfamPF08609. Fes1. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFES1_CANAL
AccessionPrimary (citable) accession number: Q59NN8
Secondary accession number(s): Q59NT5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names