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Q59NN8

- FES1_CANAL

UniProt

Q59NN8 - FES1_CANAL

Protein

Hsp70 nucleotide exchange factor FES1

Gene

FES1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins By similarity.By similarity

    GO - Biological processi

    1. regulation of translation Source: UniProtKB-KW

    Keywords - Biological processi

    Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hsp70 nucleotide exchange factor FES1
    Gene namesi
    Name:FES1
    ORF Names:CaO19.11133, CaO19.3649
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000409. orf19.3649.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Hsp70 nucleotide exchange factor FES1PRO_0000285388Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0000409.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59NN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati74 – 11542ARM 1Add
    BLAST
    Repeati118 – 15841ARM 2Add
    BLAST
    Repeati202 – 24342ARM 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the FES1 family.Curated
    Contains 3 ARM repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG310365.
    OrthoDBiEOG776T0T.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013918. Nucleotide_exch_fac_Fes1.
    [Graphical view]
    PfamiPF08609. Fes1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59NN8-1 [UniParc]FASTAAdd to Basket

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    MEKLLHWTIA QQSGDKAALE KIGEPDQKAL NQLFGGPDEA TLMKESIKVV    50
    ESTDVSLEDK EIALENFEML IENLDNANNI GNLKLWNPLI DILAKEDTPV 100
    ELKVLICGII GTAVQNNPKS QEDFNETEGL SELIELAQDD KKFELQSKAL 150
    CAISSFIRYF QPGYAKFEKL QGLKLINFDN KNNKYQLRIL SLISSILSNG 200
    LDDSLKAQFK EAKLPHYLAS VLNEDSNTSL VDKSLNIVSQ LNQLNYEFSL 250
    EEKYEINRGI QVVEGLSEKL NIDDLNNAKQ ATSS 284
    Length:284
    Mass (Da):31,838
    Last modified:April 26, 2005 - v1
    Checksum:iFD7A89939BBC5FC0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511C → F in allele CaO19.11133.
    Natural varianti159 – 1591Y → N in allele CaO19.11133.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000203 Genomic DNA. Translation: EAK92090.1.
    AACQ01000201 Genomic DNA. Translation: EAK92139.1.
    RefSeqiXP_711322.1. XM_706230.1.
    XP_711370.1. XM_706278.1.

    Genome annotation databases

    GeneIDi3647037.
    3647080.
    KEGGical:CaO19.11133.
    cal:CaO19.3649.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000203 Genomic DNA. Translation: EAK92090.1 .
    AACQ01000201 Genomic DNA. Translation: EAK92139.1 .
    RefSeqi XP_711322.1. XM_706230.1.
    XP_711370.1. XM_706278.1.

    3D structure databases

    ProteinModelPortali Q59NN8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647037.
    3647080.
    KEGGi cal:CaO19.11133.
    cal:CaO19.3649.

    Organism-specific databases

    CGDi CAL0000409. orf19.3649.

    Phylogenomic databases

    eggNOGi NOG310365.
    OrthoDBi EOG776T0T.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013918. Nucleotide_exch_fac_Fes1.
    [Graphical view ]
    Pfami PF08609. Fes1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiFES1_CANAL
    AccessioniPrimary (citable) accession number: Q59NN8
    Secondary accession number(s): Q59NT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3