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Q59NG5 (MUS81_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endonuclease MUS81

EC=3.1.22.-
Gene names
Name:MUS81
ORF Names:CaO19.11682, CaO19.4206
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length614 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) By similarity.

Cofactor

Magnesium By similarity.

Subunit structure

Interacts with EME1 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the XPF family.

Contains 1 ERCC4 domain.

Ontologies

Keywords
   Biological processDNA damage
DNA recombination
DNA repair
Meiosis
   Cellular componentNucleus
   LigandMagnesium
Metal-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA recombination

Inferred from electronic annotation. Source: UniProtKB-KW

DNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

meiotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

endonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 614614Crossover junction endonuclease MUS81
PRO_0000223641

Regions

Domain324 – 42198ERCC4

Sequences

Sequence LengthMass (Da)Tools
Q59NG5 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 11B248C3953A29A2

FASTA61470,663
        10         20         30         40         50         60 
MSVVNDDFKP LLIQWVEEEA INATKRGSKM VDLYNKILFQ LRGYELPICD LKTLKSIKYV 

        70         80         90        100        110        120 
GDKTANQLRK KIAKHCKENE LTLPRGFMDV AEKHRLDLEE SNLTSSTSTI KTTNKRAKTS 

       130        140        150        160        170        180 
SKSKPKYVPK HRSGGFAILI ALYLYDKDRN GMTKERIIAG ATPYCDRSFS NNAASKEFYS 

       190        200        210        220        230        240 
AWSSAKTLEN HNLISTTGRS PKIYFLTDEG VSLAQQLKTA IGLSSPPEGS KKNDRNMIME 

       250        260        270        280        290        300 
QSFDNGIRLD TSFELSSPAG RAMLSSSPIR RISNPVHSNR AIQKMLEKEL RNGETPPSSQ 

       310        320        330        340        350        360 
HDAGNRIYDG IKYEVWRKED YEVIVYMDNR EIRSRADRDH FQTRLQTLGV KCEVKPLSSG 

       370        380        390        400        410        420 
DVLWVGRNTS TGTEAVLNYL CERKRLDDLC DSIKDGRFQE QKNRMKKTGI KHCYYLVEDM 

       430        440        450        460        470        480 
VSYQDKVYDL MDSIQSSLTQ TMTTARLYLR RFKDIDETTA FIASNTKVIE NLKSNLIVIK 

       490        500        510        520        530        540 
PQDIKNQQDY LNILLKFRNK FEKTQPHQDN PDYECVQLFS RFQDMLGKTN QMTVKEMFIL 

       550        560        570        580        590        600 
MLMTIRGVSL EKAVVIQNRF PTPKSLLEYY HTEHATTDTN IKRDLMMNEF KDQIGNKKIG 

       610 
KALSEKIYNV WGKP 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000206 Genomic DNA. Translation: EAK92023.1.
AACQ01000205 Genomic DNA. Translation: EAK92046.1.
RefSeqXP_711258.1. XM_706166.1.
XP_711281.1. XM_706189.1.

3D structure databases

ProteinModelPortalQ59NG5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647121.
3647146.
KEGGcal:CaO19.11682.
cal:CaO19.4206.

Organism-specific databases

CGDCAL0000062. orf19.4206.

Phylogenomic databases

eggNOGCOG1948.
KOK08991.
OrthoDBEOG76MKJ6.

Family and domain databases

Gene3D3.40.50.10130. 1 hit.
InterProIPR010996. DNA_pol_b-like_N.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamPF02732. ERCC4. 1 hit.
[Graphical view]
SMARTSM00891. ERCC4. 1 hit.
[Graphical view]
SUPFAMSSF47802. SSF47802. 1 hit.
SSF52980. SSF52980. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMUS81_CANAL
AccessionPrimary (citable) accession number: Q59NG5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names