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Q59NG5

- MUS81_CANAL

UniProt

Q59NG5 - MUS81_CANAL

Protein

Crossover junction endonuclease MUS81

Gene

MUS81

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) By similarity.By similarity

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. endonuclease activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. meiotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, Meiosis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endonuclease MUS81 (EC:3.1.22.-)
    Gene namesi
    Name:MUS81
    ORF Names:CaO19.11682, CaO19.4206
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000062. orf19.4206.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Crossover junction endonuclease MUS81PRO_0000223641Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with EME1.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0000062.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59NG5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini324 – 42198ERCC4Add
    BLAST

    Sequence similaritiesi

    Belongs to the XPF family.Curated
    Contains 1 ERCC4 domain.Curated

    Phylogenomic databases

    eggNOGiCOG1948.
    KOiK08991.
    OrthoDBiEOG76MKJ6.

    Family and domain databases

    Gene3Di3.40.50.10130. 1 hit.
    InterProiIPR010996. DNA_pol_b-like_N.
    IPR020819. DNA_repair_nuc_XPF/helicase.
    IPR006166. ERCC4_domain.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view]
    PfamiPF02732. ERCC4. 1 hit.
    [Graphical view]
    SMARTiSM00891. ERCC4. 1 hit.
    [Graphical view]
    SUPFAMiSSF47802. SSF47802. 1 hit.
    SSF52980. SSF52980. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59NG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVVNDDFKP LLIQWVEEEA INATKRGSKM VDLYNKILFQ LRGYELPICD    50
    LKTLKSIKYV GDKTANQLRK KIAKHCKENE LTLPRGFMDV AEKHRLDLEE 100
    SNLTSSTSTI KTTNKRAKTS SKSKPKYVPK HRSGGFAILI ALYLYDKDRN 150
    GMTKERIIAG ATPYCDRSFS NNAASKEFYS AWSSAKTLEN HNLISTTGRS 200
    PKIYFLTDEG VSLAQQLKTA IGLSSPPEGS KKNDRNMIME QSFDNGIRLD 250
    TSFELSSPAG RAMLSSSPIR RISNPVHSNR AIQKMLEKEL RNGETPPSSQ 300
    HDAGNRIYDG IKYEVWRKED YEVIVYMDNR EIRSRADRDH FQTRLQTLGV 350
    KCEVKPLSSG DVLWVGRNTS TGTEAVLNYL CERKRLDDLC DSIKDGRFQE 400
    QKNRMKKTGI KHCYYLVEDM VSYQDKVYDL MDSIQSSLTQ TMTTARLYLR 450
    RFKDIDETTA FIASNTKVIE NLKSNLIVIK PQDIKNQQDY LNILLKFRNK 500
    FEKTQPHQDN PDYECVQLFS RFQDMLGKTN QMTVKEMFIL MLMTIRGVSL 550
    EKAVVIQNRF PTPKSLLEYY HTEHATTDTN IKRDLMMNEF KDQIGNKKIG 600
    KALSEKIYNV WGKP 614
    Length:614
    Mass (Da):70,663
    Last modified:April 26, 2005 - v1
    Checksum:i11B248C3953A29A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000206 Genomic DNA. Translation: EAK92023.1.
    AACQ01000205 Genomic DNA. Translation: EAK92046.1.
    RefSeqiXP_711258.1. XM_706166.1.
    XP_711281.1. XM_706189.1.

    Genome annotation databases

    GeneIDi3647121.
    3647146.
    KEGGical:CaO19.11682.
    cal:CaO19.4206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000206 Genomic DNA. Translation: EAK92023.1 .
    AACQ01000205 Genomic DNA. Translation: EAK92046.1 .
    RefSeqi XP_711258.1. XM_706166.1.
    XP_711281.1. XM_706189.1.

    3D structure databases

    ProteinModelPortali Q59NG5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647121.
    3647146.
    KEGGi cal:CaO19.11682.
    cal:CaO19.4206.

    Organism-specific databases

    CGDi CAL0000062. orf19.4206.

    Phylogenomic databases

    eggNOGi COG1948.
    KOi K08991.
    OrthoDBi EOG76MKJ6.

    Family and domain databases

    Gene3Di 3.40.50.10130. 1 hit.
    InterProi IPR010996. DNA_pol_b-like_N.
    IPR020819. DNA_repair_nuc_XPF/helicase.
    IPR006166. ERCC4_domain.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view ]
    Pfami PF02732. ERCC4. 1 hit.
    [Graphical view ]
    SMARTi SM00891. ERCC4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47802. SSF47802. 1 hit.
    SSF52980. SSF52980. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiMUS81_CANAL
    AccessioniPrimary (citable) accession number: Q59NG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3