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Q59NG5

- MUS81_CANAL

UniProt

Q59NG5 - MUS81_CANAL

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Protein

Crossover junction endonuclease MUS81

Gene
MUS81, CaO19.11682, CaO19.4206
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) By similarity.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. meiotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Meiosis

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endonuclease MUS81 (EC:3.1.22.-)
Gene namesi
Name:MUS81
ORF Names:CaO19.11682, CaO19.4206
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000062. orf19.4206.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Crossover junction endonuclease MUS81PRO_0000223641Add
BLAST

Interactioni

Subunit structurei

Interacts with EME1 By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0000062.

Structurei

3D structure databases

ProteinModelPortaliQ59NG5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini324 – 42198ERCC4Add
BLAST

Sequence similaritiesi

Belongs to the XPF family.
Contains 1 ERCC4 domain.

Phylogenomic databases

eggNOGiCOG1948.
KOiK08991.
OrthoDBiEOG76MKJ6.

Family and domain databases

Gene3Di3.40.50.10130. 1 hit.
InterProiIPR010996. DNA_pol_b-like_N.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02732. ERCC4. 1 hit.
[Graphical view]
SMARTiSM00891. ERCC4. 1 hit.
[Graphical view]
SUPFAMiSSF47802. SSF47802. 1 hit.
SSF52980. SSF52980. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59NG5-1 [UniParc]FASTAAdd to Basket

« Hide

MSVVNDDFKP LLIQWVEEEA INATKRGSKM VDLYNKILFQ LRGYELPICD    50
LKTLKSIKYV GDKTANQLRK KIAKHCKENE LTLPRGFMDV AEKHRLDLEE 100
SNLTSSTSTI KTTNKRAKTS SKSKPKYVPK HRSGGFAILI ALYLYDKDRN 150
GMTKERIIAG ATPYCDRSFS NNAASKEFYS AWSSAKTLEN HNLISTTGRS 200
PKIYFLTDEG VSLAQQLKTA IGLSSPPEGS KKNDRNMIME QSFDNGIRLD 250
TSFELSSPAG RAMLSSSPIR RISNPVHSNR AIQKMLEKEL RNGETPPSSQ 300
HDAGNRIYDG IKYEVWRKED YEVIVYMDNR EIRSRADRDH FQTRLQTLGV 350
KCEVKPLSSG DVLWVGRNTS TGTEAVLNYL CERKRLDDLC DSIKDGRFQE 400
QKNRMKKTGI KHCYYLVEDM VSYQDKVYDL MDSIQSSLTQ TMTTARLYLR 450
RFKDIDETTA FIASNTKVIE NLKSNLIVIK PQDIKNQQDY LNILLKFRNK 500
FEKTQPHQDN PDYECVQLFS RFQDMLGKTN QMTVKEMFIL MLMTIRGVSL 550
EKAVVIQNRF PTPKSLLEYY HTEHATTDTN IKRDLMMNEF KDQIGNKKIG 600
KALSEKIYNV WGKP 614
Length:614
Mass (Da):70,663
Last modified:April 26, 2005 - v1
Checksum:i11B248C3953A29A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000206 Genomic DNA. Translation: EAK92023.1.
AACQ01000205 Genomic DNA. Translation: EAK92046.1.
RefSeqiXP_711258.1. XM_706166.1.
XP_711281.1. XM_706189.1.

Genome annotation databases

GeneIDi3647121.
3647146.
KEGGical:CaO19.11682.
cal:CaO19.4206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000206 Genomic DNA. Translation: EAK92023.1 .
AACQ01000205 Genomic DNA. Translation: EAK92046.1 .
RefSeqi XP_711258.1. XM_706166.1.
XP_711281.1. XM_706189.1.

3D structure databases

ProteinModelPortali Q59NG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647121.
3647146.
KEGGi cal:CaO19.11682.
cal:CaO19.4206.

Organism-specific databases

CGDi CAL0000062. orf19.4206.

Phylogenomic databases

eggNOGi COG1948.
KOi K08991.
OrthoDBi EOG76MKJ6.

Family and domain databases

Gene3Di 3.40.50.10130. 1 hit.
InterProi IPR010996. DNA_pol_b-like_N.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR011335. Restrct_endonuc-II-like.
[Graphical view ]
Pfami PF02732. ERCC4. 1 hit.
[Graphical view ]
SMARTi SM00891. ERCC4. 1 hit.
[Graphical view ]
SUPFAMi SSF47802. SSF47802. 1 hit.
SSF52980. SSF52980. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMUS81_CANAL
AccessioniPrimary (citable) accession number: Q59NG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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