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Q59NG5

- MUS81_CANAL

UniProt

Q59NG5 - MUS81_CANAL

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Protein

Crossover junction endonuclease MUS81

Gene

MUS81

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).By similarity

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. meiotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Meiosis

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endonuclease MUS81 (EC:3.1.22.-)
Gene namesi
Name:MUS81
ORF Names:CaO19.11682, CaO19.4206
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000062. orf19.4206.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Crossover junction endonuclease MUS81PRO_0000223641Add
BLAST

Interactioni

Subunit structurei

Interacts with EME1.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0000062.

Structurei

3D structure databases

ProteinModelPortaliQ59NG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini324 – 42198ERCC4Add
BLAST

Sequence similaritiesi

Belongs to the XPF family.Curated
Contains 1 ERCC4 domain.Curated

Phylogenomic databases

eggNOGiCOG1948.
InParanoidiQ59NG5.
KOiK08991.
OrthoDBiEOG76MKJ6.

Family and domain databases

Gene3Di3.40.50.10130. 1 hit.
InterProiIPR010996. DNA_pol_b-like_N.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02732. ERCC4. 1 hit.
[Graphical view]
SMARTiSM00891. ERCC4. 1 hit.
[Graphical view]
SUPFAMiSSF47802. SSF47802. 1 hit.
SSF52980. SSF52980. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59NG5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVVNDDFKP LLIQWVEEEA INATKRGSKM VDLYNKILFQ LRGYELPICD
60 70 80 90 100
LKTLKSIKYV GDKTANQLRK KIAKHCKENE LTLPRGFMDV AEKHRLDLEE
110 120 130 140 150
SNLTSSTSTI KTTNKRAKTS SKSKPKYVPK HRSGGFAILI ALYLYDKDRN
160 170 180 190 200
GMTKERIIAG ATPYCDRSFS NNAASKEFYS AWSSAKTLEN HNLISTTGRS
210 220 230 240 250
PKIYFLTDEG VSLAQQLKTA IGLSSPPEGS KKNDRNMIME QSFDNGIRLD
260 270 280 290 300
TSFELSSPAG RAMLSSSPIR RISNPVHSNR AIQKMLEKEL RNGETPPSSQ
310 320 330 340 350
HDAGNRIYDG IKYEVWRKED YEVIVYMDNR EIRSRADRDH FQTRLQTLGV
360 370 380 390 400
KCEVKPLSSG DVLWVGRNTS TGTEAVLNYL CERKRLDDLC DSIKDGRFQE
410 420 430 440 450
QKNRMKKTGI KHCYYLVEDM VSYQDKVYDL MDSIQSSLTQ TMTTARLYLR
460 470 480 490 500
RFKDIDETTA FIASNTKVIE NLKSNLIVIK PQDIKNQQDY LNILLKFRNK
510 520 530 540 550
FEKTQPHQDN PDYECVQLFS RFQDMLGKTN QMTVKEMFIL MLMTIRGVSL
560 570 580 590 600
EKAVVIQNRF PTPKSLLEYY HTEHATTDTN IKRDLMMNEF KDQIGNKKIG
610
KALSEKIYNV WGKP
Length:614
Mass (Da):70,663
Last modified:April 26, 2005 - v1
Checksum:i11B248C3953A29A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000206 Genomic DNA. Translation: EAK92023.1.
AACQ01000205 Genomic DNA. Translation: EAK92046.1.
RefSeqiXP_711258.1. XM_706166.1.
XP_711281.1. XM_706189.1.

Genome annotation databases

GeneIDi3647121.
3647146.
KEGGical:CaO19.11682.
cal:CaO19.4206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000206 Genomic DNA. Translation: EAK92023.1 .
AACQ01000205 Genomic DNA. Translation: EAK92046.1 .
RefSeqi XP_711258.1. XM_706166.1.
XP_711281.1. XM_706189.1.

3D structure databases

ProteinModelPortali Q59NG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647121.
3647146.
KEGGi cal:CaO19.11682.
cal:CaO19.4206.

Organism-specific databases

CGDi CAL0000062. orf19.4206.

Phylogenomic databases

eggNOGi COG1948.
InParanoidi Q59NG5.
KOi K08991.
OrthoDBi EOG76MKJ6.

Family and domain databases

Gene3Di 3.40.50.10130. 1 hit.
InterProi IPR010996. DNA_pol_b-like_N.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR011335. Restrct_endonuc-II-like.
[Graphical view ]
Pfami PF02732. ERCC4. 1 hit.
[Graphical view ]
SMARTi SM00891. ERCC4. 1 hit.
[Graphical view ]
SUPFAMi SSF47802. SSF47802. 1 hit.
SSF52980. SSF52980. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMUS81_CANAL
AccessioniPrimary (citable) accession number: Q59NG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3