Q59MV1 (ASF1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone chaperone ASF1

Alternative name(s):
Anti-silencing function protein 1

Gene names

Name:	ASF1
ORF Names:	CaO19.3715, CaO19.11200

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly By similarity.
Subunit structure	Interacts with histone H3 and histone H4 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the ASF1 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Molecular function	Chaperone Chromatin regulator
Gene Ontology (GO)
Biological process	chromatin assembly or disassembly Inferred from electronic annotation. Source: InterPro chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Histone chaperone ASF1		PRO_0000284029
Regions
	Coiled coil	165 – 193	29	Potential
	Compositional bias	156 – 239	84	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q59MV1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: DAD954B87F39E0BC	FASTA	247	27,993
	10 20 30 40 50 60 MSIVSLTGIE VLNNPAKFTD PYEFQITFEC LEPLKEDLEW KLTYVGSSDS LDHDQELDSI 70 80 90 100 110 120 LVGPVPVGIN SFLFKADAPS PELIPASELV SVTVIILSCS YNDKEFVRVG YYVNNEYDTE 130 140 150 160 170 180 ELRENPPAKV AIDHVVRNIL AEKPRVTRFN IVWDNEEGAD EYPPEQPEDE EEEEEEEEEG 190 200 210 220 230 240 EEEEEDEDEE DDDDDEDLNG DAVVDLEKEE ISTPRDNDED IEIDIASESE VEEGGVEEEA KVNTPKD

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000217 Genomic DNA. Translation: EAK91815.1. AACQ01000216 Genomic DNA. Translation: EAK91829.1.
RefSeq	XP_711054.1. XM_705962.1. XP_711068.1. XM_705976.1.
3D structure databases
HSSP	HSSP built from PDB template 1ROC based on UniProtKB P32447.
ProteinModelPortal	Q59MV1.
SMR	Q59MV1. Positions 2-164.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59MV1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3647340. 3647348.
KEGG	cal:CaO19.11200. cal:CaO19.3715.
Organism-specific databases
CGD	CAL0001104. ASF1.
Phylogenomic databases
PhylomeDB	Q59MV1.
Family and domain databases
InterPro	IPR017282. Hist_deposition_Asf1. IPR006818. Histone_chaperone_ASF1-like. [Graphical view]
Gene3D	G3DSA:2.60.40.1490. Anti-silence. 1 hit.
KO	K10753.
PANTHER	PTHR12040. Anti-silence. 1 hit.
Pfam	PF04729. ASF1_hist_chap. 1 hit. [Graphical view]
PIRSF	PIRSF037759. Histone_Asf1. 1 hit.
SUPFAM	SSF101546. Anti-silence. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASF1_CANAL

Accession

Primary (citable) accession number: Q59MV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program