ID   VAC8_CANAL              Reviewed;         585 AA.
AC   Q59MN0; A0A1D8PMA3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   22-FEB-2023, entry version 103.
DE   RecName: Full=Vacuolar protein 8;
GN   Name=VAC8; OrderedLocusNames=CAALFM_C405150WA;
GN   ORFNames=CaO19.745, CaO19.8364;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=16467476; DOI=10.1128/ec.5.2.359-367.2006;
RA   Barelle C.J., Richard M.L., Gaillardin C., Gow N.A.R., Brown A.J.P.;
RT   "Candida albicans VAC8 is required for vacuolar inheritance and normal
RT   hyphal branching.";
RL   Eukaryot. Cell 5:359-367(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC       from the cytoplasm to vacuole. Vacuole inheritance has a role in the
CC       regulation of hyphal cell division. {ECO:0000269|PubMed:16467476}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; CP017626; AOW29255.1; -; Genomic_DNA.
DR   RefSeq; XP_710992.1; XM_705900.1.
DR   AlphaFoldDB; Q59MN0; -.
DR   SMR; Q59MN0; -.
DR   STRING; 237561.Q59MN0; -.
DR   EnsemblFungi; C4_05150W_A-T; C4_05150W_A-T-p1; C4_05150W_A.
DR   GeneID; 3647410; -.
DR   KEGG; cal:CAALFM_C405150WA; -.
DR   CGD; CAL0000185656; VAC8.
DR   VEuPathDB; FungiDB:C4_05150W_A; -.
DR   eggNOG; KOG4224; Eukaryota.
DR   HOGENOM; CLU_021483_0_0_1; -.
DR   InParanoid; Q59MN0; -.
DR   OMA; VWDKPDG; -.
DR   OrthoDB; 2721872at2759; -.
DR   PRO; PR:Q59MN0; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:1903561; C:extracellular vesicle; IDA:CGD.
DR   GO; GO:0000324; C:fungal-type vacuole; ISS:CGD.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0045121; C:membrane raft; IEA:EnsemblFungi.
DR   GO; GO:0071563; C:Myo2p-Vac17p-Vac8p transport complex; IEA:EnsemblFungi.
DR   GO; GO:0071561; C:nucleus-vacuole junction; IEA:EnsemblFungi.
DR   GO; GO:0000407; C:phagophore assembly site; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0071255; P:Cvt vesicle assembly; IEA:EnsemblFungi.
DR   GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR   GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR   GO; GO:0030448; P:hyphal growth; IMP:CGD.
DR   GO; GO:0071562; P:nucleus-vacuole junction assembly; IBA:GO_Central.
DR   GO; GO:0000425; P:pexophagy; IEA:EnsemblFungi.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IEA:EnsemblFungi.
DR   GO; GO:1903044; P:protein localization to membrane raft; IEA:EnsemblFungi.
DR   GO; GO:0034517; P:ribophagy; IEA:EnsemblFungi.
DR   GO; GO:0042144; P:vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR   GO; GO:0000011; P:vacuole inheritance; IMP:CGD.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045156; Vac8.
DR   PANTHER; PTHR47249; VACUOLAR PROTEIN 8; 1.
DR   PANTHER; PTHR47249:SF1; VACUOLAR PROTEIN 8; 1.
DR   Pfam; PF00514; Arm; 7.
DR   SMART; SM00185; ARM; 9.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50176; ARM_REPEAT; 7.
PE   3: Inferred from homology;
KW   Lipoprotein; Membrane; Myristate; Palmitate; Reference proteome; Repeat;
KW   Vacuole.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..585
FT                   /note="Vacuolar protein 8"
FT                   /id="PRO_0000256208"
FT   REPEAT          39..76
FT                   /note="ARM 1"
FT   REPEAT          77..116
FT                   /note="ARM 2"
FT   REPEAT          118..157
FT                   /note="ARM 3"
FT   REPEAT          159..198
FT                   /note="ARM 4"
FT   REPEAT          200..239
FT                   /note="ARM 5"
FT   REPEAT          243..282
FT                   /note="ARM 6"
FT   REPEAT          284..323
FT                   /note="ARM 7"
FT   REPEAT          325..365
FT                   /note="ARM 8"
FT   REPEAT          409..448
FT                   /note="ARM 9"
FT   REGION          531..565
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..564
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
FT   LIPID           4
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           5
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           7
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   585 AA;  63407 MW;  01FA4050F69A1649 CRC64;
     MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP LRALSTLVYS
     ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD SEVQRAACGA LGNLAVNTEN
     KILIVEMGGL EPLIRQMMST NIEVQCNAVG CITNLATQDD NKSKIAKSGA LIPLTKLAKS
     KDIRVQRNAT GALLNMTHSG ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD
     EVNRKKLAST EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV
     QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE EIQCHAVSTL
     RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA CFAILALADD LKPKLYESHI
     IDVLIPLTFS ENGEVCGNSA AALANLCSRV SNEHKQYILN NWAQPNEGIY GFLIRFLESG
     SPTFEHIALW TILQLLESNN TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT
     TNITNNNTNT NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG
//