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Protein

Vacuolar protein 8

Gene

VAC8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division.1 Publication

GO - Biological processi

  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • hyphal growth Source: CGD
  • vacuole inheritance Source: CGD

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein 8
Gene namesi
Name:VAC8
Ordered Locus Names:CAALFM_C405150WA
ORF Names:CaO19.745, CaO19.8364
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Organism-specific databases

CGDiCAL0000185656 VAC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002562082 – 585Vacuolar protein 8Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi4S-palmitoyl cysteineSequence analysis1
Lipidationi5S-palmitoyl cysteineSequence analysis1
Lipidationi7S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PRIDEiQ59MN0

Structurei

3D structure databases

ProteinModelPortaliQ59MN0
SMRiQ59MN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 76ARM 1Add BLAST38
Repeati77 – 116ARM 2Add BLAST40
Repeati118 – 157ARM 3Add BLAST40
Repeati159 – 198ARM 4Add BLAST40
Repeati200 – 239ARM 5Add BLAST40
Repeati243 – 282ARM 6Add BLAST40
Repeati284 – 323ARM 7Add BLAST40
Repeati325 – 365ARM 8Add BLAST41
Repeati409 – 448ARM 9Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi535 – 560Thr-richAdd BLAST26

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ59MN0
KOiK08332
OMAiATFQHIA
OrthoDBiEOG092C1KQT

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF00514 Arm, 7 hits
SMARTiView protein in SMART
SM00185 ARM, 9 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59MN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP
60 70 80 90 100
LRALSTLVYS ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD
110 120 130 140 150
SEVQRAACGA LGNLAVNTEN KILIVEMGGL EPLIRQMMST NIEVQCNAVG
160 170 180 190 200
CITNLATQDD NKSKIAKSGA LIPLTKLAKS KDIRVQRNAT GALLNMTHSG
210 220 230 240 250
ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD EVNRKKLAST
260 270 280 290 300
EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV
310 320 330 340 350
QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE
360 370 380 390 400
EIQCHAVSTL RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA
410 420 430 440 450
CFAILALADD LKPKLYESHI IDVLIPLTFS ENGEVCGNSA AALANLCSRV
460 470 480 490 500
SNEHKQYILN NWAQPNEGIY GFLIRFLESG SPTFEHIALW TILQLLESNN
510 520 530 540 550
TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT TNITNNNTNT
560 570 580
NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG
Length:585
Mass (Da):63,407
Last modified:January 23, 2007 - v3
Checksum:i01FA4050F69A1649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA Translation: AOW29255.1
RefSeqiXP_710992.1, XM_705900.1

Genome annotation databases

EnsemblFungiiAOW29255; AOW29255; CAALFM_C405150WA
GeneIDi3647410
KEGGical:CAALFM_C405150WA

Similar proteinsi

Entry informationi

Entry nameiVAC8_CANAL
AccessioniPrimary (citable) accession number: Q59MN0
Secondary accession number(s): A0A1D8PMA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health