Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q59MN0 (VAC8_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar protein 8
Gene names
Name:VAC8
ORF Names:CaO19.745, CaO19.8364
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division. Ref.1

Subcellular location

Vacuole membrane; Lipid-anchor By similarity.

Sequence similarities

Belongs to the beta-catenin family.

Contains 9 ARM repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 585584Vacuolar protein 8
PRO_0000256208

Regions

Repeat39 – 7638ARM 1
Repeat77 – 11640ARM 2
Repeat118 – 15740ARM 3
Repeat159 – 19840ARM 4
Repeat200 – 23940ARM 5
Repeat243 – 28240ARM 6
Repeat284 – 32340ARM 7
Repeat325 – 36541ARM 8
Repeat409 – 44840ARM 9
Compositional bias535 – 56026Thr-rich

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity
Lipidation41S-palmitoyl cysteine Potential
Lipidation51S-palmitoyl cysteine Potential
Lipidation71S-palmitoyl cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q59MN0 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 01FA4050F69A1649

FASTA58563,407
        10         20         30         40         50         60 
MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP LRALSTLVYS 

        70         80         90        100        110        120 
ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD SEVQRAACGA LGNLAVNTEN 

       130        140        150        160        170        180 
KILIVEMGGL EPLIRQMMST NIEVQCNAVG CITNLATQDD NKSKIAKSGA LIPLTKLAKS 

       190        200        210        220        230        240 
KDIRVQRNAT GALLNMTHSG ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD 

       250        260        270        280        290        300 
EVNRKKLAST EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV 

       310        320        330        340        350        360 
QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE EIQCHAVSTL 

       370        380        390        400        410        420 
RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA CFAILALADD LKPKLYESHI 

       430        440        450        460        470        480 
IDVLIPLTFS ENGEVCGNSA AALANLCSRV SNEHKQYILN NWAQPNEGIY GFLIRFLESG 

       490        500        510        520        530        540 
SPTFEHIALW TILQLLESNN TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT 

       550        560        570        580 
TNITNNNTNT NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG 

« Hide

References

« Hide 'large scale' references
[1]"Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching."
Barelle C.J., Richard M.L., Gaillardin C., Gow N.A.R., Brown A.J.P.
Eukaryot. Cell 5:359-367(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000222 Genomic DNA. Translation: EAK91739.1.
AACQ01000221 Genomic DNA. Translation: EAK91753.1.
RefSeqXP_710979.1. XM_705887.1.
XP_710992.1. XM_705900.1.

3D structure databases

ProteinModelPortalQ59MN0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001835.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647410.
3647417.
KEGGcal:CaO19.745.
cal:CaO19.8364.

Organism-specific databases

CGDCAL0001835. VAC8.

Phylogenomic databases

eggNOGNOG265712.
KOK08332.
OrthoDBEOG7Q8CX4.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR026958. Vac8.
[Graphical view]
PANTHERPTHR23315:SF8. PTHR23315:SF8. 1 hit.
PfamPF00514. Arm. 6 hits.
[Graphical view]
SMARTSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
PROSITEPS50176. ARM_REPEAT. 7 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVAC8_CANAL
AccessionPrimary (citable) accession number: Q59MN0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 55 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names