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Q59MN0

- VAC8_CANAL

UniProt

Q59MN0 - VAC8_CANAL

Protein

Vacuolar protein 8

Gene

VAC8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division.1 Publication

    GO - Biological processi

    1. filamentous growth Source: CGD
    2. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    3. hyphal growth Source: CGD
    4. vacuole inheritance Source: CGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein 8
    Gene namesi
    Name:VAC8
    ORF Names:CaO19.745, CaO19.8364
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001835. VAC8.

    Subcellular locationi

    Vacuole membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. fungal-type vacuole Source: CGD
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 585584Vacuolar protein 8PRO_0000256208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Lipidationi4 – 41S-palmitoyl cysteineSequence Analysis
    Lipidationi5 – 51S-palmitoyl cysteineSequence Analysis
    Lipidationi7 – 71S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0001835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59MN0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati39 – 7638ARM 1Add
    BLAST
    Repeati77 – 11640ARM 2Add
    BLAST
    Repeati118 – 15740ARM 3Add
    BLAST
    Repeati159 – 19840ARM 4Add
    BLAST
    Repeati200 – 23940ARM 5Add
    BLAST
    Repeati243 – 28240ARM 6Add
    BLAST
    Repeati284 – 32340ARM 7Add
    BLAST
    Repeati325 – 36541ARM 8Add
    BLAST
    Repeati409 – 44840ARM 9Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi535 – 56026Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 9 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG265712.
    KOiK08332.
    OrthoDBiEOG7Q8CX4.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view]
    PfamiPF00514. Arm. 6 hits.
    [Graphical view]
    SMARTiSM00185. ARM. 8 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50176. ARM_REPEAT. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q59MN0-1 [UniParc]FASTAAdd to Basket

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    MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP    50
    LRALSTLVYS ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD 100
    SEVQRAACGA LGNLAVNTEN KILIVEMGGL EPLIRQMMST NIEVQCNAVG 150
    CITNLATQDD NKSKIAKSGA LIPLTKLAKS KDIRVQRNAT GALLNMTHSG 200
    ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD EVNRKKLAST 250
    EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV 300
    QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE 350
    EIQCHAVSTL RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA 400
    CFAILALADD LKPKLYESHI IDVLIPLTFS ENGEVCGNSA AALANLCSRV 450
    SNEHKQYILN NWAQPNEGIY GFLIRFLESG SPTFEHIALW TILQLLESNN 500
    TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT TNITNNNTNT 550
    NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG 585
    Length:585
    Mass (Da):63,407
    Last modified:January 23, 2007 - v3
    Checksum:i01FA4050F69A1649
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000222 Genomic DNA. Translation: EAK91739.1.
    AACQ01000221 Genomic DNA. Translation: EAK91753.1.
    RefSeqiXP_710979.1. XM_705887.1.
    XP_710992.1. XM_705900.1.

    Genome annotation databases

    GeneIDi3647410.
    3647417.
    KEGGical:CaO19.745.
    cal:CaO19.8364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000222 Genomic DNA. Translation: EAK91739.1 .
    AACQ01000221 Genomic DNA. Translation: EAK91753.1 .
    RefSeqi XP_710979.1. XM_705887.1.
    XP_710992.1. XM_705900.1.

    3D structure databases

    ProteinModelPortali Q59MN0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001835.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647410.
    3647417.
    KEGGi cal:CaO19.745.
    cal:CaO19.8364.

    Organism-specific databases

    CGDi CAL0001835. VAC8.

    Phylogenomic databases

    eggNOGi NOG265712.
    KOi K08332.
    OrthoDBi EOG7Q8CX4.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view ]
    Pfami PF00514. Arm. 6 hits.
    [Graphical view ]
    SMARTi SM00185. ARM. 8 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50176. ARM_REPEAT. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching."
      Barelle C.J., Richard M.L., Gaillardin C., Gow N.A.R., Brown A.J.P.
      Eukaryot. Cell 5:359-367(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiVAC8_CANAL
    AccessioniPrimary (citable) accession number: Q59MN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3