Q59MN0 (VAC8_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar protein 8

Gene names

Name:	VAC8
ORF Names:	CaO19.745, CaO19.8364

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division. Ref.1
Subcellular location	Vacuole membrane; Lipid-anchor By similarity.
Sequence similarities	Belongs to the beta-catenin family. Contains 9 ARM repeats.

Ontologies

Keywords
Cellular component	Membrane Vacuole
Domain	Repeat
PTM	Lipoprotein Myristate Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to biotic stimulus Inferred from mutant phenotype PubMed 19040629. Source: CGD filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype PubMed 19040629. Source: CGD hyphal growth Inferred from mutant phenotype Ref.1. Source: CGD vacuole inheritance Inferred from mutant phenotype Ref.1PubMed 19040629. Source: CGD
Cellular_component	fungal-type vacuole Inferred from sequence or structural similarity Ref.1. Source: CGD vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 585	584	Vacuolar protein 8		PRO_0000256208
Regions
	Repeat	39 – 76	38	ARM 1
	Repeat	77 – 116	40	ARM 2
	Repeat	118 – 157	40	ARM 3
	Repeat	159 – 198	40	ARM 4
	Repeat	200 – 239	40	ARM 5
	Repeat	243 – 282	40	ARM 6
	Repeat	284 – 323	40	ARM 7
	Repeat	325 – 365	41	ARM 8
	Repeat	409 – 448	40	ARM 9
	Compositional bias	535 – 560	26	Thr-rich
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity
	Lipidation	4	1	S-palmitoyl cysteine Potential
	Lipidation	5	1	S-palmitoyl cysteine Potential
	Lipidation	7	1	S-palmitoyl cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59MN0 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 01FA4050F69A1649	FASTA	585	63,407
	10 20 30 40 50 60 MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP LRALSTLVYS 70 80 90 100 110 120 ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD SEVQRAACGA LGNLAVNTEN 130 140 150 160 170 180 KILIVEMGGL EPLIRQMMST NIEVQCNAVG CITNLATQDD NKSKIAKSGA LIPLTKLAKS 190 200 210 220 230 240 KDIRVQRNAT GALLNMTHSG ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD 250 260 270 280 290 300 EVNRKKLAST EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV 310 320 330 340 350 360 QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE EIQCHAVSTL 370 380 390 400 410 420 RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA CFAILALADD LKPKLYESHI 430 440 450 460 470 480 IDVLIPLTFS ENGEVCGNSA AALANLCSRV SNEHKQYILN NWAQPNEGIY GFLIRFLESG 490 500 510 520 530 540 SPTFEHIALW TILQLLESNN TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT 550 560 570 580 TNITNNNTNT NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching." Barelle C.J., Richard M.L., Gaillardin C., Gow N.A.R., Brown A.J.P. Eukaryot. Cell 5:359-367(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000222 Genomic DNA. Translation: EAK91739.1. AACQ01000221 Genomic DNA. Translation: EAK91753.1.
RefSeq	XP_710979.1. XM_705887.1. XP_710992.1. XM_705900.1.
3D structure databases
ProteinModelPortal	Q59MN0.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001835.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3647410. 3647417.
KEGG	cal:CaO19.745. cal:CaO19.8364.
Organism-specific databases
CGD	CAL0001835. VAC8.
Phylogenomic databases
eggNOG	NOG265712.
KO	K08332.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR026958. Vac8. [Graphical view]
PANTHER	PTHR23315:SF8. PTHR23315:SF8. 1 hit.
SMART	SM00185. ARM. 8 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 7 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VAC8_CANAL

Accession

Primary (citable) accession number: Q59MN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 51 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program