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Protein

Vacuolar protein 8

Gene

VAC8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division.1 Publication

GO - Biological processi

  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • hyphal growth Source: CGD
  • vacuole inheritance Source: CGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein 8
Gene namesi
Name:VAC8
ORF Names:CaO19.745, CaO19.8364
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000185656. VAC8.

Subcellular locationi

GO - Cellular componenti

  • fungal-type vacuole Source: CGD
  • vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002562082 – 585Vacuolar protein 8Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi4S-palmitoyl cysteineSequence analysis1
Lipidationi5S-palmitoyl cysteineSequence analysis1
Lipidationi7S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PRIDEiQ59MN0.

Structurei

3D structure databases

ProteinModelPortaliQ59MN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 76ARM 1Add BLAST38
Repeati77 – 116ARM 2Add BLAST40
Repeati118 – 157ARM 3Add BLAST40
Repeati159 – 198ARM 4Add BLAST40
Repeati200 – 239ARM 5Add BLAST40
Repeati243 – 282ARM 6Add BLAST40
Repeati284 – 323ARM 7Add BLAST40
Repeati325 – 365ARM 8Add BLAST41
Repeati409 – 448ARM 9Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi535 – 560Thr-richAdd BLAST26

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ59MN0.
KOiK08332.
OrthoDBiEOG092C1KQT.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 7 hits.
[Graphical view]
SMARTiSM00185. ARM. 9 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59MN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP
60 70 80 90 100
LRALSTLVYS ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD
110 120 130 140 150
SEVQRAACGA LGNLAVNTEN KILIVEMGGL EPLIRQMMST NIEVQCNAVG
160 170 180 190 200
CITNLATQDD NKSKIAKSGA LIPLTKLAKS KDIRVQRNAT GALLNMTHSG
210 220 230 240 250
ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD EVNRKKLAST
260 270 280 290 300
EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV
310 320 330 340 350
QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE
360 370 380 390 400
EIQCHAVSTL RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA
410 420 430 440 450
CFAILALADD LKPKLYESHI IDVLIPLTFS ENGEVCGNSA AALANLCSRV
460 470 480 490 500
SNEHKQYILN NWAQPNEGIY GFLIRFLESG SPTFEHIALW TILQLLESNN
510 520 530 540 550
TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT TNITNNNTNT
560 570 580
NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG
Length:585
Mass (Da):63,407
Last modified:January 23, 2007 - v3
Checksum:i01FA4050F69A1649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000222 Genomic DNA. Translation: EAK91739.1.
AACQ01000221 Genomic DNA. Translation: EAK91753.1.
RefSeqiXP_710979.1. XM_705887.1.
XP_710992.1. XM_705900.1.

Genome annotation databases

EnsemblFungiiEAK91739; EAK91739; CaO19.8364.
EAK91753; EAK91753; CaO19.745.
GeneIDi3647410.
3647417.
KEGGical:CaO19.745.
cal:CaO19.8364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000222 Genomic DNA. Translation: EAK91739.1.
AACQ01000221 Genomic DNA. Translation: EAK91753.1.
RefSeqiXP_710979.1. XM_705887.1.
XP_710992.1. XM_705900.1.

3D structure databases

ProteinModelPortaliQ59MN0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59MN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK91739; EAK91739; CaO19.8364.
EAK91753; EAK91753; CaO19.745.
GeneIDi3647410.
3647417.
KEGGical:CaO19.745.
cal:CaO19.8364.

Organism-specific databases

CGDiCAL0000185656. VAC8.

Phylogenomic databases

InParanoidiQ59MN0.
KOiK08332.
OrthoDBiEOG092C1KQT.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 7 hits.
[Graphical view]
SMARTiSM00185. ARM. 9 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAC8_CANAL
AccessioniPrimary (citable) accession number: Q59MN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.