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Q59MN0

- VAC8_CANAL

UniProt

Q59MN0 - VAC8_CANAL

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Protein

Vacuolar protein 8

Gene

VAC8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division.1 Publication

GO - Biological processi

  1. filamentous growth Source: CGD
  2. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  3. hyphal growth Source: CGD
  4. vacuole inheritance Source: CGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein 8
Gene namesi
Name:VAC8
ORF Names:CaO19.745, CaO19.8364
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001835. VAC8.

Subcellular locationi

Vacuole membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. fungal-type vacuole Source: CGD
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 585584Vacuolar protein 8PRO_0000256208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi4 – 41S-palmitoyl cysteineSequence Analysis
Lipidationi5 – 51S-palmitoyl cysteineSequence Analysis
Lipidationi7 – 71S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001835.

Structurei

3D structure databases

ProteinModelPortaliQ59MN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 7638ARM 1Add
BLAST
Repeati77 – 11640ARM 2Add
BLAST
Repeati118 – 15740ARM 3Add
BLAST
Repeati159 – 19840ARM 4Add
BLAST
Repeati200 – 23940ARM 5Add
BLAST
Repeati243 – 28240ARM 6Add
BLAST
Repeati284 – 32340ARM 7Add
BLAST
Repeati325 – 36541ARM 8Add
BLAST
Repeati409 – 44840ARM 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi535 – 56026Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG265712.
InParanoidiQ59MN0.
KOiK08332.
OrthoDBiEOG7Q8CX4.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 6 hits.
[Graphical view]
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59MN0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP
60 70 80 90 100
LRALSTLVYS ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD
110 120 130 140 150
SEVQRAACGA LGNLAVNTEN KILIVEMGGL EPLIRQMMST NIEVQCNAVG
160 170 180 190 200
CITNLATQDD NKSKIAKSGA LIPLTKLAKS KDIRVQRNAT GALLNMTHSG
210 220 230 240 250
ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD EVNRKKLAST
260 270 280 290 300
EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV
310 320 330 340 350
QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE
360 370 380 390 400
EIQCHAVSTL RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA
410 420 430 440 450
CFAILALADD LKPKLYESHI IDVLIPLTFS ENGEVCGNSA AALANLCSRV
460 470 480 490 500
SNEHKQYILN NWAQPNEGIY GFLIRFLESG SPTFEHIALW TILQLLESNN
510 520 530 540 550
TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT TNITNNNTNT
560 570 580
NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG
Length:585
Mass (Da):63,407
Last modified:January 23, 2007 - v3
Checksum:i01FA4050F69A1649
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000222 Genomic DNA. Translation: EAK91739.1.
AACQ01000221 Genomic DNA. Translation: EAK91753.1.
RefSeqiXP_710979.1. XM_705887.1.
XP_710992.1. XM_705900.1.

Genome annotation databases

GeneIDi3647410.
3647417.
KEGGical:CaO19.745.
cal:CaO19.8364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000222 Genomic DNA. Translation: EAK91739.1 .
AACQ01000221 Genomic DNA. Translation: EAK91753.1 .
RefSeqi XP_710979.1. XM_705887.1.
XP_710992.1. XM_705900.1.

3D structure databases

ProteinModelPortali Q59MN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001835.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647410.
3647417.
KEGGi cal:CaO19.745.
cal:CaO19.8364.

Organism-specific databases

CGDi CAL0001835. VAC8.

Phylogenomic databases

eggNOGi NOG265712.
InParanoidi Q59MN0.
KOi K08332.
OrthoDBi EOG7Q8CX4.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view ]
Pfami PF00514. Arm. 6 hits.
[Graphical view ]
SMARTi SM00185. ARM. 8 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50176. ARM_REPEAT. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching."
    Barelle C.J., Richard M.L., Gaillardin C., Gow N.A.R., Brown A.J.P.
    Eukaryot. Cell 5:359-367(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiVAC8_CANAL
AccessioniPrimary (citable) accession number: Q59MN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3