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Q59MN0

- VAC8_CANAL

UniProt

Q59MN0 - VAC8_CANAL

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Protein
Vacuolar protein 8
Gene
VAC8, CaO19.745, CaO19.8364
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division.1 Publication

GO - Biological processi

  1. filamentous growth Source: CGD
  2. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  3. hyphal growth Source: CGD
  4. vacuole inheritance Source: CGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein 8
Gene namesi
Name:VAC8
ORF Names:CaO19.745, CaO19.8364
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001835. VAC8.

Subcellular locationi

GO - Cellular componenti

  1. fungal-type vacuole Source: CGD
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 585584Vacuolar protein 8
PRO_0000256208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Lipidationi4 – 41S-palmitoyl cysteine Reviewed prediction
Lipidationi5 – 51S-palmitoyl cysteine Reviewed prediction
Lipidationi7 – 71S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001835.

Structurei

3D structure databases

ProteinModelPortaliQ59MN0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 7638ARM 1
Add
BLAST
Repeati77 – 11640ARM 2
Add
BLAST
Repeati118 – 15740ARM 3
Add
BLAST
Repeati159 – 19840ARM 4
Add
BLAST
Repeati200 – 23940ARM 5
Add
BLAST
Repeati243 – 28240ARM 6
Add
BLAST
Repeati284 – 32340ARM 7
Add
BLAST
Repeati325 – 36541ARM 8
Add
BLAST
Repeati409 – 44840ARM 9
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi535 – 56026Thr-rich
Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 9 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG265712.
KOiK08332.
OrthoDBiEOG7Q8CX4.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 6 hits.
[Graphical view]
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59MN0-1 [UniParc]FASTAAdd to Basket

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MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP    50
LRALSTLVYS ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD 100
SEVQRAACGA LGNLAVNTEN KILIVEMGGL EPLIRQMMST NIEVQCNAVG 150
CITNLATQDD NKSKIAKSGA LIPLTKLAKS KDIRVQRNAT GALLNMTHSG 200
ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD EVNRKKLAST 250
EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV 300
QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE 350
EIQCHAVSTL RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA 400
CFAILALADD LKPKLYESHI IDVLIPLTFS ENGEVCGNSA AALANLCSRV 450
SNEHKQYILN NWAQPNEGIY GFLIRFLESG SPTFEHIALW TILQLLESNN 500
TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT TNITNNNTNT 550
NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG 585
Length:585
Mass (Da):63,407
Last modified:January 23, 2007 - v3
Checksum:i01FA4050F69A1649
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000222 Genomic DNA. Translation: EAK91739.1.
AACQ01000221 Genomic DNA. Translation: EAK91753.1.
RefSeqiXP_710979.1. XM_705887.1.
XP_710992.1. XM_705900.1.

Genome annotation databases

GeneIDi3647410.
3647417.
KEGGical:CaO19.745.
cal:CaO19.8364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000222 Genomic DNA. Translation: EAK91739.1 .
AACQ01000221 Genomic DNA. Translation: EAK91753.1 .
RefSeqi XP_710979.1. XM_705887.1.
XP_710992.1. XM_705900.1.

3D structure databases

ProteinModelPortali Q59MN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001835.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647410.
3647417.
KEGGi cal:CaO19.745.
cal:CaO19.8364.

Organism-specific databases

CGDi CAL0001835. VAC8.

Phylogenomic databases

eggNOGi NOG265712.
KOi K08332.
OrthoDBi EOG7Q8CX4.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view ]
Pfami PF00514. Arm. 6 hits.
[Graphical view ]
SMARTi SM00185. ARM. 8 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50176. ARM_REPEAT. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching."
    Barelle C.J., Richard M.L., Gaillardin C., Gow N.A.R., Brown A.J.P.
    Eukaryot. Cell 5:359-367(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiVAC8_CANAL
AccessioniPrimary (citable) accession number: Q59MN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi