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Q59MF7 (Q59MF7_CANAL) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding104 – 1063NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding338 – 3436NADP By similarity PIRSR PIRSR000108-4
Region123 – 1297Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2801Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3031Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1061Substrate By similarity PIRSR PIRSR000108-2
Binding site1111NADP By similarity PIRSR PIRSR000108-4
Binding site1381Substrate By similarity PIRSR PIRSR000108-2
Binding site1611Substrate By similarity PIRSR PIRSR000108-2
Binding site2881NADP By similarity PIRSR PIRSR000108-4
Binding site3561NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1681Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2401Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q59MF7 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 7C474A3E705EE341

FASTA43348,562
        10         20         30         40         50         60 
MIRTTTTRAI NRTAMLQNHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI IWQKIKDQLI 

        70         80         90        100        110        120 
LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV KCATITPDEA RVKEFNLKKM 

       130        140        150        160        170        180 
WLSPNGTIRN ILGGTVFRES IIIPCIPRLI PGWKEPIVIG RHAFGDQYKA TDLVISEPGK 

       190        200        210        220        230        240 
LELRFTPENG GETQTHKVYD YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK 

       250        260        270        280        290        300 
NTILKKYDGR FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY 

       310        320        330        340        350        360 
DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG KETSTNSIAS 

       370        380        390        400        410        420 
IFAWTRGLAQ RGRLDETPEV VDFADKLEKA TIDTVEVDRI MTKDLALAMG KTDRSAYVTT 

       430 
TEFLDAVADR LKK 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000227 Genomic DNA. Translation: EAK91661.1.
AACQ01000226 Genomic DNA. Translation: EAK91676.1.
RefSeqXP_710904.1. XM_705812.1.
XP_710919.1. XM_705827.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003500.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647474.
3647488.
KEGGcal:CaO19.12678.
cal:CaO19.5211.

Organism-specific databases

CGDCAL0003500. IDP1.

Phylogenomic databases

eggNOGCOG0538.
KOK00031.
OrthoDBEOG7G4QQD.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ59MF7_CANAL
AccessionPrimary (citable) accession number: Q59MF7
Entry history
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)