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Q59MF7

- Q59MF7_CANAL

UniProt

Q59MF7 - Q59MF7_CANAL

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Protein
Isocitrate dehydrogenase [NADP]
Gene
IDP1, CaO19.12678, CaO19.5211
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Substrate By similarityUniRule annotation
Binding sitei111 – 1111NADP By similarity
Binding sitei138 – 1381Substrate By similarityUniRule annotation
Binding sitei161 – 1611Substrate By similarityUniRule annotation
Sitei168 – 1681Critical for catalysis By similarityUniRule annotation
Sitei240 – 2401Critical for catalysis By similarityUniRule annotation
Metal bindingi280 – 2801Magnesium or manganese By similarityUniRule annotation
Binding sitei288 – 2881NADP By similarity
Metal bindingi303 – 3031Magnesium or manganese By similarityUniRule annotation
Binding sitei356 – 3561NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1063NADP By similarity
Nucleotide bindingi338 – 3436NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:IDP1Imported
ORF Names:CaO19.12678Imported, CaO19.5211Imported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003500. IDP1.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003500.

Structurei

3D structure databases

ProteinModelPortaliQ59MF7.
SMRiQ59MF7. Positions 32-433.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1297Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59MF7-1 [UniParc]FASTAAdd to Basket

« Hide

MIRTTTTRAI NRTAMLQNHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI    50
IWQKIKDQLI LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV 100
KCATITPDEA RVKEFNLKKM WLSPNGTIRN ILGGTVFRES IIIPCIPRLI 150
PGWKEPIVIG RHAFGDQYKA TDLVISEPGK LELRFTPENG GETQTHKVYD 200
YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK NTILKKYDGR 250
FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY 300
DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG 350
KETSTNSIAS IFAWTRGLAQ RGRLDETPEV VDFADKLEKA TIDTVEVDRI 400
MTKDLALAMG KTDRSAYVTT TEFLDAVADR LKK 433
Length:433
Mass (Da):48,562
Last modified:April 26, 2005 - v1
Checksum:i7C474A3E705EE341
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000227 Genomic DNA. Translation: EAK91661.1.
AACQ01000226 Genomic DNA. Translation: EAK91676.1.
RefSeqiXP_710904.1. XM_705812.1.
XP_710919.1. XM_705827.1.

Genome annotation databases

GeneIDi3647474.
3647488.
KEGGical:CaO19.12678.
cal:CaO19.5211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000227 Genomic DNA. Translation: EAK91661.1 .
AACQ01000226 Genomic DNA. Translation: EAK91676.1 .
RefSeqi XP_710904.1. XM_705812.1.
XP_710919.1. XM_705827.1.

3D structure databases

ProteinModelPortali Q59MF7.
SMRi Q59MF7. Positions 32-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647474.
3647488.
KEGGi cal:CaO19.12678.
cal:CaO19.5211.

Organism-specific databases

CGDi CAL0003500. IDP1.

Phylogenomic databases

eggNOGi COG0538.
KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiQ59MF7_CANAL
AccessioniPrimary (citable) accession number: Q59MF7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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