Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q59MF7

- Q59MF7_CANAL

UniProt

Q59MF7 - Q59MF7_CANAL

Protein

Isocitrate dehydrogenase [NADP]

Gene

IDP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061SubstrateUniRule annotation
    Binding sitei111 – 1111NADPUniRule annotation
    Binding sitei138 – 1381SubstrateUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Sitei168 – 1681Critical for catalysisUniRule annotation
    Sitei240 – 2401Critical for catalysisUniRule annotation
    Metal bindingi280 – 2801Magnesium or manganeseUniRule annotation
    Binding sitei288 – 2881NADPUniRule annotation
    Metal bindingi303 – 3031Magnesium or manganeseUniRule annotation
    Binding sitei356 – 3561NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi104 – 1063NADPUniRule annotation
    Nucleotide bindingi338 – 3436NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:IDP1Imported
    ORF Names:CaO19.12678Imported, CaO19.5211Imported
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003500. IDP1.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0003500.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni123 – 1297Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    KOiK00031.
    OrthoDBiEOG7G4QQD.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59MF7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRTTTTRAI NRTAMLQNHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI    50
    IWQKIKDQLI LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV 100
    KCATITPDEA RVKEFNLKKM WLSPNGTIRN ILGGTVFRES IIIPCIPRLI 150
    PGWKEPIVIG RHAFGDQYKA TDLVISEPGK LELRFTPENG GETQTHKVYD 200
    YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK NTILKKYDGR 250
    FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY 300
    DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG 350
    KETSTNSIAS IFAWTRGLAQ RGRLDETPEV VDFADKLEKA TIDTVEVDRI 400
    MTKDLALAMG KTDRSAYVTT TEFLDAVADR LKK 433
    Length:433
    Mass (Da):48,562
    Last modified:April 26, 2005 - v1
    Checksum:i7C474A3E705EE341
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000227 Genomic DNA. Translation: EAK91661.1.
    AACQ01000226 Genomic DNA. Translation: EAK91676.1.
    RefSeqiXP_710904.1. XM_705812.1.
    XP_710919.1. XM_705827.1.

    Genome annotation databases

    GeneIDi3647474.
    3647488.
    KEGGical:CaO19.12678.
    cal:CaO19.5211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000227 Genomic DNA. Translation: EAK91661.1 .
    AACQ01000226 Genomic DNA. Translation: EAK91676.1 .
    RefSeqi XP_710904.1. XM_705812.1.
    XP_710919.1. XM_705827.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647474.
    3647488.
    KEGGi cal:CaO19.12678.
    cal:CaO19.5211.

    Organism-specific databases

    CGDi CAL0003500. IDP1.

    Phylogenomic databases

    eggNOGi COG0538.
    KOi K00031.
    OrthoDBi EOG7G4QQD.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876Imported.

    Entry informationi

    Entry nameiQ59MF7_CANAL
    AccessioniPrimary (citable) accession number: Q59MF7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3