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Q59MF7

- Q59MF7_CANAL

UniProt

Q59MF7 - Q59MF7_CANAL

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Protein

Isocitrate dehydrogenase [NADP]

Gene

IDP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061SubstrateUniRule annotation
Binding sitei111 – 1111NADPUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Sitei168 – 1681Critical for catalysisUniRule annotation
Sitei240 – 2401Critical for catalysisUniRule annotation
Metal bindingi280 – 2801Magnesium or manganeseUniRule annotation
Binding sitei288 – 2881NADPUniRule annotation
Metal bindingi303 – 3031Magnesium or manganeseUniRule annotation
Binding sitei356 – 3561NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1063NADPUniRule annotation
Nucleotide bindingi338 – 3436NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:IDP1Imported
ORF Names:CaO19.12678Imported, CaO19.5211Imported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003500. IDP1.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003500.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1297Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59MF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRTTTTRAI NRTAMLQNHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI
60 70 80 90 100
IWQKIKDQLI LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV
110 120 130 140 150
KCATITPDEA RVKEFNLKKM WLSPNGTIRN ILGGTVFRES IIIPCIPRLI
160 170 180 190 200
PGWKEPIVIG RHAFGDQYKA TDLVISEPGK LELRFTPENG GETQTHKVYD
210 220 230 240 250
YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK NTILKKYDGR
260 270 280 290 300
FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY
310 320 330 340 350
DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG
360 370 380 390 400
KETSTNSIAS IFAWTRGLAQ RGRLDETPEV VDFADKLEKA TIDTVEVDRI
410 420 430
MTKDLALAMG KTDRSAYVTT TEFLDAVADR LKK
Length:433
Mass (Da):48,562
Last modified:April 26, 2005 - v1
Checksum:i7C474A3E705EE341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000227 Genomic DNA. Translation: EAK91661.1.
AACQ01000226 Genomic DNA. Translation: EAK91676.1.
RefSeqiXP_710904.1. XM_705812.1.
XP_710919.1. XM_705827.1.

Genome annotation databases

GeneIDi3647474.
3647488.
KEGGical:CaO19.12678.
cal:CaO19.5211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000227 Genomic DNA. Translation: EAK91661.1 .
AACQ01000226 Genomic DNA. Translation: EAK91676.1 .
RefSeqi XP_710904.1. XM_705812.1.
XP_710919.1. XM_705827.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647474.
3647488.
KEGGi cal:CaO19.12678.
cal:CaO19.5211.

Organism-specific databases

CGDi CAL0003500. IDP1.

Phylogenomic databases

eggNOGi COG0538.
KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314Imported and SC5314 / ATCC MYA-2876Imported.

Entry informationi

Entry nameiQ59MF7_CANAL
AccessioniPrimary (citable) accession number: Q59MF7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3