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Protein
Submitted name:

Isocitrate dehydrogenase [NADP], mitochondrial

Gene

IDP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061SubstrateUniRule annotation
Binding sitei111 – 1111NADPUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Sitei168 – 1681Critical for catalysisUniRule annotation
Sitei240 – 2401Critical for catalysisUniRule annotation
Metal bindingi280 – 2801Magnesium or manganeseUniRule annotation
Binding sitei288 – 2881NADPUniRule annotation
Metal bindingi303 – 3031Magnesium or manganeseUniRule annotation
Binding sitei356 – 3561NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1063NADPUniRule annotation
Nucleotide bindingi338 – 3436NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP], mitochondrialImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:IDP1Imported
ORF Names:CaO19.12678Imported, CaO19.5211Imported, W5Q_02016Imported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003500. IDP1.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003500.

Structurei

3D structure databases

ProteinModelPortaliQ59MF7.
SMRiQ59MF7. Positions 32-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1297Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
InParanoidiQ59MF7.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59MF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTTTTRAI NRTAMLQNHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI
60 70 80 90 100
IWQKIKDQLI LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV
110 120 130 140 150
KCATITPDEA RVKEFNLKKM WLSPNGTIRN ILGGTVFRES IIIPCIPRLI
160 170 180 190 200
PGWKEPIVIG RHAFGDQYKA TDLVISEPGK LELRFTPENG GETQTHKVYD
210 220 230 240 250
YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK NTILKKYDGR
260 270 280 290 300
FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY
310 320 330 340 350
DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG
360 370 380 390 400
KETSTNSIAS IFAWTRGLAQ RGRLDETPEV VDFADKLEKA TIDTVEVDRI
410 420 430
MTKDLALAMG KTDRSAYVTT TEFLDAVADR LKK
Length:433
Mass (Da):48,562
Last modified:April 26, 2005 - v1
Checksum:i7C474A3E705EE341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000227 Genomic DNA. Translation: EAK91661.1.
AACQ01000226 Genomic DNA. Translation: EAK91676.1.
AJJF01000006 Genomic DNA. Translation: KHC81629.1.
RefSeqiXP_710904.1. XM_705812.1.
XP_710919.1. XM_705827.1.

Genome annotation databases

GeneIDi3647474.
3647488.
KEGGical:CaO19.12678.
cal:CaO19.5211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000227 Genomic DNA. Translation: EAK91661.1.
AACQ01000226 Genomic DNA. Translation: EAK91676.1.
AJJF01000006 Genomic DNA. Translation: KHC81629.1.
RefSeqiXP_710904.1. XM_705812.1.
XP_710919.1. XM_705827.1.

3D structure databases

ProteinModelPortaliQ59MF7.
SMRiQ59MF7. Positions 32-433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0003500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3647474.
3647488.
KEGGical:CaO19.12678.
cal:CaO19.5211.

Organism-specific databases

CGDiCAL0003500. IDP1.

Phylogenomic databases

eggNOGiCOG0538.
InParanoidiQ59MF7.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314Imported and SC5314 / ATCC MYA-2876Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SC5314Imported.

Entry informationi

Entry nameiQ59MF7_CANAL
AccessioniPrimary (citable) accession number: Q59MF7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.