Q59MC8 (MDM34_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial distribution and morphology protein 34

Gene names

Name:	MDM34
ORF Names:	CaO19.1826, CaO19.9385

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10 By similarity. HAMAP-Rule MF_03105
Subunit structure	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34 By similarity.
Subcellular location	Mitochondrion outer membrane; Multi-pass membrane protein By similarity. Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids By similarity. HAMAP-Rule MF_03105
Domain	Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin. HAMAP-Rule MF_03105
Sequence similarities	Belongs to the MDM34 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane beta strand
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity PubMed 15964282. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 622	622	Mitochondrial distribution and morphology protein 34 HAMAP-Rule MF_03105		PRO_0000384333

Sequences

	Sequence		Length	Mass (Da)
	Q59MC8 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 55B1C4DAD0E87C28	FASTA	622	70,083
	10 20 30 40 50 60 MSFKVNWNSL ETEPLTNWTK ELLTSALNSG KSPNILALNI TIKDLNFGKI APDFEILEIG 70 80 90 100 110 120 ELDRDRFRGI FKIDYQGDFH LTLHTKVQAN PLNIYYHNSL EKEVCNYSQD EFITPNFLLS 130 140 150 160 170 180 NEQFAIPLDL KLSDIKINGI GIIVFSKSKG LTLVFRNDPL DSIKVSSTFD TVQVLANFLQ 190 200 210 220 230 240 KQIENQIRDL FRETLPTLIH QLSLKYLSLD NNINEIKSKL SQQDSVSMTN NELASSLKLF 250 260 270 280 290 300 DDEENEFPLI YSSKNLQKNM QLFKSRETFR LSAPKFKNIV QRTRLDKFTK SYPNLLNSLY 310 320 330 340 350 360 ANNADLQHRF VNNINHGHNN NSNTSSNGIP IELLVSHDDK QHYDKTDDLL KDISSIQANN 370 380 390 400 410 420 FYKYSNKDAP NKPKRRRIKV HKKSKAKQDD NTVKASELQN VDSTFMESRS ISPQETIDTT 430 440 450 460 470 480 STLIESAPIT RNVSTNIKSP TLETMSTGSS SSASSQVIAH PTPKRAHQPA DTTVSTTTIN 490 500 510 520 530 540 KENHIDYIKA RNLYQDFIQM SQSPGYYDKV ISNGGGIGLG NSGGNYFGFN GNGNGLERTM 550 560 570 580 590 600 SASPIKHLNK DKKSINYIDT SKINEKLNQF RLDGGKNSAN TNNSSGGKNF RPGFTRNESN 610 620 GQQGILFEAF NFPSVAPPPP YC

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000230 Genomic DNA. Translation: EAK91634.1. AACQ01000229 Genomic DNA. Translation: EAK91643.1.
RefSeq	XP_710877.1. XM_705785.1. XP_710886.1. XM_705794.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001630.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3647513. 3647517.
KEGG	cal:CaO19.1826. cal:CaO19.9385.
Organism-specific databases
CGD	CAL0001630. MDM34.
Phylogenomic databases
eggNOG	NOG74242.
Family and domain databases
HAMAP	MF_03105. Mdm34.
InterPro	IPR019411. DUF2404. [Graphical view]
Pfam	PF10296. DUF2404. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDM34_CANAL

Accession

Primary (citable) accession number: Q59MC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program