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Q59MC8

- MDM34_CANAL

UniProt

Q59MC8 - MDM34_CANAL

Protein

Mitochondrial distribution and morphology protein 34

Gene

MDM34

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.UniRule annotation

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: CGD

    GO - Biological processi

    1. mitochondrial genome maintenance Source: UniProtKB-HAMAP
    2. regulation of transcription, DNA-templated Source: CGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial distribution and morphology protein 34UniRule annotation
    Gene namesi
    Name:MDM34UniRule annotation
    ORF Names:CaO19.1826, CaO19.9385
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001630. MDM34.

    Subcellular locationi

    Mitochondrion outer membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
    Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.UniRule annotation

    GO - Cellular componenti

    1. ERMES complex Source: UniProtKB-HAMAP
    2. integral component of mitochondrial outer membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Mitochondrial distribution and morphology protein 34PRO_0000384333Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.UniRule annotation

    Protein-protein interaction databases

    BioGridi1230610. 1 interaction.
    STRINGi5476.CAL0001630.

    Family & Domainsi

    Domaini

    Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.

    Sequence similaritiesi

    Belongs to the MDM34 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiNOG74242.
    KOiK17775.
    OrthoDBiEOG7Z3FDQ.

    Family and domain databases

    HAMAPiMF_03105. Mdm34.
    InterProiIPR019411. DUF2404.
    IPR027536. Mdm34.
    [Graphical view]
    PfamiPF10296. DUF2404. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59MC8-1 [UniParc]FASTAAdd to Basket

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    MSFKVNWNSL ETEPLTNWTK ELLTSALNSG KSPNILALNI TIKDLNFGKI    50
    APDFEILEIG ELDRDRFRGI FKIDYQGDFH LTLHTKVQAN PLNIYYHNSL 100
    EKEVCNYSQD EFITPNFLLS NEQFAIPLDL KLSDIKINGI GIIVFSKSKG 150
    LTLVFRNDPL DSIKVSSTFD TVQVLANFLQ KQIENQIRDL FRETLPTLIH 200
    QLSLKYLSLD NNINEIKSKL SQQDSVSMTN NELASSLKLF DDEENEFPLI 250
    YSSKNLQKNM QLFKSRETFR LSAPKFKNIV QRTRLDKFTK SYPNLLNSLY 300
    ANNADLQHRF VNNINHGHNN NSNTSSNGIP IELLVSHDDK QHYDKTDDLL 350
    KDISSIQANN FYKYSNKDAP NKPKRRRIKV HKKSKAKQDD NTVKASELQN 400
    VDSTFMESRS ISPQETIDTT STLIESAPIT RNVSTNIKSP TLETMSTGSS 450
    SSASSQVIAH PTPKRAHQPA DTTVSTTTIN KENHIDYIKA RNLYQDFIQM 500
    SQSPGYYDKV ISNGGGIGLG NSGGNYFGFN GNGNGLERTM SASPIKHLNK 550
    DKKSINYIDT SKINEKLNQF RLDGGKNSAN TNNSSGGKNF RPGFTRNESN 600
    GQQGILFEAF NFPSVAPPPP YC 622
    Length:622
    Mass (Da):70,083
    Last modified:April 26, 2005 - v1
    Checksum:i55B1C4DAD0E87C28
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000230 Genomic DNA. Translation: EAK91634.1.
    AACQ01000229 Genomic DNA. Translation: EAK91643.1.
    RefSeqiXP_710877.1. XM_705785.1.
    XP_710886.1. XM_705794.1.

    Genome annotation databases

    GeneIDi3647513.
    3647517.
    KEGGical:CaO19.1826.
    cal:CaO19.9385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000230 Genomic DNA. Translation: EAK91634.1 .
    AACQ01000229 Genomic DNA. Translation: EAK91643.1 .
    RefSeqi XP_710877.1. XM_705785.1.
    XP_710886.1. XM_705794.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1230610. 1 interaction.
    STRINGi 5476.CAL0001630.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647513.
    3647517.
    KEGGi cal:CaO19.1826.
    cal:CaO19.9385.

    Organism-specific databases

    CGDi CAL0001630. MDM34.

    Phylogenomic databases

    eggNOGi NOG74242.
    KOi K17775.
    OrthoDBi EOG7Z3FDQ.

    Family and domain databases

    HAMAPi MF_03105. Mdm34.
    InterProi IPR019411. DUF2404.
    IPR027536. Mdm34.
    [Graphical view ]
    Pfami PF10296. DUF2404. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiMDM34_CANAL
    AccessioniPrimary (citable) accession number: Q59MC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3