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Q59MC8 (MDM34_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial distribution and morphology protein 34
Gene names
Name:MDM34
ORF Names:CaO19.1826, CaO19.9385
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10 By similarity. HAMAP-Rule MF_03105

Subunit structure

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34 By similarity.

Subcellular location

Mitochondrion outer membrane; Multi-pass membrane protein By similarity. Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids By similarity. HAMAP-Rule MF_03105

Domain

Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin. HAMAP-Rule MF_03105

Sequence similarities

Belongs to the MDM34 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622Mitochondrial distribution and morphology protein 34 HAMAP-Rule MF_03105
PRO_0000384333

Sequences

Sequence LengthMass (Da)Tools
Q59MC8 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 55B1C4DAD0E87C28

FASTA62270,083
        10         20         30         40         50         60 
MSFKVNWNSL ETEPLTNWTK ELLTSALNSG KSPNILALNI TIKDLNFGKI APDFEILEIG 

        70         80         90        100        110        120 
ELDRDRFRGI FKIDYQGDFH LTLHTKVQAN PLNIYYHNSL EKEVCNYSQD EFITPNFLLS 

       130        140        150        160        170        180 
NEQFAIPLDL KLSDIKINGI GIIVFSKSKG LTLVFRNDPL DSIKVSSTFD TVQVLANFLQ 

       190        200        210        220        230        240 
KQIENQIRDL FRETLPTLIH QLSLKYLSLD NNINEIKSKL SQQDSVSMTN NELASSLKLF 

       250        260        270        280        290        300 
DDEENEFPLI YSSKNLQKNM QLFKSRETFR LSAPKFKNIV QRTRLDKFTK SYPNLLNSLY 

       310        320        330        340        350        360 
ANNADLQHRF VNNINHGHNN NSNTSSNGIP IELLVSHDDK QHYDKTDDLL KDISSIQANN 

       370        380        390        400        410        420 
FYKYSNKDAP NKPKRRRIKV HKKSKAKQDD NTVKASELQN VDSTFMESRS ISPQETIDTT 

       430        440        450        460        470        480 
STLIESAPIT RNVSTNIKSP TLETMSTGSS SSASSQVIAH PTPKRAHQPA DTTVSTTTIN 

       490        500        510        520        530        540 
KENHIDYIKA RNLYQDFIQM SQSPGYYDKV ISNGGGIGLG NSGGNYFGFN GNGNGLERTM 

       550        560        570        580        590        600 
SASPIKHLNK DKKSINYIDT SKINEKLNQF RLDGGKNSAN TNNSSGGKNF RPGFTRNESN 

       610        620 
GQQGILFEAF NFPSVAPPPP YC 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000230 Genomic DNA. Translation: EAK91634.1.
AACQ01000229 Genomic DNA. Translation: EAK91643.1.
RefSeqXP_710877.1. XM_705785.1.
XP_710886.1. XM_705794.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1230610. 1 interaction.
STRING5476.CAL0001630.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647513.
3647517.
KEGGcal:CaO19.1826.
cal:CaO19.9385.

Organism-specific databases

CGDCAL0001630. MDM34.

Phylogenomic databases

eggNOGNOG74242.
KOK17775.
OrthoDBEOG7Z3FDQ.

Family and domain databases

HAMAPMF_03105. Mdm34.
InterProIPR019411. DUF2404.
IPR027536. Mdm34.
[Graphical view]
PfamPF10296. DUF2404. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDM34_CANAL
AccessionPrimary (citable) accession number: Q59MC8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names