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Protein

Mitochondrial distribution and morphology protein 34

Gene

MDM34

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 34UniRule annotation
Gene namesi
Name:MDM34UniRule annotation
Ordered Locus Names:CAALFM_C106230CA
ORF Names:CaO19.1826, CaO19.9385
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000184363. MDM34.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

  • Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003843331 – 623Mitochondrial distribution and morphology protein 34Add BLAST623

Proteomic databases

PRIDEiQ59MC8.

Interactioni

Subunit structurei

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.UniRule annotation

Protein-protein interaction databases

BioGridi1230606. 1 interactor.

Family & Domainsi

Domaini

Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.

Sequence similaritiesi

Belongs to the MDM34 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

InParanoidiQ59MC8.
KOiK17775.
OrthoDBiEOG092C1T1W.

Family and domain databases

HAMAPiMF_03105. Mdm34. 1 hit.
InterProiView protein in InterPro
IPR027536. Mdm34.

Sequencei

Sequence statusi: Complete.

Q59MC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKVNWNSL ETEPLTNWTK ELLTSALNSG KSPNILALNI TIKDLNFGKI
60 70 80 90 100
APDFEILEIG ELDRDRFRGI FKIDYQGDFH LTLHTKVQAN PLNIYYHNSL
110 120 130 140 150
EKEVCNYSQD EFITPNFLLS NEQFAIPLDL KLSDIKINGI GIIVFSKSKG
160 170 180 190 200
LTLVFRNDPL DSIKVSSTFD TVQVLANFLQ KQIENQIRDL FRETLPTLIH
210 220 230 240 250
QLSLKYLSLD NNINEIKSKL SQQDSVSMTN NELASSLKLF DDEENEFPLI
260 270 280 290 300
YSSKNLQKNM QLFKSRETFR LSAPKFKNIV QRTRLDKFTK SYPNLLNSLY
310 320 330 340 350
ANNADLQHRF VNNINHGHNN NSNTSSTGIP IELLVSHDDK QHYGKTDNLL
360 370 380 390 400
KDISSIQANN FYKYSNKDAP NKPKRRRIKV HKKSKVKQDD NTVKASELQN
410 420 430 440 450
VDSTFMESRS ISPQETIDTT STLIESAPMT RNVSTNIKSP TLETMSTGSS
460 470 480 490 500
SSASSQVIAH PTPKRAHQPA DSTVSTTTIN KENHIDYIKA RNLYQDFIQM
510 520 530 540 550
SQSPGYYDKV ISNGRGIGLG NSGGNYFGFN GNGNGLERTM SASPIKHLNK
560 570 580 590 600
DKKSINYIDT SKINEKLNQF RLDGGKNSAN TNNSSGGKNF RPGFTRNESN
610 620
GQQGILFEAF NFPSVAPPPP PYC
Length:623
Mass (Da):70,239
Last modified:March 15, 2017 - v2
Checksum:i699AAAEA6DD3FD24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW26285.1.

Genome annotation databases

EnsemblFungiiEAK91634; EAK91634; CaO19.1826.
EAK91643; EAK91643; CaO19.9385.
KEGGical:CaO19.1826.
cal:CaO19.9385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW26285.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1230606. 1 interactor.

Proteomic databases

PRIDEiQ59MC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK91634; EAK91634; CaO19.1826.
EAK91643; EAK91643; CaO19.9385.
KEGGical:CaO19.1826.
cal:CaO19.9385.

Organism-specific databases

CGDiCAL0000184363. MDM34.

Phylogenomic databases

InParanoidiQ59MC8.
KOiK17775.
OrthoDBiEOG092C1T1W.

Family and domain databases

HAMAPiMF_03105. Mdm34. 1 hit.
InterProiView protein in InterPro
IPR027536. Mdm34.
ProtoNetiSearch...

Entry informationi

Entry nameiMDM34_CANAL
AccessioniPrimary (citable) accession number: Q59MC8
Secondary accession number(s): A0A1D8PDR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 15, 2017
Last modified: March 15, 2017
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.