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Protein

Mitochondrial distribution and morphology protein 34

Gene

MDM34

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.UniRule annotation

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 34UniRule annotation
Gene namesi
Name:MDM34UniRule annotation
ORF Names:CaO19.1826, CaO19.9385
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001630. MDM34.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

  • Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Mitochondrial distribution and morphology protein 34PRO_0000384333Add
BLAST

Interactioni

Subunit structurei

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.UniRule annotation

Protein-protein interaction databases

BioGridi1230610. 1 interaction.
STRINGi5476.CAL0001630.

Family & Domainsi

Domaini

Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.

Sequence similaritiesi

Belongs to the MDM34 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG74242.
InParanoidiQ59MC8.
KOiK17775.
OrthoDBiEOG7Z3FDQ.

Family and domain databases

HAMAPiMF_03105. Mdm34.
InterProiIPR019411. DUF2404.
IPR027536. Mdm34.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59MC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKVNWNSL ETEPLTNWTK ELLTSALNSG KSPNILALNI TIKDLNFGKI
60 70 80 90 100
APDFEILEIG ELDRDRFRGI FKIDYQGDFH LTLHTKVQAN PLNIYYHNSL
110 120 130 140 150
EKEVCNYSQD EFITPNFLLS NEQFAIPLDL KLSDIKINGI GIIVFSKSKG
160 170 180 190 200
LTLVFRNDPL DSIKVSSTFD TVQVLANFLQ KQIENQIRDL FRETLPTLIH
210 220 230 240 250
QLSLKYLSLD NNINEIKSKL SQQDSVSMTN NELASSLKLF DDEENEFPLI
260 270 280 290 300
YSSKNLQKNM QLFKSRETFR LSAPKFKNIV QRTRLDKFTK SYPNLLNSLY
310 320 330 340 350
ANNADLQHRF VNNINHGHNN NSNTSSNGIP IELLVSHDDK QHYDKTDDLL
360 370 380 390 400
KDISSIQANN FYKYSNKDAP NKPKRRRIKV HKKSKAKQDD NTVKASELQN
410 420 430 440 450
VDSTFMESRS ISPQETIDTT STLIESAPIT RNVSTNIKSP TLETMSTGSS
460 470 480 490 500
SSASSQVIAH PTPKRAHQPA DTTVSTTTIN KENHIDYIKA RNLYQDFIQM
510 520 530 540 550
SQSPGYYDKV ISNGGGIGLG NSGGNYFGFN GNGNGLERTM SASPIKHLNK
560 570 580 590 600
DKKSINYIDT SKINEKLNQF RLDGGKNSAN TNNSSGGKNF RPGFTRNESN
610 620
GQQGILFEAF NFPSVAPPPP YC
Length:622
Mass (Da):70,083
Last modified:April 26, 2005 - v1
Checksum:i55B1C4DAD0E87C28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000230 Genomic DNA. Translation: EAK91634.1.
AACQ01000229 Genomic DNA. Translation: EAK91643.1.
RefSeqiXP_710877.1. XM_705785.1.
XP_710886.1. XM_705794.1.

Genome annotation databases

GeneIDi3647513.
3647517.
KEGGical:CaO19.1826.
cal:CaO19.9385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000230 Genomic DNA. Translation: EAK91634.1.
AACQ01000229 Genomic DNA. Translation: EAK91643.1.
RefSeqiXP_710877.1. XM_705785.1.
XP_710886.1. XM_705794.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1230610. 1 interaction.
STRINGi5476.CAL0001630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3647513.
3647517.
KEGGical:CaO19.1826.
cal:CaO19.9385.

Organism-specific databases

CGDiCAL0001630. MDM34.

Phylogenomic databases

eggNOGiNOG74242.
InParanoidiQ59MC8.
KOiK17775.
OrthoDBiEOG7Z3FDQ.

Family and domain databases

HAMAPiMF_03105. Mdm34.
InterProiIPR019411. DUF2404.
IPR027536. Mdm34.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMDM34_CANAL
AccessioniPrimary (citable) accession number: Q59MC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 26, 2005
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.