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Q59MC8

- MDM34_CANAL

UniProt

Q59MC8 - MDM34_CANAL

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Protein

Mitochondrial distribution and morphology protein 34

Gene
MDM34, CaO19.1826, CaO19.9385
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10 By similarity.UniRule annotation

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: CGD

GO - Biological processi

  1. mitochondrial genome maintenance Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: CGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 34
Gene namesi
Name:MDM34
ORF Names:CaO19.1826, CaO19.9385
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001630. MDM34.

Subcellular locationi

Mitochondrion outer membrane; Multi-pass membrane protein By similarity
Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids By similarity.UniRule annotation

GO - Cellular componenti

  1. ERMES complex Source: UniProtKB-HAMAP
  2. integral component of mitochondrial outer membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Mitochondrial distribution and morphology protein 34UniRule annotationPRO_0000384333Add
BLAST

Interactioni

Subunit structurei

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34 By similarity.

Protein-protein interaction databases

BioGridi1230610. 1 interaction.
STRINGi5476.CAL0001630.

Family & Domainsi

Domaini

Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.UniRule annotation

Sequence similaritiesi

Belongs to the MDM34 family.

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG74242.
KOiK17775.
OrthoDBiEOG7Z3FDQ.

Family and domain databases

HAMAPiMF_03105. Mdm34.
InterProiIPR019411. DUF2404.
IPR027536. Mdm34.
[Graphical view]
PfamiPF10296. DUF2404. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59MC8-1 [UniParc]FASTAAdd to Basket

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MSFKVNWNSL ETEPLTNWTK ELLTSALNSG KSPNILALNI TIKDLNFGKI    50
APDFEILEIG ELDRDRFRGI FKIDYQGDFH LTLHTKVQAN PLNIYYHNSL 100
EKEVCNYSQD EFITPNFLLS NEQFAIPLDL KLSDIKINGI GIIVFSKSKG 150
LTLVFRNDPL DSIKVSSTFD TVQVLANFLQ KQIENQIRDL FRETLPTLIH 200
QLSLKYLSLD NNINEIKSKL SQQDSVSMTN NELASSLKLF DDEENEFPLI 250
YSSKNLQKNM QLFKSRETFR LSAPKFKNIV QRTRLDKFTK SYPNLLNSLY 300
ANNADLQHRF VNNINHGHNN NSNTSSNGIP IELLVSHDDK QHYDKTDDLL 350
KDISSIQANN FYKYSNKDAP NKPKRRRIKV HKKSKAKQDD NTVKASELQN 400
VDSTFMESRS ISPQETIDTT STLIESAPIT RNVSTNIKSP TLETMSTGSS 450
SSASSQVIAH PTPKRAHQPA DTTVSTTTIN KENHIDYIKA RNLYQDFIQM 500
SQSPGYYDKV ISNGGGIGLG NSGGNYFGFN GNGNGLERTM SASPIKHLNK 550
DKKSINYIDT SKINEKLNQF RLDGGKNSAN TNNSSGGKNF RPGFTRNESN 600
GQQGILFEAF NFPSVAPPPP YC 622
Length:622
Mass (Da):70,083
Last modified:April 26, 2005 - v1
Checksum:i55B1C4DAD0E87C28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000230 Genomic DNA. Translation: EAK91634.1.
AACQ01000229 Genomic DNA. Translation: EAK91643.1.
RefSeqiXP_710877.1. XM_705785.1.
XP_710886.1. XM_705794.1.

Genome annotation databases

GeneIDi3647513.
3647517.
KEGGical:CaO19.1826.
cal:CaO19.9385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000230 Genomic DNA. Translation: EAK91634.1 .
AACQ01000229 Genomic DNA. Translation: EAK91643.1 .
RefSeqi XP_710877.1. XM_705785.1.
XP_710886.1. XM_705794.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1230610. 1 interaction.
STRINGi 5476.CAL0001630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647513.
3647517.
KEGGi cal:CaO19.1826.
cal:CaO19.9385.

Organism-specific databases

CGDi CAL0001630. MDM34.

Phylogenomic databases

eggNOGi NOG74242.
KOi K17775.
OrthoDBi EOG7Z3FDQ.

Family and domain databases

HAMAPi MF_03105. Mdm34.
InterProi IPR019411. DUF2404.
IPR027536. Mdm34.
[Graphical view ]
Pfami PF10296. DUF2404. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMDM34_CANAL
AccessioniPrimary (citable) accession number: Q59MC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi