Reviewed, UniProtKB/Swiss-Prot Q59M70 (MCR1_CANAL)

Names and origin

Protein names

Recommended name:
    NADH-cytochrome b5 reductase 2
    EC=1.6.2.2
Alternative name(s):
    Mitochondrial cytochrome b reductase

Gene names

Name:	MCR1
ORF Names:	CaO19.3507, CaO19.11001

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May mediate the reduction of outer membrane cytochrome b5 By similarity.
Catalytic activity	NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.
Cofactor	FAD By similarity.
Subcellular location	Mitochondrion outer membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Contains 1 FAD-binding FR-type domain.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane
Ligand	FAD Flavoprotein NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytochrome-b5 reductase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	NADH-cytochrome b5 reductase 2		PRO_0000330176
Regions
	Transmembrane	14 – 30	17	Potential
	Domain	51 – 155	105	FAD-binding FR-type
	Nucleotide binding	158 – 193	36	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59M70-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 7F16134D770DBDFB	FASTA	301	33,460
	10 20 30 40 50 60 MLTHHLSKLA TPKFLVPFAG ATALSIGLAL QYSTSNNYIA NETGKTFTDS NEWVDLKLSK 70 80 90 100 110 120 SIDLTHNTKH LVFKLKDEND VSGLITASCL LTKFVTPKGN NVIRPYTPVS DVNQSGEIDF 130 140 150 160 170 180 VIKKYDGGKM SSHIFDLKEG ETLSFKGPIV KWKWEPNQFK SIALIGGGTG ITPLYQLLHQ 190 200 210 220 230 240 ITSNPKDNTK VNLIYGNLTP EDILLKKEID AIASKHKDQV KVHYFVDKAD EKKWEGQIGF 250 260 270 280 290 300 ITKEFLQKEL EKPGSDFKVF VCGPPGLYKA ISGPKVSPTD QGELTGALKD LGFEKEHVFK F

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000234 Genomic DNA. Translation: EAK91585.1. AACQ01000233 Genomic DNA. Translation: EAK91601.1.
RefSeq	XP_710831.1. XP_710845.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3647561. 3647575.
KEGG	cal:CaO19.11001. cal:CaO19.3507.
Organism-specific databases
CGD	CAL0005780. MCR1.
Phylogenomic databases
OMA	Q59M70. YANVSPD.
Family and domain databases
InterPro	IPR017927. Fd_Rdtase_FAD-bd. IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase. IPR001834. NADH-Cyt_B5_reductase. IPR008333. OxRdtase_FAD-bd. IPR001433. OxRdtase_FAD/NAD_bd. [Graphical view]
Pfam	PF00970. FAD_binding_6. 1 hit. PF00175. NAD_binding_1. 1 hit. [Graphical view]
PRINTS	PR00406. CYTB5RDTASE. PR00371. FPNCR.
PROSITE	PS51384. FAD_FR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MCR1_CANAL

Accession

Primary (citable) accession number: Q59M70

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 26, 2005
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)