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Q59LR2

- ATR_CANAL

UniProt

Q59LR2 - ATR_CANAL

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Protein

Serine/threonine-protein kinase MEC1

Gene

MEC1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to drug Source: CGD
  2. chromosome organization Source: CGD
  3. DNA repair Source: UniProtKB-KW
  4. histone H4 acetylation Source: CGD
  5. meiotic nuclear division Source: UniProtKB-KW
  6. positive regulation of transcription from RNA polymerase II promoter Source: CGD
  7. rRNA transcription Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, Meiosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase MEC1 (EC:2.7.11.1)
Alternative name(s):
ATR homolog
DNA-damage checkpoint kinase MEC1
Mitosis entry checkpoint protein 1
Gene namesi
Name:MEC1
ORF Names:CaO19.1283, CaO19.8870
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003061. MEC1.

Subcellular locationi

Nucleus By similarity
Note: Localizes to nuclear DNA repair foci in response to DNA double strand breaks.By similarity

GO - Cellular componenti

  1. NuA4 histone acetyltransferase complex Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23252325Serine/threonine-protein kinase MEC1PRO_0000227709Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003061.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1363 – 1886524FATPROSITE-ProRule annotationAdd
BLAST
Domaini2019 – 2325307PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2293 – 232533FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5032.
InParanoidiQ59LR2.
KOiK02543.
OrthoDBiEOG7ZWD92.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR012993. UME.
[Graphical view]
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08064. UME. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
SM00802. UME. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59LR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSNQSISTT ELLQFLTDIE TNIDDHETDF RKLLLYLLRF TNEKLIVIAQ
60 70 80 90 100
EENKTPTELQ LLSKLIDTIE LVLSKKTPLL STLLTIEDVN IIHTTGSGSL
110 120 130 140 150
VYEVPLHEWC ISFALSHIPN FVSHTAGLNQ LKRLVFLIVN LVSTQLHSFK
160 170 180 190 200
VIKSTRIHLL KTLDDNLNFC LQNLLSANTF LFKSKLTTAV NLFSIVHDYD
210 220 230 240 250
ISQKLSLNLN NYQLKFESCS RKIWFILNEI SLVSELDNLN LLDCLKSVFI
260 270 280 290 300
LDQSSALVLN VSVGWNQIGF LLSCIVEYLQ QDFRTLDSNT NNFEFVNLNR
310 320 330 340 350
SISLSLLNVY IVCFDKDLLE NFMSFSNIKG ILSKLIYDDS IPSVIRKTLN
360 370 380 390 400
IVQYTYQLMS NPDGDDIKLY STSVYNDYVW TPFVDSELES LRARLLDLQG
410 420 430 440 450
NHEDSRKEEL LSFSIDETHK LAKSTNSLNY TDEKAWIRTV KKLIGIDKNV
460 470 480 490 500
LEDETTLYTL VTALSHYPCI LKGDYDYTIN ECTKCGFGPL TKNNYSSIDP
510 520 530 540 550
NRFPLNYSTE ATTLQDIIQQ FLIPKLETQQ DPLLCCNTLL LIFNFYASFS
560 570 580 590 600
PMADMQDHNI LDFLLRLLAT NDNRDVRMLV ARILPLYLIQ SKDDKLLDET
610 620 630 640 650
FKYIFQKVTS IDFSSQHRLH FGESTIRAVV ELATVSTGER LCAIYFKLVD
660 670 680 690 700
WLGEQNEQHS NYVYCGILNL ASAKSLPPHK LLSPYLPSVA EIIIKKPQVF
710 720 730 740 750
ERIIKVSMVT KNYFLNRTKE YTVPRILEYY KDPTLLTQIA NAAGLEVGKL
760 770 780 790 800
LANCLPRILA TYLTKESVNE RYIMKVLSSV CPDYKMIHTE ELFTRIGDIT
810 820 830 840 850
WYILLEIQMD EFGNIRNLAN ITRALECVCK NVSLRKNGSE LTKNNSINDL
860 870 880 890 900
IEDQVLLLVQ KFSDVTHSSR GAKPYLELKN SFYAIEFLIK GHIDAITSAL
910 920 930 940 950
GQLSTCLQAT LEEPNFHVLS LRCWNELIKK VPPSHLISLI DIIISIILQK
960 970 980 990 1000
FESFGSEAKS IAIEILRKIY EEIKDKYNRY SLYFLSLPFL SYMEEYQMVK
1010 1020 1030 1040 1050
EFRNMKSPSR AMIFSEFTRR LQTSNMYVVK HALFDLSNYF EKYQINCQKD
1060 1070 1080 1090 1100
LFKDPGLTPA ITSLVRTILD TAAKFKNKDT TVSTACAKAL AIIGALDSNK
1110 1120 1130 1140 1150
FQFKTVKSLI IISSDFEDIE ENSTFLVDLI ENHLLKIFWA SNDPHKQLFA
1160 1170 1180 1190 1200
AYVMQSFLAV MGLDERVLNT KDNRVWNKFT DVAKSTLTPF LKSKYAAPKP
1210 1220 1230 1240 1250
KLDNLKFPFF KLGMKYETWL VDVTLFLLKR ASIDNGKGNQ KAKTRKLIFQ
1260 1270 1280 1290 1300
SYAVLIQREH DIPLCEHLLR YVALSHVINE GVPEDLHKEF LHILKMDSKS
1310 1320 1330 1340 1350
TSPDRAEQLK LCYQAIFSVL DYFNQWVSNM RVVTSNSGSE LTSSDIRHKM
1360 1370 1380 1390 1400
DAVAKFSSFP QDLLTTRSAE CDAYERTIMY LENCYRDSQS EKSFKLSNLN
1410 1420 1430 1440 1450
GAATLQDMYA HIDDYDALNG TLKMFSTNNL NEKLTTFQYS DSWSLAHESF
1460 1470 1480 1490 1500
EALGSTKNSV SNNTKLLQSL NEHGLYNEVL STLSARTDSN DLKSIPLDWS
1510 1520 1530 1540 1550
LMGLHAAVYK GDSKQLEKWL QVTNSIGKPH DMETMINYEL AKALSFLFQS
1560 1570 1580 1590 1600
RIDMFKGSMD KLYNIIGCSL VPSVSSNFTR NITLMNQLHA IYDVSLIVLS
1610 1620 1630 1640 1650
QDSEDTLDLR IGNVDQDFDT QRNILTLHNV ANTVMKNPAM ISKNLLRESS
1660 1670 1680 1690 1700
LARKYNRLDI STRSIVQAMS LEDDQANIEF AELQWAQGKQ SEAIKCLFDI
1710 1720 1730 1740 1750
LKDNKFHDDK SKAKVQLQYA NWLDESNHLS AHQIITEYNK AFHLNMVDEK
1760 1770 1780 1790 1800
CNFDIGKYYN KLMESSNDES GEYEHLTVRN YIRAVSVGTT YIFEALPKVL
1810 1820 1830 1840 1850
TIWLDFADKS NKSNAAENRL KQIIDDLYNA IANVPNYSWY TVLTQILSRI
1860 1870 1880 1890 1900
VHEHEPSFKV LKRIVQNVTL EYPKHCVWYI FSHARSSDKV RKRRVRELLN
1910 1920 1930 1940 1950
QVCTQDGNDT LPKSTMAAGN LFAKLIKIAE LKIPKTNRKR QMSLLQDFEV
1960 1970 1980 1990 2000
DLSEPIDDLV IPIQSNLQIQ IPSHLNSKHK GFSRSSSISF DGFDDNVNIF
2010 2020 2030 2040 2050
FSLQMPRQLT VRGSDGNAYR LMVKSDDTRK DAKVVEFTTM VNRILSTSTE
2060 2070 2080 2090 2100
ARKRGLQIAN YSVVPLSDHF GIIEFVMNVQ TMKGVISEQR KRQGIPINER
2110 2120 2130 2140 2150
KVFMHIDSLQ KAKKKDSKQL DKLVAGFRAI MDRCPPVLHT WFVEQFSDPS
2160 2170 2180 2190 2200
AWYMARNAFT RSSAVMSMVG YIMGLGDRHC ENILIFKNTG AVLHIDFDCL
2210 2220 2230 2240 2250
FEKGTTLPTP EIVPFRLTQN MVDAMGITGV DGIYRITCEV TGTLLRENEQ
2260 2270 2280 2290 2300
ILMNILETLI YDPLIDWRNH NPREDLSKVR KKIRGLINED EGLPMNIHGQ
2310 2320
VDVLIQEATS LERLSQMYAG WAAYM
Length:2,325
Mass (Da):266,517
Last modified:April 26, 2005 - v1
Checksum:iB82E8A4C049EA6B5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti803 – 8031I → V in allele CaO19.8870.
Natural varianti915 – 9151N → D in allele CaO19.8870.
Natural varianti995 – 9951E → D in allele CaO19.8870.
Natural varianti1108 – 11081S → Q in allele CaO19.8870.
Natural varianti1170 – 11701T → I in allele CaO19.8870.
Natural varianti1252 – 12521Y → C in allele CaO19.8870.
Natural varianti1523 – 15231T → I in allele CaO19.8870.
Natural varianti1601 – 16011Q → K in allele CaO19.8870.
Natural varianti1899 – 18991L → F in allele CaO19.8870.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000249 Genomic DNA. Translation: EAK91416.1.
AACQ01000250 Genomic DNA. Translation: EAK91407.1.
RefSeqiXP_710655.1. XM_705563.1.
XP_710664.1. XM_705572.1.

Genome annotation databases

GeneIDi3647733.
3647742.
KEGGical:CaO19.1283.
cal:CaO19.8870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000249 Genomic DNA. Translation: EAK91416.1 .
AACQ01000250 Genomic DNA. Translation: EAK91407.1 .
RefSeqi XP_710655.1. XM_705563.1.
XP_710664.1. XM_705572.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647733.
3647742.
KEGGi cal:CaO19.1283.
cal:CaO19.8870.

Organism-specific databases

CGDi CAL0003061. MEC1.

Phylogenomic databases

eggNOGi COG5032.
InParanoidi Q59LR2.
KOi K02543.
OrthoDBi EOG7ZWD92.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR012993. UME.
[Graphical view ]
Pfami PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08064. UME. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
SM00802. UME. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiATR_CANAL
AccessioniPrimary (citable) accession number: Q59LR2
Secondary accession number(s): Q59LQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3