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Q59LR2 (ATR_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase MEC1

EC=2.7.11.1
Alternative name(s):
ATR homolog
DNA-damage checkpoint kinase MEC1
Mitosis entry checkpoint protein 1
Gene names
Name:MEC1
ORF Names:CaO19.1283, CaO19.8870
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length2325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Nucleus By similarity. Note: Localizes to nuclear DNA repair foci in response to DNA double strand breaks By similarity.

Sequence similarities

Belongs to the PI3/PI4-kinase family. ATM subfamily.

Contains 1 FAT domain.

Contains 1 FATC domain.

Contains 1 PI3K/PI4K domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23252325Serine/threonine-protein kinase MEC1
PRO_0000227709

Regions

Domain1363 – 1886524FAT
Domain2019 – 2325307PI3K/PI4K
Domain2293 – 232533FATC

Natural variations

Natural variant8031I → V in allele CaO19.8870.
Natural variant9151N → D in allele CaO19.8870.
Natural variant9951E → D in allele CaO19.8870.
Natural variant11081S → Q in allele CaO19.8870.
Natural variant11701T → I in allele CaO19.8870.
Natural variant12521Y → C in allele CaO19.8870.
Natural variant15231T → I in allele CaO19.8870.
Natural variant16011Q → K in allele CaO19.8870.
Natural variant18991L → F in allele CaO19.8870.

Sequences

Sequence LengthMass (Da)Tools
Q59LR2 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: B82E8A4C049EA6B5

FASTA2,325266,517
        10         20         30         40         50         60 
MTSNQSISTT ELLQFLTDIE TNIDDHETDF RKLLLYLLRF TNEKLIVIAQ EENKTPTELQ 

        70         80         90        100        110        120 
LLSKLIDTIE LVLSKKTPLL STLLTIEDVN IIHTTGSGSL VYEVPLHEWC ISFALSHIPN 

       130        140        150        160        170        180 
FVSHTAGLNQ LKRLVFLIVN LVSTQLHSFK VIKSTRIHLL KTLDDNLNFC LQNLLSANTF 

       190        200        210        220        230        240 
LFKSKLTTAV NLFSIVHDYD ISQKLSLNLN NYQLKFESCS RKIWFILNEI SLVSELDNLN 

       250        260        270        280        290        300 
LLDCLKSVFI LDQSSALVLN VSVGWNQIGF LLSCIVEYLQ QDFRTLDSNT NNFEFVNLNR 

       310        320        330        340        350        360 
SISLSLLNVY IVCFDKDLLE NFMSFSNIKG ILSKLIYDDS IPSVIRKTLN IVQYTYQLMS 

       370        380        390        400        410        420 
NPDGDDIKLY STSVYNDYVW TPFVDSELES LRARLLDLQG NHEDSRKEEL LSFSIDETHK 

       430        440        450        460        470        480 
LAKSTNSLNY TDEKAWIRTV KKLIGIDKNV LEDETTLYTL VTALSHYPCI LKGDYDYTIN 

       490        500        510        520        530        540 
ECTKCGFGPL TKNNYSSIDP NRFPLNYSTE ATTLQDIIQQ FLIPKLETQQ DPLLCCNTLL 

       550        560        570        580        590        600 
LIFNFYASFS PMADMQDHNI LDFLLRLLAT NDNRDVRMLV ARILPLYLIQ SKDDKLLDET 

       610        620        630        640        650        660 
FKYIFQKVTS IDFSSQHRLH FGESTIRAVV ELATVSTGER LCAIYFKLVD WLGEQNEQHS 

       670        680        690        700        710        720 
NYVYCGILNL ASAKSLPPHK LLSPYLPSVA EIIIKKPQVF ERIIKVSMVT KNYFLNRTKE 

       730        740        750        760        770        780 
YTVPRILEYY KDPTLLTQIA NAAGLEVGKL LANCLPRILA TYLTKESVNE RYIMKVLSSV 

       790        800        810        820        830        840 
CPDYKMIHTE ELFTRIGDIT WYILLEIQMD EFGNIRNLAN ITRALECVCK NVSLRKNGSE 

       850        860        870        880        890        900 
LTKNNSINDL IEDQVLLLVQ KFSDVTHSSR GAKPYLELKN SFYAIEFLIK GHIDAITSAL 

       910        920        930        940        950        960 
GQLSTCLQAT LEEPNFHVLS LRCWNELIKK VPPSHLISLI DIIISIILQK FESFGSEAKS 

       970        980        990       1000       1010       1020 
IAIEILRKIY EEIKDKYNRY SLYFLSLPFL SYMEEYQMVK EFRNMKSPSR AMIFSEFTRR 

      1030       1040       1050       1060       1070       1080 
LQTSNMYVVK HALFDLSNYF EKYQINCQKD LFKDPGLTPA ITSLVRTILD TAAKFKNKDT 

      1090       1100       1110       1120       1130       1140 
TVSTACAKAL AIIGALDSNK FQFKTVKSLI IISSDFEDIE ENSTFLVDLI ENHLLKIFWA 

      1150       1160       1170       1180       1190       1200 
SNDPHKQLFA AYVMQSFLAV MGLDERVLNT KDNRVWNKFT DVAKSTLTPF LKSKYAAPKP 

      1210       1220       1230       1240       1250       1260 
KLDNLKFPFF KLGMKYETWL VDVTLFLLKR ASIDNGKGNQ KAKTRKLIFQ SYAVLIQREH 

      1270       1280       1290       1300       1310       1320 
DIPLCEHLLR YVALSHVINE GVPEDLHKEF LHILKMDSKS TSPDRAEQLK LCYQAIFSVL 

      1330       1340       1350       1360       1370       1380 
DYFNQWVSNM RVVTSNSGSE LTSSDIRHKM DAVAKFSSFP QDLLTTRSAE CDAYERTIMY 

      1390       1400       1410       1420       1430       1440 
LENCYRDSQS EKSFKLSNLN GAATLQDMYA HIDDYDALNG TLKMFSTNNL NEKLTTFQYS 

      1450       1460       1470       1480       1490       1500 
DSWSLAHESF EALGSTKNSV SNNTKLLQSL NEHGLYNEVL STLSARTDSN DLKSIPLDWS 

      1510       1520       1530       1540       1550       1560 
LMGLHAAVYK GDSKQLEKWL QVTNSIGKPH DMETMINYEL AKALSFLFQS RIDMFKGSMD 

      1570       1580       1590       1600       1610       1620 
KLYNIIGCSL VPSVSSNFTR NITLMNQLHA IYDVSLIVLS QDSEDTLDLR IGNVDQDFDT 

      1630       1640       1650       1660       1670       1680 
QRNILTLHNV ANTVMKNPAM ISKNLLRESS LARKYNRLDI STRSIVQAMS LEDDQANIEF 

      1690       1700       1710       1720       1730       1740 
AELQWAQGKQ SEAIKCLFDI LKDNKFHDDK SKAKVQLQYA NWLDESNHLS AHQIITEYNK 

      1750       1760       1770       1780       1790       1800 
AFHLNMVDEK CNFDIGKYYN KLMESSNDES GEYEHLTVRN YIRAVSVGTT YIFEALPKVL 

      1810       1820       1830       1840       1850       1860 
TIWLDFADKS NKSNAAENRL KQIIDDLYNA IANVPNYSWY TVLTQILSRI VHEHEPSFKV 

      1870       1880       1890       1900       1910       1920 
LKRIVQNVTL EYPKHCVWYI FSHARSSDKV RKRRVRELLN QVCTQDGNDT LPKSTMAAGN 

      1930       1940       1950       1960       1970       1980 
LFAKLIKIAE LKIPKTNRKR QMSLLQDFEV DLSEPIDDLV IPIQSNLQIQ IPSHLNSKHK 

      1990       2000       2010       2020       2030       2040 
GFSRSSSISF DGFDDNVNIF FSLQMPRQLT VRGSDGNAYR LMVKSDDTRK DAKVVEFTTM 

      2050       2060       2070       2080       2090       2100 
VNRILSTSTE ARKRGLQIAN YSVVPLSDHF GIIEFVMNVQ TMKGVISEQR KRQGIPINER 

      2110       2120       2130       2140       2150       2160 
KVFMHIDSLQ KAKKKDSKQL DKLVAGFRAI MDRCPPVLHT WFVEQFSDPS AWYMARNAFT 

      2170       2180       2190       2200       2210       2220 
RSSAVMSMVG YIMGLGDRHC ENILIFKNTG AVLHIDFDCL FEKGTTLPTP EIVPFRLTQN 

      2230       2240       2250       2260       2270       2280 
MVDAMGITGV DGIYRITCEV TGTLLRENEQ ILMNILETLI YDPLIDWRNH NPREDLSKVR 

      2290       2300       2310       2320 
KKIRGLINED EGLPMNIHGQ VDVLIQEATS LERLSQMYAG WAAYM 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000249 Genomic DNA. Translation: EAK91416.1.
AACQ01000250 Genomic DNA. Translation: EAK91407.1.
RefSeqXP_710655.1. XM_705563.1.
XP_710664.1. XM_705572.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003061.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647733.
3647742.
KEGGcal:CaO19.1283.
cal:CaO19.8870.

Organism-specific databases

CGDCAL0003061. MEC1.

Phylogenomic databases

eggNOGCOG5032.
KOK02543.
OrthoDBEOG7ZWD92.

Family and domain databases

Gene3D1.10.1070.11. 2 hits.
InterProIPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR012993. UME.
[Graphical view]
PfamPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08064. UME. 1 hit.
[Graphical view]
SMARTSM00146. PI3Kc. 1 hit.
SM00802. UME. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATR_CANAL
AccessionPrimary (citable) accession number: Q59LR2
Secondary accession number(s): Q59LQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names