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Q59LR2

- ATR_CANAL

UniProt

Q59LR2 - ATR_CANAL

Protein

Serine/threonine-protein kinase MEC1

Gene

MEC1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to drug Source: CGD
    2. chromosome organization Source: CGD
    3. DNA repair Source: UniProtKB-KW
    4. histone H4 acetylation Source: CGD
    5. meiotic nuclear division Source: UniProtKB-KW
    6. positive regulation of transcription from RNA polymerase II promoter Source: CGD
    7. rRNA transcription Source: CGD

    Keywords - Molecular functioni

    Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair, Meiosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase MEC1 (EC:2.7.11.1)
    Alternative name(s):
    ATR homolog
    DNA-damage checkpoint kinase MEC1
    Mitosis entry checkpoint protein 1
    Gene namesi
    Name:MEC1
    ORF Names:CaO19.1283, CaO19.8870
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003061. MEC1.

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes to nuclear DNA repair foci in response to DNA double strand breaks.By similarity

    GO - Cellular componenti

    1. NuA4 histone acetyltransferase complex Source: CGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23252325Serine/threonine-protein kinase MEC1PRO_0000227709Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0003061.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1363 – 1886524FATPROSITE-ProRule annotationAdd
    BLAST
    Domaini2019 – 2325307PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST
    Domaini2293 – 232533FATCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated
    Contains 1 FAT domain.PROSITE-ProRule annotation
    Contains 1 FATC domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    KOiK02543.
    OrthoDBiEOG7ZWD92.

    Family and domain databases

    Gene3Di1.10.1070.11. 2 hits.
    InterProiIPR016024. ARM-type_fold.
    IPR003152. FATC.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003151. PIK-rel_kinase_FAT.
    IPR014009. PIK_FAT.
    IPR012993. UME.
    [Graphical view]
    PfamiPF02259. FAT. 1 hit.
    PF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF08064. UME. 1 hit.
    [Graphical view]
    SMARTiSM00146. PI3Kc. 1 hit.
    SM00802. UME. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 6 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59LR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSNQSISTT ELLQFLTDIE TNIDDHETDF RKLLLYLLRF TNEKLIVIAQ     50
    EENKTPTELQ LLSKLIDTIE LVLSKKTPLL STLLTIEDVN IIHTTGSGSL 100
    VYEVPLHEWC ISFALSHIPN FVSHTAGLNQ LKRLVFLIVN LVSTQLHSFK 150
    VIKSTRIHLL KTLDDNLNFC LQNLLSANTF LFKSKLTTAV NLFSIVHDYD 200
    ISQKLSLNLN NYQLKFESCS RKIWFILNEI SLVSELDNLN LLDCLKSVFI 250
    LDQSSALVLN VSVGWNQIGF LLSCIVEYLQ QDFRTLDSNT NNFEFVNLNR 300
    SISLSLLNVY IVCFDKDLLE NFMSFSNIKG ILSKLIYDDS IPSVIRKTLN 350
    IVQYTYQLMS NPDGDDIKLY STSVYNDYVW TPFVDSELES LRARLLDLQG 400
    NHEDSRKEEL LSFSIDETHK LAKSTNSLNY TDEKAWIRTV KKLIGIDKNV 450
    LEDETTLYTL VTALSHYPCI LKGDYDYTIN ECTKCGFGPL TKNNYSSIDP 500
    NRFPLNYSTE ATTLQDIIQQ FLIPKLETQQ DPLLCCNTLL LIFNFYASFS 550
    PMADMQDHNI LDFLLRLLAT NDNRDVRMLV ARILPLYLIQ SKDDKLLDET 600
    FKYIFQKVTS IDFSSQHRLH FGESTIRAVV ELATVSTGER LCAIYFKLVD 650
    WLGEQNEQHS NYVYCGILNL ASAKSLPPHK LLSPYLPSVA EIIIKKPQVF 700
    ERIIKVSMVT KNYFLNRTKE YTVPRILEYY KDPTLLTQIA NAAGLEVGKL 750
    LANCLPRILA TYLTKESVNE RYIMKVLSSV CPDYKMIHTE ELFTRIGDIT 800
    WYILLEIQMD EFGNIRNLAN ITRALECVCK NVSLRKNGSE LTKNNSINDL 850
    IEDQVLLLVQ KFSDVTHSSR GAKPYLELKN SFYAIEFLIK GHIDAITSAL 900
    GQLSTCLQAT LEEPNFHVLS LRCWNELIKK VPPSHLISLI DIIISIILQK 950
    FESFGSEAKS IAIEILRKIY EEIKDKYNRY SLYFLSLPFL SYMEEYQMVK 1000
    EFRNMKSPSR AMIFSEFTRR LQTSNMYVVK HALFDLSNYF EKYQINCQKD 1050
    LFKDPGLTPA ITSLVRTILD TAAKFKNKDT TVSTACAKAL AIIGALDSNK 1100
    FQFKTVKSLI IISSDFEDIE ENSTFLVDLI ENHLLKIFWA SNDPHKQLFA 1150
    AYVMQSFLAV MGLDERVLNT KDNRVWNKFT DVAKSTLTPF LKSKYAAPKP 1200
    KLDNLKFPFF KLGMKYETWL VDVTLFLLKR ASIDNGKGNQ KAKTRKLIFQ 1250
    SYAVLIQREH DIPLCEHLLR YVALSHVINE GVPEDLHKEF LHILKMDSKS 1300
    TSPDRAEQLK LCYQAIFSVL DYFNQWVSNM RVVTSNSGSE LTSSDIRHKM 1350
    DAVAKFSSFP QDLLTTRSAE CDAYERTIMY LENCYRDSQS EKSFKLSNLN 1400
    GAATLQDMYA HIDDYDALNG TLKMFSTNNL NEKLTTFQYS DSWSLAHESF 1450
    EALGSTKNSV SNNTKLLQSL NEHGLYNEVL STLSARTDSN DLKSIPLDWS 1500
    LMGLHAAVYK GDSKQLEKWL QVTNSIGKPH DMETMINYEL AKALSFLFQS 1550
    RIDMFKGSMD KLYNIIGCSL VPSVSSNFTR NITLMNQLHA IYDVSLIVLS 1600
    QDSEDTLDLR IGNVDQDFDT QRNILTLHNV ANTVMKNPAM ISKNLLRESS 1650
    LARKYNRLDI STRSIVQAMS LEDDQANIEF AELQWAQGKQ SEAIKCLFDI 1700
    LKDNKFHDDK SKAKVQLQYA NWLDESNHLS AHQIITEYNK AFHLNMVDEK 1750
    CNFDIGKYYN KLMESSNDES GEYEHLTVRN YIRAVSVGTT YIFEALPKVL 1800
    TIWLDFADKS NKSNAAENRL KQIIDDLYNA IANVPNYSWY TVLTQILSRI 1850
    VHEHEPSFKV LKRIVQNVTL EYPKHCVWYI FSHARSSDKV RKRRVRELLN 1900
    QVCTQDGNDT LPKSTMAAGN LFAKLIKIAE LKIPKTNRKR QMSLLQDFEV 1950
    DLSEPIDDLV IPIQSNLQIQ IPSHLNSKHK GFSRSSSISF DGFDDNVNIF 2000
    FSLQMPRQLT VRGSDGNAYR LMVKSDDTRK DAKVVEFTTM VNRILSTSTE 2050
    ARKRGLQIAN YSVVPLSDHF GIIEFVMNVQ TMKGVISEQR KRQGIPINER 2100
    KVFMHIDSLQ KAKKKDSKQL DKLVAGFRAI MDRCPPVLHT WFVEQFSDPS 2150
    AWYMARNAFT RSSAVMSMVG YIMGLGDRHC ENILIFKNTG AVLHIDFDCL 2200
    FEKGTTLPTP EIVPFRLTQN MVDAMGITGV DGIYRITCEV TGTLLRENEQ 2250
    ILMNILETLI YDPLIDWRNH NPREDLSKVR KKIRGLINED EGLPMNIHGQ 2300
    VDVLIQEATS LERLSQMYAG WAAYM 2325
    Length:2,325
    Mass (Da):266,517
    Last modified:April 26, 2005 - v1
    Checksum:iB82E8A4C049EA6B5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti803 – 8031I → V in allele CaO19.8870.
    Natural varianti915 – 9151N → D in allele CaO19.8870.
    Natural varianti995 – 9951E → D in allele CaO19.8870.
    Natural varianti1108 – 11081S → Q in allele CaO19.8870.
    Natural varianti1170 – 11701T → I in allele CaO19.8870.
    Natural varianti1252 – 12521Y → C in allele CaO19.8870.
    Natural varianti1523 – 15231T → I in allele CaO19.8870.
    Natural varianti1601 – 16011Q → K in allele CaO19.8870.
    Natural varianti1899 – 18991L → F in allele CaO19.8870.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000249 Genomic DNA. Translation: EAK91416.1.
    AACQ01000250 Genomic DNA. Translation: EAK91407.1.
    RefSeqiXP_710655.1. XM_705563.1.
    XP_710664.1. XM_705572.1.

    Genome annotation databases

    GeneIDi3647733.
    3647742.
    KEGGical:CaO19.1283.
    cal:CaO19.8870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000249 Genomic DNA. Translation: EAK91416.1 .
    AACQ01000250 Genomic DNA. Translation: EAK91407.1 .
    RefSeqi XP_710655.1. XM_705563.1.
    XP_710664.1. XM_705572.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003061.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647733.
    3647742.
    KEGGi cal:CaO19.1283.
    cal:CaO19.8870.

    Organism-specific databases

    CGDi CAL0003061. MEC1.

    Phylogenomic databases

    eggNOGi COG5032.
    KOi K02543.
    OrthoDBi EOG7ZWD92.

    Family and domain databases

    Gene3Di 1.10.1070.11. 2 hits.
    InterProi IPR016024. ARM-type_fold.
    IPR003152. FATC.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003151. PIK-rel_kinase_FAT.
    IPR014009. PIK_FAT.
    IPR012993. UME.
    [Graphical view ]
    Pfami PF02259. FAT. 1 hit.
    PF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF08064. UME. 1 hit.
    [Graphical view ]
    SMARTi SM00146. PI3Kc. 1 hit.
    SM00802. UME. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 6 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiATR_CANAL
    AccessioniPrimary (citable) accession number: Q59LR2
    Secondary accession number(s): Q59LQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3