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Q59LR2

- ATR_CANAL

UniProt

Q59LR2 - ATR_CANAL

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Protein

Serine/threonine-protein kinase MEC1

Gene
MEC1, CaO19.1283, CaO19.8870
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to drug Source: CGD
  2. chromosome organization Source: CGD
  3. DNA repair Source: UniProtKB-KW
  4. histone H4 acetylation Source: CGD
  5. meiotic nuclear division Source: UniProtKB-KW
  6. positive regulation of transcription from RNA polymerase II promoter Source: CGD
  7. rRNA transcription Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, Meiosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase MEC1 (EC:2.7.11.1)
Alternative name(s):
ATR homolog
DNA-damage checkpoint kinase MEC1
Mitosis entry checkpoint protein 1
Gene namesi
Name:MEC1
ORF Names:CaO19.1283, CaO19.8870
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003061. MEC1.

Subcellular locationi

Nucleus By similarity
Note: Localizes to nuclear DNA repair foci in response to DNA double strand breaks By similarity.

GO - Cellular componenti

  1. NuA4 histone acetyltransferase complex Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23252325Serine/threonine-protein kinase MEC1PRO_0000227709Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003061.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1363 – 1886524FATAdd
BLAST
Domaini2019 – 2325307PI3K/PI4KAdd
BLAST
Domaini2293 – 232533FATCAdd
BLAST

Sequence similaritiesi

Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 1 PI3K/PI4K domain.

Phylogenomic databases

eggNOGiCOG5032.
KOiK02543.
OrthoDBiEOG7ZWD92.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR012993. UME.
[Graphical view]
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08064. UME. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
SM00802. UME. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59LR2-1 [UniParc]FASTAAdd to Basket

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MTSNQSISTT ELLQFLTDIE TNIDDHETDF RKLLLYLLRF TNEKLIVIAQ     50
EENKTPTELQ LLSKLIDTIE LVLSKKTPLL STLLTIEDVN IIHTTGSGSL 100
VYEVPLHEWC ISFALSHIPN FVSHTAGLNQ LKRLVFLIVN LVSTQLHSFK 150
VIKSTRIHLL KTLDDNLNFC LQNLLSANTF LFKSKLTTAV NLFSIVHDYD 200
ISQKLSLNLN NYQLKFESCS RKIWFILNEI SLVSELDNLN LLDCLKSVFI 250
LDQSSALVLN VSVGWNQIGF LLSCIVEYLQ QDFRTLDSNT NNFEFVNLNR 300
SISLSLLNVY IVCFDKDLLE NFMSFSNIKG ILSKLIYDDS IPSVIRKTLN 350
IVQYTYQLMS NPDGDDIKLY STSVYNDYVW TPFVDSELES LRARLLDLQG 400
NHEDSRKEEL LSFSIDETHK LAKSTNSLNY TDEKAWIRTV KKLIGIDKNV 450
LEDETTLYTL VTALSHYPCI LKGDYDYTIN ECTKCGFGPL TKNNYSSIDP 500
NRFPLNYSTE ATTLQDIIQQ FLIPKLETQQ DPLLCCNTLL LIFNFYASFS 550
PMADMQDHNI LDFLLRLLAT NDNRDVRMLV ARILPLYLIQ SKDDKLLDET 600
FKYIFQKVTS IDFSSQHRLH FGESTIRAVV ELATVSTGER LCAIYFKLVD 650
WLGEQNEQHS NYVYCGILNL ASAKSLPPHK LLSPYLPSVA EIIIKKPQVF 700
ERIIKVSMVT KNYFLNRTKE YTVPRILEYY KDPTLLTQIA NAAGLEVGKL 750
LANCLPRILA TYLTKESVNE RYIMKVLSSV CPDYKMIHTE ELFTRIGDIT 800
WYILLEIQMD EFGNIRNLAN ITRALECVCK NVSLRKNGSE LTKNNSINDL 850
IEDQVLLLVQ KFSDVTHSSR GAKPYLELKN SFYAIEFLIK GHIDAITSAL 900
GQLSTCLQAT LEEPNFHVLS LRCWNELIKK VPPSHLISLI DIIISIILQK 950
FESFGSEAKS IAIEILRKIY EEIKDKYNRY SLYFLSLPFL SYMEEYQMVK 1000
EFRNMKSPSR AMIFSEFTRR LQTSNMYVVK HALFDLSNYF EKYQINCQKD 1050
LFKDPGLTPA ITSLVRTILD TAAKFKNKDT TVSTACAKAL AIIGALDSNK 1100
FQFKTVKSLI IISSDFEDIE ENSTFLVDLI ENHLLKIFWA SNDPHKQLFA 1150
AYVMQSFLAV MGLDERVLNT KDNRVWNKFT DVAKSTLTPF LKSKYAAPKP 1200
KLDNLKFPFF KLGMKYETWL VDVTLFLLKR ASIDNGKGNQ KAKTRKLIFQ 1250
SYAVLIQREH DIPLCEHLLR YVALSHVINE GVPEDLHKEF LHILKMDSKS 1300
TSPDRAEQLK LCYQAIFSVL DYFNQWVSNM RVVTSNSGSE LTSSDIRHKM 1350
DAVAKFSSFP QDLLTTRSAE CDAYERTIMY LENCYRDSQS EKSFKLSNLN 1400
GAATLQDMYA HIDDYDALNG TLKMFSTNNL NEKLTTFQYS DSWSLAHESF 1450
EALGSTKNSV SNNTKLLQSL NEHGLYNEVL STLSARTDSN DLKSIPLDWS 1500
LMGLHAAVYK GDSKQLEKWL QVTNSIGKPH DMETMINYEL AKALSFLFQS 1550
RIDMFKGSMD KLYNIIGCSL VPSVSSNFTR NITLMNQLHA IYDVSLIVLS 1600
QDSEDTLDLR IGNVDQDFDT QRNILTLHNV ANTVMKNPAM ISKNLLRESS 1650
LARKYNRLDI STRSIVQAMS LEDDQANIEF AELQWAQGKQ SEAIKCLFDI 1700
LKDNKFHDDK SKAKVQLQYA NWLDESNHLS AHQIITEYNK AFHLNMVDEK 1750
CNFDIGKYYN KLMESSNDES GEYEHLTVRN YIRAVSVGTT YIFEALPKVL 1800
TIWLDFADKS NKSNAAENRL KQIIDDLYNA IANVPNYSWY TVLTQILSRI 1850
VHEHEPSFKV LKRIVQNVTL EYPKHCVWYI FSHARSSDKV RKRRVRELLN 1900
QVCTQDGNDT LPKSTMAAGN LFAKLIKIAE LKIPKTNRKR QMSLLQDFEV 1950
DLSEPIDDLV IPIQSNLQIQ IPSHLNSKHK GFSRSSSISF DGFDDNVNIF 2000
FSLQMPRQLT VRGSDGNAYR LMVKSDDTRK DAKVVEFTTM VNRILSTSTE 2050
ARKRGLQIAN YSVVPLSDHF GIIEFVMNVQ TMKGVISEQR KRQGIPINER 2100
KVFMHIDSLQ KAKKKDSKQL DKLVAGFRAI MDRCPPVLHT WFVEQFSDPS 2150
AWYMARNAFT RSSAVMSMVG YIMGLGDRHC ENILIFKNTG AVLHIDFDCL 2200
FEKGTTLPTP EIVPFRLTQN MVDAMGITGV DGIYRITCEV TGTLLRENEQ 2250
ILMNILETLI YDPLIDWRNH NPREDLSKVR KKIRGLINED EGLPMNIHGQ 2300
VDVLIQEATS LERLSQMYAG WAAYM 2325
Length:2,325
Mass (Da):266,517
Last modified:April 26, 2005 - v1
Checksum:iB82E8A4C049EA6B5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti803 – 8031I → V in allele CaO19.8870.
Natural varianti915 – 9151N → D in allele CaO19.8870.
Natural varianti995 – 9951E → D in allele CaO19.8870.
Natural varianti1108 – 11081S → Q in allele CaO19.8870.
Natural varianti1170 – 11701T → I in allele CaO19.8870.
Natural varianti1252 – 12521Y → C in allele CaO19.8870.
Natural varianti1523 – 15231T → I in allele CaO19.8870.
Natural varianti1601 – 16011Q → K in allele CaO19.8870.
Natural varianti1899 – 18991L → F in allele CaO19.8870.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000249 Genomic DNA. Translation: EAK91416.1.
AACQ01000250 Genomic DNA. Translation: EAK91407.1.
RefSeqiXP_710655.1. XM_705563.1.
XP_710664.1. XM_705572.1.

Genome annotation databases

GeneIDi3647733.
3647742.
KEGGical:CaO19.1283.
cal:CaO19.8870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000249 Genomic DNA. Translation: EAK91416.1 .
AACQ01000250 Genomic DNA. Translation: EAK91407.1 .
RefSeqi XP_710655.1. XM_705563.1.
XP_710664.1. XM_705572.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647733.
3647742.
KEGGi cal:CaO19.1283.
cal:CaO19.8870.

Organism-specific databases

CGDi CAL0003061. MEC1.

Phylogenomic databases

eggNOGi COG5032.
KOi K02543.
OrthoDBi EOG7ZWD92.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR012993. UME.
[Graphical view ]
Pfami PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08064. UME. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
SM00802. UME. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiATR_CANAL
AccessioniPrimary (citable) accession number: Q59LR2
Secondary accession number(s): Q59LQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi