Reviewed, UniProtKB/Swiss-Prot Q59LF2 (ALG2_CANAL)

Names and origin

Protein names

Recommended name:
    Alpha-1,3-mannosyltransferase ALG2
    EC=2.4.1.-
Alternative name(s):
    GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase
    Asparagine-linked glycosylation protein 2

Gene names

Name:	ALG2
ORF Names:	CaO19.1221, CaO19.8808

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Mannosylates Man2GlcNAc(2)-dolichol diphosphate and Man1GlcNAc(2)-dolichol diphosphate to form Man3GlcNAc(2)-dolichol diphosphate By similarity.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 1 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Alpha-1,3-mannosyltransferase ALG2		PRO_0000080263
Regions
	Transmembrane	80 – 100	21	Potential
Amino acid modifications
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	289	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59LF2-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 21F8239880384A72	FASTA	428	48,767
	10 20 30 40 50 60 MSKRQENKKI AFIHPDLGIG GAERLVVDAA VGLQDFGHDI IIYTSHCDLT HCFEEVSSGQ 70 80 90 100 110 120 LKVSVHGDSL PTNLFGKLHI FFAILRQFYL VCWLIFTGTI KNYDYFIVDQ LSFCIPLLKM 130 140 150 160 170 180 FCNSNCQVLF YCHFPDQLLV RRTSFLKKLY RVPFDAIEEY TTGSSDQIVV NSNFTKQIFH 190 200 210 220 230 240 DTFKKLNHID PQVVYPCVDT ETIVDTNTSS NSEVSKFFKD SPFFLSINRF ERSKNIELAI 250 260 270 280 290 300 KSFARMNKLM VTNKKPRLVI AGGYDSRVAE NVEYLAELST LCDELNLINF TIRGKLIMMP 310 320 330 340 350 360 PSVDVLFLPS ISTQLKNSLI QQTELLLYTP PREHFGIVPL EAMLAKTPVL AINFGGPLET 370 380 390 400 410 420 VVNYNGNNLD EATGYTETGD FTKWSKIIMK HYNLDESTKI KLGENGRNRV INKFSRKKLA QSLDNILN

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000257 Genomic DNA. Translation: EAK91318.1. AACQ01000256 Genomic DNA. Translation: EAK91329.1.
RefSeq	XP_710571.1. XP_710581.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3647825. 3647832.
KEGG	cal:CaO19.1221. cal:CaO19.8808.
Organism-specific databases
CGD	CAL0002829. ALG2.
Phylogenomic databases
OrthoDB	EOG9WM69S
Family and domain databases
InterPro	IPR001296. Glyco_trans_1. [Graphical view]
Pfam	PF00534. Glycos_transf_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALG2_CANAL

Accession

Primary (citable) accession number: Q59LF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	April 26, 2005
Last modified:	November 24, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)