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Protein

Mitochondrial glycine transporter

Gene

CAALFM_CR04920WA

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
Ordered Locus Names:CAALFM_CR04920WA
ORF Names:CaO19.1804
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000196262 orf19.1804

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 53Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei83 – 109Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei138 – 163Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei211 – 234Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei273 – 299Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei329 – 347Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789311 – 362Mitochondrial glycine transporterAdd BLAST362

Structurei

3D structure databases

ProteinModelPortaliQ59KC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 108Solcar 1UniRule annotationAdd BLAST87
Repeati132 – 236Solcar 2UniRule annotationAdd BLAST105
Repeati269 – 354Solcar 3UniRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ59KC4
KOiK15118
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 2 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q59KC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPPLSSPV PQVKTTQNGK SPDATVHLLA GAIAGLVSAV TLQPFDLLKT
60 70 80 90 100
RLQQQQLTTK QEVRTTLTKE LKKLTRVKDL WRGTLPSTLR TSIGAGLYFT
110 120 130 140 150
TLSKMRTSWG EYKQSKDSSI NLKSNSSILP KLTAMENLTT GFIARGIVGY
160 170 180 190 200
ITMPITIIKT RFESNLYNYN SMYEGISGIY LDDKKQQQQI RNPSINKGVG
210 220 230 240 250
GGGSWKNFFK GSVATLARDC PYAGLYVLTY EAFKNDLIPL IIPNSSLSLS
260 270 280 290 300
SSSSLSSSSS LFVFNDNNRS SIINSTAAVL AASTCTTITA PFDAIKTRLQ
310 320 330 340 350
LTNEEGGSMT TVLKKMLRED GGIKNLFRGL SLRLGRKGIS AGISWCIYEE
360
LIKSNYFQSK FL
Length:362
Mass (Da):39,667
Last modified:April 26, 2005 - v1
Checksum:i41B086AF38D5C95E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW31225.1
RefSeqiXP_710191.1, XM_705099.2

Genome annotation databases

EnsemblFungiiAOW31225; AOW31225; CAALFM_CR04920WA
GeneIDi3648207
KEGGical:CAALFM_CR04920WA

Similar proteinsi

Entry informationi

Entry nameiS2538_CANAL
AccessioniPrimary (citable) accession number: Q59KC4
Secondary accession number(s): A0A1D8PSV7, Q59KD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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