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Q59K86 (3HAO_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Biosynthesis of nicotinic acid protein 1
Gene names
Name:BNA1
ORF Names:CaO19.3515
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1711713-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361984

Sites

Metal binding491Iron; catalytic By similarity
Metal binding551Iron; catalytic By similarity
Metal binding931Iron; catalytic By similarity
Metal binding1221Divalent metal cation By similarity
Metal binding1251Divalent metal cation By similarity
Metal binding1591Divalent metal cation By similarity
Metal binding1621Divalent metal cation By similarity
Binding site451Dioxygen By similarity
Binding site551Substrate By similarity
Binding site971Substrate By similarity
Binding site1071Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59K86 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: EAADB3DA38113136

FASTA17119,545
        10         20         30         40         50         60 
MVLGQPINII KWIEENGDLL KPPVNNFCLH RGGFTIMIVG GPNERSDYHI NQTPEYFYQF 

        70         80         90        100        110        120 
KGTMCLKVVD DGEFKDIFIN EGDSFLLPPN VPHNPCRYEN TIGIVVEQDR PAGVNDKVRW 

       130        140        150        160        170 
YCQKCQTVIH EVEFYLTDLG TQIKEAIVKF DADLDARTCK NCGTVNSSRR D 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000315 Genomic DNA. Translation: EAK90890.1.
RefSeqXP_710160.1. XM_705068.1.

3D structure databases

ProteinModelPortalQ59K86.
SMRQ59K86. Positions 6-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005808.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3648245.
KEGGcal:CaO19.3515.

Organism-specific databases

CGDCAL0005808. orf19.3515.

Phylogenomic databases

eggNOGNOG77058.
KOK00452.
OrthoDBEOG7QK0Q0.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_CANAL
AccessionPrimary (citable) accession number: Q59K86
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names