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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45DioxygenUniRule annotation1
Metal bindingi49Iron; catalyticUniRule annotation1
Metal bindingi55Iron; catalyticUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Metal bindingi93Iron; catalyticUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei107SubstrateUniRule annotation1
Metal bindingi122Divalent metal cationUniRule annotation1
Metal bindingi125Divalent metal cationUniRule annotation1
Metal bindingi159Divalent metal cationUniRule annotation1
Metal bindingi162Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
Ordered Locus Names:CAALFM_CR05440WA
ORF Names:CaO19.3515
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000184857 orf19.3515
EuPathDBiFungiDB:CR_05440W_A

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003619841 – 1713-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST171

Structurei

3D structure databases

ProteinModelPortaliQ59K86
SMRiQ59K86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

InParanoidiQ59K86
KOiK00452
OMAiNARKDYH
OrthoDBiEOG092C5CUF

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00825 3_HAO, 1 hit
InterProiView protein in InterPro
IPR010329 3hydroanth_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR15497 PTHR15497, 1 hit
PfamiView protein in Pfam
PF06052 3-HAO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR03037 anthran_nbaC, 1 hit

Sequencei

Sequence statusi: Complete.

Q59K86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLGQPINII KWIEENGDLL KPPVNNFCLH RGGFTIMIVG GPNERSDYHI
60 70 80 90 100
NQTPEYFYQF KGTMCLKVVD DGEFKDIFIN EGDSFLLPPN VPHNPCRYEN
110 120 130 140 150
TIGIVVEQDR PAGVNDKVRW YCQKCQTVIH EVEFYLTDLG TQIKEAIVKF
160 170
DADLDARTCK NCGTVNSSRR D
Length:171
Mass (Da):19,545
Last modified:April 26, 2005 - v1
Checksum:iEAADB3DA38113136
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW31263.1
RefSeqiXP_710160.1, XM_705068.1

Genome annotation databases

EnsemblFungiiAOW31263; AOW31263; CAALFM_CR05440WA
GeneIDi3648245
KEGGical:CAALFM_CR05440WA

Similar proteinsi

Entry informationi

Entry namei3HAO_CANAL
AccessioniPrimary (citable) accession number: Q59K86
Secondary accession number(s): A0A1D8PSZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health