Q59HC6 (Q59HC6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: DNA cytosine methyltransferase 3 alpha isoform a variant EMBL BAD92070.1
Organism	Homo sapiens (Human) EMBL BAD92070.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	811 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Methyltransferase EMBL BAD92070.1 Transferase
Gene Ontology (GO)
Biological process	DNA methylation Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92070.1

Sequences

	Sequence		Length	Mass (Da)
	Q59HC6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: F69CFB26CCEAA4D5	FASTA	811	89,707
	10 20 30 40 50 60 LSPPKTTIIP SPKPSSPPAP RSPSLPPGAQ MPAMPSSGPG DTSSSAAERE EDRKDGEEQE 70 80 90 100 110 120 EPRGKEERQE PSTTARKVGR PGRKRKHPPV ESGDTPKDPA VISKSPSMAQ DSGASELLPN 130 140 150 160 170 180 GDLEKRSEPQ PEEGSPAGGQ KGGAPAEGEG AAETLPEASR AVENGCCTPK EGRGAPAEAG 190 200 210 220 230 240 KEQKETNIES MKMEGSRGRL RGGLGWESSL RQRPMPRLTF QAGDPYYISK RKRDEWLARW 250 260 270 280 290 300 KREAEKKAKV IAGMNAVEEN QGPGESQKVE EASPPAVQQP TDPASPTVAT TPEPVGSDAG 310 320 330 340 350 360 DKNATKAGDD EPEYEDGRGF GIGELVWGKL RGFSWWPGRI VSWWMTGRSR AAEGTRWVMW 370 380 390 400 410 420 FGDGKFSVVC VEKLMPLSSF CSAFHQATYN KQPMYRKAIY EVLQVASSRA GKLFPVCHDS 430 440 450 460 470 480 DESDTAKAVE VQNKPMIEWA LGGFQPSGPK GLEPPEEEKN PYKEVYTDMW VEPEAAAYAP 490 500 510 520 530 540 PPPAKKPRKS TAEKPKVKEI IDERTRERLV YEVRQKCRNI EDICISCGSL NVTLEHPLFV 550 560 570 580 590 600 GGMCQNCKNC FLECAYQYDD DGYQSYCTIC CGGREVLMCG NNNCCRCFCV ECVDLLVGPG 610 620 630 640 650 660 AAQAAIKEDP WNCYMCGHKG TYGLLRRRED WPSRLQMFFA NNHDQEFDPP KVYPPVPAEK 670 680 690 700 710 720 RKPIRVLSLF DGIATGLLVL KDLGIQVDRY IASEVCEDSI TVGMVRHQGK IMYVGDVRSV 730 740 750 760 770 780 TQKHIQEWGP FDLVIGGSPC NDLSIVNPAR KGLYEGTGRL FFEFYRLLHD ARPKEGDDRP 790 800 810 FFWLFENVVA MGVSDKRDIS RFLEVQNSHL Y

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92070.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB208833 mRNA. Translation: BAD92070.1.
IPI	IPI00329216.
UniGene	Hs.515840.
3D structure databases
ProteinModelPortal	Q59HC6.
SMR	Q59HC6. Positions 313-455, 505-811.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59HC6.
Protein family/group databases
REBASE	4119. M.HsaDnmt3A.
Proteomic databases
PRIDE	Q59HC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	prNOG10274.
GeneTree	ENSGT00390000008341.
HOVERGEN	HBG051381.
Gene expression databases
ArrayExpress	Q59HC6.
Bgee	Q59HC6.
Family and domain databases
InterPro	IPR018117. C5_DNA_meth_AS. IPR001525. C5_MeTfrase. IPR000313. PWWP. IPR011011. Znf_FYVE_PHD. [Graphical view]
Pfam	PF00145. DNA_methylase. 1 hit. PF00855. PWWP. 1 hit. [Graphical view]
SMART	SM00293. PWWP. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS00094. C5_MTASE_1. 1 hit. PS50812. PWWP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59HC6_HUMAN

Accession

Primary (citable) accession number: Q59HC6

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.