ID   Q59HB4_HUMAN            Unreviewed;       197 AA.
AC   Q59HB4;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Methylmalonyl Coenzyme A mutase variant {ECO:0000313|EMBL:BAD92082.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92082.1};
RN   [1] {ECO:0000313|EMBL:BAD92082.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92082.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922};
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DR   EMBL; AB208845; BAD92082.1; -; mRNA.
DR   AlphaFoldDB; Q59HB4; -.
DR   SMR; Q59HB4; -.
DR   MaxQB; Q59HB4; -.
DR   PeptideAtlas; Q59HB4; -.
DR   ProteomicsDB; 62669; -.
DR   GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006790; P:sulfur compound metabolic process; IEA:UniProt.
DR   CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   InterPro; IPR006159; Acid_CoA_mut_C.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR036724; Cobalamin-bd_sf.
DR   NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR   PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          61..193
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92082.1"
SQ   SEQUENCE   197 AA;  21587 MW;  81DBFF96AF6E785F CRC64;
     TRYLARCTVG EITDALKKVF GEHKANDRMV SGAYRQEFGE SKEITSAIKR VHKFMEREGR
     RPRLLVAKMG QDGHDRGAKV IATGFADLGF DVDIGPLFQT PREVAQQAVD ADVHAVGIST
     LAAGHKTLVP ELIKELNSLG RPDILVMCGG VIPPQDYEFL FEVGVSNVFG PGTRIPKAAV
     QVLDDIEKCL EKKQQSV
//