ID   Q59HA9_HUMAN            Unreviewed;      1136 AA.
AC   Q59HA9;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92087.1};
RN   [1] {ECO:0000313|EMBL:BAD92087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92087.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC       channel in the central nervous system and plays an important role in
CC       excitatory synaptic transmission. L-glutamate acts as an excitatory
CC       neurotransmitter at many synapses in the central nervous system.
CC       {ECO:0000256|RuleBase:RU367118}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC       Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC       ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC       {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034099}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. NR2B/GRIN2B subfamily. {ECO:0000256|ARBA:ARBA00038189}.
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DR   EMBL; AB208850; BAD92087.1; -; mRNA.
DR   AlphaFoldDB; Q59HA9; -.
DR   SMR; Q59HA9; -.
DR   PeptideAtlas; Q59HA9; -.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004970; F:glutamate-gated receptor activity; IEA:UniProt.
DR   GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_Glu_rcpt_met.
DR   InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   InterPro; IPR018884; NMDAR2_C.
DR   InterPro; IPR001638; Solute-binding_3/MltF_N.
DR   PANTHER; PTHR18966:SF382; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B; 1.
DR   PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   Pfam; PF10565; NMDAR2_C; 1.
DR   Pfam; PF00497; SBP_bac_3; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU367118};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU367118};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW   ECO:0000256|RuleBase:RU367118}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW   ECO:0000256|RuleBase:RU367118};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT   DOMAIN          83..451
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00079"
FT   DOMAIN          92..155
FT                   /note="Ionotropic glutamate receptor L-glutamate and
FT                   glycine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00918"
FT   REGION          726..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          813..846
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          923..953
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        731..749
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        923..943
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92087.1"
SQ   SEQUENCE   1136 AA;  127509 MW;  0FADF7E257B2FEB9 CRC64;
     LSFSEDGYQM HPKLVIILLN KERKWERVGK WKDKSLQMKY YVWPRMCPET EEQEDDHLSI
     VTLEEAPFVI VESVDPLSGT CMRNTVPCQK RIVTENKTDE EPGYIKKCCK GFCIDILKKI
     SKSVKFTYDL YLVTNGKHGK KINGTWNGMI GEVVMKRAYM AVGSLTINEE RSEVVDFSVP
     FIETGISVMV SRSNGTVSPS AFLEPFSADV WVMMFVMLLI VSAVAVFVFE YFSPVGYNRC
     LADGREPGGP SFTIGKAIWL LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF AVIFLASYTA
     NLAAFMIQEE YVDQVSGLSD KKFQRPNDFS PPFRFGTVPN GSTERNIRNN YAEMHAYMGK
     FNQRGVDDAL LSLKTGKLDA FIYDAAVLNY MAGRDEGCKL VTIGSGKVFA STGYGIAIQK
     DSGWKRQVDL AILQLFGDGE MEELEALWLT GICHNEKNEV MSSQLDIDNM AGVFYMLGAA
     MALSLITFIC EHLFYWQFRH CFMGVCSGKP GMVFSISRGI YSCIHGVAIE ERQSVMNSPT
     ATMNNTHSNI LRLLRTAKNM ANLSGVNGSP QSALDFIRRE SSVYDISEHR RSFTHSDCKS
     YNNPPCEENL FSDYISEVER TFGNLQLKDS NVYQDHYHHH HRPHSIGSAS SIDGLYDCDN
     PPFTTQSRSI SKKPLDIGLP SSKHSQLSDL YGKFSFKSDR YSGHDDLIRS DVSDISTHTV
     TYGNIEGNAA KRRKQQYKDS LKKRPASAKS RREFDEIELA YRRRPPRSPD HKRYFRDKEG
     LRDFYLDQFR TKENSPHWEH VDLTDIYKER SDDFKRDSVS GGGPCTNRSH IKHGTGDKHG
     VVSGVPAPWE KNLTNVEWED RSGGNFCRSC PSKLHNYSTT VTGQNSGRQA CIRCEACKKA
     GNLYDISEDN SLQELDQPAA PVAVTSNAST TKYPQSPTNS KAQKKNRNKL RRQHSYDTFV
     DLQKEEAALA PRSVSLKDKG RFMDGSPYAH MFEMSAGEST FANNKSSVPT AGHHHHNNPG
     GGYMLSKSLY PDRVTQNPFI PTFGDDQCLL HGSKSYFFRQ PTVAGASKAR PDFRALVTNK
     PVVSALHGAV PARFQKDICI GNQSNPCVPN NKNPRAFNGS SNGHVYEKLS SIESDV
//