Q59HA9 (Q59HA9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Glutamate [NMDA] receptor subunit epsilon 2 variant EMBL BAD92087.1
Organism	Homo sapiens (Human) EMBL BAD92087.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1136 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane SAAS SAAS019594 Membrane Postsynaptic cell membrane SAAS SAAS019594 Synapse
Domain	Transmembrane Transmembrane helix SAAS SAAS019594
Molecular function	Ion channel Ligand-gated ion channel SAAS SAAS019594 Receptor SAAS SAAS019594 EMBL BAD92087.1
Gene Ontology (GO)
Biological_process	behavioral fear response Inferred from electronic annotation. Source: Compara behavioral response to pain Inferred from electronic annotation. Source: Compara detection of mechanical stimulus involved in sensory perception of pain Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara ionotropic glutamate receptor signaling pathway Inferred from electronic annotation. Source: GOC learning Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara regulation of synaptic plasticity Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara sensory organ development Inferred from electronic annotation. Source: Compara startle response Inferred from electronic annotation. Source: Compara suckling behavior Inferred from electronic annotation. Source: Compara
Cellular_component	N-methyl-D-aspartate selective glutamate receptor complex Inferred from electronic annotation. Source: Compara cell junction Inferred from electronic annotation. Source: UniProtKB-KW outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro postsynaptic density Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	N-methyl-D-aspartate selective glutamate receptor activity Inferred from electronic annotation. Source: Compara calcium channel activity Inferred from electronic annotation. Source: Compara extracellular-glutamate-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92087.1

Sequences

	Sequence		Length	Mass (Da)
	Q59HA9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 0FADF7E257B2FEB9	FASTA	1,136	127,509
	10 20 30 40 50 60 LSFSEDGYQM HPKLVIILLN KERKWERVGK WKDKSLQMKY YVWPRMCPET EEQEDDHLSI 70 80 90 100 110 120 VTLEEAPFVI VESVDPLSGT CMRNTVPCQK RIVTENKTDE EPGYIKKCCK GFCIDILKKI 130 140 150 160 170 180 SKSVKFTYDL YLVTNGKHGK KINGTWNGMI GEVVMKRAYM AVGSLTINEE RSEVVDFSVP 190 200 210 220 230 240 FIETGISVMV SRSNGTVSPS AFLEPFSADV WVMMFVMLLI VSAVAVFVFE YFSPVGYNRC 250 260 270 280 290 300 LADGREPGGP SFTIGKAIWL LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF AVIFLASYTA 310 320 330 340 350 360 NLAAFMIQEE YVDQVSGLSD KKFQRPNDFS PPFRFGTVPN GSTERNIRNN YAEMHAYMGK 370 380 390 400 410 420 FNQRGVDDAL LSLKTGKLDA FIYDAAVLNY MAGRDEGCKL VTIGSGKVFA STGYGIAIQK 430 440 450 460 470 480 DSGWKRQVDL AILQLFGDGE MEELEALWLT GICHNEKNEV MSSQLDIDNM AGVFYMLGAA 490 500 510 520 530 540 MALSLITFIC EHLFYWQFRH CFMGVCSGKP GMVFSISRGI YSCIHGVAIE ERQSVMNSPT 550 560 570 580 590 600 ATMNNTHSNI LRLLRTAKNM ANLSGVNGSP QSALDFIRRE SSVYDISEHR RSFTHSDCKS 610 620 630 640 650 660 YNNPPCEENL FSDYISEVER TFGNLQLKDS NVYQDHYHHH HRPHSIGSAS SIDGLYDCDN 670 680 690 700 710 720 PPFTTQSRSI SKKPLDIGLP SSKHSQLSDL YGKFSFKSDR YSGHDDLIRS DVSDISTHTV 730 740 750 760 770 780 TYGNIEGNAA KRRKQQYKDS LKKRPASAKS RREFDEIELA YRRRPPRSPD HKRYFRDKEG 790 800 810 820 830 840 LRDFYLDQFR TKENSPHWEH VDLTDIYKER SDDFKRDSVS GGGPCTNRSH IKHGTGDKHG 850 860 870 880 890 900 VVSGVPAPWE KNLTNVEWED RSGGNFCRSC PSKLHNYSTT VTGQNSGRQA CIRCEACKKA 910 920 930 940 950 960 GNLYDISEDN SLQELDQPAA PVAVTSNAST TKYPQSPTNS KAQKKNRNKL RRQHSYDTFV 970 980 990 1000 1010 1020 DLQKEEAALA PRSVSLKDKG RFMDGSPYAH MFEMSAGEST FANNKSSVPT AGHHHHNNPG 1030 1040 1050 1060 1070 1080 GGYMLSKSLY PDRVTQNPFI PTFGDDQCLL HGSKSYFFRQ PTVAGASKAR PDFRALVTNK 1090 1100 1110 1120 1130 PVVSALHGAV PARFQKDICI GNQSNPCVPN NKNPRAFNGS SNGHVYEKLS SIESDV

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92087.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB208850 mRNA. Translation: BAD92087.1.
IPI	IPI00297933.
UniGene	Hs.654430.
3D structure databases
ProteinModelPortal	Q59HA9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59HA9.
Proteomic databases
PRIDE	Q59HA9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG052635.
Gene expression databases
ArrayExpress	Q59HA9.
Bgee	Q59HA9.
Family and domain databases
InterPro	IPR019594. Glu_rcpt_Glu/Gly-bd. IPR001320. Iontro_glu_rcpt. IPR001508. NMDA_rcpt. IPR018884. NMDAR2_C. IPR001638. SBP_bac_3. [Graphical view]
Pfam	PF00060. Lig_chan. 1 hit. PF10565. NMDAR2_C. 1 hit. PF00497. SBP_bac_3. 1 hit. [Graphical view]
PRINTS	PR00177. NMDARECEPTOR.
SMART	SM00918. Lig_chan-Glu_bd. 1 hit. SM00079. PBPe. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59HA9_HUMAN

Accession

Primary (citable) accession number: Q59HA9

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.