SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q59HA9

- Q59HA9_HUMAN

UniProt

Q59HA9 - Q59HA9_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Glutamate [NMDA] receptor subunit epsilon 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. extracellular-glutamate-gated ion channel activity Source: InterPro
  3. N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. behavioral response to pain Source: Ensembl
  3. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  4. in utero embryonic development Source: Ensembl
  5. learning Source: Ensembl
  6. memory Source: Ensembl
  7. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  8. regulation of synaptic plasticity Source: Ensembl
  9. response to ethanol Source: Ensembl
  10. sensory organ development Source: Ensembl
  11. startle response Source: Ensembl
  12. suckling behavior Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotations, ReceptorSAAS annotationsImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate [NMDA] receptor subunit epsilon 2 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
  3. postsynaptic density Source: Ensembl
  4. postsynaptic membrane Source: UniProtKB-KW
  5. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotations, Membrane, Postsynaptic cell membraneSAAS annotations, Synapse

PTM / Processingi

Proteomic databases

PRIDEiQ59HA9.

Expressioni

Gene expression databases

ArrayExpressiQ59HA9.
BgeeiQ59HA9.

Structurei

3D structure databases

ProteinModelPortaliQ59HA9.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG052635.

Family and domain databases

InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59HA9-1 [UniParc]FASTAAdd to Basket

« Hide

LSFSEDGYQM HPKLVIILLN KERKWERVGK WKDKSLQMKY YVWPRMCPET     50
EEQEDDHLSI VTLEEAPFVI VESVDPLSGT CMRNTVPCQK RIVTENKTDE 100
EPGYIKKCCK GFCIDILKKI SKSVKFTYDL YLVTNGKHGK KINGTWNGMI 150
GEVVMKRAYM AVGSLTINEE RSEVVDFSVP FIETGISVMV SRSNGTVSPS 200
AFLEPFSADV WVMMFVMLLI VSAVAVFVFE YFSPVGYNRC LADGREPGGP 250
SFTIGKAIWL LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF AVIFLASYTA 300
NLAAFMIQEE YVDQVSGLSD KKFQRPNDFS PPFRFGTVPN GSTERNIRNN 350
YAEMHAYMGK FNQRGVDDAL LSLKTGKLDA FIYDAAVLNY MAGRDEGCKL 400
VTIGSGKVFA STGYGIAIQK DSGWKRQVDL AILQLFGDGE MEELEALWLT 450
GICHNEKNEV MSSQLDIDNM AGVFYMLGAA MALSLITFIC EHLFYWQFRH 500
CFMGVCSGKP GMVFSISRGI YSCIHGVAIE ERQSVMNSPT ATMNNTHSNI 550
LRLLRTAKNM ANLSGVNGSP QSALDFIRRE SSVYDISEHR RSFTHSDCKS 600
YNNPPCEENL FSDYISEVER TFGNLQLKDS NVYQDHYHHH HRPHSIGSAS 650
SIDGLYDCDN PPFTTQSRSI SKKPLDIGLP SSKHSQLSDL YGKFSFKSDR 700
YSGHDDLIRS DVSDISTHTV TYGNIEGNAA KRRKQQYKDS LKKRPASAKS 750
RREFDEIELA YRRRPPRSPD HKRYFRDKEG LRDFYLDQFR TKENSPHWEH 800
VDLTDIYKER SDDFKRDSVS GGGPCTNRSH IKHGTGDKHG VVSGVPAPWE 850
KNLTNVEWED RSGGNFCRSC PSKLHNYSTT VTGQNSGRQA CIRCEACKKA 900
GNLYDISEDN SLQELDQPAA PVAVTSNAST TKYPQSPTNS KAQKKNRNKL 950
RRQHSYDTFV DLQKEEAALA PRSVSLKDKG RFMDGSPYAH MFEMSAGEST 1000
FANNKSSVPT AGHHHHNNPG GGYMLSKSLY PDRVTQNPFI PTFGDDQCLL 1050
HGSKSYFFRQ PTVAGASKAR PDFRALVTNK PVVSALHGAV PARFQKDICI 1100
GNQSNPCVPN NKNPRAFNGS SNGHVYEKLS SIESDV 1136
Length:1,136
Mass (Da):127,509
Last modified:April 26, 2005 - v1
Checksum:i0FADF7E257B2FEB9
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB208850 mRNA. Translation: BAD92087.1.
UniGeneiHs.654430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB208850 mRNA. Translation: BAD92087.1 .
UniGenei Hs.654430.

3D structure databases

ProteinModelPortali Q59HA9.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59HA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052635.

Gene expression databases

ArrayExpressi Q59HA9.
Bgeei Q59HA9.

Family and domain databases

InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59HA9_HUMAN
AccessioniPrimary (citable) accession number: Q59HA9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi