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Q59HA9

- Q59HA9_HUMAN

UniProt

Q59HA9 - Q59HA9_HUMAN

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Protein
Submitted name:

Glutamate [NMDA] receptor subunit epsilon 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. extracellular-glutamate-gated ion channel activity Source: InterPro
  3. N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. behavioral response to pain Source: Ensembl
  3. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  4. in utero embryonic development Source: Ensembl
  5. learning Source: Ensembl
  6. memory Source: Ensembl
  7. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  8. regulation of synaptic plasticity Source: Ensembl
  9. response to ethanol Source: Ensembl
  10. sensory organ development Source: Ensembl
  11. startle response Source: Ensembl
  12. suckling behavior Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate [NMDA] receptor subunit epsilon 2 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. neuronal postsynaptic density Source: Ensembl
  3. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
  4. postsynaptic membrane Source: UniProtKB-KW
  5. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Proteomic databases

PRIDEiQ59HA9.

Expressioni

Gene expression databases

BgeeiQ59HA9.
ExpressionAtlasiQ59HA9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ59HA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG052635.

Family and domain databases

InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59HA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LSFSEDGYQM HPKLVIILLN KERKWERVGK WKDKSLQMKY YVWPRMCPET
60 70 80 90 100
EEQEDDHLSI VTLEEAPFVI VESVDPLSGT CMRNTVPCQK RIVTENKTDE
110 120 130 140 150
EPGYIKKCCK GFCIDILKKI SKSVKFTYDL YLVTNGKHGK KINGTWNGMI
160 170 180 190 200
GEVVMKRAYM AVGSLTINEE RSEVVDFSVP FIETGISVMV SRSNGTVSPS
210 220 230 240 250
AFLEPFSADV WVMMFVMLLI VSAVAVFVFE YFSPVGYNRC LADGREPGGP
260 270 280 290 300
SFTIGKAIWL LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF AVIFLASYTA
310 320 330 340 350
NLAAFMIQEE YVDQVSGLSD KKFQRPNDFS PPFRFGTVPN GSTERNIRNN
360 370 380 390 400
YAEMHAYMGK FNQRGVDDAL LSLKTGKLDA FIYDAAVLNY MAGRDEGCKL
410 420 430 440 450
VTIGSGKVFA STGYGIAIQK DSGWKRQVDL AILQLFGDGE MEELEALWLT
460 470 480 490 500
GICHNEKNEV MSSQLDIDNM AGVFYMLGAA MALSLITFIC EHLFYWQFRH
510 520 530 540 550
CFMGVCSGKP GMVFSISRGI YSCIHGVAIE ERQSVMNSPT ATMNNTHSNI
560 570 580 590 600
LRLLRTAKNM ANLSGVNGSP QSALDFIRRE SSVYDISEHR RSFTHSDCKS
610 620 630 640 650
YNNPPCEENL FSDYISEVER TFGNLQLKDS NVYQDHYHHH HRPHSIGSAS
660 670 680 690 700
SIDGLYDCDN PPFTTQSRSI SKKPLDIGLP SSKHSQLSDL YGKFSFKSDR
710 720 730 740 750
YSGHDDLIRS DVSDISTHTV TYGNIEGNAA KRRKQQYKDS LKKRPASAKS
760 770 780 790 800
RREFDEIELA YRRRPPRSPD HKRYFRDKEG LRDFYLDQFR TKENSPHWEH
810 820 830 840 850
VDLTDIYKER SDDFKRDSVS GGGPCTNRSH IKHGTGDKHG VVSGVPAPWE
860 870 880 890 900
KNLTNVEWED RSGGNFCRSC PSKLHNYSTT VTGQNSGRQA CIRCEACKKA
910 920 930 940 950
GNLYDISEDN SLQELDQPAA PVAVTSNAST TKYPQSPTNS KAQKKNRNKL
960 970 980 990 1000
RRQHSYDTFV DLQKEEAALA PRSVSLKDKG RFMDGSPYAH MFEMSAGEST
1010 1020 1030 1040 1050
FANNKSSVPT AGHHHHNNPG GGYMLSKSLY PDRVTQNPFI PTFGDDQCLL
1060 1070 1080 1090 1100
HGSKSYFFRQ PTVAGASKAR PDFRALVTNK PVVSALHGAV PARFQKDICI
1110 1120 1130
GNQSNPCVPN NKNPRAFNGS SNGHVYEKLS SIESDV
Length:1,136
Mass (Da):127,509
Last modified:April 26, 2005 - v1
Checksum:i0FADF7E257B2FEB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB208850 mRNA. Translation: BAD92087.1.
UniGeneiHs.654430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB208850 mRNA. Translation: BAD92087.1 .
UniGenei Hs.654430.

3D structure databases

ProteinModelPortali Q59HA9.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59HA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052635.

Gene expression databases

Bgeei Q59HA9.
ExpressionAtlasi Q59HA9. baseline and differential.

Family and domain databases

InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR018884. NMDAR2_C.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF00060. Lig_chan. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59HA9_HUMAN
AccessioniPrimary (citable) accession number: Q59HA9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.