Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q59HA9

- Q59HA9_HUMAN

UniProt

Q59HA9 - Q59HA9_HUMAN

Protein
Submitted name:

Glutamate [NMDA] receptor subunit epsilon 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. calcium channel activity Source: Ensembl
    2. extracellular-glutamate-gated ion channel activity Source: InterPro
    3. N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl

    GO - Biological processi

    1. behavioral fear response Source: Ensembl
    2. behavioral response to pain Source: Ensembl
    3. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
    4. in utero embryonic development Source: Ensembl
    5. learning Source: Ensembl
    6. memory Source: Ensembl
    7. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    8. regulation of synaptic plasticity Source: Ensembl
    9. response to ethanol Source: Ensembl
    10. sensory organ development Source: Ensembl
    11. startle response Source: Ensembl
    12. suckling behavior Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glutamate [NMDA] receptor subunit epsilon 2 variantImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
    3. postsynaptic density Source: Ensembl
    4. postsynaptic membrane Source: UniProtKB-KW
    5. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

    PTM / Processingi

    Proteomic databases

    PRIDEiQ59HA9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ59HA9.
    BgeeiQ59HA9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59HA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG052635.

    Family and domain databases

    InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR018884. NMDAR2_C.
    IPR001638. SBP_bac_3.
    [Graphical view]
    PfamiPF00060. Lig_chan. 1 hit.
    PF10565. NMDAR2_C. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59HA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    LSFSEDGYQM HPKLVIILLN KERKWERVGK WKDKSLQMKY YVWPRMCPET     50
    EEQEDDHLSI VTLEEAPFVI VESVDPLSGT CMRNTVPCQK RIVTENKTDE 100
    EPGYIKKCCK GFCIDILKKI SKSVKFTYDL YLVTNGKHGK KINGTWNGMI 150
    GEVVMKRAYM AVGSLTINEE RSEVVDFSVP FIETGISVMV SRSNGTVSPS 200
    AFLEPFSADV WVMMFVMLLI VSAVAVFVFE YFSPVGYNRC LADGREPGGP 250
    SFTIGKAIWL LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF AVIFLASYTA 300
    NLAAFMIQEE YVDQVSGLSD KKFQRPNDFS PPFRFGTVPN GSTERNIRNN 350
    YAEMHAYMGK FNQRGVDDAL LSLKTGKLDA FIYDAAVLNY MAGRDEGCKL 400
    VTIGSGKVFA STGYGIAIQK DSGWKRQVDL AILQLFGDGE MEELEALWLT 450
    GICHNEKNEV MSSQLDIDNM AGVFYMLGAA MALSLITFIC EHLFYWQFRH 500
    CFMGVCSGKP GMVFSISRGI YSCIHGVAIE ERQSVMNSPT ATMNNTHSNI 550
    LRLLRTAKNM ANLSGVNGSP QSALDFIRRE SSVYDISEHR RSFTHSDCKS 600
    YNNPPCEENL FSDYISEVER TFGNLQLKDS NVYQDHYHHH HRPHSIGSAS 650
    SIDGLYDCDN PPFTTQSRSI SKKPLDIGLP SSKHSQLSDL YGKFSFKSDR 700
    YSGHDDLIRS DVSDISTHTV TYGNIEGNAA KRRKQQYKDS LKKRPASAKS 750
    RREFDEIELA YRRRPPRSPD HKRYFRDKEG LRDFYLDQFR TKENSPHWEH 800
    VDLTDIYKER SDDFKRDSVS GGGPCTNRSH IKHGTGDKHG VVSGVPAPWE 850
    KNLTNVEWED RSGGNFCRSC PSKLHNYSTT VTGQNSGRQA CIRCEACKKA 900
    GNLYDISEDN SLQELDQPAA PVAVTSNAST TKYPQSPTNS KAQKKNRNKL 950
    RRQHSYDTFV DLQKEEAALA PRSVSLKDKG RFMDGSPYAH MFEMSAGEST 1000
    FANNKSSVPT AGHHHHNNPG GGYMLSKSLY PDRVTQNPFI PTFGDDQCLL 1050
    HGSKSYFFRQ PTVAGASKAR PDFRALVTNK PVVSALHGAV PARFQKDICI 1100
    GNQSNPCVPN NKNPRAFNGS SNGHVYEKLS SIESDV 1136
    Length:1,136
    Mass (Da):127,509
    Last modified:April 26, 2005 - v1
    Checksum:i0FADF7E257B2FEB9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB208850 mRNA. Translation: BAD92087.1.
    UniGeneiHs.654430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB208850 mRNA. Translation: BAD92087.1 .
    UniGenei Hs.654430.

    3D structure databases

    ProteinModelPortali Q59HA9.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q59HA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG052635.

    Gene expression databases

    ArrayExpressi Q59HA9.
    Bgeei Q59HA9.

    Family and domain databases

    InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR018884. NMDAR2_C.
    IPR001638. SBP_bac_3.
    [Graphical view ]
    Pfami PF00060. Lig_chan. 1 hit.
    PF10565. NMDAR2_C. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ59HA9_HUMAN
    AccessioniPrimary (citable) accession number: Q59HA9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.