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Protein

RBR-type E3 ubiquitin transferase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RBR-type E3 ubiquitin transferaseSAAS annotation (EC:2.3.2.31SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

MaxQBiQ59HA2
PeptideAtlasiQ59HA2
PRIDEiQ59HA2

Structurei

3D structure databases

ProteinModelPortaliQ59HA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 165RING-typeInterPro annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 221Sequence analysisAdd BLAST21
Coiled coili294 – 314Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the RBR family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1815 Eukaryota
ENOG410XP9Y LUCA
HOGENOMiHOG000216611
HOVERGENiHBG018737

Family and domain databases

InterProiView protein in InterPro
IPR031126 Ariadne-2
IPR031127 E3_UB_ligase_RBR
IPR002867 IBR_dom
IPR001841 Znf_RING
IPR017907 Znf_RING_CS
PANTHERiPTHR11685 PTHR11685, 1 hit
PTHR11685:SF210 PTHR11685:SF210, 1 hit
PfamiView protein in Pfam
PF01485 IBR, 2 hits
SMARTiView protein in SMART
SM00647 IBR, 2 hits
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q59HA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VGITGVSCMA QDCPLRTPED FVFPLLPNEE LREKYRRYLF RDYVESHYQL
60 70 80 90 100
QLCPGADCPM VIRVQEPRAR RVQCNRCNEV FCFKCRQMYH APTDCATIRK
110 120 130 140 150
WLTKCADDSE TANYISAHTK DCPKCNICIE KNGGCNHMQC SKCKHDFCWM
160 170 180 190 200
CLGDWKTHGS EYYECSRYKE NPDIVNQSQQ AQAREALKKY LFYFERWENH
210 220 230 240 250
NKSLQLEAQT YQRIHEKIQE RVMNNLGTWI DWQYLQNAAK LLAKCRYTLQ
260 270 280 290 300
YTYPYAYYME SGPRKKLFEY QQAQLEAEIE NLSWKVERAD SYDRGDLENQ
310
MHIAEQRRRT LLKDFHDT
Length:318
Mass (Da):38,012
Last modified:April 26, 2005 - v1
Checksum:i7A91DA9FE321C056
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208857 mRNA Translation: BAD92094.1
UniGeneiHs.633601

Similar proteinsi

Entry informationi

Entry nameiQ59HA2_HUMAN
AccessioniPrimary (citable) accession number: Q59HA2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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