UniProtKB - Q59H80 (Q59H80_HUMAN)
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Protein
Submitted name:
DNA topoisomerase II, beta isozyme variant
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: InterPro
- DNA binding Source: InterPro
- DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro
GO - Biological processi
- DNA topological change Source: InterPro
Keywordsi
Molecular function | IsomeraseImported |
Names & Taxonomyi
Protein namesi | Submitted name: DNA topoisomerase II, beta isozyme variantImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 97 – 570 | TOP4cInterPro annotationAdd BLAST | 474 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 542 – 562 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0355 Eukaryota COG0187 LUCA COG0188 LUCA |
HOVERGENi | HBG052998 |
Family and domain databases
Gene3Di | 1.10.268.101 hit 3.40.50.6701 hit 3.90.199.103 hits |
InterProi | View protein in InterPro IPR012542 DTHCT IPR001241 Topo_IIA IPR013760 Topo_IIA-like_dom_sf IPR002205 Topo_IIA_A/C IPR013758 Topo_IIA_A/C_ab IPR013757 Topo_IIA_A_a_sf IPR013759 Topo_IIA_B_C IPR031660 TOPRIM_C |
PANTHERi | PTHR10169 PTHR10169, 1 hit |
Pfami | View protein in Pfam PF00521 DNA_topoisoIV, 1 hit PF08070 DTHCT, 1 hit PF16898 TOPRIM_C, 1 hit |
SMARTi | View protein in SMART SM00434 TOP4c, 1 hit |
SUPFAMi | SSF56719 SSF56719, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59H80-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RMEKHIENQK AWKIKYYKGL GTSTAKEAKE YFADMERHRI LFRYAGPEDD
60 70 80 90 100
AAITLAFSKK KIDDRKEWLT NFMEDRRQRR LHGLPEQFLY GTATKHLTYN
110 120 130 140 150
DFINKELILF SNSDNERSIP SLVDGFKPGQ RKVLFTCFKR NDKREVKVAQ
160 170 180 190 200
LAGSVAEMSA YHHGEQALMM TIVNLAQNFV GSNNINLLQP IGQFGTRLHG
210 220 230 240 250
GKDAASPRYI FTMLSTLARL LFPAVDDNLL KFLYDDNQRV EPEWYIPIIP
260 270 280 290 300
MVLINGAEGI GTGWACKLPN YDAREIVNNV RRMLDGLDPH PMLPNYKNFK
310 320 330 340 350
GTIQELGQNQ YAVSGEIFVV DRNTVEITEL PVRTWTQVYK EQVLEPMLNG
360 370 380 390 400
TDKTPALISD YKEYHTDTTV KFVVKMTEEK LAQAEAAGLH KVFKLQTTLT
410 420 430 440 450
CNSMVLFDHM GCLKKYETVQ DILKEFFDLR LSYYGLRKEW LVGMLGAEST
460 470 480 490 500
KLNNQARFIL EKIQGKITIE NRSKKDLIQM LVQRGYESDP VKAWKEAQEK
510 520 530 540 550
AAEEDETQNQ HDDSSSDSGT PSGPDFNYIL NMSLWSLTKE KVEELIKQRD
560 570 580 590 600
AKGREVNDLK RKSPSDLWKE DLAAFVEELD KVESQEREDV LAGMSGKAIK
610 620 630 640 650
GKVGKPKVKK LQLEETMPSP YGRRIIPEIT AMKADASKKL LKKKKGDLDT
660 670 680 690 700
AAVKVEFDEE FSGAPVEGAG EEALTPSVPI NKGPKPKREK KEPGTRVRKT
710 720 730 740 750
PTSSGKPSAK KVKKRNPWSD DESKSESDLE ETEPVVIPRD SLLRRAAAER
760 770 780 790 800
PKYTFDFSEE EDDDADDDDD DNNDLEELKV KASPITNDGE DEFVPSDGLD
810 820 830 840 850
KDEYTFSPGK SKATPEKSLH DKKSQDFGNL FSFPSYSQKS EDDSAKFDSN
860 870 880 890 900
EEDSASVFSP SFGLKQTDKV PSKTVAAKKG KPSSDTVPKP KRAPKQKKVV
910 920 930 940 950
EAVNSDSDSE FGIPKKTTTP KGKGRGAKKR KASGSENEGD YNPGRKTSKT
960 970 980 990 1000
TSKKPKKTSF DQDSDVDIFP SDFPTEPPSL PRTGRARKEV KYFAESDEEE
DDVDFAMFN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB208879 mRNA Translation: BAD92116.1 |
RefSeqi | NP_001059.2, NM_001068.3 |
UniGenei | Hs.475733 |
Genome annotation databases
GeneIDi | 7155 |
Similar proteinsi
Entry informationi
Entry namei | Q59H80_HUMAN | |
Accessioni | Q59H80Primary (citable) accession number: Q59H80 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 28, 2018 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |