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UniProtKB - Q59H80 (Q59H80_HUMAN)

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Protein
Submitted name:

DNA topoisomerase II, beta isozyme variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionIsomeraseImported

Names & Taxonomyi

Protein namesi
Submitted name:
DNA topoisomerase II, beta isozyme variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ59H80.
PeptideAtlasiQ59H80.
PRIDEiQ59H80.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396704.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 570TOP4cInterPro annotationAdd BLAST474

Phylogenomic databases

eggNOGiKOG0355. Eukaryota.
COG0187. LUCA.
COG0188. LUCA.
HOVERGENiHBG052998.
KOiK03164.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProiView protein in InterPro
IPR024946. Arg_repress_C-like.
IPR012542. DTHCT.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR031660. TOPRIM_C.
PANTHERiPTHR10169. PTHR10169. 1 hit.
PfamiView protein in Pfam
PF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF16898. TOPRIM_C. 1 hit.
SMARTiView protein in SMART
SM00434. TOP4c. 1 hit.
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59H80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RMEKHIENQK AWKIKYYKGL GTSTAKEAKE YFADMERHRI LFRYAGPEDD 
        60         70         80         90        100
AAITLAFSKK KIDDRKEWLT NFMEDRRQRR LHGLPEQFLY GTATKHLTYN 
       110        120        130        140        150
DFINKELILF SNSDNERSIP SLVDGFKPGQ RKVLFTCFKR NDKREVKVAQ 
       160        170        180        190        200
LAGSVAEMSA YHHGEQALMM TIVNLAQNFV GSNNINLLQP IGQFGTRLHG 
       210        220        230        240        250
GKDAASPRYI FTMLSTLARL LFPAVDDNLL KFLYDDNQRV EPEWYIPIIP 
       260        270        280        290        300
MVLINGAEGI GTGWACKLPN YDAREIVNNV RRMLDGLDPH PMLPNYKNFK 
       310        320        330        340        350
GTIQELGQNQ YAVSGEIFVV DRNTVEITEL PVRTWTQVYK EQVLEPMLNG 
       360        370        380        390        400
TDKTPALISD YKEYHTDTTV KFVVKMTEEK LAQAEAAGLH KVFKLQTTLT 
       410        420        430        440        450
CNSMVLFDHM GCLKKYETVQ DILKEFFDLR LSYYGLRKEW LVGMLGAEST 
       460        470        480        490        500
KLNNQARFIL EKIQGKITIE NRSKKDLIQM LVQRGYESDP VKAWKEAQEK 
       510        520        530        540        550
AAEEDETQNQ HDDSSSDSGT PSGPDFNYIL NMSLWSLTKE KVEELIKQRD 
       560        570        580        590        600
AKGREVNDLK RKSPSDLWKE DLAAFVEELD KVESQEREDV LAGMSGKAIK 
       610        620        630        640        650
GKVGKPKVKK LQLEETMPSP YGRRIIPEIT AMKADASKKL LKKKKGDLDT 
       660        670        680        690        700
AAVKVEFDEE FSGAPVEGAG EEALTPSVPI NKGPKPKREK KEPGTRVRKT 
       710        720        730        740        750
PTSSGKPSAK KVKKRNPWSD DESKSESDLE ETEPVVIPRD SLLRRAAAER 
       760        770        780        790        800
PKYTFDFSEE EDDDADDDDD DNNDLEELKV KASPITNDGE DEFVPSDGLD 
       810        820        830        840        850
KDEYTFSPGK SKATPEKSLH DKKSQDFGNL FSFPSYSQKS EDDSAKFDSN 
       860        870        880        890        900
EEDSASVFSP SFGLKQTDKV PSKTVAAKKG KPSSDTVPKP KRAPKQKKVV 
       910        920        930        940        950
EAVNSDSDSE FGIPKKTTTP KGKGRGAKKR KASGSENEGD YNPGRKTSKT 
       960        970        980        990       1000
TSKKPKKTSF DQDSDVDIFP SDFPTEPPSL PRTGRARKEV KYFAESDEEE 

DDVDFAMFN
Length:1,009
Mass (Da):114,006
Last modified:April 26, 2005 - v1
Checksum:i6E69FB71236E0D4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208879 mRNA. Translation: BAD92116.1.
RefSeqiNP_001059.2. NM_001068.3.
UniGeneiHs.475733.

Genome annotation databases

GeneIDi7155.
KEGGihsa:7155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208879 mRNA. Translation: BAD92116.1.
RefSeqiNP_001059.2. NM_001068.3.
UniGeneiHs.475733.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396704.

Proteomic databases

PaxDbiQ59H80.
PeptideAtlasiQ59H80.
PRIDEiQ59H80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7155.
KEGGihsa:7155.

Organism-specific databases

CTDi7155.

Phylogenomic databases

eggNOGiKOG0355. Eukaryota.
COG0187. LUCA.
COG0188. LUCA.
HOVERGENiHBG052998.
KOiK03164.

Miscellaneous databases

GenomeRNAii7155.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProiView protein in InterPro
IPR024946. Arg_repress_C-like.
IPR012542. DTHCT.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR031660. TOPRIM_C.
PANTHERiPTHR10169. PTHR10169. 1 hit.
PfamiView protein in Pfam
PF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF16898. TOPRIM_C. 1 hit.
SMARTiView protein in SMART
SM00434. TOP4c. 1 hit.
SUPFAMiSSF56719. SSF56719. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59H80_HUMAN
AccessioniPrimary (citable) accession number: Q59H80
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.