Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

DNA topoisomerase II, beta isozyme variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Names & Taxonomyi

Protein namesi
Submitted name:
DNA topoisomerase II, beta isozyme variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ59H80.
PeptideAtlasiQ59H80.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396704.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 570474TOP4cInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0355. Eukaryota.
COG0187. LUCA.
COG0188. LUCA.
HOVERGENiHBG052998.
KOiK03164.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR012542. DTHCT.
IPR028467. Top2b.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR031660. TOPRIM_C.
[Graphical view]
PANTHERiPTHR10169:SF36. PTHR10169:SF36. 1 hit.
PfamiPF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF16898. TOPRIM_C. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59H80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RMEKHIENQK AWKIKYYKGL GTSTAKEAKE YFADMERHRI LFRYAGPEDD
60 70 80 90 100
AAITLAFSKK KIDDRKEWLT NFMEDRRQRR LHGLPEQFLY GTATKHLTYN
110 120 130 140 150
DFINKELILF SNSDNERSIP SLVDGFKPGQ RKVLFTCFKR NDKREVKVAQ
160 170 180 190 200
LAGSVAEMSA YHHGEQALMM TIVNLAQNFV GSNNINLLQP IGQFGTRLHG
210 220 230 240 250
GKDAASPRYI FTMLSTLARL LFPAVDDNLL KFLYDDNQRV EPEWYIPIIP
260 270 280 290 300
MVLINGAEGI GTGWACKLPN YDAREIVNNV RRMLDGLDPH PMLPNYKNFK
310 320 330 340 350
GTIQELGQNQ YAVSGEIFVV DRNTVEITEL PVRTWTQVYK EQVLEPMLNG
360 370 380 390 400
TDKTPALISD YKEYHTDTTV KFVVKMTEEK LAQAEAAGLH KVFKLQTTLT
410 420 430 440 450
CNSMVLFDHM GCLKKYETVQ DILKEFFDLR LSYYGLRKEW LVGMLGAEST
460 470 480 490 500
KLNNQARFIL EKIQGKITIE NRSKKDLIQM LVQRGYESDP VKAWKEAQEK
510 520 530 540 550
AAEEDETQNQ HDDSSSDSGT PSGPDFNYIL NMSLWSLTKE KVEELIKQRD
560 570 580 590 600
AKGREVNDLK RKSPSDLWKE DLAAFVEELD KVESQEREDV LAGMSGKAIK
610 620 630 640 650
GKVGKPKVKK LQLEETMPSP YGRRIIPEIT AMKADASKKL LKKKKGDLDT
660 670 680 690 700
AAVKVEFDEE FSGAPVEGAG EEALTPSVPI NKGPKPKREK KEPGTRVRKT
710 720 730 740 750
PTSSGKPSAK KVKKRNPWSD DESKSESDLE ETEPVVIPRD SLLRRAAAER
760 770 780 790 800
PKYTFDFSEE EDDDADDDDD DNNDLEELKV KASPITNDGE DEFVPSDGLD
810 820 830 840 850
KDEYTFSPGK SKATPEKSLH DKKSQDFGNL FSFPSYSQKS EDDSAKFDSN
860 870 880 890 900
EEDSASVFSP SFGLKQTDKV PSKTVAAKKG KPSSDTVPKP KRAPKQKKVV
910 920 930 940 950
EAVNSDSDSE FGIPKKTTTP KGKGRGAKKR KASGSENEGD YNPGRKTSKT
960 970 980 990 1000
TSKKPKKTSF DQDSDVDIFP SDFPTEPPSL PRTGRARKEV KYFAESDEEE

DDVDFAMFN
Length:1,009
Mass (Da):114,006
Last modified:April 26, 2005 - v1
Checksum:i6E69FB71236E0D4D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208879 mRNA. Translation: BAD92116.1.
RefSeqiNP_001059.2. NM_001068.3.
UniGeneiHs.475733.

Genome annotation databases

GeneIDi7155.
KEGGihsa:7155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208879 mRNA. Translation: BAD92116.1.
RefSeqiNP_001059.2. NM_001068.3.
UniGeneiHs.475733.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396704.

Proteomic databases

PaxDbiQ59H80.
PeptideAtlasiQ59H80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7155.
KEGGihsa:7155.

Organism-specific databases

CTDi7155.

Phylogenomic databases

eggNOGiKOG0355. Eukaryota.
COG0187. LUCA.
COG0188. LUCA.
HOVERGENiHBG052998.
KOiK03164.

Miscellaneous databases

GenomeRNAii7155.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR012542. DTHCT.
IPR028467. Top2b.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR031660. TOPRIM_C.
[Graphical view]
PANTHERiPTHR10169:SF36. PTHR10169:SF36. 1 hit.
PfamiPF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF16898. TOPRIM_C. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59H80_HUMAN
AccessioniPrimary (citable) accession number: Q59H80
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.