DNA topoisomerase II, beta isozyme variant

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
DNA binding Source: InterPro
DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA topological change Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	IsomeraseImported

Molecular function

IsomeraseImported

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: DNA topoisomerase II, beta isozyme variantImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q59H80
PRIDEⁱ	Q59H80

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	97 – 570	TOP4cInterPro annotationAdd BLAST		474

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	542 – 562	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0355 Eukaryota COG0187 LUCA COG0188 LUCA
HOVERGENⁱ	HBG052998

Family and domain databases

Gene3Dⁱ	1.10.268.101 hit 3.40.50.6701 hit 3.90.199.103 hits
InterProⁱ	View protein in InterPro IPR012542 DTHCT IPR001241 Topo_IIA IPR013760 Topo_IIA-like_dom_sf IPR002205 Topo_IIA_A/C IPR013758 Topo_IIA_A/C_ab IPR013757 Topo_IIA_A_a_sf IPR013759 Topo_IIA_B_C IPR031660 TOPRIM_C
PANTHERⁱ	PTHR10169 PTHR10169, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00521 DNA_topoisoIV, 1 hit PF08070 DTHCT, 1 hit PF16898 TOPRIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00434 TOP4c, 1 hit
SUPFAMⁱ	SSF56719 SSF56719, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q59H80-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
RMEKHIENQK AWKIKYYKGL GTSTAKEAKE YFADMERHRI LFRYAGPEDD 
        60         70         80         90        100
AAITLAFSKK KIDDRKEWLT NFMEDRRQRR LHGLPEQFLY GTATKHLTYN 
       110        120        130        140        150
DFINKELILF SNSDNERSIP SLVDGFKPGQ RKVLFTCFKR NDKREVKVAQ 
       160        170        180        190        200
LAGSVAEMSA YHHGEQALMM TIVNLAQNFV GSNNINLLQP IGQFGTRLHG 
       210        220        230        240        250
GKDAASPRYI FTMLSTLARL LFPAVDDNLL KFLYDDNQRV EPEWYIPIIP 
       260        270        280        290        300
MVLINGAEGI GTGWACKLPN YDAREIVNNV RRMLDGLDPH PMLPNYKNFK 
       310        320        330        340        350
GTIQELGQNQ YAVSGEIFVV DRNTVEITEL PVRTWTQVYK EQVLEPMLNG 
       360        370        380        390        400
TDKTPALISD YKEYHTDTTV KFVVKMTEEK LAQAEAAGLH KVFKLQTTLT 
       410        420        430        440        450
CNSMVLFDHM GCLKKYETVQ DILKEFFDLR LSYYGLRKEW LVGMLGAEST 
       460        470        480        490        500
KLNNQARFIL EKIQGKITIE NRSKKDLIQM LVQRGYESDP VKAWKEAQEK 
       510        520        530        540        550
AAEEDETQNQ HDDSSSDSGT PSGPDFNYIL NMSLWSLTKE KVEELIKQRD 
       560        570        580        590        600
AKGREVNDLK RKSPSDLWKE DLAAFVEELD KVESQEREDV LAGMSGKAIK 
       610        620        630        640        650
GKVGKPKVKK LQLEETMPSP YGRRIIPEIT AMKADASKKL LKKKKGDLDT 
       660        670        680        690        700
AAVKVEFDEE FSGAPVEGAG EEALTPSVPI NKGPKPKREK KEPGTRVRKT 
       710        720        730        740        750
PTSSGKPSAK KVKKRNPWSD DESKSESDLE ETEPVVIPRD SLLRRAAAER 
       760        770        780        790        800
PKYTFDFSEE EDDDADDDDD DNNDLEELKV KASPITNDGE DEFVPSDGLD 
       810        820        830        840        850
KDEYTFSPGK SKATPEKSLH DKKSQDFGNL FSFPSYSQKS EDDSAKFDSN 
       860        870        880        890        900
EEDSASVFSP SFGLKQTDKV PSKTVAAKKG KPSSDTVPKP KRAPKQKKVV 
       910        920        930        940        950
EAVNSDSDSE FGIPKKTTTP KGKGRGAKKR KASGSENEGD YNPGRKTSKT 
       960        970        980        990       1000
TSKKPKKTSF DQDSDVDIFP SDFPTEPPSL PRTGRARKEV KYFAESDEEE 

DDVDFAMFN

Length:1,009

Mass (Da):114,006

Last modified:April 26, 2005 - v1

Checksum:ⁱ6E69FB71236E0D4D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB208879 mRNA Translation: BAD92116.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001059.2, NM_001068.3
UniGeneⁱ	Hs.475733

Genome annotation databases

GeneIDⁱ	7155

GeneIDⁱ

7155

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q59H80	A0A2G9RN52 A0A060XDE5 UPI00052269A9 UPI0006B1ACAD UPI000528488A A0A2I4DA43 A0A2D4GGV0 A0A2D4GGU9 A0A2D4KUQ3 A0A226N6V2	Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) Haliaeetus albicilla (White-tailed sea-eagle) Thamnophis sirtalis Mesitornis unicolor (brown roatelo) Austrofundulus limnaeus Micrurus corallinus (Brazilian coral snake) Micrurus paraensis Colinus virginianus (Northern bobwhite) (Tetrao virginianus)	875	UniRef50_A0A2G9RN52	Cluster: Uncharacterized protein (Fragment)	11

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB208879 mRNA Translation: BAD92116.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001059.2, NM_001068.3
UniGeneⁱ	Hs.475733

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q59H80
PRIDEⁱ	Q59H80

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	7155

GeneIDⁱ

7155

Organism-specific databases

CTDⁱ	7155

CTDⁱ

7155

Phylogenomic databases

eggNOGⁱ	KOG0355 Eukaryota COG0187 LUCA COG0188 LUCA
HOVERGENⁱ	HBG052998

Miscellaneous databases

GenomeRNAiⁱ	7155

GenomeRNAiⁱ

7155

Family and domain databases

Gene3Dⁱ	1.10.268.101 hit 3.40.50.6701 hit 3.90.199.103 hits
InterProⁱ	View protein in InterPro IPR012542 DTHCT IPR001241 Topo_IIA IPR013760 Topo_IIA-like_dom_sf IPR002205 Topo_IIA_A/C IPR013758 Topo_IIA_A/C_ab IPR013757 Topo_IIA_A_a_sf IPR013759 Topo_IIA_B_C IPR031660 TOPRIM_C
PANTHERⁱ	PTHR10169 PTHR10169, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00521 DNA_topoisoIV, 1 hit PF08070 DTHCT, 1 hit PF16898 TOPRIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00434 TOP4c, 1 hit
SUPFAMⁱ	SSF56719 SSF56719, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q59H80_HUMAN
Accessionⁱ	Q59H80Primary (citable) accession number: Q59H80
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 26, 2005
	Last sequence update:	April 26, 2005
	Last modified:	February 28, 2018
	This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q59H80 (Q59H80_HUMAN)

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DNA topoisomerase II, beta isozyme variant

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Proteomic databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q59H80 (Q59H80_HUMAN)

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DNA topoisomerase II, beta isozyme variant

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ