DNA topoisomerase II, beta isozyme variant

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: InterPro
• DNA binding, bending Source: InterPro
• DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• DNA topological change Source: InterPro

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Molecular functionⁱ

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• nucleus Source: InterPro

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	97 – 570	474	TOP4cInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi SMART:SM00434			Add BLAST

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

        10         20         30         40         50
RMEKHIENQK AWKIKYYKGL GTSTAKEAKE YFADMERHRI LFRYAGPEDD 
        60         70         80         90        100
AAITLAFSKK KIDDRKEWLT NFMEDRRQRR LHGLPEQFLY GTATKHLTYN 
       110        120        130        140        150
DFINKELILF SNSDNERSIP SLVDGFKPGQ RKVLFTCFKR NDKREVKVAQ 
       160        170        180        190        200
LAGSVAEMSA YHHGEQALMM TIVNLAQNFV GSNNINLLQP IGQFGTRLHG 
       210        220        230        240        250
GKDAASPRYI FTMLSTLARL LFPAVDDNLL KFLYDDNQRV EPEWYIPIIP 
       260        270        280        290        300
MVLINGAEGI GTGWACKLPN YDAREIVNNV RRMLDGLDPH PMLPNYKNFK 
       310        320        330        340        350
GTIQELGQNQ YAVSGEIFVV DRNTVEITEL PVRTWTQVYK EQVLEPMLNG 
       360        370        380        390        400
TDKTPALISD YKEYHTDTTV KFVVKMTEEK LAQAEAAGLH KVFKLQTTLT 
       410        420        430        440        450
CNSMVLFDHM GCLKKYETVQ DILKEFFDLR LSYYGLRKEW LVGMLGAEST 
       460        470        480        490        500
KLNNQARFIL EKIQGKITIE NRSKKDLIQM LVQRGYESDP VKAWKEAQEK 
       510        520        530        540        550
AAEEDETQNQ HDDSSSDSGT PSGPDFNYIL NMSLWSLTKE KVEELIKQRD 
       560        570        580        590        600
AKGREVNDLK RKSPSDLWKE DLAAFVEELD KVESQEREDV LAGMSGKAIK 
       610        620        630        640        650
GKVGKPKVKK LQLEETMPSP YGRRIIPEIT AMKADASKKL LKKKKGDLDT 
       660        670        680        690        700
AAVKVEFDEE FSGAPVEGAG EEALTPSVPI NKGPKPKREK KEPGTRVRKT 
       710        720        730        740        750
PTSSGKPSAK KVKKRNPWSD DESKSESDLE ETEPVVIPRD SLLRRAAAER 
       760        770        780        790        800
PKYTFDFSEE EDDDADDDDD DNNDLEELKV KASPITNDGE DEFVPSDGLD 
       810        820        830        840        850
KDEYTFSPGK SKATPEKSLH DKKSQDFGNL FSFPSYSQKS EDDSAKFDSN 
       860        870        880        890        900
EEDSASVFSP SFGLKQTDKV PSKTVAAKKG KPSSDTVPKP KRAPKQKKVV 
       910        920        930        940        950
EAVNSDSDSE FGIPKKTTTP KGKGRGAKKR KASGSENEGD YNPGRKTSKT 
       960        970        980        990       1000
TSKKPKKTSF DQDSDVDIFP SDFPTEPPSL PRTGRARKEV KYFAESDEEE 

DDVDFAMFN                                             

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.</p><p><a href='../manual/non_ter' target='_top'>More...</a></p>Non-terminal residuei	1 – 1	1	Imported <p>Information which has been imported from another database using automatic procedures.</p> <p><a href="/manual/evidences#ECO:0000313">More…</a></p> Automatic assertion inferred from database entriesi EMBL:BAD92116.1

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ