Q59H32 (Q59H32_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Protocadherin gamma subfamily A, 3 isoform 1 variant EMBL BAD92164.1
Organism	Homo sapiens (Human) EMBL BAD92164.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	961 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain By similarity. SAAS SAAS015919
Sequence similarities	Contains 6 cadherin domains. SAAS SAAS013164

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS013164
Cellular component	Cell membrane SAAS SAAS013164 Membrane
Domain	Repeat SAAS SAAS013164 Transmembrane Transmembrane helix SAAS SAAS013164
Ligand	Calcium SAAS SAAS013164 RuleBase RU000484
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92164.1

Sequences

	Sequence		Length	Mass (Da)
	Q59H32 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: B0BB55883E84BCD2	FASTA	961	104,536
	10 20 30 40 50 60 KTSFLEKIRL ESVVGNWNRI QRKRFTEKEM TNCLSFRNGR GLALLCALLG TLCETGSGQI 70 80 90 100 110 120 RYSVSEELDK GSFVGNIAND LGLEPRELAE RGVRIVSRGR TQLFSLNSQS GSLVTAERID 130 140 150 160 170 180 REELCAQIPL CLVKINILVE DKLKIFEVEI EIKDINDNAP NFPTEELEIK IGELTVPGTR 190 200 210 220 230 240 FPIKTAFDPD VGINSLQNYK LSPNDYFSLA VNSVSEGAKY PELVLERALD REKKEIHQLV 250 260 270 280 290 300 LVASDGGDPV HSGNLHIQVI VLDANDNPPM FTQPEYRVSV WENVPVGTRL LTVNATDPDE 310 320 330 340 350 360 GFNAQVSYIL DKMPGKIAEI FHLNSVSGEV SILKSLDYED AMFYEIKIEA QDGPGLLSRA 370 380 390 400 410 420 KILVTVLDVN DNAPEITITS LTSSVPEEGT VGREIALIDV HDRDSGQNGQ VEVFVLGNLP 430 440 450 460 470 480 FKLEKSIDQY YRLVTATSLD REQISEYNIS LRASDGGSPP LSTETHITLH VIDINDNPPT 490 500 510 520 530 540 FPHLSYSAYI PENNPRGASI FSVTAQDPDS NNNARITYAL TEDTLQGAPL SSFVSINSNT 550 560 570 580 590 600 GVLYALRSFD YEQFRDLKLL VTASDSGNPP LSSNVSLNLF VLDQNDNAPE ILYPALPTDG 610 620 630 640 650 660 STGVELAPRS AEPGYLVTKV VAVDRDSGQN AWLSYRLLKA SEPGLFSVGL HTGEVRTARA 670 680 690 700 710 720 LLDRDALKQS LVVAVQDHGQ PPLSATVTLT VAVADRIPDI LADLGSLEPS AKPNDSDLTL 730 740 750 760 770 780 YLVVAVAAVS CVFLAFVIVL LALRLRRWHK SRLLQASGGG LASTPGSHFV GADGVRAFLQ 790 800 810 820 830 840 TYSHEVSLTA DSRKSHLIFP QPNYADTLIS QESCEKSEPL LITQDLLEMK GDSNLLQQAP 850 860 870 880 890 900 PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM ILASASEAAD GSSTLGGGAG 910 920 930 940 950 960 TMGLSARYGP QFTLQHVPDY RQNVYIPGSN ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92164.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB208927 mRNA. Translation: BAD92164.1.
IPI	IPI00295053.
UniGene	Hs.368160.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q59H32.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000220892.
HOVERGEN	HBG054878.
Gene expression databases
ArrayExpress	Q59H32.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 4 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59H32_HUMAN

Accession

Primary (citable) accession number: Q59H32

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.