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Protein
Submitted name:

Protocadherin gamma subfamily A, 3 isoform 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin gamma subfamily A, 3 isoform 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei718 – 743HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ59H32.
PeptideAtlasiQ59H32.
PRIDEiQ59H32.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000253812.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 160CAInterPro annotationAdd BLAST113
Domaini184 – 269CAInterPro annotationAdd BLAST86
Domaini293 – 374CAInterPro annotationAdd BLAST82
Domaini398 – 479CAInterPro annotationAdd BLAST82
Domaini503 – 589CAInterPro annotationAdd BLAST87
Domaini620 – 698CAInterPro annotationAdd BLAST79

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
PfamiView protein in Pfam
PF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 6 hits.
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 3 hits.

Sequencei

Sequence statusi: Fragment.

Q59H32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KTSFLEKIRL ESVVGNWNRI QRKRFTEKEM TNCLSFRNGR GLALLCALLG
60 70 80 90 100
TLCETGSGQI RYSVSEELDK GSFVGNIAND LGLEPRELAE RGVRIVSRGR
110 120 130 140 150
TQLFSLNSQS GSLVTAERID REELCAQIPL CLVKINILVE DKLKIFEVEI
160 170 180 190 200
EIKDINDNAP NFPTEELEIK IGELTVPGTR FPIKTAFDPD VGINSLQNYK
210 220 230 240 250
LSPNDYFSLA VNSVSEGAKY PELVLERALD REKKEIHQLV LVASDGGDPV
260 270 280 290 300
HSGNLHIQVI VLDANDNPPM FTQPEYRVSV WENVPVGTRL LTVNATDPDE
310 320 330 340 350
GFNAQVSYIL DKMPGKIAEI FHLNSVSGEV SILKSLDYED AMFYEIKIEA
360 370 380 390 400
QDGPGLLSRA KILVTVLDVN DNAPEITITS LTSSVPEEGT VGREIALIDV
410 420 430 440 450
HDRDSGQNGQ VEVFVLGNLP FKLEKSIDQY YRLVTATSLD REQISEYNIS
460 470 480 490 500
LRASDGGSPP LSTETHITLH VIDINDNPPT FPHLSYSAYI PENNPRGASI
510 520 530 540 550
FSVTAQDPDS NNNARITYAL TEDTLQGAPL SSFVSINSNT GVLYALRSFD
560 570 580 590 600
YEQFRDLKLL VTASDSGNPP LSSNVSLNLF VLDQNDNAPE ILYPALPTDG
610 620 630 640 650
STGVELAPRS AEPGYLVTKV VAVDRDSGQN AWLSYRLLKA SEPGLFSVGL
660 670 680 690 700
HTGEVRTARA LLDRDALKQS LVVAVQDHGQ PPLSATVTLT VAVADRIPDI
710 720 730 740 750
LADLGSLEPS AKPNDSDLTL YLVVAVAAVS CVFLAFVIVL LALRLRRWHK
760 770 780 790 800
SRLLQASGGG LASTPGSHFV GADGVRAFLQ TYSHEVSLTA DSRKSHLIFP
810 820 830 840 850
QPNYADTLIS QESCEKSEPL LITQDLLEMK GDSNLLQQAP PNTDWRFSQA
860 870 880 890 900
QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM ILASASEAAD GSSTLGGGAG
910 920 930 940 950
TMGLSARYGP QFTLQHVPDY RQNVYIPGSN ATLTNAAGKR DGKAPAGGNG
960
NKKKSGKKEK K
Length:961
Mass (Da):104,536
Last modified:April 26, 2005 - v1
Checksum:iB0BB55883E84BCD2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208927 mRNA. Translation: BAD92164.1.
UniGeneiHs.368160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208927 mRNA. Translation: BAD92164.1.
UniGeneiHs.368160.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000253812.

Proteomic databases

PaxDbiQ59H32.
PeptideAtlasiQ59H32.
PRIDEiQ59H32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
PfamiView protein in Pfam
PF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 6 hits.
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59H32_HUMAN
AccessioniPrimary (citable) accession number: Q59H32
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 10, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.