Q59H18 (TNI3K_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase TNNI3K
EC=2.7.11.1

Alternative name(s):
Cardiac ankyrin repeat kinase
Cardiac troponin I-interacting kinase
TNNI3-interacting kinase

Gene names

Name:	TNNI3K
Synonyms:	CARK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	835 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cardiac physiology. Ref.1
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Ref.1
Cofactor	Magnesium. Ref.1
Subunit structure	Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB. Ref.1
Subcellular location	Nucleus. Cytoplasm. Note: Expressed at lower levels in the cytoplasm. Ref.1
Tissue specificity	Highly expressed in both adult and fetal heart. Ref.1
Post-translational modification	Autophosphorylated. Ref.1
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 10 ANK repeats. Contains 1 protein kinase domain.
Sequence caution	The sequence BAD92178.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAE45949.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.1PubMed 18205602. Source: UniProtKB nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase activity Inferred from direct assay Ref.1. Source: UniProtKB protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TNNI3	P19429	2	EBI-704142,EBI-704146

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 Ref.1 (identifier: Q59H18-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q59H18-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGNYKSRPTQTCT → MAAARDPPEV...NSFTILLIHS

Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

Isoform 3 (identifier: Q59H18-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGNYKSRPTQTCT → MAAARDPPEV...NSFTILLIHS
     591-596: SHNILL → RYFFPK
     597-835: Missing.

Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

Isoform 4 (identifier: Q59H18-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGNYKSRPTQTCT → MAAARDPPEV...NSFTILLIHS
     708-742: GRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSP → AKSRPSHYPVSSVYTETLKKKNEDRFGMWIEYLRR
     743-835: Missing.

Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 835	835	Serine/threonine-protein kinase TNNI3K		PRO_0000086757
Regions
	Repeat	66 – 96	31	ANK 1
	Repeat	100 – 129	30	ANK 2
	Repeat	133 – 162	30	ANK 3
	Repeat	166 – 195	30	ANK 4
	Repeat	199 – 228	30	ANK 5
	Repeat	234 – 263	30	ANK 6
	Repeat	269 – 298	30	ANK 7
	Repeat	304 – 335	32	ANK 8
	Repeat	339 – 368	30	ANK 9
	Repeat	381 – 410	30	ANK 10
	Domain	463 – 723	261	Protein kinase
	Nucleotide binding	469 – 477	9	ATP By similarity
	Coiled coil	21 – 51	31	Potential
	Compositional bias	733 – 746	14	Poly-Ser
Sites
	Active site	588	1	Proton acceptor By similarity
	Binding site	490	1	ATP
Natural variations
	Alternative sequence	1 – 13	13	MGNYK…TQTCT → MAAARDPPEVSLREATQRKL RRFSELRGKLVARGEFWDIV AITAADEKQELAYNQQLSEK LKRKELPLGVQYHVFVDPAG AKIGNGGSTLCALQCLEKLY GDKWNSFTILLIHS in isoform 1, isoform 3 and isoform 4.		VSP_039403
	Alternative sequence	591 – 596	6	SHNILL → RYFFPK in isoform 3.		VSP_051882
	Alternative sequence	597 – 835	239	Missing in isoform 3.		VSP_051883
	Alternative sequence	708 – 742	35	GRPEF…GSLSP → AKSRPSHYPVSSVYTETLKK KNEDRFGMWIEYLRR in isoform 4.		VSP_051884
	Alternative sequence	743 – 835	93	Missing in isoform 4.		VSP_051885
	Natural variant	151	1	D → H. Ref.10 Corresponds to variant rs34874695 [ dbSNP | Ensembl ].		VAR_041223
	Natural variant	263	1	P → L. Ref.10 Corresponds to variant rs34521608 [ dbSNP | Ensembl ].		VAR_041224
	Natural variant	309	1	F → L. Ref.10		VAR_041225
	Natural variant	430	1	S → L in a colorectal adenocarcinoma sample; somatic mutation. Ref.10		VAR_041226
	Natural variant	510	1	V → L. Ref.10 Corresponds to variant rs34335537 [ dbSNP | Ensembl ].		VAR_041227
	Natural variant	629	1	R → G in a colorectal cancer sample; somatic mutation. Ref.9		VAR_035639
	Natural variant	637	1	T → M. Ref.10 Corresponds to variant rs2274260 [ dbSNP | Ensembl ].		VAR_041228
	Natural variant	686	1	I → T. Ref.10 Corresponds to variant rs3737564 [ dbSNP | Ensembl ].		VAR_041229
	Natural variant	785	1	A → G. Ref.5 Corresponds to variant rs45578635 [ dbSNP | Ensembl ].		VAR_038821
	Natural variant	798	1	M → I in a head & Neck squamous cell carcinoma sample; somatic mutation. Ref.10		VAR_041230
	Natural variant	833	1	D → Y. Ref.5 Corresponds to variant rs45614933 [ dbSNP | Ensembl ].		VAR_038822
Experimental info
	Mutagenesis	490	1	K → R: Loss of autophosphorylation activity. Ref.1
	Sequence conflict	127	1	I → V in AAH32865. Ref.8
	Sequence conflict	250	1	I → M in CAE45949. Ref.4
	Sequence conflict	367	1	N → S in CAE45949. Ref.4
	Sequence conflict	629	1	R → L in AAH32865. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified July 13, 2010. Version 3. Checksum: 3B21484B434F46E8	FASTA	835	92,851
	10 20 30 40 50 60 MGNYKSRPTQ TCTDEWKKKV SESYVITIER LEDDLQIKEK ELTELRNIFG SDEAFSKVNL 70 80 90 100 110 120 NYRTENGLSL LHLCCICGGK KSHIRTLMLK GLRPSRLTRN GFTALHLAVY KDNAELITSL 130 140 150 160 170 180 LHSGADIQQV GYGGLTALHI ATIAGHLEAA DVLLQHGANV NIQDAVFFTP LHIAAYYGHE 190 200 210 220 230 240 QVTRLLLKFG ADVNVSGEVG DRPLHLASAK GFLNIAKLLM EEGSKADVNA QDNEDHVPLH 250 260 270 280 290 300 FCSRFGHHDI VKYLLQSDLE VQPHVVNIYG DTPLHLACYN GKFEVAKEII QISGTESLTK 310 320 330 340 350 360 ENIFSETAFH SACTYGKSID LVKFLLDQNV ININHQGRDG HTGLHSACYH GHIRLVQFLL 370 380 390 400 410 420 DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL LKHYKRPQDE LPCNEYSQPG 430 440 450 460 470 480 GDGSYVSVPS PLGKIKSMTK EKADILLLRA GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG 490 500 510 520 530 540 RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCQLNHPC VIQFVGACLN DPSQFAIVTQ 550 560 570 580 590 600 YISGGSLFSL LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG 610 620 630 640 650 660 HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS YALCLWEILT 670 680 690 700 710 720 GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLIR GWNACPEGRP EFSEVVMKLE 730 740 750 760 770 780 ECLCNIELMS PASSNSSGSL SPSSSSDCLV NRGGPGRSHV AALRSRFELE YALNARSYAA 790 800 810 820 830 LSQSAGQYSS QGLSLEEMKR SLQYTPIDKY GYVSDPMSSM HFHSCRNSSS FEDSS
	Isoform 1 [UniParc]. Checksum: 081220549646863F	FASTA	936	104,179
	10 20 30 40 50 60 MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 70 80 90 100 110 120 LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSDEWKKK 130 140 150 160 170 180 VSESYVITIE RLEDDLQIKE KELTELRNIF GSDEAFSKVN LNYRTENGLS LLHLCCICGG 190 200 210 220 230 240 KKSHIRTLML KGLRPSRLTR NGFTALHLAV YKDNAELITS LLHSGADIQQ VGYGGLTALH 250 260 270 280 290 300 IATIAGHLEA ADVLLQHGAN VNIQDAVFFT PLHIAAYYGH EQVTRLLLKF GADVNVSGEV 310 320 330 340 350 360 GDRPLHLASA KGFLNIAKLL MEEGSKADVN AQDNEDHVPL HFCSRFGHHD IVKYLLQSDL 370 380 390 400 410 420 EVQPHVVNIY GDTPLHLACY NGKFEVAKEI IQISGTESLT KENIFSETAF HSACTYGKSI 430 440 450 460 470 480 DLVKFLLDQN VININHQGRD GHTGLHSACY HGHIRLVQFL LDNGADMNLV ACDPSRSSGE 490 500 510 520 530 540 KDEQTCLMWA YEKGHDAIVT LLKHYKRPQD ELPCNEYSQP GGDGSYVSVP SPLGKIKSMT 550 560 570 580 590 600 KEKADILLLR AGLPSHFHLQ LSEIEFHEII GSGSFGKVYK GRCRNKIVAI KRYRANTYCS 610 620 630 640 650 660 KSDVDMFCRE VSILCQLNHP CVIQFVGACL NDPSQFAIVT QYISGGSLFS LLHEQKRILD 670 680 690 700 710 720 LQSKLIIAVD VAKGMEYLHN LTQPIIHRDL NSHNILLYED GHAVVADFGE SRFLQSLDED 730 740 750 760 770 780 NMTKQPGNLR WMAPEVFTQC TRYTIKADVF SYALCLWEIL TGEIPFAHLK PAAAAADMAY 790 800 810 820 830 840 HHIRPPIGYS IPKPISSLLI RGWNACPEGR PEFSEVVMKL EECLCNIELM SPASSNSSGS 850 860 870 880 890 900 LSPSSSSDCL VNRGGPGRSH VAALRSRFEL EYALNARSYA ALSQSAGQYS SQGLSLEEMK 910 920 930 RSLQYTPIDK YGYVSDPMSS MHFHSCRNSS SFEDSS
	Isoform 3 [UniParc]. Checksum: 7567E27D45485C9C	FASTA	697	77,957
	10 20 30 40 50 60 MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 70 80 90 100 110 120 LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSDEWKKK 130 140 150 160 170 180 VSESYVITIE RLEDDLQIKE KELTELRNIF GSDEAFSKVN LNYRTENGLS LLHLCCICGG 190 200 210 220 230 240 KKSHIRTLML KGLRPSRLTR NGFTALHLAV YKDNAELITS LLHSGADIQQ VGYGGLTALH 250 260 270 280 290 300 IATIAGHLEA ADVLLQHGAN VNIQDAVFFT PLHIAAYYGH EQVTRLLLKF GADVNVSGEV 310 320 330 340 350 360 GDRPLHLASA KGFLNIAKLL MEEGSKADVN AQDNEDHVPL HFCSRFGHHD IVKYLLQSDL 370 380 390 400 410 420 EVQPHVVNIY GDTPLHLACY NGKFEVAKEI IQISGTESLT KENIFSETAF HSACTYGKSI 430 440 450 460 470 480 DLVKFLLDQN VININHQGRD GHTGLHSACY HGHIRLVQFL LDNGADMNLV ACDPSRSSGE 490 500 510 520 530 540 KDEQTCLMWA YEKGHDAIVT LLKHYKRPQD ELPCNEYSQP GGDGSYVSVP SPLGKIKSMT 550 560 570 580 590 600 KEKADILLLR AGLPSHFHLQ LSEIEFHEII GSGSFGKVYK GRCRNKIVAI KRYRANTYCS 610 620 630 640 650 660 KSDVDMFCRE VSILCQLNHP CVIQFVGACL NDPSQFAIVT QYISGGSLFS LLHEQKRILD 670 680 690 LQSKLIIAVD VAKGMEYLHN LTQPIIHRDL NRYFFPK
	Isoform 4 [UniParc]. Checksum: 3001399FAEAD7B24	FASTA	843	94,517
	10 20 30 40 50 60 MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 70 80 90 100 110 120 LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSDEWKKK 130 140 150 160 170 180 VSESYVITIE RLEDDLQIKE KELTELRNIF GSDEAFSKVN LNYRTENGLS LLHLCCICGG 190 200 210 220 230 240 KKSHIRTLML KGLRPSRLTR NGFTALHLAV YKDNAELITS LLHSGADIQQ VGYGGLTALH 250 260 270 280 290 300 IATIAGHLEA ADVLLQHGAN VNIQDAVFFT PLHIAAYYGH EQVTRLLLKF GADVNVSGEV 310 320 330 340 350 360 GDRPLHLASA KGFLNIAKLL MEEGSKADVN AQDNEDHVPL HFCSRFGHHD IVKYLLQSDL 370 380 390 400 410 420 EVQPHVVNIY GDTPLHLACY NGKFEVAKEI IQISGTESLT KENIFSETAF HSACTYGKSI 430 440 450 460 470 480 DLVKFLLDQN VININHQGRD GHTGLHSACY HGHIRLVQFL LDNGADMNLV ACDPSRSSGE 490 500 510 520 530 540 KDEQTCLMWA YEKGHDAIVT LLKHYKRPQD ELPCNEYSQP GGDGSYVSVP SPLGKIKSMT 550 560 570 580 590 600 KEKADILLLR AGLPSHFHLQ LSEIEFHEII GSGSFGKVYK GRCRNKIVAI KRYRANTYCS 610 620 630 640 650 660 KSDVDMFCRE VSILCQLNHP CVIQFVGACL NDPSQFAIVT QYISGGSLFS LLHEQKRILD 670 680 690 700 710 720 LQSKLIIAVD VAKGMEYLHN LTQPIIHRDL NSHNILLYED GHAVVADFGE SRFLQSLDED 730 740 750 760 770 780 NMTKQPGNLR WMAPEVFTQC TRYTIKADVF SYALCLWEIL TGEIPFAHLK PAAAAADMAY 790 800 810 820 830 840 HHIRPPIGYS IPKPISSLLI RGWNACPEAK SRPSHYPVSS VYTETLKKKN EDRFGMWIEY LRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I." Zhao Y., Meng X.-M., Wei Y.-J., Zhao X.-W., Liu D.-Q., Cao H.-Q., Liew C.-C., Ding J.-F. J. Mol. Med. 81:297-304(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION, INTERACTION WITH TNNI3; ACTC; ACTA1; MYBPC3; AIP; BABP3 AND HADHB, MUTAGENESIS OF LYS-490. Tissue: Heart.
[2]	"Cardiac ankyrin repeat kinase (CARK)." Jeyaseelan R. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Fetal kidney.
[5]	SeattleSNPs variation discovery resource Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-785 AND TYR-833.
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Brain.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-629.
[10]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-151; LEU-263; LEU-309; LEU-430; LEU-510; MET-637; THR-686 AND ILE-798.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF116826 mRNA. Translation: AAD29632.1. AY303691 mRNA. Translation: AAP72030.1. AB208941 Transcribed RNA. Translation: BAD92178.1. Different initiation. BX640903 mRNA. Translation: CAE45949.1. Different initiation. DQ822519 Genomic DNA. Translation: ABG46944.1. BX470253 , AC093158, AC098692, AC105271, AC119672 Genomic DNA. Translation: CAI16293.1. CH471059 Genomic DNA. Translation: EAX06415.1. BC032865 mRNA. Translation: AAH32865.1. BC113539 mRNA. Translation: AAI13540.1. BC117262 mRNA. Translation: AAI17263.1.
IPI	IPI00006465. IPI00644212. IPI00645178. IPI00655547.
RefSeq	NP_001106279.1. NM_001112808.2. NP_001186256.1. NM_001199327.1. NP_057062.1. NM_015978.2.
UniGene	Hs.480085.
3D structure databases
ProteinModelPortal	Q59H18.
SMR	Q59H18. Positions 38-721.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q59H18. 7 interactions.
PTM databases
PhosphoSite	Q59H18.
Polymorphism databases
DMDM	300669705.
Proteomic databases
PRIDE	Q59H18.
Protocols and materials databases
DNASU	51086.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326637; ENSP00000322251; ENSG00000116783. ENST00000370891; ENSP00000359928; ENSG00000116783.
GeneID	100526835. 51086.
KEGG	hsa:100526835. hsa:51086.
UCSC	uc001dgc.2. human. uc001dgd.3. human. uc001dge.2. human. uc001dgf.2. human.
Organism-specific databases
CTD	100526835. 51086.
GeneCards	GC01P074669. GC01P074671.
HGNC	HGNC:19661. TNNI3K.
MIM	613932. gene.
neXtProt	NX_Q59H18.
PharmGKB	PA134976654.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000234421.
HOVERGEN	HBG079513.
InParanoid	Q59H18.
OMA	HVVNIYG.
PhylomeDB	Q59H18.
Gene expression databases
ArrayExpress	Q59H18.
Bgee	Q59H18.
CleanEx	HS_TNNI3K.
Genevestigator	Q59H18.
GermOnline	ENSG00000116783. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 3 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 10 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 6 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q59H18.
ChEMBL	CHEMBL5260.
NextBio	53751.
SOURCE	Search...

Entry information

Entry name

TNI3K_HUMAN

Accession

Primary (citable) accession number: Q59H18
Secondary accession number(s): Q17RN0 , Q49AR1, Q6MZS9, Q9Y2V6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.