Q59H14 (Q59H14_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: PREDICTED: integrin, alpha D variant EMBL BAD92182.1
Organism	Homo sapiens (Human) EMBL BAD92182.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1177 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU003762.
Sequence similarities	Belongs to the integrin alpha chain family. RuleBase RU003762

Ontologies

Keywords
Biological process	Cell adhesion RuleBase RU003762 SAAS SAAS013519
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS013519
Molecular function	Integrin RuleBase RU003762 SAAS SAAS013519 EMBL BAD92182.1 Receptor RuleBase RU003762 SAAS SAAS013519
Gene Ontology (GO)
Biological_process	activated T cell proliferation Inferred from electronic annotation. Source: Compara cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integrin complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92182.1

Sequences

	Sequence		Length	Mass (Da)
	Q59H14 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A7BBC68CE26B49C3	FASTA	1,177	128,451
	10 20 30 40 50 60 CALSPTFHFP STRCSGMTFG TVLLLSVLAS YHGFNLDVEE PTIFQEDAGG FGQSVVQFGG 70 80 90 100 110 120 SRLVVGAPLE VVAANQTGRL YDCAAATGMC QPIPLHIRPE AVNMSLGLTL AASTNGSRLL 130 140 150 160 170 180 ACGPTLHRVC GENSYSKGSC LLLGSRWEII QTVPDATPEC PHQEMDIVFL IDGSGSIDQN 190 200 210 220 230 240 DFNQMKGFVQ AVMGQFEGTD TLFALMQYSN LLKIHFTFTQ FRTSPSQQSL VDPIVQLKGL 250 260 270 280 290 300 TFTATGILTV VTQLFHHKNG ARKSAKKILI VITDGQKYKD PLEYSDVIPQ AEKAGIIRYA 310 320 330 340 350 360 IGVGHAFQGP TARQELNTIS SAPPQDHVFK VDNFAALGSI QKQLQEKIYA VEGTQSRASS 370 380 390 400 410 420 SFQHEMSQEG FSTALTMDGL FLGAVGSFSW SGGAFLYPPN MSPTFINMSQ ENVDMRDSYL 430 440 450 460 470 480 GYSTELALWK GVQNLVLGAP RYQHTGKAVI FTQVSRQWRK KAEVTGTQIG SYFGASLCSV 490 500 510 520 530 540 DVDSDGSTDL ILIGAPHYYE QTRGGQVSVC PLPRGRVQWQ CDAVLRGEQG HPWGRFGAAL 550 560 570 580 590 600 TVLGDVNEDK LIDVAIGAPG EQENRGAVYL FHGASESGIS PSHSQRIASS QLSPRLQYFG 610 620 630 640 650 660 QALSGGQDLT QDGLMDLAVG ARGQVLLLRS LPVLKVGVAM RFSPVEVAKA VYRCWEEKPS 670 680 690 700 710 720 ALEAGDATVC LTIQKSSLDQ LGDIQSSVRF DLALDPGRLT SRAIFNETKN PTLTRRKTLG 730 740 750 760 770 780 LGIHCETLKL LLPDCVEDVV SPIILHLNFS LVREPIPSPQ NLRPVLAVGS QDLFTASLPF 790 800 810 820 830 840 EKNCGQDGLC EGDLGVTLSF SGLQTLTVGS SLELNVIVTV WNAGEDSYGT VVSLYYPAGL 850 860 870 880 890 900 SHRRVSGAQK QPHQSALRLA CETVPTEDEG LRSSRCSVNH PIFHEGSNGT FIVTFDVSYK 910 920 930 940 950 960 ATLGDRMLMR ASASSENNKA SSSKATFQLE LPVKYAVYTM ISRQEESTKY FNFATSDEKK 970 980 990 1000 1010 1020 MKEAEHRYRV NNLSQRDLAI SINFWVPVLL NGVAVWDVVM EAPSQSLPCV SERKPPQHSD 1030 1040 1050 1060 1070 1080 FLTQISRSPM LDCSIADCLQ FRCDVPSFSV QEELDFTLKG NLSFGWVRET LQKKVLVVSV 1090 1100 1110 1120 1130 1140 AEITFDTSVY SQLPGQEAFM RAQMEMVLEE DEVYNAIPII MGSSVGALLL LALITATLYK 1150 1160 1170 LGFFKRHYKE MLEDKPEDTA TFSGDDFSCV APNVPLS

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Spleen EMBL BAD92182.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB208945 mRNA. Translation: BAD92182.1.
IPI	IPI00942758.
RefSeq	NP_005344.2. NM_005353.2.
UniGene	Hs.679163.
3D structure databases
ProteinModelPortal	Q59H14.
SMR	Q59H14. Positions 166-346, 355-1175.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59H14.
Proteomic databases
PRIDE	Q59H14.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3681.
KEGG	hsa:3681.
Organism-specific databases
CTD	3681.
PharmGKB	PA29946.
Phylogenomic databases
HOGENOM	HOG000113114.
HOVERGEN	HBG100530.
KO	K06594.
OMA	ELNTIGS.
OrthoDB	EOG4TQM86.
Gene expression databases
ArrayExpress	Q59H14.
Bgee	Q59H14.
Family and domain databases
InterPro	IPR013519. Int_alpha_beta-p. IPR000413. Integrin_alpha. IPR013649. Integrin_alpha-2. IPR018184. Integrin_alpha_C_CS. IPR002035. VWF_A. [Graphical view]
Pfam	PF00357. Integrin_alpha. 1 hit. PF08441. Integrin_alpha2. 1 hit. PF00092. VWA. 1 hit. [Graphical view]
PRINTS	PR01185. INTEGRINA.
SMART	SM00191. Int_alpha. 5 hits. SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS51470. FG_GAP. 7 hits. PS00242. INTEGRIN_ALPHA. 1 hit. PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3681.
NextBio	14407.

Entry information

Entry name

Q59H14_HUMAN

Accession

Primary (citable) accession number: Q59H14

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	March 6, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.