ID   Q59H01_HUMAN            Unreviewed;       895 AA.
AC   Q59H01;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   13-SEP-2023, entry version 82.
DE   SubName: Full=Protocadherin gamma subfamily A, 7 isoform 1 variant {ECO:0000313|EMBL:BAD92195.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92195.1};
RN   [1] {ECO:0000313|EMBL:BAD92195.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92195.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC       involved in the establishment and maintenance of specific neuronal
CC       connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   EMBL; AB208958; BAD92195.1; -; mRNA.
DR   AlphaFoldDB; Q59H01; -.
DR   PeptideAtlas; Q59H01; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR031904; Cadherin_CBD.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF56; PROTOCADHERIN GAMMA-A7; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   Pfam; PF15974; Cadherin_tail; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        652..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          38..96
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          97..205
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          206..310
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          311..415
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          416..525
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          542..645
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          768..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          865..895
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92195.1"
SQ   SEQUENCE   895 AA;  97572 MW;  9CBD698A3B1CD864 CRC64;
     ETDKGSFVGD IAKDLGLEPR ELAERGVRII SRGRTQLFAL NQRSGSLVTA GRIDREEICA
     QSARCLVNFN ILMEDKMNLY PIDVEIIDIN DNVPRFLTEE INVKIMENTA PGVRFPLSEA
     GDPDVGTNSL QSYQLSPNRH FSLAVQSGDD GTKYPELVLE RVLDREEERV HHLVFTASDG
     GDPPRSSTAH IQVTVVDVND HTPVFSLPQY QVTVPENVPV GTRLLTVHAI DLDEGVNGEV
     TYSFRKITPK LPKMFHLNSL TGEISTLEGL DYEETAFYEM EVQAQDGPGS LTKAKVLITV
     LDVNDNAPEV TMTSLSSSIP EDTPLGTVIA LFYLQDRDSG KNGEVTCTIP ENLPFKLEKS
     IDNYYRLVTT KNLDRETLSL YNITLKATDG GTPPLSRETH IFMQVADTND NPPTFPHSSY
     SVYIAENNPR GASIFLVTAQ DHDSEDNAQI TYSLAEDTIQ GAPVSSYVSI NSDTGVLYAL
     QSFDYEQLRE LQLRVTAHDS GDPPLSSNMS LSLFVLDQND NPPEILYPAL PTDGSTGMEL
     APRSAEPGYL VTKVVAVDKD SGQNAWLSYL LLKASEPGLF AVGLYTGEVR TARALLDRDA
     LKQSLVVAVQ DHGQPPLSAT VTLTVAVADS IPEVLADLGS LEPSDGPYNY DLTLYLVVAV
     ATVSCVFLAF VLVLLALRLR RWHKSRLLQA SEGGLANVPT SHFVGMDGVQ AFLQTYSHEV
     SLTADSRKSH LIFPQPNYVD MLISQESCEK NDSLLTSVDF QECKENLPSI QQAPPNTDWR
     FSQAQRPGTS GSQNGDDTGT WPNNQFDTEM LQAMILASAS EAADGSSTLG GGAGTMGLSA
     RYGPQFTLQH VPDYRQNVYI PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
//