Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal transducer and activator of transcription

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Enzyme and pathway databases

SignaLinkiQ59GY7.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

MaxQBiQ59GY7.
PaxDbiQ59GY7.
PeptideAtlasiQ59GY7.

Expressioni

Gene expression databases

GenevisibleiQ59GY7. HS.

Structurei

3D structure databases

ProteinModelPortaliQ59GY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini560 – 657SH2InterPro annotationAdd BLAST98

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOVERGENiHBG107486.
KOiK11223.

Family and domain databases

Gene3Di1.10.532.10. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR001217. STAT.
IPR035858. STAT5a/5b.
IPR036535. STAT_N_sf.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
PANTHERiPTHR11801. PTHR11801. 2 hits.
PTHR11801:SF47. PTHR11801:SF47. 2 hits.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59GY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TAMAGWIQAQ QLQGDALRQM QVLYGQHFPI EVRHYLAQWI ESQPWDAIDL
60 70 80 90 100
DNPQDRAQAT QLLEGLVQEL QKKAEHQVGE DGFLLKIKLG HYATQLQKTY
110 120 130 140 150
DRCPLELVRC IRHILYNEQR LVREANNCSS PAGILVDAMS QKHLQINQTF
160 170 180 190 200
EELRLVTQDT ENELKKLQQT QEYFIIQYQE SLRIQAQFAQ LAQLSPQERL
210 220 230 240 250
SRETALQQKQ VSLEAWLQRE AQTLQQYRVE LAEKHQKTLQ LLRKQQTIIL
260 270 280 290 300
DDELIQWKRR QQLAGNGGPP EGSLDVLQSW CEKLAEIIWQ NRQQIRRAEH
310 320 330 340 350
LCQQLPIPGP VEEMLAEVNA TITDIISALV TSTFIIEKQP PQVLKTQTKF
360 370 380 390 400
AATVRLLVGG KLNVHMNPPQ VKATIISEQQ AKSLLKNENT RNECSGEILN
410 420 430 440 450
NCCVMEYHQA TGTLSAHFRN MSLKRIKRAD RRGAESVTEE KFTVLFESQF
460 470 480 490 500
SVGSNELVFQ VKGRVPFAVP DKVLWPQLCE ALNMKFKAEV QSNRGLTKEN
510 520 530 540 550
LVFLAQKLFN NSSSHLEDYS GLSVSWSQFN RENLPGWNYT FWQWFDGVME
560 570 580 590 600
VLKKHHKPHW NDGAILGFVN KQQAHDLLIN KPDGTFLLRF SDSEIGGITI
610 620 630 640 650
AWKFDSPERN LWNLKPFTTR DFSIRSLADR LGDLSYLIYV FPDRPKDEVF
660 670 680 690 700
SKYYTPVLAK AVDGYVKPQI KQVVPEFVNA SADAGGSSAT YMDQAPSPAV
710 720 730 740 750
CPQAPYNMYP QNPDHVLDQD GEFDLDETMD VARHVEELLR RPMDSLDSRL
760
SPPAGLFTSA RGSLS
Length:765
Mass (Da):87,535
Last modified:April 26, 2005 - v1
Checksum:i9C1359E4174275E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208972 mRNA. Translation: BAD92209.1.
RefSeqiNP_001275647.1. NM_001288718.1.
NP_001275648.1. NM_001288719.1.
NP_001275649.1. NM_001288720.1.
NP_003143.2. NM_003152.3.
UniGeneiHs.437058.

Genome annotation databases

GeneIDi6776.
KEGGihsa:6776.

Similar proteinsi

Entry informationi

Entry nameiQ59GY7_HUMAN
AccessioniPrimary (citable) accession number: Q59GY7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.