Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal transducer and activator of transcription

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Enzyme and pathway databases

SignaLinkiQ59GY7

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

MaxQBiQ59GY7
PeptideAtlasiQ59GY7

Expressioni

Gene expression databases

GenevisibleiQ59GY7 HS

Structurei

3D structure databases

ProteinModelPortaliQ59GY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini560 – 657SH2InterPro annotationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili150 – 170Sequence analysisAdd BLAST21
Coiled coili217 – 237Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
HOVERGENiHBG107486
KOiK11223

Family and domain databases

Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035858 STAT5a/5b
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 2 hits
PTHR11801:SF47 PTHR11801:SF47, 2 hits
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q59GY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TAMAGWIQAQ QLQGDALRQM QVLYGQHFPI EVRHYLAQWI ESQPWDAIDL
60 70 80 90 100
DNPQDRAQAT QLLEGLVQEL QKKAEHQVGE DGFLLKIKLG HYATQLQKTY
110 120 130 140 150
DRCPLELVRC IRHILYNEQR LVREANNCSS PAGILVDAMS QKHLQINQTF
160 170 180 190 200
EELRLVTQDT ENELKKLQQT QEYFIIQYQE SLRIQAQFAQ LAQLSPQERL
210 220 230 240 250
SRETALQQKQ VSLEAWLQRE AQTLQQYRVE LAEKHQKTLQ LLRKQQTIIL
260 270 280 290 300
DDELIQWKRR QQLAGNGGPP EGSLDVLQSW CEKLAEIIWQ NRQQIRRAEH
310 320 330 340 350
LCQQLPIPGP VEEMLAEVNA TITDIISALV TSTFIIEKQP PQVLKTQTKF
360 370 380 390 400
AATVRLLVGG KLNVHMNPPQ VKATIISEQQ AKSLLKNENT RNECSGEILN
410 420 430 440 450
NCCVMEYHQA TGTLSAHFRN MSLKRIKRAD RRGAESVTEE KFTVLFESQF
460 470 480 490 500
SVGSNELVFQ VKGRVPFAVP DKVLWPQLCE ALNMKFKAEV QSNRGLTKEN
510 520 530 540 550
LVFLAQKLFN NSSSHLEDYS GLSVSWSQFN RENLPGWNYT FWQWFDGVME
560 570 580 590 600
VLKKHHKPHW NDGAILGFVN KQQAHDLLIN KPDGTFLLRF SDSEIGGITI
610 620 630 640 650
AWKFDSPERN LWNLKPFTTR DFSIRSLADR LGDLSYLIYV FPDRPKDEVF
660 670 680 690 700
SKYYTPVLAK AVDGYVKPQI KQVVPEFVNA SADAGGSSAT YMDQAPSPAV
710 720 730 740 750
CPQAPYNMYP QNPDHVLDQD GEFDLDETMD VARHVEELLR RPMDSLDSRL
760
SPPAGLFTSA RGSLS
Length:765
Mass (Da):87,535
Last modified:April 26, 2005 - v1
Checksum:i9C1359E4174275E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208972 mRNA Translation: BAD92209.1
RefSeqiNP_001275647.1, NM_001288718.1
NP_001275648.1, NM_001288719.1
NP_001275649.1, NM_001288720.1
NP_003143.2, NM_003152.3
UniGeneiHs.437058

Genome annotation databases

GeneIDi6776
KEGGihsa:6776

Similar proteinsi

Entry informationi

Entry nameiQ59GY7_HUMAN
AccessioniPrimary (citable) accession number: Q59GY7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health