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Protein

Signal transducer and activator of transcription

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

SignaLinkiQ59GY7.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

EPDiQ59GY7.
PaxDbiQ59GY7.
PRIDEiQ59GY7.

Expressioni

Gene expression databases

BgeeiQ59GY7.
GenevisibleiQ59GY7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341208.

Structurei

3D structure databases

ProteinModelPortaliQ59GY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini560 – 65798SH2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOVERGENiHBG107486.
KOiK11223.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59GY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TAMAGWIQAQ QLQGDALRQM QVLYGQHFPI EVRHYLAQWI ESQPWDAIDL
60 70 80 90 100
DNPQDRAQAT QLLEGLVQEL QKKAEHQVGE DGFLLKIKLG HYATQLQKTY
110 120 130 140 150
DRCPLELVRC IRHILYNEQR LVREANNCSS PAGILVDAMS QKHLQINQTF
160 170 180 190 200
EELRLVTQDT ENELKKLQQT QEYFIIQYQE SLRIQAQFAQ LAQLSPQERL
210 220 230 240 250
SRETALQQKQ VSLEAWLQRE AQTLQQYRVE LAEKHQKTLQ LLRKQQTIIL
260 270 280 290 300
DDELIQWKRR QQLAGNGGPP EGSLDVLQSW CEKLAEIIWQ NRQQIRRAEH
310 320 330 340 350
LCQQLPIPGP VEEMLAEVNA TITDIISALV TSTFIIEKQP PQVLKTQTKF
360 370 380 390 400
AATVRLLVGG KLNVHMNPPQ VKATIISEQQ AKSLLKNENT RNECSGEILN
410 420 430 440 450
NCCVMEYHQA TGTLSAHFRN MSLKRIKRAD RRGAESVTEE KFTVLFESQF
460 470 480 490 500
SVGSNELVFQ VKGRVPFAVP DKVLWPQLCE ALNMKFKAEV QSNRGLTKEN
510 520 530 540 550
LVFLAQKLFN NSSSHLEDYS GLSVSWSQFN RENLPGWNYT FWQWFDGVME
560 570 580 590 600
VLKKHHKPHW NDGAILGFVN KQQAHDLLIN KPDGTFLLRF SDSEIGGITI
610 620 630 640 650
AWKFDSPERN LWNLKPFTTR DFSIRSLADR LGDLSYLIYV FPDRPKDEVF
660 670 680 690 700
SKYYTPVLAK AVDGYVKPQI KQVVPEFVNA SADAGGSSAT YMDQAPSPAV
710 720 730 740 750
CPQAPYNMYP QNPDHVLDQD GEFDLDETMD VARHVEELLR RPMDSLDSRL
760
SPPAGLFTSA RGSLS
Length:765
Mass (Da):87,535
Last modified:April 26, 2005 - v1
Checksum:i9C1359E4174275E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208972 mRNA. Translation: BAD92209.1.
RefSeqiNP_001275647.1. NM_001288718.1.
NP_001275648.1. NM_001288719.1.
NP_001275649.1. NM_001288720.1.
NP_003143.2. NM_003152.3.
UniGeneiHs.437058.

Genome annotation databases

GeneIDi6776.
KEGGihsa:6776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208972 mRNA. Translation: BAD92209.1.
RefSeqiNP_001275647.1. NM_001288718.1.
NP_001275648.1. NM_001288719.1.
NP_001275649.1. NM_001288720.1.
NP_003143.2. NM_003152.3.
UniGeneiHs.437058.

3D structure databases

ProteinModelPortaliQ59GY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341208.

Proteomic databases

EPDiQ59GY7.
PaxDbiQ59GY7.
PRIDEiQ59GY7.

Protocols and materials databases

DNASUi6776.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6776.
KEGGihsa:6776.

Organism-specific databases

CTDi6776.

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOVERGENiHBG107486.
KOiK11223.

Enzyme and pathway databases

SignaLinkiQ59GY7.

Miscellaneous databases

GenomeRNAii6776.
NextBioi26450.

Gene expression databases

BgeeiQ59GY7.
GenevisibleiQ59GY7. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59GY7_HUMAN
AccessioniPrimary (citable) accession number: Q59GY7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 16, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.