ID   Q59GY0_HUMAN            Unreviewed;       212 AA.
AC   Q59GY0;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   24-JAN-2024, entry version 81.
DE   SubName: Full=Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C variant {ECO:0000313|EMBL:BAD92216.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92216.1};
RN   [1] {ECO:0000313|EMBL:BAD92216.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92216.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family. {ECO:0000256|ARBA:ARBA00006576}.
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DR   EMBL; AB208979; BAD92216.1; -; mRNA.
DR   AlphaFoldDB; Q59GY0; -.
DR   SMR; Q59GY0; -.
DR   IntAct; Q59GY0; 1.
DR   MINT; Q59GY0; -.
DR   PeptideAtlas; Q59GY0; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01283; cytidine_deaminase; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_dom.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   PANTHER; PTHR13857:SF46; DNA DC-DU-EDITING ENZYME APOBEC-3C; 1.
DR   PANTHER; PTHR13857; MRNA EDITING ENZYME; 1.
DR   Pfam; PF18782; NAD2; 1.
DR   SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1.
DR   PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein {ECO:0000313|EMBL:BAD92216.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          51..160
FT                   /note="CMP/dCMP-type deaminase"
FT                   /evidence="ECO:0000259|PROSITE:PS51747"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92216.1"
SQ   SEQUENCE   212 AA;  25196 MW;  D8B4CC2B887DA4FC CRC64;
     RKRSHSASEK SGTGTSISKR LNMNPQIRNP MKAMYPGTFY FQFKNLWEAN DRNETWLCFT
     VEGIKRRSVV SWKTGVFRNQ VDSETHCHAE RCFLSWFCDD ILSPNTKYQV TWYTSWSPCP
     DCAGEVAEFL ARHSNVNLTI FTARLYYFQY PCYQEGLRSL SQEGVAVEIM DYEDFKYCWE
     NFVYNDNEPF KPWKGLKTNF RLLKRRLRES LQ
//